MX2020005282A - Vector para la produccion de particulas aav. - Google Patents

Vector para la produccion de particulas aav.

Info

Publication number
MX2020005282A
MX2020005282A MX2020005282A MX2020005282A MX2020005282A MX 2020005282 A MX2020005282 A MX 2020005282A MX 2020005282 A MX2020005282 A MX 2020005282A MX 2020005282 A MX2020005282 A MX 2020005282A MX 2020005282 A MX2020005282 A MX 2020005282A
Authority
MX
Mexico
Prior art keywords
production
vector
aav particles
repgenes
nucleic acid
Prior art date
Application number
MX2020005282A
Other languages
English (en)
Inventor
Ryan Cawood
Alissa Sarah Bray
Thomas Augustus Payne
Original Assignee
Oxford Genetics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=61283699&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2020005282(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Oxford Genetics Ltd filed Critical Oxford Genetics Ltd
Publication of MX2020005282A publication Critical patent/MX2020005282A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14151—Methods of production or purification of viral material
    • C12N2750/14152—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invencion se refiere a la produccion de plasmidos que son utiles en la produccion de particulas de virus adenoasociados (AAV). En particular, la invencion proporciona moleculas de acido nucleico que comprenden genes cap y genes rep, en donde los genes cap y rep se asocian ambos operativamente con el mismo promotor. La invencion proporciona, ademas, celulas huesped que comprenden moleculas de acido nucleico de la invencion y metodos para su uso.
MX2020005282A 2018-01-19 2019-01-18 Vector para la produccion de particulas aav. MX2020005282A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1800903.5A GB201800903D0 (en) 2018-01-19 2018-01-19 Vectors
PCT/GB2019/050134 WO2019141993A1 (en) 2018-01-19 2019-01-18 Vector for the production of aav particles

Publications (1)

Publication Number Publication Date
MX2020005282A true MX2020005282A (es) 2020-08-13

Family

ID=61283699

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020005282A MX2020005282A (es) 2018-01-19 2019-01-18 Vector para la produccion de particulas aav.

Country Status (12)

Country Link
US (1) US11697824B2 (es)
EP (1) EP3697917B1 (es)
JP (1) JP7140830B2 (es)
KR (1) KR102499953B1 (es)
CN (1) CN111511922B (es)
AU (1) AU2019208480B2 (es)
BR (1) BR112020010300A2 (es)
CA (1) CA3083376C (es)
GB (1) GB201800903D0 (es)
MX (1) MX2020005282A (es)
SG (1) SG11202004734UA (es)
WO (1) WO2019141993A1 (es)

