SG11202004734UA - Vector for the production of aav particles - Google Patents
Vector for the production of aav particlesInfo
- Publication number
- SG11202004734UA SG11202004734UA SG11202004734UA SG11202004734UA SG11202004734UA SG 11202004734U A SG11202004734U A SG 11202004734UA SG 11202004734U A SG11202004734U A SG 11202004734UA SG 11202004734U A SG11202004734U A SG 11202004734UA SG 11202004734U A SG11202004734U A SG 11202004734UA
- Authority
- SG
- Singapore
- Prior art keywords
- vector
- production
- aav particles
- aav
- particles
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14151—Methods of production or purification of viral material
- C12N2750/14152—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1800903.5A GB201800903D0 (en) | 2018-01-19 | 2018-01-19 | Vectors |
| PCT/GB2019/050134 WO2019141993A1 (en) | 2018-01-19 | 2019-01-18 | Vector for the production of aav particles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202004734UA true SG11202004734UA (en) | 2020-06-29 |
Family
ID=61283699
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202004734UA SG11202004734UA (en) | 2018-01-19 | 2019-01-18 | Vector for the production of aav particles |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US11697824B2 (en) |
| EP (1) | EP3697917B1 (en) |
| JP (1) | JP7140830B2 (en) |
| KR (1) | KR102499953B1 (en) |
| CN (1) | CN111511922B (en) |
| AU (1) | AU2019208480B2 (en) |
| BR (1) | BR112020010300A2 (en) |
| CA (1) | CA3083376C (en) |
| GB (1) | GB201800903D0 (en) |
| MX (1) | MX2020005282A (en) |
| SG (1) | SG11202004734UA (en) |
| WO (1) | WO2019141993A1 (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201800903D0 (en) | 2018-01-19 | 2018-03-07 | Oxford Genetics Ltd | Vectors |
| JP2023513891A (en) * | 2020-02-04 | 2023-04-04 | オックスフォード ジェネティクス リミテッド | Adeno-associated virus vector production process |
| GB202001484D0 (en) * | 2020-02-04 | 2020-03-18 | Oxford Genetics Ltd | DNA amplification method |
| US20230159950A1 (en) * | 2020-03-17 | 2023-05-25 | Biogen Ma Inc. | Methods and compositions for production of recombinant adeno-associated viruses |
| WO2023060113A1 (en) * | 2021-10-05 | 2023-04-13 | Regenxbio Inc. | Compositions and methods for recombinant aav production |
| WO2023086822A2 (en) * | 2021-11-09 | 2023-05-19 | Asimov Inc. | Stable production systems for aav vector production |
| WO2023178220A1 (en) * | 2022-03-16 | 2023-09-21 | Regenxbio Inc. | Compositions and methods for recombinant aav production |
| WO2023214578A1 (en) * | 2022-05-02 | 2023-11-09 | 株式会社シンプロジェン | Virus-derived construct plasmid library and construction of same |
| TW202400802A (en) * | 2022-05-02 | 2024-01-01 | 日商新博基股份有限公司 | Plasmid for virus-derived structure |
| CN114657153A (en) * | 2022-05-24 | 2022-06-24 | 上海健士拜生物科技有限公司 | rAAV recombinant packaging plasmid, plasmid system for rAAV packaging and preparation method of rAAV |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5622856A (en) | 1995-08-03 | 1997-04-22 | Avigen | High efficiency helper system for AAV vector production |
| DE69632201T2 (en) | 1995-12-01 | 2005-04-21 | Crucell Holland Bv | Regulated expression of proteins in stable transfected mammalian cells |
| CA2264499A1 (en) | 1996-09-06 | 1998-03-12 | The Trustees Of The University Of Pennsylvania | Methods using cre-lox for production of recombinant adeno-associated viruses |
| EP0856585A1 (en) | 1997-01-29 | 1998-08-05 | Introgene B.V. | A conditional replication and expression system |
| ATE270324T1 (en) | 1997-04-14 | 2004-07-15 | Cell Genesys Inc | METHODS FOR INCREASE THE EFFICIENCY OF RECOMBINANT AAV PRODUCTS |
| US6037177A (en) | 1997-08-08 | 2000-03-14 | Cell Genesys, Inc. | Method for increasing the efficiency of recombinant AAV production |
| AU9397098A (en) | 1997-09-19 | 1999-04-12 | Trustees Of The University Of Pennsylvania, The | Methods and cell line useful for production of recombinant adeno-associated viruses |
| EP1027451A1 (en) * | 1997-10-08 | 2000-08-16 | Advanced Research & Technology Institute | Chimeric parvovirus-based recombinant vector system that specifically targets the erythroid lineage |
| CA2347129A1 (en) | 1998-09-22 | 2000-03-30 | University Of Florida | Methods for large-scale production of recombinant aav vectors |
| US7115391B1 (en) | 1999-10-01 | 2006-10-03 | Genovo, Inc. | Production of recombinant AAV using adenovirus comprising AAV rep/cap genes |
