CY1124518T1 - Μεταλλαγες πρωτεϊνης φακελου hiv που σταθεροποιουν το τριμερες - Google Patents
Μεταλλαγες πρωτεϊνης φακελου hiv που σταθεροποιουν το τριμερεςInfo
- Publication number
- CY1124518T1 CY1124518T1 CY20201100952T CY201100952T CY1124518T1 CY 1124518 T1 CY1124518 T1 CY 1124518T1 CY 20201100952 T CY20201100952 T CY 20201100952T CY 201100952 T CY201100952 T CY 201100952T CY 1124518 T1 CY1124518 T1 CY 1124518T1
- Authority
- CY
- Cyprus
- Prior art keywords
- hiv envelope
- envelope protein
- hiv
- envelope proteins
- trimer
- Prior art date
Links
- 101710091045 Envelope protein Proteins 0.000 title abstract 9
- 101710188315 Protein X Proteins 0.000 title abstract 9
- 102100021696 Syncytin-1 Human genes 0.000 title abstract 9
- 239000013638 trimer Substances 0.000 title abstract 3
- 230000035772 mutation Effects 0.000 title abstract 2
- 230000000087 stabilizing effect Effects 0.000 title 1
- 241000725303 Human immunodeficiency virus Species 0.000 abstract 7
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 238000006467 substitution reaction Methods 0.000 abstract 2
- 239000013598 vector Substances 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/08—RNA viruses
- C07K14/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus human T-cell leukaemia-lymphoma virus
- C07K14/155—Lentiviridae, e.g. human immunodeficiency virus [HIV], visna-maedi virus or equine infectious anaemia virus
- C07K14/16—HIV-1 ; HIV-2
- C07K14/162—HIV-1 ; HIV-2 env, e.g. gp160, gp110/120, gp41, V3, peptid T, CD4-Binding site
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/02—Recovery or purification
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- AIDS & HIV (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Παρέχονται πρωτεΐνες φακέλου του ιού της ανθρώπινης ανοσοανεπάρκειας (HIV) που διαθέτουν μεταλλαγές οι οποίες σταθεροποιούν την τριμερή μορφή της πρωτεΐνης του φακέλου. Οι πρωτεΐνες φακέλου του HIV διαθέτουν ορισμένες υποκαταστάσεις αμινοξέων σε καθορισμένες θέσεις στην πρωτεϊνική αλληλουχία του φακέλου. Οι πρωτεΐνες φακέλου του HIV που περιγράφονται εδώ διαθέτουν βελτιωμένο ποσοστό σχηματισμού τριμερούς ή/και βελτιωμένη απόδοση τριμερούς σε σύγκριση με μια πρωτεΐνη φακέλου του HIV η οποία δεν διαθέτει μία ή περισσότερες από τις υποδεικνυόμενες υποκαταστάσεις αμινοξέων. Παρέχονται, επίσης, μόρια και φορείς νουκλεϊκού οξέος που κωδικοποιούν τις πρωτεΐνες φακέλου του HIV, καθώς και\συνθέσεις που περιέχουν τις πρωτεΐνες φακέλου του HIV, νουκλεϊκά οξέα και φορείς.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16188866 | 2016-09-15 | ||
PCT/EP2017/073141 WO2018050747A1 (en) | 2016-09-15 | 2017-09-14 | Trimer stabilizing hiv envelope protein mutations |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1124518T1 true CY1124518T1 (el) | 2022-03-24 |
Family
ID=57017955
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20201100952T CY1124518T1 (el) | 2016-09-15 | 2020-10-09 | Μεταλλαγες πρωτεϊνης φακελου hiv που σταθεροποιουν το τριμερες |
Country Status (30)
Country | Link |
---|---|
US (3) | US10793607B2 (el) |
EP (2) | EP3512543B1 (el) |
JP (2) | JP7178344B2 (el) |
KR (1) | KR102513146B1 (el) |
CN (1) | CN109689091A (el) |
AR (1) | AR109528A1 (el) |
AU (2) | AU2017327672B2 (el) |
BR (1) | BR112019004593A2 (el) |
CA (1) | CA3036959A1 (el) |
CY (1) | CY1124518T1 (el) |
DK (1) | DK3512543T3 (el) |
EA (1) | EA201990715A1 (el) |
ES (1) | ES2824525T3 (el) |
HR (1) | HRP20201458T1 (el) |
HU (1) | HUE052008T2 (el) |
IL (2) | IL294832A (el) |
LT (1) | LT3512543T (el) |
MA (1) | MA46230B1 (el) |
MD (1) | MD3512543T2 (el) |
MX (1) | MX2019002938A (el) |
MY (1) | MY190534A (el) |
PH (1) | PH12019500280A1 (el) |
PL (1) | PL3512543T3 (el) |
PT (1) | PT3512543T (el) |
RS (1) | RS60919B1 (el) |
SG (2) | SG11201901206SA (el) |
SI (1) | SI3512543T1 (el) |
TW (1) | TWI742158B (el) |
WO (1) | WO2018050747A1 (el) |
ZA (1) | ZA201901597B (el) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
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PT3390430T (pt) | 2015-12-15 | 2019-11-20 | Janssen Vaccines & Prevention Bv | Antígenos, vetores, composições para o vírus da imunodeficiência humana e métodos da sua utilização |
WO2017152146A2 (en) | 2016-03-03 | 2017-09-08 | Duke University | Compositions and methods for inducing hiv-1 antibodies |
