CL2019000392A1 - Métodos para detectar aav. - Google Patents
Métodos para detectar aav.Info
- Publication number
- CL2019000392A1 CL2019000392A1 CL2019000392A CL2019000392A CL2019000392A1 CL 2019000392 A1 CL2019000392 A1 CL 2019000392A1 CL 2019000392 A CL2019000392 A CL 2019000392A CL 2019000392 A CL2019000392 A CL 2019000392A CL 2019000392 A1 CL2019000392 A1 CL 2019000392A1
- Authority
- CL
- Chile
- Prior art keywords
- methods
- aav
- particles
- heterogeneity
- particle
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000002245 particle Substances 0.000 abstract 6
- 241000700605 Viruses Species 0.000 abstract 2
- 102100025907 Dyslexia-associated protein KIAA0319-like protein Human genes 0.000 abstract 1
- 101710205593 Dyslexia-associated protein KIAA0319-like protein Proteins 0.000 abstract 1
- 230000021736 acetylation Effects 0.000 abstract 1
- 238000006640 acetylation reaction Methods 0.000 abstract 1
- 230000006240 deamidation Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000026683 transduction Effects 0.000 abstract 1
- 238000010361 transduction Methods 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
- G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14123—Virus like particles [VLP]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14151—Methods of production or purification of viral material
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N2030/022—Column chromatography characterised by the kind of separation mechanism
- G01N2030/027—Liquid chromatography
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/01—DNA viruses
- G01N2333/075—Adenoviridae
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Photoreceptors In Electrophotography (AREA)
Abstract
EN LA PRESENTE MEMORIA SE PROPORCIONAN MÉTODOS PARA DETERMINAR EL SEROTIPO DE UNA PARTÍCULA DE VIRUS Y/O PARA DETERMINAR LA HETEROGENEIDAD DE UNA PARTÍCULA DE VIRUS (P. EJ., UNA PARTÍCULA DE AAV). EN OTRAS REALIZACIONES, LA INVENCIÓN PROPORCIONA MÉTODOS PARA DETERMINAR LA HETEROGENEIDAD DE PARTÍCULAS DE AAV. EN ALGUNOS ASPECTOS, LA INVENCIÓN PROPORCIONA PARTÍCULAS VIRALES (P. EJ., PARTÍCULAS DE AAVR) CON ESTABILIDAD MEJORADA Y/O EFICIENCIA DE LA TRANSDUCCIÓN MEJORADA MEDIANTE EL INCREMENTO DE LA ACETILACIÓN Y/O DESAMIDACIÓN DE LAS PROTEÍNAS DE LA CÁPSIDE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662375314P | 2016-08-15 | 2016-08-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2019000392A1 true CL2019000392A1 (es) | 2019-05-10 |
Family
ID=59762045
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2019000392A CL2019000392A1 (es) | 2016-08-15 | 2019-02-13 | Métodos para detectar aav. |
CL2019002912A CL2019002912A1 (es) | 2016-08-15 | 2019-10-14 | Métodos para detectar aav. (divisional solicitud 201900392). |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2019002912A CL2019002912A1 (es) | 2016-08-15 | 2019-10-14 | Métodos para detectar aav. (divisional solicitud 201900392). |
Country Status (23)
Country | Link |
---|---|
US (2) | US11698377B2 (es) |
EP (2) | EP3851449A1 (es) |
JP (3) | JP7021191B2 (es) |
KR (3) | KR102538037B1 (es) |
CN (1) | CN110168080B (es) |
AU (2) | AU2017312951B2 (es) |
BR (1) | BR112019002934A2 (es) |
CA (1) | CA3033856A1 (es) |
CL (2) | CL2019000392A1 (es) |
CR (1) | CR20190127A (es) |
CY (1) | CY1124364T1 (es) |
DK (1) | DK3497207T3 (es) |
ES (1) | ES2863674T3 (es) |
HU (1) | HUE053747T2 (es) |
IL (1) | IL264819B1 (es) |
MA (1) | MA55748A (es) |
MX (2) | MX2019001938A (es) |
PH (1) | PH12019500316A1 (es) |
SG (2) | SG11201901221YA (es) |
TN (1) | TN2019000047A1 (es) |
TW (2) | TW202309068A (es) |
WO (1) | WO2018035059A1 (es) |
ZA (1) | ZA201900945B (es) |
Families Citing this family (19)
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GB201508026D0 (en) | 2015-05-11 | 2015-06-24 | Ucl Business Plc | Capsid |
