EA201691981A1 - Улучшенные транспортные молекулы модулярного антигена и их применение - Google Patents

Улучшенные транспортные молекулы модулярного антигена и их применение

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Publication number
EA201691981A1
EA201691981A1 EA201691981A EA201691981A EA201691981A1 EA 201691981 A1 EA201691981 A1 EA 201691981A1 EA 201691981 A EA201691981 A EA 201691981A EA 201691981 A EA201691981 A EA 201691981A EA 201691981 A1 EA201691981 A1 EA 201691981A1
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EA
Eurasian Patent Office
Prior art keywords
molecules
imat
application
module
transport molecules
Prior art date
Application number
EA201691981A
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English (en)
Other versions
EA034692B1 (ru
Inventor
Хорст Розе
Дания Бирте Райхе
Харальд Таммен
Original Assignee
Бёрингер Ингельхайм Ветмедика Гмбх
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Application filed by Бёрингер Ингельхайм Ветмедика Гмбх filed Critical Бёрингер Ингельхайм Ветмедика Гмбх
Publication of EA201691981A1 publication Critical patent/EA201691981A1/ru
Publication of EA034692B1 publication Critical patent/EA034692B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/35—Allergens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/06—Fusion polypeptide containing a localisation/targetting motif containing a lysosomal/endosomal localisation signal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation

Abstract

Настоящее изобретение относится к (изолированным) рекомбинантным белкам, которые также называются как улучшенные молекулы MAT (iMAT), включающим по крайней мере один транслокационный модуль, по крайней мере один нацеливающий модуль и по крайней мере один антигенный модуль, где по крайней мере один остаток цистеина является замещенным с помощью отличного аминокислотного остатка. Такие молекулы iMAT являются полезными, в частности, в качестве вакцин, например, для терапии, и/или для профилактики аллергий и/или инфекционных заболеваний, и/или для предотвращения передачи инфекционных заболеваний у лошадей. Настоящее изобретение дополнительно относится к нуклеиновым кислотам, которые кодируют такие молекулы iMAT, соответствующим векторам и первичным клеткам и линиям клеток.
EA201691981A 2014-03-31 2015-03-27 Улучшенные транспортные молекулы модулярного антигена и их применение EA034692B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14162575 2014-03-31
PCT/EP2015/056670 WO2015150243A1 (en) 2014-03-31 2015-03-27 Improved modular antigen transportation molecules and uses therof

Publications (2)

Publication Number Publication Date
EA201691981A1 true EA201691981A1 (ru) 2017-03-31
EA034692B1 EA034692B1 (ru) 2020-03-06

Family

ID=50433975

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201691981A EA034692B1 (ru) 2014-03-31 2015-03-27 Улучшенные транспортные молекулы модулярного антигена и их применение

Country Status (12)

Country Link
US (2) US9920101B2 (ru)
EP (1) EP3125933B1 (ru)
JP (1) JP6370398B2 (ru)
KR (1) KR20160138283A (ru)
CN (1) CN106132996B (ru)
AR (1) AR100310A1 (ru)
AU (1) AU2015239770B2 (ru)
CA (1) CA2943690A1 (ru)
EA (1) EA034692B1 (ru)
MX (1) MX2016012840A (ru)
TW (1) TWI705823B (ru)
WO (1) WO2015150243A1 (ru)

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* Cited by examiner, † Cited by third party
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CN106132996B (zh) 2014-03-31 2020-10-09 勃林格殷格翰动物保健有限公司 经改良的模块化抗原转运分子及其用途
US10898568B2 (en) 2015-09-30 2021-01-26 Boehringer Ingelheim Vetmedica Gmbh Modular antigen transportation molecules and uses thereof in animals
US11547662B2 (en) 2017-10-25 2023-01-10 Allero Therapeutics B.V. Treatment of immune diseases by administration of antigen-specific formulations
US20220047648A1 (en) * 2019-01-09 2022-02-17 Md Healthcare Inc. Nanovesicles derived from bacteria of genus rhodococcus, and use thereof
CN110343160A (zh) * 2019-07-26 2019-10-18 四川农业大学 黄粉虫ym47蛋白、其编码基因及应用
KR200491545Y1 (ko) 2019-10-29 2020-04-24 김용호 맞춤형 기능성 베개
KR200494146Y1 (ko) 2019-10-29 2021-08-12 김용호 맞춤형 기능성 베개

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US5804604A (en) 1989-12-21 1998-09-08 Biogen, Inc. Tat-derived transport polypeptides and fusion proteins
US5633234A (en) 1993-01-22 1997-05-27 The Johns Hopkins University Lysosomal targeting of immunogens
WO1994018999A1 (en) 1993-02-26 1994-09-01 Immtech International, Inc. A mutant protein and methods and materials for making and using it
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JP3993035B2 (ja) 2001-07-19 2007-10-17 松下電器産業株式会社 データ記録方法、記録媒体、および再生装置
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UY31930A (es) * 2008-06-25 2010-01-29 Boheringer Ingelheim Pharma Kg Pestivirus atenuados recombinantes, en particular a csfv, bvdv o bdv atenuado recombinante
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CN106132996B (zh) 2014-03-31 2020-10-09 勃林格殷格翰动物保健有限公司 经改良的模块化抗原转运分子及其用途
US10898568B2 (en) 2015-09-30 2021-01-26 Boehringer Ingelheim Vetmedica Gmbh Modular antigen transportation molecules and uses thereof in animals
CN107389010A (zh) * 2017-07-25 2017-11-24 爱佩仪中测（成都）精密仪器有限公司 提高三维测量仪器测量精度的支撑机构

Also Published As

Publication number Publication date
CN106132996B (zh) 2020-10-09
EA034692B1 (ru) 2020-03-06
US9920101B2 (en) 2018-03-20
AU2015239770B2 (en) 2020-07-02
EP3125933B1 (en) 2022-05-18
TWI705823B (zh) 2020-10-01
US20180170978A1 (en) 2018-06-21
CN106132996A (zh) 2016-11-16
US20150274790A1 (en) 2015-10-01
WO2015150243A1 (en) 2015-10-08
US10919945B2 (en) 2021-02-16
EP3125933A1 (en) 2017-02-08
JP6370398B2 (ja) 2018-08-08
CA2943690A1 (en) 2015-10-08
MX2016012840A (es) 2017-05-09
KR20160138283A (ko) 2016-12-02
JP2017510268A (ja) 2017-04-13
AR100310A1 (es) 2016-09-28
AU2015239770A1 (en) 2016-08-04
TW201607554A (zh) 2016-03-01

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