SG10201913002QA - Methods for detecting aav - Google Patents

Methods for detecting aav

Info

Publication number
SG10201913002QA
SG10201913002QA SG10201913002QA SG10201913002QA SG10201913002QA SG 10201913002Q A SG10201913002Q A SG 10201913002QA SG 10201913002Q A SG10201913002Q A SG 10201913002QA SG 10201913002Q A SG10201913002Q A SG 10201913002QA SG 10201913002Q A SG10201913002Q A SG 10201913002QA
Authority
SG
Singapore
Prior art keywords
methods
aav
detecting
detecting aav
Prior art date
Application number
SG10201913002QA
Inventor
Xiaoying Jin
Catherine O'riordan
Lin Liu
Kate Zhang
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=59762045&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG10201913002Q(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of SG10201913002QA publication Critical patent/SG10201913002QA/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14123—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14151—Methods of production or purification of viral material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/01—DNA viruses
    • G01N2333/075—Adenoviridae

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Photoreceptors In Electrophotography (AREA)
SG10201913002QA 2016-08-15 2017-08-14 Methods for detecting aav SG10201913002QA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662375314P 2016-08-15 2016-08-15

Publications (1)

Publication Number Publication Date
SG10201913002QA true SG10201913002QA (en) 2020-03-30

Family

ID=59762045

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201913002QA SG10201913002QA (en) 2016-08-15 2017-08-14 Methods for detecting aav
SG11201901221YA SG11201901221YA (en) 2016-08-15 2017-08-14 Methods for detecting aav

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201901221YA SG11201901221YA (en) 2016-08-15 2017-08-14 Methods for detecting aav

Country Status (23)

Country Link
US (2) US11698377B2 (en)
EP (2) EP3851449A1 (en)
JP (3) JP7021191B2 (en)
KR (3) KR20230078834A (en)
CN (1) CN110168080B (en)
AU (2) AU2017312951B2 (en)
BR (1) BR112019002934A2 (en)
CA (1) CA3033856A1 (en)
CL (2) CL2019000392A1 (en)
CR (1) CR20190127A (en)
CY (1) CY1124364T1 (en)
DK (1) DK3497207T3 (en)
ES (1) ES2863674T3 (en)
HU (1) HUE053747T2 (en)
IL (1) IL264819B1 (en)
MA (1) MA55748A (en)
MX (2) MX2019001938A (en)
PH (1) PH12019500316A1 (en)
SG (2) SG10201913002QA (en)
TN (1) TN2019000047A1 (en)
TW (2) TWI781953B (en)
WO (1) WO2018035059A1 (en)
ZA (1) ZA201900945B (en)

