MX369491B - Compuestos tricíclicos como agentes anticancerígenos. - Google Patents

Compuestos tricíclicos como agentes anticancerígenos.

Info

Publication number
MX369491B
MX369491B MX2016007928A MX2016007928A MX369491B MX 369491 B MX369491 B MX 369491B MX 2016007928 A MX2016007928 A MX 2016007928A MX 2016007928 A MX2016007928 A MX 2016007928A MX 369491 B MX369491 B MX 369491B
Authority
MX
Mexico
Prior art keywords
tricyclic compounds
anticancer agents
compounds
tricyclic
compositions
Prior art date
Application number
MX2016007928A
Other languages
English (en)
Other versions
MX2016007928A (es
Inventor
Y Lee Francis
Vaccaro Wayne
S Tokarski John
V Gavai Ashvinikumar
V Delucca George
O'malley Daniel
Gill Patrice
A Quesnelle Claude
J Norris Derek
Kumar Mandal Sunil
V Debenedetto Mikkel
P Degnan Andrew
Fang Haiquan
D Hill Matthew
Huang Hong
d schmitz William
E Starrett John Jr
Ching Han Wen-
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MX2016007928A publication Critical patent/MX2016007928A/es
Publication of MX369491B publication Critical patent/MX369491B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)

Abstract

La presente invención se refiere a compuestos tricíclicos, composiciones farmacéuticamente aceptables que comprenden compuestos de la invención y métodos para usar esas composiciones en el tratamiento de diversos trastornos.
MX2016007928A 2013-12-24 2014-12-23 Compuestos tricíclicos como agentes anticancerígenos. MX369491B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361920500P 2013-12-24 2013-12-24
PCT/US2014/072031 WO2015100282A1 (en) 2013-12-24 2014-12-23 Tricyclic compounds as anticancer agents

Publications (2)

Publication Number Publication Date
MX2016007928A MX2016007928A (es) 2016-08-03
MX369491B true MX369491B (es) 2019-11-11

Family

ID=52293305

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016007928A MX369491B (es) 2013-12-24 2014-12-23 Compuestos tricíclicos como agentes anticancerígenos.

Country Status (33)

