SG11201901206SA - Trimer stabilizing hiv envelope protein mutations - Google Patents

Trimer stabilizing hiv envelope protein mutations

Info

Publication number
SG11201901206SA
SG11201901206SA SG11201901206SA SG11201901206SA SG11201901206SA SG 11201901206S A SG11201901206S A SG 11201901206SA SG 11201901206S A SG11201901206S A SG 11201901206SA SG 11201901206S A SG11201901206S A SG 11201901206SA SG 11201901206S A SG11201901206S A SG 11201901206SA
Authority
SG
Singapore
Prior art keywords
archimedesweg
leiden
international
rule
hiv
Prior art date
Application number
SG11201901206SA
Inventor
Lucy Rutten
Daphné TRUAN
Nika Strokappe
Johannes Langedijk
Original Assignee
Janssen Vaccines & Prevention Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Vaccines & Prevention Bv filed Critical Janssen Vaccines & Prevention Bv
Publication of SG11201901206SA publication Critical patent/SG11201901206SA/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08—RNA viruses
    • C07K14/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus human T-cell leukaemia-lymphoma virus
    • C07K14/155—Lentiviridae, e.g. visna-maedi virus, equine infectious virus, FIV, SIV
    • C07K14/16—HIV-1 ; HIV-2
    • C07K14/162—HIV-1 ; HIV-2 env, e.g. gp160, gp110/120, gp41, V3, peptid T, CD4-Binding site
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/21—Retroviridae, e.g. equine infectious anemia virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/02—Recovery or purification

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111101111 0111010101111101111101 0 01111111111111111111111111111111111111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\" WO 2018/050747 Al 22 March 2018 (22.03.2018) WIP0 I PCT (51) International Patent Classification: Declarations under Rule 4.17: A61K 39/12 (2006.01) C07K 14/005 (2006.01) — as to applicant's entitlement to apply for and be granted a (21) International Application Number: patent (Rule 4.17(ii)) PCT/EP2017/073141 — of inventorship (Rule 4.17(iv)) (22) International Filing Date: Published: 14 September 2017 (14.09.2017) — with international search report (Art. 21(3)) — (25) Filing Language: English before the expiration of the time limit for amending the claims and to be republished in the event of receipt of (26) Publication Language: English amendments (Rule 48.2(h)) — with sequence listing part of description (Rule 5.2(a)) (30) Priority Data: 16188866.4 15 September 2016 (15.09.2016) EP (71) Applicant: JANSSEN VACCINES & PREVENTION B.V. [NL/NL]; Archimedesweg 4, 2333 CN Leiden (NL). (72) Inventors: RUTTEN, Lucy; Archimedesweg 4-6, 2333 CN Leiden (NL). TRUAN, Daphne; Archimedesweg 4-6, 2333 CN Leiden (NL). STROKAPPE, Nika, Mindy; Archimedesweg 4-6, 2333 CN Leiden (NL). _ LANGEDIJK, Johannes, Petrus, Maria; Archimedesweg 4-6, 2333 CN Leiden (NL). — = Agent: VERHAGE, Richard, A et al.; Archimedesweg (74) 4-6, 2333 CN Leiden (NL). = Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (81) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, = = CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, = KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, = MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, = = TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. _ Designated States (unless otherwise indicated, for every — (84) _ _ kind of regional protection available): ARIPO (BW, GH, = GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, = UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, = TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, = EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, — MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). = 1-1 IN 71- (54) Title: TRIMER STABILIZING HIV ENVELOPE PROTEIN MUTATIONS IN 0 (57) : Human immunodeficiency virus (HIV) envelope proteins having mutations that stabilize the trimeric form of the en- i ln 0 velope protein are provided. The HIV envelope proteins have certain amino acid substitutions at specified positions in the envelope ----- protein sequence. The HIV envelope proteins described herein have an improved percentage of trimer formation and/or an improved GC trimer yield as compared to an HIV envelope protein that does not have one or more of the indicated amino acid substitutions. Also 1-1 © provided are nucleic acid molecules and vectors encoding the HIV envelope proteins, as well as compositions containing the HIV f'1 envelope proteins, nucleic acid, and vectors. 0
SG11201901206SA 2016-09-15 2017-09-14 Trimer stabilizing hiv envelope protein mutations SG11201901206SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16188866 2016-09-15
PCT/EP2017/073141 WO2018050747A1 (en) 2016-09-15 2017-09-14 Trimer stabilizing hiv envelope protein mutations

