MX2019000252A - Administracion viral oncolitica pseudotipada de polipeptidos terapeuticos. - Google Patents

Administracion viral oncolitica pseudotipada de polipeptidos terapeuticos.

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Publication number
MX2019000252A
MX2019000252A MX2019000252A MX2019000252A MX2019000252A MX 2019000252 A MX2019000252 A MX 2019000252A MX 2019000252 A MX2019000252 A MX 2019000252A MX 2019000252 A MX2019000252 A MX 2019000252A MX 2019000252 A MX2019000252 A MX 2019000252A
Authority
MX
Mexico
Prior art keywords
pseudotyped oncolytic
viral delivery
therapeutic polypeptides
oncolytic viral
pseudotyped
Prior art date
Application number
MX2019000252A
Other languages
English (en)
Inventor
Evnin Luke
Original Assignee
Oncorus Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncorus Inc filed Critical Oncorus Inc
Publication of MX2019000252A publication Critical patent/MX2019000252A/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
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    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

En el presente documento se describen virus oncolíticos pseudotipados que comprenden ácidos nucleicos que codifican una molécula de engrane. En algunas realizaciones, los virus oncolíticos pseudotipados comprenden ácidos nucleicos que codifican una molécula activa y una o más moléculas terapéuticas. Las composiciones farmacéuticas que contienen el virus oncolítico pseudotipado y los métodos para tratar el cáncer usando los virus oncolíticos pseudotipados se proporcionan adicionalmente en este documento.
MX2019000252A 2016-06-30 2017-06-30 Administracion viral oncolitica pseudotipada de polipeptidos terapeuticos. MX2019000252A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662357195P 2016-06-30 2016-06-30
PCT/US2017/040354 WO2018006005A1 (en) 2016-06-30 2017-06-30 Pseudotyped oncolytic viral delivery of therapeutic polypeptides

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MX2019000252A true MX2019000252A (es) 2019-10-09

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US (3) US20180057594A1 (es)
EP (1) EP3478321A4 (es)
JP (3) JP2019519245A (es)
KR (1) KR20190035714A (es)
CN (1) CN109983121A (es)
AU (1) AU2017290828A1 (es)
BR (1) BR112019000015A2 (es)
CA (1) CA3029426A1 (es)
IL (2) IL263879B (es)
MX (1) MX2019000252A (es)
RU (2) RU2021127872A (es)
SG (1) SG11201811600PA (es)
WO (1) WO2018006005A1 (es)

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US10888549B2 (en) 2016-03-07 2021-01-12 The Johns Hopkins University Pharmaceutical agents targeting cancer stem cells
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