Country Link
US (1) US20160318928A1 (es)
EP (2) EP3087071B1 (es)
JP (2) JP6466456B2 (es)
KR (1) KR102457145B1 (es)
CN (2) CN106029663B (es)
AR (2) AR099379A1 (es)
AU (1) AU2014369982B2 (es)
BR (1) BR112016013744B1 (es)
CA (1) CA2934953C (es)
CL (1) CL2016001629A1 (es)
CY (2) CY1121076T1 (es)
DK (2) DK3087071T3 (es)
EA (2) EA032469B1 (es)
ES (2) ES2698998T3 (es)
HR (2) HRP20181849T1 (es)
HU (2) HUE041719T2 (es)
IL (1) IL246359B (es)
LT (2) LT3087071T (es)
MA (1) MA39211B1 (es)
MX (1) MX369491B (es)
MY (1) MY176489A (es)
NZ (1) NZ722326A (es)
PE (1) PE20160844A1 (es)
PH (1) PH12016500953A1 (es)
PL (2) PL3466949T3 (es)
PT (2) PT3087071T (es)
RS (2) RS61479B1 (es)
SG (1) SG11201605097SA (es)
SI (2) SI3087071T1 (es)
TN (1) TN2016000238A1 (es)
TW (2) TWI726544B (es)
UY (1) UY35916A (es)
WO (1) WO2015100282A1 (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2961747B1 (en) 2013-02-27 2017-11-15 Bristol-Myers Squibb Company Carbazole compounds useful as bromodomain inhibitors
RU2016122654A (ru) 2013-11-08 2017-12-14 Дана-Фарбер Кэнсер Инститьют, Инк. Комбинированная терапия злокачественной опухоли с использованием ингибиторов бромодоменового и экстратерминального (вет) белка
HUE041719T2 (hu) * 2013-12-24 2019-05-28 Bristol Myers Squibb Co Triciklikus vegyületek mint rákellenes szerek
US9458156B2 (en) 2014-12-23 2016-10-04 Bristol-Myers Squibb Company Tricyclic compounds as anticancer agents
CN107074861A (zh) * 2014-02-28 2017-08-18 密执安大学评议会 作为bet溴结构域抑制剂的9h嘧啶并[4，5‑b]吲哚和相关类似物
US9725449B2 (en) 2015-05-12 2017-08-08 Bristol-Myers Squibb Company Tricyclic compounds as anticancer agents
EP3307740B1 (en) * 2015-05-12 2019-12-18 Bristol-Myers Squibb Company 5h-pyrido[3,2-b]indole compounds as anticancer agents
CA2991628C (en) * 2015-07-16 2020-04-07 Bioxcel Therapeutics, Inc. A novel approach for treatment of cancer using immunomodulation
MX2018003824A (es) * 2015-10-02 2019-04-01 Dana Farber Cancer Inst Inc Terapia de combinación de inhibidores de bromodominios y bloqueo de puntos de control.
CN108137589B (zh) * 2016-01-20 2021-03-26 宁波文达医药科技有限公司 作为布罗莫区结构域抑制剂的咔啉衍生物
WO2017124934A1 (zh) * 2016-01-20 2017-07-27 宁波文达医药科技有限公司 作为布罗莫区结构域抑制剂的含膦咔啉衍生物
CN108770356A (zh) * 2016-02-05 2018-11-06 正大天晴药业集团股份有限公司 溴区结构域蛋白抑制剂的三环类化合物及其制备、药物组合物和用途
BR112018067330A2 (pt) 2016-03-01 2019-01-22 Corcept Therapeutics Inc método para o tratamento de paciente com carga tumoral
US10150754B2 (en) * 2016-04-19 2018-12-11 Celgene Quanticel Research, Inc. Histone demethylase inhibitors
CN108069976A (zh) 2016-11-10 2018-05-25 山东罗欣药业集团股份有限公司 一种含氮大环类化合物、其制备方法、药物组合物及应用
CN109824693B (zh) * 2017-04-18 2020-12-08 四川大学 Brd4抑制剂及其在肿瘤治疗药物中的应用
CN111356695B (zh) * 2017-10-27 2022-12-30 北京加科思新药研发有限公司 新的三环化合物
CA3104927C (en) * 2018-06-25 2023-09-12 Jacobio Pharmaceuticals Co., Ltd. Tricyclic compounds
CN108840868B (zh) * 2018-08-01 2019-10-18 上海山的实业有限公司 具有抗肿瘤活性的吲哚并吡啶酮类化合物的制备方法及应用
US11234971B2 (en) 2018-12-19 2022-02-01 Corcept Therapeutics Incorporated Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent
WO2020132046A1 (en) 2018-12-19 2020-06-25 Corcept Therapeutics Incorporated Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent
CN113544129B (zh) * 2019-04-04 2024-07-23 上海华汇拓医药科技有限公司 三环类化合物制备方法及其在医药领域的应用
CN110003204B (zh) * 2019-04-30 2020-08-11 上海勋和医药科技有限公司 一种bet蛋白抑制剂、其制备方法及用途
US10947253B2 (en) 2019-08-05 2021-03-16 Ankh Life Sciences Limited Fused polycyclic dimers
AU2020360170A1 (en) 2019-09-30 2022-05-19 Kyowa Kirin Co., Ltd. Bet degrader
KR20230136618A (ko) * 2021-01-22 2023-09-26 징루이 바이오파마 컴퍼니, 리미티드 항암제로서의 트리시클릭 화합물
KR20230148208A (ko) * 2021-02-25 2023-10-24 임팩트 바이오메디신스, 인코포레이티드 골수섬유증과 같은 혈액 악성종양을 치료하기 위한 bet 억제제 단독 또는 페드라티닙 또는 룩솔리티닙과의 조합물의 용도
JP2024517608A (ja) * 2021-05-06 2024-04-23 ラジエル セラピューティクス エルティーディー． 結晶性カルバゾール誘導体
WO2024099441A1 (en) * 2022-11-11 2024-05-16 Jingrui Biopharma (Shandong) Co., Ltd. Bromodomain and extra-terminal (bet) protein degrader

