SI2699264T1 - Protitelesa in druge molekule, ki vežejo B7-H1 in PD-1 - Google Patents

Protitelesa in druge molekule, ki vežejo B7-H1 in PD-1 Download PDF

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SI2699264T1
SI2699264T1 SI201231320T SI201231320T SI2699264T1 SI 2699264 T1 SI2699264 T1 SI 2699264T1 SI 201231320 T SI201231320 T SI 201231320T SI 201231320 T SI201231320 T SI 201231320T SI 2699264 T1 SI2699264 T1 SI 2699264T1
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antibody
antigen
binding fragment
human
constant
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SI201231320T
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Solomon Langermann
Linda Liu
Shannon Marshall
Sheng Yao
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Medimmune Llc
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/55—Fab or Fab'
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins

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Claims (11)

  1. Protitelesa in druge molekule, ki vežejo B7-H1 in PD-1 Patentni zahtevki
    1. Protitelo ali njegov delec, ki veže antigen, ki se veže na humani PD-1, ki vsebuje variabilno področje lahke verige, ki vsebuje zaporedje aminokislin SEQ ID NO:98 in variabilno področje težke verige, ki vsebuje zaporedje aminokislin SEQ ID NO: 106.
  2. 2. Protitelo ali njegov delec, ki veže antigen po zahtevku 1, kjer protitelo ali njegov delec, ki veže antigen (A) oslabi zmožnost liganda PD-1, da se veže na PD-1; (B) oslabi ali v celoti nevtralizira zmožnost PD-1, da posreduje signalno transdukcijo; (C) posreduje proliferacijo T celic; ali (D) izboljšuje proizvodnjo IFN-γ.
  3. 3. Protitelo ali njegov delec, ki veže antigen po zahtevku 1 ali zahtevku 2, ki vsebuje vsaj del konstantnega področja imunoglobulina (Fc).
  4. 4. Protitelo ali njegov delec, ki veže antigen po zahtevku 3, kjer je konstantno področje imunoglobulina (Fc) konstantno področje humanega imunoglobulina (Fc).
  5. 5. Protitelo ali njegov delec, ki veže antigen po zahtevku 4, kjer so humane konstantne domene domene IgA, IgD, IgE, IgG ali IgM.
  6. 6. Protitelo ali njegov delec, ki veže antigen po kateremkoli zahtevku od 3 do 5, kjer so konstantne domene humanega IgG domene IgGl, IgG2, IgG3, or IgG4.
  7. 7. Protitelo ali njegov delec, ki veže antigen po kateremkoli zahtevku od 1 do 6, kjer je protitelo ali njegov delec, ki veže antigen zaznavno označeno ali vsebuje konjugiran toksin, zdravilo, receptor, encim, ligand receptorja.
  8. 8. Protitelo ali njegov delec, ki veže antigen po kateremkoli zahtevku od 1 do 7, kjer je protitelo monoklonsko protitelo, humano protitelo, himerno protitelo, humanizirano protitelo ali protitelo z eno verigo.
  9. 9. Protitelo ali njegov delec, ki veže antigen po kateremkoli zahtevku od 1 do 8, kjer je protitelo bispecifično, trispecifično ali večspecifično protitelo.
  10. 10. Farmacevtski sestavek, ki vsebuje protitelo ali njegov delec, ki veže antigen po kateremkoli zahtevku od 1 do 9 in fiziološko sprejemljiv nosilec ali ekscipient.
  11. 11. Farmacevtski sestavek po zahtevku 10, za uporabo v zdravljenju raka ali nalezljivih bolezni.
SI201231320T 2011-04-20 2012-04-19 Protitelesa in druge molekule, ki vežejo B7-H1 in PD-1 SI2699264T1 (sl)

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Application Number Priority Date Filing Date Title
US201161477414P 2011-04-20 2011-04-20
PCT/US2012/034223 WO2012145493A1 (en) 2011-04-20 2012-04-19 Antibodies and other molecules that bind b7-h1 and pd-1
EP12774724.4A EP2699264B1 (en) 2011-04-20 2012-04-19 Antibodies and other molecules that bind b7-h1 and pd-1

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EP (2) EP3403672A1 (sl)
JP (2) JP6072771B2 (sl)
KR (1) KR101970025B1 (sl)
CN (1) CN103608040B (sl)
AU (1) AU2012245477C1 (sl)
CA (1) CA2833636A1 (sl)
CY (1) CY1120626T1 (sl)
DK (1) DK2699264T3 (sl)
ES (1) ES2669310T3 (sl)
HR (1) HRP20180893T1 (sl)
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LT (1) LT2699264T (sl)
MX (1) MX338353B (sl)
PL (1) PL2699264T3 (sl)
PT (1) PT2699264T (sl)
RS (1) RS57324B1 (sl)
RU (1) RU2625034C2 (sl)
SI (1) SI2699264T1 (sl)
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