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AU2018307569C1 (en) 2017-07-25 2025-05-29 Oxford Genetics Limited Adenoviral vectors
GB201800903D0 (en) 2018-01-19 2018-03-07 Oxford Genetics Ltd Vectors
GB201901571D0 (en) 2019-02-05 2019-03-27 Oxford Genetics Ltd Inducible AAV sysyem
MX2022009560A (es) * 2020-02-04 2022-09-09 Oxford Genetics Ltd Proceso de fabricacion de vectores virales adenoasociados.
GB202001484D0 (en) * 2020-02-04 2020-03-18 Oxford Genetics Ltd DNA amplification method
WO2021188740A1 (en) * 2020-03-17 2021-09-23 Biogen Ma, Inc. Methods and compositions for production of recombinant adeno-associated viruses
JP2023536148A (ja) 2020-07-30 2023-08-23 シェイプ セラピューティクス インク． Ｒａａｖウイルス粒子の誘導産生のための安定な細胞株
JP7670269B2 (ja) * 2021-01-14 2025-04-30 学校法人日本医科大学 不死化間葉系細胞を含む細胞集団を製造する方法及び不死化間葉系細胞を含む細胞集団
WO2022250491A1 (en) * 2021-05-27 2022-12-01 Neuracle Genetics Inc. Novel dual helper plasmid
US12305188B2 (en) 2021-05-27 2025-05-20 Neuracle Genetics Inc. Dual helper plasmid
WO2023060113A1 (en) * 2021-10-05 2023-04-13 Regenxbio Inc. Compositions and methods for recombinant aav production
CN118202060A (zh) * 2021-10-05 2024-06-14 再生生物股份有限公司 用于重组aav生产的组合物和方法
JP2024537896A (ja) 2021-10-18 2024-10-16 リジェネロン・ファーマシューティカルズ・インコーポレイテッド アデノウイルス随伴ウイルスポリヌクレオチドを含む真核細胞
KR20240101620A9 (ko) * 2021-11-09 2025-12-10 아시모브 인코포레이티드 Aav 벡터 생산을 위한 안정한 생산 시스템
EP4502166A4 (en) * 2022-03-25 2025-09-24 Univ Jichi Medical EFFICIENT ADENO-ASSOCIATED VIRAL (AAV) VECTOR PRODUCTION SYSTEM
WO2023214578A1 (ja) * 2022-05-02 2023-11-09 株式会社シンプロジェン ウイルス由来構築物プラスミドライブラリーおよびその構築
TW202400802A (zh) * 2022-05-02 2024-01-01 日商新博基股份有限公司 源自病毒之構築物質體
CN114657153A (zh) * 2022-05-24 2022-06-24 上海健士拜生物科技有限公司 rAAV重组包装质粒、用于rAAV包装的质粒系统和rAAV的制备方法
CN116064672B (zh) * 2022-09-15 2025-02-14 思鹏生物科技(苏州)有限公司 利用ires基因提升aav包装效率的方法及其功能基因
JP2025538441A (ja) * 2022-11-16 2025-11-28 フォージ バイオロジクス，インコーポレイテッド アデノウイルスヘルパープラスミド
WO2024143440A1 (ja) 2022-12-28 2024-07-04 富士フイルム株式会社 アデノ随伴ウイルスの製造方法、およびベクターのセット
WO2024160232A1 (zh) * 2023-02-01 2024-08-08 纽福斯(苏州)生物科技有限公司 质粒包装系统及其应用
WO2025063664A1 (ko) * 2023-09-18 2025-03-27 삼성바이오에피스 주식회사 재조합 aav 생산을 위한 단일 벡터 시스템
EP4545643A1 (en) * 2023-10-23 2025-04-30 Sartorius Stedim Cellca GmbH Plasmids for improved aav titers and empty full ratios
WO2025087987A1 (en) * 2023-10-23 2025-05-01 Sartorius Stedim Cellca Gmbh Plasmids for improved aav titers and empty full ratios
WO2025217308A1 (en) * 2024-04-10 2025-10-16 Solid Biosciences Inc. Method of aav production

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GB201800903D0 (en) 2018-01-19 2018-03-07 Oxford Genetics Ltd Vectors
GB201901571D0 (en) 2019-02-05 2019-03-27 Oxford Genetics Ltd Inducible AAV sysyem

Also Published As

Publication number Publication date
JP2021510496A (ja) 2021-04-30
WO2019141993A1 (en) 2019-07-25
EP3697917B1 (en) 2024-05-15
JP7140830B2 (ja) 2022-09-21
US11697824B2 (en) 2023-07-11
AU2019208480A1 (en) 2020-07-16
KR20200120613A (ko) 2020-10-21
KR102499953B1 (ko) 2023-02-14
CN111511922A (zh) 2020-08-07
AU2019208480B2 (en) 2022-01-20
US20210163987A1 (en) 2021-06-03
CA3083376A1 (en) 2019-07-25
CN111511922B (zh) 2023-06-09
CA3083376C (en) 2022-09-20
BR112020010300A2 (pt) 2020-11-17
GB201800903D0 (en) 2018-03-07
EP3697917A1 (en) 2020-08-26
SG11202004734UA (en) 2020-06-29

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