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3427093A (en) * 1992-01-15 1993-08-03 E.I. Du Pont De Nemours And Company Bridged heterocyclic fungicides
WO2005039569A1 (en) 2003-10-18 2005-05-06 Bayer Healthcare Ag 5-substituted 2-(phenylmethyl) thio-4-phenyl-4h-1,2,4-triazole derivatives and related compounds as gaba-agonists for the treatment of urinary incontinence and related diseases
EP1686949A2 (en) * 2003-11-24 2006-08-09 Viropharma Incorporated Compounds, compositions and methods for treatment and prophylaxis of hepatitis c viral infections and associated diseases
TWI380996B (zh) 2004-09-17 2013-01-01 Hoffmann La Roche 抗ｏｘ４０ｌ抗體
JP5238936B2 (ja) 2005-03-25 2013-07-17 ジーアイティーアール，インク． Ｇｉｔｒ結合分子およびその使用
GB0507298D0 (en) 2005-04-11 2005-05-18 Novartis Ag Organic compounds
PT1879573E (pt) 2005-05-10 2013-03-25 Incyte Corp Moduladores de indoleamina 2,3-dioxigenase e métodos de utilização do mesmo
DK1907424T3 (en) 2005-07-01 2015-11-09 Squibb & Sons Llc HUMAN MONOCLONAL ANTIBODIES TO PROGRAMMED death ligand 1 (PD-L1)
WO2007075598A2 (en) 2005-12-20 2007-07-05 Incyte Corporation N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
US7696166B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
EP2064207B1 (en) 2006-09-19 2013-11-06 Incyte Corporation N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
CL2007002650A1 (es) 2006-09-19 2008-02-08 Incyte Corp Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras.
UY30892A1 (es) 2007-02-07 2008-09-02 Smithkline Beckman Corp Inhibidores de la actividad akt
EP1987839A1 (en) 2007-04-30 2008-11-05 I.N.S.E.R.M. Institut National de la Sante et de la Recherche Medicale Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease
ES2776406T3 (es) 2007-07-12 2020-07-30 Gitr Inc Terapias de combinación que emplean moléculas de enlazamiento a GITR
EP2044949A1 (en) 2007-10-05 2009-04-08 Immutep Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response
CA2932121A1 (en) 2007-11-30 2009-06-11 Newlink Genetics Corporation Ido inhibitors
FR2927330B1 (fr) 2008-02-07 2010-02-19 Sanofi Aventis Derives de 5,6-bisaryl-2-pyridine-carboxamide, leur preparation et leur application en therapeutique comme antagonistes des recepteurs a l'urotensine ii
AR072999A1 (es) 2008-08-11 2010-10-06 Medarex Inc Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
CN114835812A (zh) 2008-12-09 2022-08-02 霍夫曼-拉罗奇有限公司 抗-pd-l1抗体及它们用于增强t细胞功能的用途
ES2490867T3 (es) * 2008-12-19 2014-09-04 Bristol-Myers Squibb Company Inhibidores de carbazol y carbolina quinasas
PT3023438T (pt) 2009-09-03 2020-05-08 Merck Sharp & Dohme Anticorpos anti-gitr
WO2011056652A1 (en) 2009-10-28 2011-05-12 Newlink Genetics Imidazole derivatives as ido inhibitors
JP5677451B2 (ja) 2009-12-10 2015-02-25 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 優先的にヒトｃｓｆ１ｒ細胞外ドメイン４に結合する抗体及びそれらの使用