JOP20190200A1 (ar) | 2017-02-28 | 2019-08-27 | Univ Pennsylvania | تركيبات نافعة في معالجة ضمور العضل النخاعي |
SG11201907714UA (en) | 2017-02-28 | 2019-09-27 | Univ Pennsylvania | Adeno-associated virus (aav) clade f vector and uses therefor |
KR20210006327A (ko) * | 2018-02-27 | 2021-01-18 | 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 | 캡시드 탈아미드화가 감소된 신규 아데노-연관 바이러스(aav) 벡터 및 이의 용도 |
CA3091806A1 (en) * | 2018-02-27 | 2019-09-06 | The Trustees Of The University Of Pennsylvania | Novel adeno-associated virus (aav) vectors, aav vectors having reduced capsid deamidation and uses therefor |
US20210010028A1 (en) * | 2018-03-06 | 2021-01-14 | Voyager Therapeutics, Inc. | Insect cell manufactured partial self-complementary aav genomes |
US11391707B2 (en) * | 2018-07-27 | 2022-07-19 | Waters Technologies Corporation | Liquid chromatography/mass spectrometry methods for the analysis of polar molecules |
US20210317478A1 (en) * | 2018-08-21 | 2021-10-14 | Massachusetts Eye And Ear Infirmary | Compositions and methods for modulating transduction efficiency of adeno-associated viruses |
EP3870976B1 (en) * | 2018-10-25 | 2023-11-29 | Regeneron Pharmaceuticals, Inc. | Methods for analysis of viral capsid protein composition |
US20230204595A1 (en) | 2020-01-03 | 2023-06-29 | Sarepta Therapeutics, Inc. | Methods for analyzing aav capsid proteins |
JP2023513004A (ja) | 2020-01-29 | 2023-03-30 | ジェンザイム・コーポレーション | 眼科遺伝子療法のための改変されたアデノ随伴ウイルスカプシドタンパク質およびその使用方法 |
CN111517359B (zh) * | 2020-04-23 | 2021-08-20 | 江南大学 | 一种手性硫化铜超粒子的合成方法 |
RU2748540C1 (ru) * | 2021-02-08 | 2021-05-26 | Автономная некоммерческая образовательная организация высшего образования "Сколковский институт науки и технологий" | Способ детектирования вируса SARS-CoV-2 методом масс-спектрометрии |
EP4295158A1 (en) * | 2021-02-19 | 2023-12-27 | Waters Technologies Corporation | Methods for peptide mapping of adeno-associated virus (aav) proteins |
WO2022224965A1 (ja) * | 2021-04-20 | 2022-10-27 | 株式会社ユニバーサル・バイオサンプリング | 検体保持カード及びそれを用いた検体の検査方法 |
WO2023287724A1 (en) * | 2021-07-12 | 2023-01-19 | Regeneron Pharmaceuticals, Inc. | Online native mass spectrometry methods for assaying viral particles |
KR20240031375A (ko) * | 2021-07-12 | 2024-03-07 | 리제너론 파아마슈티컬스, 인크. | 2차원 액체 크로마토그래피-질량 분광분석을 사용하여 바이러스 입자를 특성화하는 방법 |
CN113552349B (zh) * | 2021-07-30 | 2022-07-19 | 上海勉亦生物科技有限公司 | Aav蛋白外壳的检测方法 |
WO2023132338A1 (ja) * | 2022-01-06 | 2023-07-13 | 富士フイルム株式会社 | タンパク質における糖が結合したアミノ酸部位を同定する方法、及びキット |
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US6204059B1 (en) * | 1994-06-30 | 2001-03-20 | University Of Pittsburgh | AAV capsid vehicles for molecular transfer |
WO1998010088A1 (en) | 1996-09-06 | 1998-03-12 | Trustees Of The University Of Pennsylvania | An inducible method for production of recombinant adeno-associated viruses utilizing t7 polymerase |
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US6989264B2 (en) | 1997-09-05 | 2006-01-24 | Targeted Genetics Corporation | Methods for generating high titer helper-free preparations of released recombinant AAV vectors |
JP4827353B2 (ja) | 1999-08-09 | 2011-11-30 | ターゲティッド ジェネティクス コーポレイション | 鎖内塩基対を形成するような配列の設計による、組換えウイルスベクターからの一本鎖の異種ヌクレオチド配列の発現の増大 |
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WO2006119432A2 (en) | 2005-04-29 | 2006-11-09 | The Government Of The U.S.A., As Rep. By The Sec., Dept. Of Health & Human Services | Isolation, cloning and characterization of new adeno-associated virus (aav) serotypes |
EP2311967B1 (en) * | 2005-10-20 | 2017-09-20 | UniQure IP B.V. | Improved AAV vectors produced in insect cells |
WO2007120542A2 (en) | 2006-03-30 | 2007-10-25 | The Board Of Trustees Of The Leland Stanford Junior University | Aav capsid library and aav capsid proteins |
