SG11201810015YA - Particle for the encapsidation of a genome engineering system - Google Patents
Particle for the encapsidation of a genome engineering systemInfo
- Publication number
- SG11201810015YA SG11201810015YA SG11201810015YA SG11201810015YA SG11201810015YA SG 11201810015Y A SG11201810015Y A SG 11201810015YA SG 11201810015Y A SG11201810015Y A SG 11201810015YA SG 11201810015Y A SG11201810015Y A SG 11201810015YA SG 11201810015Y A SG11201810015Y A SG 11201810015YA
- Authority
- SG
- Singapore
- Prior art keywords
- encapsidation
- particle
- engineering system
- genome engineering
- viral rnas
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/85—Fusion polypeptide containing an RNA binding domain
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16023—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16041—Use of virus, viral particle or viral elements as a vector
- C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16051—Methods of production or purification of viral material
- C12N2740/16052—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/18011—Details ssRNA Bacteriophages positive-sense
- C12N2795/18111—Leviviridae
- C12N2795/18122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/24—Vectors characterised by the absence of particular element, e.g. selectable marker, viral origin of replication
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/50—Vectors for producing vectors
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
PARTICLE FOR THE ENCAPSIDATION OF A GENOME ENGINEERING SYSTEM The present invention relates to a retroviral particle comprising a protein derived from the Gag polyprotein, an envelope protein, optionally an integrase and at least two encapsidated non-viral RNAs, the encapsidated non-viral RNAs each comprising an RNA sequence of interest bound to an encapsidation sequence, each encapsidation sequence being recognized by a binding domain introduced into the protein derived from the Gag polyprotein and/or into the integrase, and at least one of said sequences of interest of the encapsidated non-viral RNAs comprises a part coding a nuclease. (No Suitable Figure)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1654332A FR3051196B1 (en) | 2016-05-13 | 2016-05-13 | PARTICLE FOR ENCAPSIDATION OF A GENOME ENGINEERING SYSTEM |
FR1660309 | 2016-10-24 | ||
FR1752818 | 2017-03-31 | ||
PCT/FR2017/051164 WO2017194902A2 (en) | 2016-05-13 | 2017-05-12 | Particle for the encapsidation of a genome engineering system |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201810015YA true SG11201810015YA (en) | 2018-12-28 |
Family
ID=59070995
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201810015YA SG11201810015YA (en) | 2016-05-13 | 2017-05-12 | Particle for the encapsidation of a genome engineering system |
Country Status (11)
Country | Link |
---|---|
US (1) | US10870865B2 (en) |
EP (1) | EP3455239B1 (en) |
JP (1) | JP6982001B2 (en) |
AU (1) | AU2017263137B2 (en) |
CA (1) | CA3024376A1 (en) |
DK (1) | DK3455239T3 (en) |
ES (1) | ES2886919T3 (en) |
IL (1) | IL262941B (en) |
PT (1) | PT3455239T (en) |
SG (1) | SG11201810015YA (en) |
WO (1) | WO2017194902A2 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016185125A1 (en) * | 2015-05-15 | 2016-11-24 | Vectalys | Retroviral particle comprising at least two encapsidated non-viral rnas |
EP3788155A1 (en) * | 2018-05-01 | 2021-03-10 | Wake Forest University Health Sciences | Lentiviral-based vectors and related systems and methods for eukaryotic gene editing |
CN108504689B (en) * | 2018-05-29 | 2021-01-29 | 上海本导基因技术有限公司 | Lentiviral vectors and methods of delivering exogenous RNA thereof |