WO2011104334A1 (en) 2010-02-26 2011-09-01 Boehringer Ingelheim International Gmbh 4 - [cycloalkyloxy (hetero) arylamino] thieno [2, 3 - d] pyrimidines having mnkl/ mnk2 inhibiting activity for pharmaceutical compositions
AU2011223782B2 (en) 2010-03-04 2014-09-18 Macrogenics, Inc. Antibodies reactive with B7-H3, immunologically active fragments thereof and uses thereof
KR101647871B1 (ko) 2010-03-05 2016-08-11 에프. 호프만-라 로슈 아게 인간 ｃｓｆ-1ｒ에 대한 항체 및 이의 용도
CA2789076C (en) 2010-03-05 2017-11-21 F. Hoffmann-La Roche Ag Antibodies against human colony stimulating factor-1 receptor and uses thereof
TWI503323B (zh) * 2010-03-29 2015-10-11 Oncotherapy Science Inc 三環化合物以及含此化合物之ｐｂｋ抑制劑
SI2566517T1 (sl) 2010-05-04 2019-01-31 Five Prime Therapeutics, Inc. Protitelesa, ki vežejo CSF1R
US8933072B2 (en) 2010-06-16 2015-01-13 Vitae Pharmaceuticals, Inc. Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
ES2699648T3 (es) 2010-09-09 2019-02-12 Pfizer Moléculas de unión a 4-1BB
NZ609448A (en) * 2010-12-16 2015-07-31 Hoffmann La Roche Tricyclic pi3k inhibitor compounds and methods of use
US8580399B2 (en) * 2011-04-08 2013-11-12 Universal Display Corporation Substituted oligoazacarbazoles for light emitting diodes
NO2694640T3 (es) 2011-04-15 2018-03-17
RU2625034C2 (ru) 2011-04-20 2017-07-11 МЕДИММЬЮН, ЭлЭлСи Антитела и другие молекулы, которые связывают в7-н1 и pd-1
EP2762477A1 (en) * 2011-09-28 2014-08-06 Idemitsu Kosan Co., Ltd Material for organic electroluminescent element, and organic electroluminescent element produced using same
SG11201402603WA (en) 2011-11-28 2014-06-27 Merck Patent Gmbh Anti-pd-l1 antibodies and uses thereof
US10023643B2 (en) 2011-12-15 2018-07-17 Hoffmann-La Roche Inc. Antibodies against human CSF-1R and uses thereof
KR20140127855A (ko) 2012-02-06 2014-11-04 제넨테크, 인크. Csf1r 억제제를 사용하는 조성물 및 방법
AR090263A1 (es) 2012-03-08 2014-10-29 Hoffmann La Roche Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma
AU2012374617B2 (en) 2012-05-11 2015-09-17 Five Prime Therapeutics, Inc. Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (CSF1R)
AR091649A1 (es) 2012-07-02 2015-02-18 Bristol Myers Squibb Co Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos
EP2890398A4 (en) 2012-08-31 2016-03-09 Five Prime Therapeutics Inc METHODS OF TREATING DISEASES WITH ANTIBODIES THAT BIND COLONY STIMULATING FACTOR RECEIVER 1 (CSF1R)
UA115576C2 (uk) 2012-12-06 2017-11-27 Байєр Фарма Акцієнгезелльшафт Похідні бензимідазолу як антагоністи ер4
US9492460B2 (en) * 2013-02-27 2016-11-15 Bristol-Myers Squibb Company Carbazole compounds useful as bromodomain inhibitors
EP2961747B1 (en) * 2013-02-27 2017-11-15 Bristol-Myers Squibb Company Carbazole compounds useful as bromodomain inhibitors
AU2014249192B2 (en) * 2013-03-11 2017-12-21 The Regents Of The University Of Michigan BET bromodomain inhibitors and therapeutic methods using the same
HUE041719T2 (hu) * 2013-12-24 2019-05-28 Bristol Myers Squibb Co Triciklikus vegyületek mint rákellenes szerek