Publications (1)

Publication Number Publication Date
SG11201901206SA true SG11201901206SA (en) 2019-04-29

Family

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SG10202001956UA SG10202001956UA (en) 2016-09-15 2017-09-14 Trimer stabilizing hiv envelope protein mutations
SG11201901206SA SG11201901206SA (en) 2016-09-15 2017-09-14 Trimer stabilizing hiv envelope protein mutations

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Country Status (30)

Country Link
US (3) US10793607B2 (en)
EP (2) EP3747463A1 (en)
JP (2) JP7178344B2 (en)
KR (1) KR102513146B1 (en)
CN (1) CN109689091A (en)
AR (1) AR109528A1 (en)
AU (2) AU2017327672B2 (en)
BR (1) BR112019004593A2 (en)
CA (1) CA3036959A1 (en)
CY (1) CY1124518T1 (en)
DK (1) DK3512543T3 (en)
EA (1) EA201990715A1 (en)
ES (1) ES2824525T3 (en)
HR (1) HRP20201458T1 (en)
HU (1) HUE052008T2 (en)
IL (2) IL265186B (en)
LT (1) LT3512543T (en)
MA (1) MA46230B1 (en)
MD (1) MD3512543T2 (en)
MX (1) MX2019002938A (en)
MY (1) MY190534A (en)
PH (1) PH12019500280A1 (en)
PL (1) PL3512543T3 (en)
PT (1) PT3512543T (en)
RS (1) RS60919B1 (en)
SG (2) SG10202001956UA (en)
SI (1) SI3512543T1 (en)
TW (1) TWI742158B (en)
WO (1) WO2018050747A1 (en)
ZA (1) ZA201901597B (en)

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CY1124518T1 (en) 2022-03-24
ES2824525T3 (en) 2021-05-12
US20200369731A1 (en) 2020-11-26
KR102513146B1 (en) 2023-03-23
US11820796B2 (en) 2023-11-21
AU2020267278B2 (en) 2023-07-20
KR20190050786A (en) 2019-05-13
BR112019004593A2 (en) 2019-07-02
US11365222B2 (en) 2022-06-21
EP3512543A1 (en) 2019-07-24
IL265186A (en) 2019-05-30
US10793607B2 (en) 2020-10-06
IL265186B (en) 2022-09-01
IL294832A (en) 2022-09-01
LT3512543T (en) 2020-11-10
PL3512543T3 (en) 2021-01-11
WO2018050747A1 (en) 2018-03-22
HRP20201458T1 (en) 2020-12-11
US20180072777A1 (en) 2018-03-15
ZA201901597B (en) 2022-12-21
PH12019500280A1 (en) 2019-10-28
TW201819401A (en) 2018-06-01
HUE052008T2 (en) 2021-04-28
AU2017327672A1 (en) 2019-02-28
MX2019002938A (en) 2019-10-15
CA3036959A1 (en) 2018-03-22
DK3512543T3 (en) 2020-10-12
NZ750773A (en) 2021-02-26
MA46230A (en) 2019-07-24
PT3512543T (en) 2020-10-13
MY190534A (en) 2022-04-27
EA201990715A1 (en) 2019-08-30
JP2019534690A (en) 2019-12-05
SG10202001956UA (en) 2020-04-29
JP7178344B2 (en) 2022-11-25
CN109689091A (en) 2019-04-26
TWI742158B (en) 2021-10-11
AR109528A1 (en) 2018-12-19
AU2020267278A1 (en) 2020-12-10
US20220315627A1 (en) 2022-10-06
EP3512543B1 (en) 2020-07-22
SI3512543T1 (en) 2020-10-30
AU2017327672B2 (en) 2020-10-15
MD3512543T2 (en) 2020-11-30
MA46230B1 (en) 2020-10-28
EP3747463A1 (en) 2020-12-09
RS60919B1 (en) 2020-11-30
JP2023011941A (en) 2023-01-24

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