CA3196996A1 (en) * | 2020-11-19 | 2022-05-27 | Baisong Lu | Vectors, systems and methods for eukaryotic gene editing |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0526210D0 (en) | 2005-12-22 | 2006-02-01 | Oxford Biomedica Ltd | Vectors |
US10273462B2 (en) | 2011-07-27 | 2019-04-30 | Vectalys Sas | Virus-based vector compositions useful for transducing eukaryotic cells |
WO2016049258A2 (en) * | 2014-09-25 | 2016-03-31 | The Broad Institute Inc. | Functional screening with optimized functional crispr-cas systems |
-
2017
- 2017-05-12 ES ES17730841T patent/ES2886919T3/en active Active
- 2017-05-12 AU AU2017263137A patent/AU2017263137B2/en active Active
- 2017-05-12 US US16/301,317 patent/US10870865B2/en active Active
- 2017-05-12 CA CA3024376A patent/CA3024376A1/en active Pending
- 2017-05-12 JP JP2018559362A patent/JP6982001B2/en active Active
- 2017-05-12 EP EP17730841.8A patent/EP3455239B1/en active Active
- 2017-05-12 DK DK17730841.8T patent/DK3455239T3/en active
- 2017-05-12 PT PT177308418T patent/PT3455239T/en unknown
- 2017-05-12 WO PCT/FR2017/051164 patent/WO2017194902A2/en unknown
- 2017-05-12 SG SG11201810015YA patent/SG11201810015YA/en unknown
-
2018
- 2018-11-12 IL IL262941A patent/IL262941B/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP3455239A2 (en) | 2019-03-20 |
US10870865B2 (en) | 2020-12-22 |
WO2017194902A2 (en) | 2017-11-16 |
WO2017194902A3 (en) | 2018-01-18 |
JP2019514414A (en) | 2019-06-06 |
IL262941A (en) | 2018-12-31 |
EP3455239B1 (en) | 2021-04-07 |
PT3455239T (en) | 2021-07-13 |
CA3024376A1 (en) | 2017-11-16 |
AU2017263137B2 (en) | 2021-05-27 |
CN109415415A (en) | 2019-03-01 |
ES2886919T3 (en) | 2021-12-21 |
DK3455239T3 (en) | 2021-07-05 |
JP6982001B2 (en) | 2021-12-17 |
US20200071720A1 (en) | 2020-03-05 |
IL262941B (en) | 2022-05-01 |
AU2017263137A1 (en) | 2019-01-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2022006652A (en) | Modified capsid proteins for enhanced delivery of parvovirus vectors. | |
WO2018136396A3 (en) | Crisprs | |
SG11201810015YA (en) | Particle for the encapsidation of a genome engineering system | |
MX2019006467A (en) | Compositions and methods for enhancing gene expression. | |
CY1124453T1 (en) | POLYPEPTIDES CONTAINING DE NOVO BINDING REGIONS AND USES THEREOF | |
CY1121159T1 (en) | NON-INTEGRATED LINTER BODIES | |
PH12019501130A1 (en) | Viral delivery of neoantigens | |
CY1124518T1 (en) | TRIMER STABILIZING HIV ENVELOPE PROTEIN MUTATIONS | |
MX2019002946A (en) | Anti-pd-1(cd279) antibodies. | |
MX2017010857A (en) | Methods for targeted nucleic acid sequence coverage. | |
MX2018005392A (en) | Engineered nucleic-acid targeting nucleic acids. | |
WO2015191693A3 (en) | Method for gene editing | |
EP4349404A3 (en) | Respiratory virus vaccines | |
AU2016262093A8 (en) | Enhancing endonuclease based gene editing in primary cells | |
AU2015286820A8 (en) | Stabilization of poly(A) sequence encoding DNA sequences | |
WO2018191502A3 (en) | Anti-cd137 antibodies and methods of use thereof | |
EA201201025A1 (en) | NUCLEIC ACID MOLECULES OF INFLUENZA AND VACCINES PRODUCED FROM THEM | |
WO2017214327A3 (en) | Non-integrating viral delivery system and methods related thereto | |
WO2009124312A3 (en) | Consensus sequences of chikungunya viral proteins, nucleic acid molecules encoding the same, and compositions and methods for using the same | |
BR112018010635A2 (en) | stable cell lines for retroviral production | |
EA201992232A1 (en) | COMPOSITIONS AND METHODS FOR IMMUNOUNCOLOGY | |
MX2017008096A (en) | Pestivirus. | |
WO2012018907A3 (en) | Polypeptides for treating and/or limiting influenza infection | |
MX2017005524A (en) | Methods and compositions for recombinant dengue viruses for vaccine and diagnostic development. | |
WO2018017747A3 (en) | Oncolytic viruses targeting stat3 |