Also Published As

Publication number Publication date
DK3087071T3 (da) 2019-01-02
US20160318928A1 (en) 2016-11-03
PH12016500953A1 (en) 2016-06-27
HRP20210212T1 (hr) 2021-07-09
AU2014369982B2 (en) 2019-04-18
JP6675501B2 (ja) 2020-04-01
EA032469B1 (ru) 2019-05-31
AR123996A2 (es) 2023-02-01
PT3466949T (pt) 2021-02-25
ES2857848T3 (es) 2021-09-29
KR20160095168A (ko) 2016-08-10
KR102457145B1 (ko) 2022-10-19
MY176489A (en) 2020-08-12
WO2015100282A1 (en) 2015-07-02
DK3466949T3 (da) 2021-03-15
BR112016013744A2 (es) 2017-10-03
HUE041719T2 (hu) 2019-05-28
CL2016001629A1 (es) 2017-02-17
SI3087071T1 (sl) 2018-11-30
AU2014369982A1 (en) 2016-08-04
PL3466949T3 (pl) 2021-05-31
LT3087071T (lt) 2018-11-12
MA39211A1 (fr) 2018-08-31
HUE054183T2 (hu) 2021-08-30
LT3466949T (lt) 2021-03-25
SI3466949T1 (sl) 2021-03-31
TW202028203A (zh) 2020-08-01
JP2017505762A (ja) 2017-02-23
EP3466949B1 (en) 2020-12-23
PE20160844A1 (es) 2016-09-03
HRP20181849T1 (hr) 2018-12-28
TN2016000238A1 (en) 2017-10-06
RS58014B1 (sr) 2019-02-28
TWI736517B (zh) 2021-08-21
CN108558871B (zh) 2022-02-18
TWI726544B (zh) 2021-05-01
AR099379A1 (es) 2016-07-20
ES2698998T3 (es) 2019-02-06
CN108558871A (zh) 2018-09-21
MA39211B1 (fr) 2019-01-31
JP6466456B2 (ja) 2019-02-06
UY35916A (es) 2015-06-30
PT3087071T (pt) 2018-11-29
CN106029663A (zh) 2016-10-12
EP3466949A1 (en) 2019-04-10
TW201609725A (zh) 2016-03-16
NZ722326A (en) 2019-09-27
IL246359B (en) 2020-04-30
EA201691070A1 (ru) 2016-11-30
CN106029663B (zh) 2018-06-01
CY1124061T1 (el) 2022-05-27
EA201990240A1 (ru) 2019-06-28
MX2016007928A (es) 2016-08-03
PL3087071T3 (pl) 2019-03-29
SG11201605097SA (en) 2016-07-28
JP2019070014A (ja) 2019-05-09
RS61479B1 (sr) 2021-03-31
CA2934953C (en) 2022-09-20
IL246359A0 (en) 2016-08-31
EP3087071B1 (en) 2018-09-05
CY1121076T1 (el) 2019-12-11
BR112016013744B1 (pt) 2022-08-30
HRP20210212T8 (hr) 2021-08-20
EP3087071A1 (en) 2016-11-02
CA2934953A1 (en) 2015-07-02

Similar Documents

Publication Publication Date Title
PH12016500953A1 (en) Tricyclic compounds as anticancer agents
MX2015010921A (es) Compuestos de carbazol utiles como inhibidores de bromodominio.
MY196319A (en) Polycyclic TLR7/8 Antagonists and use Thereof in the Treatment of Immune Disorders
MX2015012502A (es) Inhibidores de proteina cinasa dependiente de adn.
MX2016002544A (es) Compuestos utiles como inmunomoduladores.
IN2015DN01156A (es)
MX2015011898A (es) Compuestos de pirazolo y usos de los mismos.
IN2014KN02601A (es)
MY181602A (en) Isochromene derivatives as phosphoinositide 3-kinases inhibitors
PH12016502291A1 (en) Indolizine derivatives as phosphoinositide 3-kinases inhibitors
MX2015014181A (es) 2-acetilnafto [2,3-b]furano -4,9-diona para uso en el tratamiento del cáncer.
MX2016003823A (es) Inhibidor selectivo de fosfatidil-inositol 3-cinasa-gamma.
AU2018253600A1 (en) Dosage forms and therapeutic uses of l-4-chlorokynurenine
MX2016006975A (es) Compuestos, composicion farmaceutica y metodos para su uso en el tratamiento de enfermedades inflamatorias.
PH12016500495A1 (en) Compositions for the treatment of hypertension and/or fibrosis
MX2015000179A (es) Composiciones y formas de dosificacion de itraconazol y metodos de uso de las mismas.
NZ629475A (en) Pharmaceutical composition comprising benzyl alcohol for the treatment of migraines
IN2013CH02437A (es)

Legal Events

Date Code Title Description
FG Grant or registration