US11318197B2 (en) | 2016-03-03 | 2022-05-03 | Duke University | Compositions and methods for inducing HIV-1 antibodies |
JP7046832B2 (ja) * | 2016-05-02 | 2022-04-04 | ザ スクリプス リサーチ インスティテュート | Hiv-1免疫原に関連した組成物および方法 |
KR102389489B1 (ko) | 2016-06-16 | 2022-04-22 | 얀센 백신스 앤드 프리벤션 비.브이. | Hiv 백신 제형 |
US10307477B2 (en) | 2016-09-02 | 2019-06-04 | Janssen Vaccines & Prevention B.V. | Methods for inducing an immune response against human immunodeficiency virus infection in subjects undergoing antiretroviral treatment |
BR112019004593A2 (pt) | 2016-09-15 | 2019-07-02 | Janssen Vaccines & Prevention Bv | mutações da proteína do envelope do hiv estabilizando o trímero |
CA3039089A1 (en) | 2016-10-03 | 2018-04-12 | Duke University | Methods to identify immunogens by targeting improbable mutations |
EP3638302B1 (en) | 2017-06-15 | 2024-03-13 | Janssen Vaccines & Prevention B.V. | Poxvirus vectors encoding hiv antigens, and methods of use thereof |
WO2019016062A1 (en) | 2017-07-19 | 2019-01-24 | Janssen Vaccines & Prevention B.V. | HIV ENVELOPE PROTEIN MUTATIONS STABILIZING TRIMERIC FORM |
AU2019285048B2 (en) | 2018-06-13 | 2023-06-08 | The Scripps Research Institute | Nanoparticle vaccines with novel structural components |
EA038287B1 (ru) * | 2018-06-18 | 2021-08-04 | Янссен Вэксинс Энд Превеншн Б.В. | Стабилизирующие тример мутации белка оболочки hiv |
CA3114870A1 (en) * | 2018-10-01 | 2020-04-09 | Duke University | Hiv-1 envelope stabilizing mutations |
US20220106610A1 (en) * | 2019-01-22 | 2022-04-07 | Bluebird Bio, Inc. | Methods and systems for manufacturing viral vectors |
CN110184298B (zh) * | 2019-05-15 | 2023-05-16 | 武汉璟泓科技股份有限公司 | Hiv突变型表面糖蛋白及其纳米化抗原与制备方法 |
US20220401546A1 (en) * | 2019-11-14 | 2022-12-22 | Emory University | HIV Immunogens, Vaccines, and Methods Related Thereto |
EP4245767A1 (en) * | 2020-11-12 | 2023-09-20 | Xiamen University | Modified membrane protein of human immunodeficiency virus and use thereof |
AR124937A1 (es) | 2021-02-23 | 2023-05-24 | Janssen Vaccines & Prevention Bv | Mutación estabilizante de trímeros de proteínas de la envoltura del vih |
WO2023156505A1 (en) | 2022-02-17 | 2023-08-24 | Janssen Vaccines & Prevention B.V. | Trimer stabilizing hiv envelope protein mutations r304v, n302m and t320l |
WO2023192835A1 (en) * | 2022-03-27 | 2023-10-05 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Base-covered hiv-1 envelope ectodomains and their use |
WO2024091921A1 (en) * | 2022-10-24 | 2024-05-02 | Duke University | Stabilization of human immunodeficiency virus (hiv) envelopes |
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US10400015B2 (en) * | 2014-09-04 | 2019-09-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Recombinant HIV-1 envelope proteins and their use |
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PT3390430T (pt) | 2015-12-15 | 2019-11-20 | Janssen Vaccines & Prevention Bv | Antígenos, vetores, composições para o vírus da imunodeficiência humana e métodos da sua utilização |
KR102389489B1 (ko) | 2016-06-16 | 2022-04-22 | 얀센 백신스 앤드 프리벤션 비.브이. | Hiv 백신 제형 |
US10307477B2 (en) | 2016-09-02 | 2019-06-04 | Janssen Vaccines & Prevention B.V. | Methods for inducing an immune response against human immunodeficiency virus infection in subjects undergoing antiretroviral treatment |
BR112019004593A2 (pt) * | 2016-09-15 | 2019-07-02 | Janssen Vaccines & Prevention Bv | mutações da proteína do envelope do hiv estabilizando o trímero |
WO2019016062A1 (en) * | 2017-07-19 | 2019-01-24 | Janssen Vaccines & Prevention B.V. | HIV ENVELOPE PROTEIN MUTATIONS STABILIZING TRIMERIC FORM |
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2017
- 2017-09-14 BR BR112019004593A patent/BR112019004593A2/pt unknown
- 2017-09-14 AR ARP170102536A patent/AR109528A1/es unknown
- 2017-09-14 ES ES17769027T patent/ES2824525T3/es active Active
- 2017-09-14 US US15/704,651 patent/US10793607B2/en active Active
- 2017-09-14 CA CA3036959A patent/CA3036959A1/en active Pending
- 2017-09-14 PT PT177690278T patent/PT3512543T/pt unknown
- 2017-09-14 MA MA46230A patent/MA46230B1/fr unknown
- 2017-09-14 IL IL294832A patent/IL294832A/en unknown
- 2017-09-14 CN CN201780054555.6A patent/CN109689091A/zh active Pending
- 2017-09-14 EP EP17769027.8A patent/EP3512543B1/en active Active
- 2017-09-14 EA EA201990715A patent/EA201990715A1/ru unknown
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