EA201591287A1 - Вакцины, содержащие стабилизированные тримеры оболочки вируса иммунодефицита человека, и способы их применения - Google Patents

Вакцины, содержащие стабилизированные тримеры оболочки вируса иммунодефицита человека, и способы их применения

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Publication number
EA201591287A1
EA201591287A1 EA201591287A EA201591287A EA201591287A1 EA 201591287 A1 EA201591287 A1 EA 201591287A1 EA 201591287 A EA201591287 A EA 201591287A EA 201591287 A EA201591287 A EA 201591287A EA 201591287 A1 EA201591287 A1 EA 201591287A1
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EA
Eurasian Patent Office
Prior art keywords
virus
methods
human immunodeficiency
trimmers
vaccines containing
Prior art date
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EA201591287A
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English (en)
Other versions
EA030983B1 (ru
Inventor
Дэн Х. Бараух
Джозеф Нколола
Original Assignee
Бет Изрейэл Диконисс Медикал Сентер, Инк.
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Application filed by Бет Изрейэл Диконисс Медикал Сентер, Инк. filed Critical Бет Изрейэл Диконисс Медикал Сентер, Инк.
Publication of EA201591287A1 publication Critical patent/EA201591287A1/ru
Publication of EA030983B1 publication Critical patent/EA030983B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/21—Retroviridae, e.g. equine infectious anemia virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08—RNA viruses
    • C07K14/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus human T-cell leukaemia-lymphoma virus
    • C07K14/155—Lentiviridae, e.g. human immunodeficiency virus [HIV], visna-maedi virus or equine infectious anaemia virus
    • C07K14/16—HIV-1 ; HIV-2
    • C07K14/162—HIV-1 ; HIV-2 env, e.g. gp160, gp110/120, gp41, V3, peptid T, CD4-Binding site
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Изобретение относится к стабилизированным тримерам оболочки (Env) вируса иммунодефицита человека (ВИЧ). Изобретение также относится к вакцинам, нуклеиновым кислотам и векторам для доставки и/или обеспечения продукции стабилизированных тримеров Env ВИЧ. Кроме того, изобретение относится к способам получения и применения стабилизированных тримеров Env ВИЧ согласно изобретению в качестве вакцин.
EA201591287A 2013-01-07 2014-01-07 ВАКЦИНЫ, СОДЕРЖАЩИЕ СТАБИЛИЗИРОВАННЫЕ ТРИМЕРЫ ОБОЛОЧКИ (Env) ВИРУСА ИММУНОДЕФИЦИТА ЧЕЛОВЕКА (ВИЧ), И СПОСОБЫ ИХ ПРИМЕНЕНИЯ EA030983B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361749737P 2013-01-07 2013-01-07
PCT/US2014/010543 WO2014107744A1 (en) 2013-01-07 2014-01-07 Stabilized human immunodeficiency virus (hiv) envelope (env) trimer vaccines and methods of using the same

Publications (2)

Publication Number Publication Date
EA201591287A1 true EA201591287A1 (ru) 2015-12-30
EA030983B1 EA030983B1 (ru) 2018-10-31

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EA201591287A EA030983B1 (ru) 2013-01-07 2014-01-07 ВАКЦИНЫ, СОДЕРЖАЩИЕ СТАБИЛИЗИРОВАННЫЕ ТРИМЕРЫ ОБОЛОЧКИ (Env) ВИРУСА ИММУНОДЕФИЦИТА ЧЕЛОВЕКА (ВИЧ), И СПОСОБЫ ИХ ПРИМЕНЕНИЯ

Country Status (18)

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US (4) US9932370B2 (ru)
EP (1) EP2983686B1 (ru)
JP (1) JP6357487B2 (ru)
KR (1) KR102020758B1 (ru)
CN (1) CN105263506B (ru)
AP (1) AP2015008634A0 (ru)
AU (2) AU2014203886B2 (ru)
CA (1) CA2897059C (ru)
EA (1) EA030983B1 (ru)
HK (1) HK1214509A1 (ru)
IL (1) IL239805A (ru)
MX (1) MX2015008815A (ru)
MY (1) MY187152A (ru)
NZ (1) NZ710727A (ru)
PH (1) PH12015501526A1 (ru)
SG (2) SG11201505229XA (ru)
WO (1) WO2014107744A1 (ru)
ZA (1) ZA201505608B (ru)

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EP2983686A4 (en) 2016-09-14
KR102020758B1 (ko) 2019-09-11
US20140302080A1 (en) 2014-10-09
SG10201705880QA (en) 2017-08-30
MX2015008815A (es) 2016-10-26
IL239805A (en) 2017-11-30
US11059863B2 (en) 2021-07-13
US9932370B2 (en) 2018-04-03
PH12015501526B1 (en) 2015-09-21
US20180186839A1 (en) 2018-07-05
MY187152A (en) 2021-09-06
AU2014203886B2 (en) 2017-11-02
US10160788B2 (en) 2018-12-25
AU2018200696A1 (en) 2018-02-22
CN105263506B (zh) 2018-03-09
CA2897059A1 (en) 2014-07-10
AP2015008634A0 (en) 2015-07-31
KR20150118131A (ko) 2015-10-21
IL239805A0 (en) 2015-08-31
PH12015501526A1 (en) 2015-09-21
US20190055290A1 (en) 2019-02-21
AU2018200696B2 (en) 2019-09-12
US20210317169A1 (en) 2021-10-14
JP6357487B2 (ja) 2018-07-11
CN105263506A (zh) 2016-01-20
HK1214509A1 (zh) 2016-07-29
CA2897059C (en) 2021-12-28
EA030983B1 (ru) 2018-10-31
JP2016503819A (ja) 2016-02-08
EP2983686A1 (en) 2016-02-17
WO2014107744A1 (en) 2014-07-10
SG11201505229XA (en) 2015-08-28
EP2983686B1 (en) 2024-05-29
ZA201505608B (en) 2018-11-28
NZ710727A (en) 2020-03-27
AU2014203886A1 (en) 2015-08-20

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