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US11827906B2 (en) * 2017-02-28 2023-11-28 The Trustees Of The University Of Pennsylvania Adeno-associated virus (AAV) clade f vector and uses therefor
JOP20190200A1 (en) 2017-02-28 2019-08-27 Univ Pennsylvania Compositions useful in treatment of spinal muscular atrophy
CA3091806A1 (en) * 2018-02-27 2019-09-06 The Trustees Of The University Of Pennsylvania Novel adeno-associated virus (aav) vectors, aav vectors having reduced capsid deamidation and uses therefor
KR20210006327A (en) * 2018-02-27 2021-01-18 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 Novel adeno-associated virus (AAV) vectors with reduced capsid deamidation and uses thereof
WO2019173434A1 (en) * 2018-03-06 2019-09-12 Voyager Therapeutics, Inc. Insect cell manufactured partial self-complementary aav genomes
CN112955239B (en) * 2018-07-27 2022-11-29 沃特世科技公司 Liquid chromatography/mass spectrometry method for polar molecule analysis
EP3841109A4 (en) * 2018-08-21 2022-09-21 Massachusetts Eye and Ear Infirmary Compositions and methods for modulating transduction efficiency of adeno-associated viruses
US11345929B2 (en) * 2018-10-25 2022-05-31 Regeneron Pharmaceuticals, Inc. Methods for analysis of viral capsid protein composition
JP2023509122A (en) 2020-01-03 2023-03-07 サレプタ セラピューティクス， インコーポレイテッド Methods for analyzing AAV capsid proteins
TW202142552A (en) 2020-01-29 2021-11-16 美商健臻公司 Modified adeno-associated viral capsid proteins for ocular gene therapy and methods of use thereof
CN111517359B (en) * 2020-04-23 2021-08-20 江南大学 Synthesis method of chiral copper sulfide super particle
RU2748540C1 (en) * 2021-02-08 2021-05-26 Автономная некоммерческая образовательная организация высшего образования "Сколковский институт науки и технологий" Method for detecting sars-cov-2 virus by mass spectrometry
WO2022175728A1 (en) * 2021-02-19 2022-08-25 Waters Technologies Corporation Methods for peptide mapping of adeno-associated virus (aav) proteins
JPWO2022224965A1 (en) * 2021-04-20 2022-10-27
US20230016717A1 (en) * 2021-07-12 2023-01-19 Regeneron Pharmaceuticals, Inc. Methods for Viral Particle Characterization Using Two-Dimensional Liquid Chromatography-Mass Spectrometry
AU2022311770A1 (en) * 2021-07-12 2024-01-25 Regeneron Pharmaceuticals, Inc. Online native mass spectrometry methods for assaying viral particles
CN113552349B (en) * 2021-07-30 2022-07-19 上海勉亦生物科技有限公司 Detection method of AAV protein coat
WO2023132338A1 (en) * 2022-01-06 2023-07-13 富士フイルム株式会社 Method and kit for identifying sugar-bound amino acid site in protein

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Also Published As

Publication number Publication date
KR102425289B1 (en) 2022-07-27
US20240044910A1 (en) 2024-02-08
CN110168080A (en) 2019-08-23
CN110168080B (en) 2024-05-31
JP2019533803A (en) 2019-11-21
WO2018035059A1 (en) 2018-02-22
DK3497207T3 (en) 2021-03-22
AU2017312951A1 (en) 2019-04-04
JP2022064980A (en) 2022-04-26
RU2019107207A (en) 2020-09-15
WO2018035059A9 (en) 2019-03-14
EP3851449A1 (en) 2021-07-21
US20210041451A1 (en) 2021-02-11
ZA201900945B (en) 2021-06-30
CR20190127A (en) 2019-06-25
CA3033856A1 (en) 2018-02-22
EP3497207A1 (en) 2019-06-19
SG11201901221YA (en) 2019-03-28
BR112019002934A2 (en) 2019-05-14
CL2019002912A1 (en) 2020-03-06
MA55748A (en) 2022-03-02
IL264819A (en) 2019-04-30
KR20220107327A (en) 2022-08-02
CL2019000392A1 (en) 2019-05-10
KR102538037B1 (en) 2023-05-30
US11698377B2 (en) 2023-07-11
JP7021191B2 (en) 2022-02-16
TW202309068A (en) 2023-03-01
AU2017312951B2 (en) 2024-02-08
TWI781953B (en) 2022-11-01
JP2024023460A (en) 2024-02-21
TN2019000047A1 (en) 2020-07-15
KR20230078834A (en) 2023-06-02
TW201825898A (en) 2018-07-16
MX2019001938A (en) 2019-07-04
PH12019500316A1 (en) 2019-08-05
ES2863674T3 (en) 2021-10-11
AU2024200349A1 (en) 2024-02-08
KR20190039253A (en) 2019-04-10
CY1124364T1 (en) 2022-07-22
RU2019107207A3 (en) 2021-04-29
MX2023009081A (en) 2023-08-08
HUE053747T2 (en) 2021-07-28
EP3497207B1 (en) 2021-01-06
IL264819B1 (en) 2024-06-01

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