EA201892561A1 - Гибридные белки gdf15 и их применение - Google Patents

Гибридные белки gdf15 и их применение

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Publication number
EA201892561A1
EA201892561A1 EA201892561A EA201892561A EA201892561A1 EA 201892561 A1 EA201892561 A1 EA 201892561A1 EA 201892561 A EA201892561 A EA 201892561A EA 201892561 A EA201892561 A EA 201892561A EA 201892561 A1 EA201892561 A1 EA 201892561A1
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EA
Eurasian Patent Office
Prior art keywords
gdf15
application
hybrid proteins
fusion proteins
proteins
Prior art date
Application number
EA201892561A
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English (en)
Inventor
Энтони Армстронг
Джудит Энн Коннор
Дженнифер Фурман
Чичи Хуан
Майкл Дж. Хантер
Сефань Линь-Шмидт
Серена Нельсон
Шамина Рангвала
Шэннон Малликан
Хосе Антонио Чавес
Original Assignee
Янссен Байотек, Инк.
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Application filed by Янссен Байотек, Инк. filed Critical Янссен Байотек, Инк.
Publication of EA201892561A1 publication Critical patent/EA201892561A1/ru

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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Abstract

Описаны гибридные белки, содержащие белок, продлевающий период полужизни, линкер и белок GDF15. Также описаны нуклеиновые кислоты, кодирующие гибридные белки, рекомбинантные клетки с ними, композиции, содержащие гибридные белки, и способы применения гибридных белков для лечения или профилактики заболеваний, расстройств или состояний.
EA201892561A 2016-05-10 2017-05-05 Гибридные белки gdf15 и их применение EA201892561A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662333886P 2016-05-10 2016-05-10
PCT/US2017/031197 WO2017196647A1 (en) 2016-05-10 2017-05-05 Gdf15 fusion proteins and uses thereof

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EA201892561A1 true EA201892561A1 (ru) 2019-04-30

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US (3) US10336812B2 (ru)
EP (1) EP3454832A4 (ru)
JP (2) JP7022879B2 (ru)
KR (2) KR20190003746A (ru)
CN (1) CN109451726A (ru)
AR (1) AR108442A1 (ru)
AU (3) AU2017263237B2 (ru)
BR (1) BR112018072946A2 (ru)
CA (1) CA3022865A1 (ru)
CL (1) CL2018003148A1 (ru)
CO (1) CO2018012096A2 (ru)
CR (2) CR20180532A (ru)
DO (1) DOP2018000245A (ru)
EA (1) EA201892561A1 (ru)
EC (1) ECSP18083561A (ru)
IL (2) IL262652B2 (ru)
MA (1) MA44986A (ru)
MX (1) MX2018013784A (ru)
MY (1) MY191030A (ru)
NI (1) NI201800121A (ru)
PE (2) PE20190352A1 (ru)
PH (1) PH12018502361A1 (ru)
SG (2) SG10201912739XA (ru)
SV (1) SV2018005781A (ru)
TW (2) TWI760333B (ru)
WO (1) WO2017196647A1 (ru)
ZA (1) ZA201808284B (ru)

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EA202092386A1 (ru) 2013-07-31 2021-04-30 Эмджен Инк. Конструкции на основе фактора дифференцировки и роста 15 (gdf15)
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JP2022513098A (ja) * 2018-11-20 2022-02-07 ヤンセン ファーマシューティカ エヌ．ベー． 体重減少及び／又は食物摂取量低減に使用するためのｇｄｆ１５類似体及び方法
JP7340027B2 (ja) * 2019-02-27 2023-09-06 デウン ファーマシューティカル カンパニー リミテッド アルブミンと結合したＳｌｉｔ３タンパク質のＬＲＲＤ２を含む骨関連疾患の予防または治療用組成物
US20220125889A1 (en) * 2019-02-27 2022-04-28 Daewoong Pharmaceutical Co., Ltd. Composition comprising albumin-coupled slit3 lrrd2 for prevention or treatment of muscle disease
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CN112618698B (zh) * 2019-10-08 2021-10-08 北京东方百泰生物科技股份有限公司 一种人白细胞介素10-Fc融合蛋白的注射制剂
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CA3159979A1 (en) * 2019-12-11 2021-06-17 Yeonchul Kim Fusion polypeptide comprising gdf15 and polypeptide region capable of o-glycosylation
CN116925237A (zh) 2019-12-31 2023-10-24 北京质肽生物医药科技有限公司 Glp-1和gdf15的融合蛋白以及其缀合物
CN114560938B (zh) * 2020-03-30 2023-05-23 中国人民解放军第四军医大学 抗gdf15中和性单克隆抗体及其应用
CN115244076B (zh) * 2020-10-27 2023-08-04 北京质肽生物医药科技有限公司 Gdf15融合蛋白及其用途
CA3226178A1 (en) * 2021-08-24 2023-03-02 Jiangyu YAN Gdf15 fusion proteins and uses thereof
WO2023154953A1 (en) 2022-02-14 2023-08-17 Ngm Biopharmaceuticals, Inc. Gdf15 polypeptides for treating and preventing autoimmune diseases

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