CY1124364T1 - Μεθοδοι για την ανιχνευση aav - Google Patents

Μεθοδοι για την ανιχνευση aav

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Publication number
CY1124364T1
CY1124364T1 CY20211100262T CY211100262T CY1124364T1 CY 1124364 T1 CY1124364 T1 CY 1124364T1 CY 20211100262 T CY20211100262 T CY 20211100262T CY 211100262 T CY211100262 T CY 211100262T CY 1124364 T1 CY1124364 T1 CY 1124364T1
Authority
CY
Cyprus
Prior art keywords
aav
methods
detection
determining
particles
Prior art date
Application number
CY20211100262T
Other languages
English (en)
Inventor
Xiaoying Jin
Catherine R. O'riordan
Lin Liu
Kate ZHANG
Original Assignee
Genzyme Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=59762045&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1124364(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genzyme Corporation filed Critical Genzyme Corporation
Publication of CY1124364T1 publication Critical patent/CY1124364T1/el

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14123—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14151—Methods of production or purification of viral material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/01—DNA viruses
    • G01N2333/075—Adenoviridae

Abstract

Στο παρόν έγγραφο διατίθενται μέθοδοι προσδιορισμού του ορότυπου σωματιδίου ιού και/ή προσδιορισμού της ετερογένειας σωματιδίου ιού (π.χ., σωματιδίου AAV). Σε άλλες υλοποιήσεις, η εφεύρεση παρέχει μεθόδους προσδιορισμού της ετερογένειας σωματιδίων AAV. Σε ορισμένες πτυχές, η εφεύρεση παρέχει ιικά σωματίδια {π.χ., σωματίδια rAAV) με βελτιωμένη σταθερότητα και/ή βελτιωμένη αποδοτικότητα μεταγωγής αυξάνοντας την ακετυλίωση και/ή την αποαμίδωση των καψιδικών πρωτεϊνών.
CY20211100262T 2016-08-15 2021-03-24 Μεθοδοι για την ανιχνευση aav CY1124364T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662375314P 2016-08-15 2016-08-15
PCT/US2017/046814 WO2018035059A1 (en) 2016-08-15 2017-08-14 Methods for detecting aav

Publications (1)

Publication Number Publication Date
CY1124364T1 true CY1124364T1 (el) 2022-07-22

Family

ID=59762045

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20211100262T CY1124364T1 (el) 2016-08-15 2021-03-24 Μεθοδοι για την ανιχνευση aav

Country Status (22)

Country Link
US (2) US11698377B2 (el)
EP (2) EP3497207B1 (el)
JP (3) JP7021191B2 (el)
KR (3) KR102425289B1 (el)
CN (1) CN110168080A (el)
AU (2) AU2017312951B2 (el)
BR (1) BR112019002934A2 (el)
CA (1) CA3033856A1 (el)
CL (2) CL2019000392A1 (el)
CR (1) CR20190127A (el)
CY (1) CY1124364T1 (el)
DK (1) DK3497207T3 (el)
ES (1) ES2863674T3 (el)
HU (1) HUE053747T2 (el)
MA (1) MA55748A (el)
MX (2) MX2019001938A (el)
PH (1) PH12019500316A1 (el)
SG (2) SG10201913002QA (el)
TN (1) TN2019000047A1 (el)
TW (2) TW202309068A (el)
WO (1) WO2018035059A1 (el)
ZA (1) ZA201900945B (el)

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Also Published As

Publication number Publication date
KR102538037B1 (ko) 2023-05-30
EP3851449A1 (en) 2021-07-21
EP3497207A1 (en) 2019-06-19
AU2017312951A1 (en) 2019-04-04
SG10201913002QA (en) 2020-03-30
KR102425289B1 (ko) 2022-07-27
BR112019002934A2 (pt) 2019-05-14
EP3497207B1 (en) 2021-01-06
JP2019533803A (ja) 2019-11-21
ZA201900945B (en) 2021-06-30
AU2024200349A1 (en) 2024-02-08
MX2019001938A (es) 2019-07-04
US20240044910A1 (en) 2024-02-08
SG11201901221YA (en) 2019-03-28
CN110168080A (zh) 2019-08-23
KR20220107327A (ko) 2022-08-02
JP2024023460A (ja) 2024-02-21
TN2019000047A1 (en) 2020-07-15
CL2019000392A1 (es) 2019-05-10
WO2018035059A1 (en) 2018-02-22
US11698377B2 (en) 2023-07-11
CA3033856A1 (en) 2018-02-22
KR20190039253A (ko) 2019-04-10
US20210041451A1 (en) 2021-02-11
RU2019107207A (ru) 2020-09-15
TW202309068A (zh) 2023-03-01
KR20230078834A (ko) 2023-06-02
RU2019107207A3 (el) 2021-04-29
CL2019002912A1 (es) 2020-03-06
TWI781953B (zh) 2022-11-01
JP7021191B2 (ja) 2022-02-16
PH12019500316A1 (en) 2019-08-05
CR20190127A (es) 2019-06-25
MX2023009081A (es) 2023-08-08
HUE053747T2 (hu) 2021-07-28
WO2018035059A9 (en) 2019-03-14
ES2863674T3 (es) 2021-10-11
TW201825898A (zh) 2018-07-16
JP2022064980A (ja) 2022-04-26
DK3497207T3 (da) 2021-03-22
AU2017312951B2 (en) 2024-02-08
MA55748A (fr) 2022-03-02

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