EP2342567A1 (en) | 2008-09-19 | 2011-07-13 | Charité Universitätsmedizin Berlin | Identification and characterisation of recombinant viral gene therapy vectors |
WO2010093784A2 (en) | 2009-02-11 | 2010-08-19 | The University Of North Carolina At Chapel Hill | Modified virus vectors and methods of making and using the same |
CA3077531C (en) | 2009-06-16 | 2022-09-20 | Genzyme Corporation | Improved methods for purification of recombinant aav vectors |
EP2826860B1 (en) | 2010-04-23 | 2018-08-22 | University of Massachusetts | CNS targeting AAV vectors and methods of use thereof |
US20130217789A1 (en) * | 2010-09-03 | 2013-08-22 | North Carolina Central University | Biodegradable liquogel and ph sensitive nanocarriers |
US8663624B2 (en) | 2010-10-06 | 2014-03-04 | The Regents Of The University Of California | Adeno-associated virus virions with variant capsid and methods of use thereof |
ES2724800T3 (es) | 2011-02-17 | 2019-09-16 | Univ Pennsylvania | Composiciones y métodos para alterar la especificidad de tejido y mejorar la transferencia génica mediada por AAV9 |
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2017
- 2017-08-14 MX MX2019001938A patent/MX2019001938A/es unknown
- 2017-08-14 ES ES17761362T patent/ES2863674T3/es active Active
- 2017-08-14 TN TNP/2019/000047A patent/TN2019000047A1/en unknown
- 2017-08-14 AU AU2017312951A patent/AU2017312951B2/en active Active
- 2017-08-14 SG SG11201901221YA patent/SG11201901221YA/en unknown
- 2017-08-14 KR KR1020227025409A patent/KR102538037B1/ko active IP Right Grant
- 2017-08-14 EP EP20210237.2A patent/EP3851449A1/en active Pending
- 2017-08-14 CN CN201780063531.7A patent/CN110168080B/zh active Active
- 2017-08-14 EP EP17761362.7A patent/EP3497207B1/en active Active
- 2017-08-14 KR KR1020197007381A patent/KR102425289B1/ko active IP Right Grant
- 2017-08-14 US US16/325,653 patent/US11698377B2/en active Active
- 2017-08-14 CA CA3033856A patent/CA3033856A1/en active Pending
- 2017-08-14 KR KR1020237017707A patent/KR20230078834A/ko not_active Application Discontinuation
- 2017-08-14 WO PCT/US2017/046814 patent/WO2018035059A1/en unknown
- 2017-08-14 IL IL264819A patent/IL264819B1/en unknown
- 2017-08-14 BR BR112019002934-6A patent/BR112019002934A2/pt unknown
- 2017-08-14 CR CR20190127A patent/CR20190127A/es unknown
- 2017-08-14 HU HUE17761362A patent/HUE053747T2/hu unknown
- 2017-08-14 SG SG10201913002QA patent/SG10201913002QA/en unknown
- 2017-08-14 JP JP2019508235A patent/JP7021191B2/ja active Active
- 2017-08-14 DK DK17761362.7T patent/DK3497207T3/da active
- 2017-08-14 MA MA055748A patent/MA55748A/fr unknown
- 2017-08-15 TW TW111138258A patent/TW202309068A/zh unknown
- 2017-08-15 TW TW106127648A patent/TWI781953B/zh active
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2019
- 2019-02-13 CL CL2019000392A patent/CL2019000392A1/es unknown
- 2019-02-14 PH PH12019500316A patent/PH12019500316A1/en unknown
- 2019-02-14 ZA ZA2019/00945A patent/ZA201900945B/en unknown
- 2019-02-15 MX MX2023009081A patent/MX2023009081A/es unknown
- 2019-10-14 CL CL2019002912A patent/CL2019002912A1/es unknown
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2021
- 2021-03-24 CY CY20211100262T patent/CY1124364T1/el unknown
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2022
- 2022-02-02 JP JP2022014629A patent/JP2022064980A/ja active Pending
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2023
- 2023-05-22 US US18/321,542 patent/US20240044910A1/en active Pending
- 2023-11-30 JP JP2023202414A patent/JP2024023460A/ja active Pending
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2024
- 2024-01-18 AU AU2024200349A patent/AU2024200349A1/en active Pending
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