HUP1500502A2 - Process for the purification of cyclosporin-a - Google Patents
Process for the purification of cyclosporin-aInfo
- Publication number
- HUP1500502A2 HUP1500502A2 HU1500502A HUP1500502A HUP1500502A2 HU P1500502 A2 HUP1500502 A2 HU P1500502A2 HU 1500502 A HU1500502 A HU 1500502A HU P1500502 A HUP1500502 A HU P1500502A HU P1500502 A2 HUP1500502 A2 HU P1500502A2
- Authority
- HU
- Hungary
- Prior art keywords
- cyclosporin
- purification
- Prior art date
Links
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title 1
- 229930105110 Cyclosporin A Natural products 0.000 title 1
- 108010036949 Cyclosporine Proteins 0.000 title 1
- 229960001265 ciclosporin Drugs 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/02—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor with moving adsorbents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
- B01D15/1892—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns the sorbent material moving as a whole, e.g. continuous annular chromatography, true moving beds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU1500502A HUP1500502A2 (en) | 2015-10-26 | 2015-10-26 | Process for the purification of cyclosporin-a |
| PCT/HU2016/050049 WO2017072542A1 (en) | 2015-10-26 | 2016-10-26 | Method for the purification of cyclosporine a |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU1500502A HUP1500502A2 (en) | 2015-10-26 | 2015-10-26 | Process for the purification of cyclosporin-a |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP1500502A2 true HUP1500502A2 (en) | 2017-04-28 |
Family
ID=89991964
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU1500502A HUP1500502A2 (en) | 2015-10-26 | 2015-10-26 | Process for the purification of cyclosporin-a |
Country Status (2)
| Country | Link |
|---|---|
| HU (1) | HUP1500502A2 (en) |
| WO (1) | WO2017072542A1 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL237299B1 (en) * | 2018-02-09 | 2021-04-06 | Boruta Zachem Biochemia Spolka Z Ograniczona Odpowiedzialnoscia | Method for purification and/or separation of lipopeptide surfactants of natural origin, using the Counter-current Chromatography |
| IT202100017864A1 (en) | 2021-07-07 | 2023-01-07 | Special Carbon Products S R L | Method for separating and producing a purified PCBM |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3851268T2 (en) | 1987-06-19 | 1995-01-26 | Sandoz Ag | Cyclic peptolides. |
| HU213553B (en) | 1992-05-25 | 1997-07-28 | Biogal Gyogyszergyar | Process for isolating of cyclosporin-a |
| JPH06279479A (en) * | 1992-07-20 | 1994-10-04 | Microbial Chem Res Found | New antibiotic substance mj202-72f3-d and its production |
| GB9618952D0 (en) | 1996-09-11 | 1996-10-23 | Sandoz Ltd | Process |
| DE19611094C2 (en) * | 1996-03-21 | 1999-06-17 | Dresden Arzneimittel | Process for the purification of cyclosporin A and / or related cyclosporins from a cyclosporin-containing crude extract using chromatographic processes using silica gel as the adsorbent |
| HU223054B1 (en) | 1997-03-25 | 2004-03-01 | BIOGAL Gyógyszergyár Rt. | Purification process for producing high purity ciklosporin a |
| FR2920674B1 (en) * | 2007-09-06 | 2014-09-12 | Inst Francais Du Petrole | CELLS AND LINK CHANNELS FOR CENTRIFUGAL SHARING CHROMATOGRAPHIC EQUIPMENT |
| TW201212991A (en) * | 2010-06-18 | 2012-04-01 | Centre Nat Rech Scient | Purification of amphoteric products, or of products liable to be converted into amphoteric products |
-
2015
- 2015-10-26 HU HU1500502A patent/HUP1500502A2/en unknown
-
2016
- 2016-10-26 WO PCT/HU2016/050049 patent/WO2017072542A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| WO2017072542A1 (en) | 2017-05-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA9A | Lapse of provisional patent protection due to relinquishment or protection considered relinquished |