BR112019002934A2 - métodos para detecção de aav - Google Patents

métodos para detecção de aav

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Publication number
BR112019002934A2
BR112019002934A2 BR112019002934-6A BR112019002934A BR112019002934A2 BR 112019002934 A2 BR112019002934 A2 BR 112019002934A2 BR 112019002934 A BR112019002934 A BR 112019002934A BR 112019002934 A2 BR112019002934 A2 BR 112019002934A2
Authority
BR
Brazil
Prior art keywords
aav
determining
detection methods
particles
heterogeneity
Prior art date
Application number
BR112019002934-6A
Other languages
English (en)
Inventor
Jin Xiaoying
R. O'riordan Catherine
Liu Lin
Zhang Kate
Original Assignee
Genzyme Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=59762045&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112019002934(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genzyme Corporation filed Critical Genzyme Corporation
Publication of BR112019002934A2 publication Critical patent/BR112019002934A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14123—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14151—Methods of production or purification of viral material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/01—DNA viruses
    • G01N2333/075—Adenoviridae

Abstract

a presente invenção refere-se a métodos para determinar o sorotipo de uma partícula de vírus e/ou determinar a heterogeneidade de uma partícula de vírus (por exemplo, uma partícula de aav). em outras modalidades, a invenção fornece métodos para determinar a heterogeneidade de partículas de aav. em alguns aspectos, a invenção fornece partículas virais (por exemplo, partículas de raav) com melhor estabilidade e/ou eficiência de transdução melhorada, aumentando a acetilação e/ou desaminação de proteínas do capsídeo.
BR112019002934-6A 2016-08-15 2017-08-14 métodos para detecção de aav BR112019002934A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662375314P 2016-08-15 2016-08-15
US62/375,314 2016-08-15
PCT/US2017/046814 WO2018035059A1 (en) 2016-08-15 2017-08-14 Methods for detecting aav

Publications (1)

Publication Number Publication Date
BR112019002934A2 true BR112019002934A2 (pt) 2019-05-14

Family

ID=59762045

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019002934-6A BR112019002934A2 (pt) 2016-08-15 2017-08-14 métodos para detecção de aav

Country Status (22)

Country Link
US (2) US11698377B2 (pt)
EP (2) EP3497207B1 (pt)
JP (3) JP7021191B2 (pt)
KR (3) KR102425289B1 (pt)
CN (1) CN110168080A (pt)
AU (2) AU2017312951B2 (pt)
BR (1) BR112019002934A2 (pt)
CA (1) CA3033856A1 (pt)
CL (2) CL2019000392A1 (pt)
CR (1) CR20190127A (pt)
CY (1) CY1124364T1 (pt)
DK (1) DK3497207T3 (pt)
ES (1) ES2863674T3 (pt)
HU (1) HUE053747T2 (pt)
MA (1) MA55748A (pt)
MX (2) MX2019001938A (pt)
PH (1) PH12019500316A1 (pt)
SG (2) SG10201913002QA (pt)
TN (1) TN2019000047A1 (pt)
TW (2) TW202309068A (pt)
WO (1) WO2018035059A1 (pt)
ZA (1) ZA201900945B (pt)

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CN111517359B (zh) * 2020-04-23 2021-08-20 江南大学 一种手性硫化铜超粒子的合成方法
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KR102538037B1 (ko) 2023-05-30
EP3851449A1 (en) 2021-07-21
EP3497207A1 (en) 2019-06-19
AU2017312951A1 (en) 2019-04-04
SG10201913002QA (en) 2020-03-30
KR102425289B1 (ko) 2022-07-27
EP3497207B1 (en) 2021-01-06
JP2019533803A (ja) 2019-11-21
ZA201900945B (en) 2021-06-30
AU2024200349A1 (en) 2024-02-08
MX2019001938A (es) 2019-07-04
US20240044910A1 (en) 2024-02-08
SG11201901221YA (en) 2019-03-28
CN110168080A (zh) 2019-08-23
KR20220107327A (ko) 2022-08-02
JP2024023460A (ja) 2024-02-21
TN2019000047A1 (en) 2020-07-15
CL2019000392A1 (es) 2019-05-10
WO2018035059A1 (en) 2018-02-22
US11698377B2 (en) 2023-07-11
CA3033856A1 (en) 2018-02-22
KR20190039253A (ko) 2019-04-10
US20210041451A1 (en) 2021-02-11
RU2019107207A (ru) 2020-09-15
TW202309068A (zh) 2023-03-01
KR20230078834A (ko) 2023-06-02
RU2019107207A3 (pt) 2021-04-29
CL2019002912A1 (es) 2020-03-06
TWI781953B (zh) 2022-11-01
JP7021191B2 (ja) 2022-02-16
PH12019500316A1 (en) 2019-08-05
CR20190127A (es) 2019-06-25
MX2023009081A (es) 2023-08-08
HUE053747T2 (hu) 2021-07-28
WO2018035059A9 (en) 2019-03-14
ES2863674T3 (es) 2021-10-11
TW201825898A (zh) 2018-07-16
JP2022064980A (ja) 2022-04-26
DK3497207T3 (da) 2021-03-22
CY1124364T1 (el) 2022-07-22
AU2017312951B2 (en) 2024-02-08
MA55748A (fr) 2022-03-02

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