| EP1339861A2 (en) | 2000-12-07 | 2003-09-03 | Universite de Nantes | Inducible highly productive raav packaging cell-lines |
| ATE452972T1 (en) | 2001-05-01 | 2010-01-15 | Ca Nat Research Council | INDUCIBLE EXPRESSION SYSTEM IN EUKARYOTIC CELLS |
| CA2369985A1 (en) * | 2002-01-18 | 2003-07-18 | Duke University | Generation of recombinant adeno-associated viral vectors by a complete adenovirus-mediated approach |
| US20030225260A1 (en) | 2002-04-30 | 2003-12-04 | Snyder Richard O. | Production of recombinant AAV virions |
| US20070202587A1 (en) | 2002-09-23 | 2007-08-30 | Applied Genetic Technologies Corporation | Recombinant AAV production in mammalian cells |
| WO2006037215A1 (en) | 2004-10-04 | 2006-04-13 | National Research Council Of Canada | Expression system, components thereof and methods of use |
| US20080044855A1 (en) | 2006-03-22 | 2008-02-21 | Yan Xu | System for regulated and enhanced baculovirus mediated transient transgene expression in mammalian cells |
| WO2007127264A2 (en) | 2006-04-28 | 2007-11-08 | The Trustees Of The University Of Pennsylvania | Scalable production method for aav |
| US8512981B2 (en) * | 2006-06-21 | 2013-08-20 | Amsterdam Molecular Therapeutics B.V. | Vectors with modified initiation codon for the translation of AAV-Rep78 useful for production of AAV |
| AU2007324073A1 (en) | 2006-10-23 | 2008-05-29 | John Guy | Suppression of mitochondrial oxidative stress |
| WO2011123088A1 (en) | 2010-04-01 | 2011-10-06 | Weidong Xiao | Compositions and methods for the production of recombinant virus vectors |
| WO2012057363A1 (en) | 2010-10-27 | 2012-05-03 | 学校法人自治医科大学 | Adeno-associated virus virions for transferring genes into neural cells |
| IL247729B2 (en) * | 2014-03-10 | 2023-09-01 | Uniqure Ip Bv | Further improved aav vectors produced in insect cells |
| CN106544325B (en) | 2015-09-23 | 2018-09-07 | 中国科学院武汉物理与数学研究所 | A kind of recombinant baculovirus and its application |
| GB201603577D0 (en) | 2016-03-01 | 2016-04-13 | Oxford Genetics Ltd | Promoter |
| GB201706090D0 (en) * | 2017-04-18 | 2017-05-31 | Glaxosmithkline Ip Dev Ltd | Methods for adeno-associated viral vector production |
| BR112019021595A2 (en) * | 2017-04-18 | 2020-05-12 | Glaxosmithkline Intellectual Property Development Limited | ADENO-ASSOCIATED VIRUS-PRODUCING CELL, NUCLEIC ACID VECTOR, METHODS FOR PRODUCING A STABLE PACKAGING OF ADEN-ASSOCIATED VIRUSES OF ADENO-ASSOCIATED VIRUS VIRUS WITH COME DEOCOULATED WITH DEFECTIVE DETICTION OF COME DEOCRATED WITH DEFEATURE ASSOCIATED, AND, ADENO-ASSOCIATED VIRUS PARTICLE WITH REPLICATION DEFECT. |
| GB201800903D0 (en) | 2018-01-19 | 2018-03-07 | Oxford Genetics Ltd | Vectors |
| GB201901571D0 (en) | 2019-02-05 | 2019-03-27 | Oxford Genetics Ltd | Inducible AAV sysyem |
-
2018
- 2018-01-19 GB GBGB1800903.5A patent/GB201800903D0/en not_active Ceased
-
2019
- 2019-01-18 JP JP2020529727A patent/JP7140830B2/en active Active
- 2019-01-18 AU AU2019208480A patent/AU2019208480B2/en active Active
- 2019-01-18 CA CA3083376A patent/CA3083376C/en active Active
- 2019-01-18 US US16/768,844 patent/US11697824B2/en active Active
- 2019-01-18 BR BR112020010300-4A patent/BR112020010300A2/en unknown
- 2019-01-18 EP EP19701721.3A patent/EP3697917B1/en active Active
- 2019-01-18 KR KR1020207020846A patent/KR102499953B1/en active IP Right Grant
- 2019-01-18 WO PCT/GB2019/050134 patent/WO2019141993A1/en unknown
- 2019-01-18 CN CN201980006731.8A patent/CN111511922B/en active Active
- 2019-01-18 MX MX2020005282A patent/MX2020005282A/en unknown
- 2019-01-18 SG SG11202004734UA patent/SG11202004734UA/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US11697824B2 (en) | 2023-07-11 |
| CA3083376A1 (en) | 2019-07-25 |
| CN111511922B (en) | 2023-06-09 |
| BR112020010300A2 (en) | 2020-11-17 |
| CN111511922A (en) | 2020-08-07 |
| EP3697917A1 (en) | 2020-08-26 |
| JP7140830B2 (en) | 2022-09-21 |
| US20210163987A1 (en) | 2021-06-03 |
| WO2019141993A1 (en) | 2019-07-25 |
| JP2021510496A (en) | 2021-04-30 |
| AU2019208480A1 (en) | 2020-07-16 |
| KR102499953B1 (en) | 2023-02-14 |
| MX2020005282A (en) | 2020-08-13 |
| CA3083376C (en) | 2022-09-20 |
| EP3697917B1 (en) | 2024-05-15 |
| KR20200120613A (en) | 2020-10-21 |
| GB201800903D0 (en) | 2018-03-07 |
| AU2019208480B2 (en) | 2022-01-20 |
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