MX2016012840A - Moléculas para transporte de antígeno modular mejoradas y sus usos. - Google Patents

Moléculas para transporte de antígeno modular mejoradas y sus usos.

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Publication number
MX2016012840A
MX2016012840A MX2016012840A MX2016012840A MX2016012840A MX 2016012840 A MX2016012840 A MX 2016012840A MX 2016012840 A MX2016012840 A MX 2016012840A MX 2016012840 A MX2016012840 A MX 2016012840A MX 2016012840 A MX2016012840 A MX 2016012840A
Authority
MX
Mexico
Prior art keywords
molecules
imat
module
improved modular
prevention
Prior art date
Application number
MX2016012840A
Other languages
English (en)
Inventor
Birte Reiche Dania
Rose Horst
Tammen Harald
Original Assignee
Boehringer Ingelheim Vetmedica Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Vetmedica Gmbh filed Critical Boehringer Ingelheim Vetmedica Gmbh
Publication of MX2016012840A publication Critical patent/MX2016012840A/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/35—Allergens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/06—Fusion polypeptide containing a localisation/targetting motif containing a lysosomal/endosomal localisation signal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Insects & Arthropods (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Botany (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invención se refiere a proteínas recombinantes (aisladas), también denominadas como moléculas MAT mejoradas (iMAT), que comprende al menos un módulo de translocación, al menos un módulo de direccionamiento y al menos un módulo del antígeno, en donde al menos un residuo de cisteína se sustituye con un residuo de aminoácido diferente. Tales moléculas iMAT son útiles específicamente como vacunas, por ejemplo, para terapia y/o prevención de alegrías y/o enfermedades infecciosas y/o prevención de transmisión de enfermedades infecciosas en equinos. La presente invención también se refiere a ácidos nucleicos que codifican tales moléculas iMAT, correspondiente vectores y células o líneas celulares primarias.
MX2016012840A 2014-03-31 2015-03-27 Moléculas para transporte de antígeno modular mejoradas y sus usos. MX2016012840A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14162575 2014-03-31
PCT/EP2015/056670 WO2015150243A1 (en) 2014-03-31 2015-03-27 Improved modular antigen transportation molecules and uses therof

Publications (1)

Publication Number Publication Date
MX2016012840A true MX2016012840A (es) 2017-05-09

Family

ID=50433975

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016012840A MX2016012840A (es) 2014-03-31 2015-03-27 Moléculas para transporte de antígeno modular mejoradas y sus usos.

Country Status (12)

Country Link
US (2) US9920101B2 (es)
EP (1) EP3125933B1 (es)
JP (1) JP6370398B2 (es)
KR (1) KR20160138283A (es)
CN (1) CN106132996B (es)
AR (1) AR100310A1 (es)
AU (1) AU2015239770B2 (es)
CA (1) CA2943690A1 (es)
EA (1) EA034692B1 (es)
MX (1) MX2016012840A (es)
TW (1) TWI705823B (es)
WO (1) WO2015150243A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2943690A1 (en) 2014-03-31 2015-10-08 Boehringer Ingelheim Vetmedica Gmbh Improved modular antigen transportation molecules and uses therof
CN108136000B (zh) 2015-09-30 2022-11-08 勃林格殷格翰动物保健有限公司 经改良的模块化抗原转运分子及其在动物中的用途
US11547662B2 (en) 2017-10-25 2023-01-10 Allero Therapeutics B.V. Treatment of immune diseases by administration of antigen-specific formulations
US20220047648A1 (en) * 2019-01-09 2022-02-17 Md Healthcare Inc. Nanovesicles derived from bacteria of genus rhodococcus, and use thereof
CN110343160A (zh) * 2019-07-26 2019-10-18 四川农业大学 黄粉虫ym47蛋白、其编码基因及应用
KR200491545Y1 (ko) 2019-10-29 2020-04-24 김용호 맞춤형 기능성 베개
KR200494146Y1 (ko) 2019-10-29 2021-08-12 김용호 맞춤형 기능성 베개

Family Cites Families (19)

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US5804604A (en) 1989-12-21 1998-09-08 Biogen, Inc. Tat-derived transport polypeptides and fusion proteins
US5633234A (en) 1993-01-22 1997-05-27 The Johns Hopkins University Lysosomal targeting of immunogens
AU6252294A (en) 1993-02-26 1994-09-14 Immtech International, Inc. A mutant protein and methods and materials for making and using it
GB9825421D0 (en) 1998-11-19 1999-01-13 Isis Innovation Process for oxidising terpenes
JP3993035B2 (ja) 2001-07-19 2007-10-17 松下電器産業株式会社 データ記録方法、記録媒体、および再生装置
DE50209178D1 (de) * 2002-10-11 2007-02-15 Imvision Gmbh Moduläre Antigen-Transporter Moleküle (MAT-Moleküle) zur Modulierung von Immunreaktionen, zugehörige Konstrukte, Verfahren und Verwendungen
EP1440979B1 (en) * 2003-01-21 2005-10-19 BIOMAY Produktions- und Handels- Aktiengesellschaft Process for the preparation of hypoallergenic mosaic proteins
WO2004094639A2 (en) 2003-04-24 2004-11-04 Im Vision Gmbh Recombinant fel d 1 allergen
EP1621615B1 (en) 2003-05-07 2010-03-17 Juridical Foundation, The Chemo-Sero-Therapeutic Research Institute Method of purifying modified acarian main allergen
DE10359351A1 (de) 2003-12-16 2005-07-21 Merck Patent Gmbh DNA-Sequenz und rekombinante Herstellung von Gruppe-4 Majorallergenen aus Getreiden
WO2007065633A1 (en) * 2005-12-05 2007-06-14 Imvision Ag Modulation of the immune response by administration of intralymphatic transduction allergen (itag) -molecules
DK2083856T3 (da) 2007-08-15 2011-01-24 Circassia Ltd Peptider til desensibilisering mod allergener
UY31930A (es) * 2008-06-25 2010-01-29 Boheringer Ingelheim Pharma Kg Pestivirus atenuados recombinantes, en particular a csfv, bvdv o bdv atenuado recombinante
JP2011212008A (ja) * 2010-03-16 2011-10-27 Olympus Corp 蛍光タンパク質およびｐＨ測定方法
WO2012121395A1 (ja) * 2011-03-09 2012-09-13 国立大学法人徳島大学 コレステロール依存性細胞溶解毒素の変異体及びそのddsへの利用
WO2012170842A2 (en) 2011-06-09 2012-12-13 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Peptide for protection of allergic respiratory disorders
CA2943690A1 (en) 2014-03-31 2015-10-08 Boehringer Ingelheim Vetmedica Gmbh Improved modular antigen transportation molecules and uses therof
CN108136000B (zh) 2015-09-30 2022-11-08 勃林格殷格翰动物保健有限公司 经改良的模块化抗原转运分子及其在动物中的用途
CN107389010A (zh) * 2017-07-25 2017-11-24 爱佩仪中测（成都）精密仪器有限公司 提高三维测量仪器测量精度的支撑机构

Also Published As

Publication number Publication date
WO2015150243A1 (en) 2015-10-08
KR20160138283A (ko) 2016-12-02
US20180170978A1 (en) 2018-06-21
JP6370398B2 (ja) 2018-08-08
CA2943690A1 (en) 2015-10-08
CN106132996B (zh) 2020-10-09
EP3125933A1 (en) 2017-02-08
JP2017510268A (ja) 2017-04-13
AR100310A1 (es) 2016-09-28
US9920101B2 (en) 2018-03-20
EP3125933B1 (en) 2022-05-18
US20150274790A1 (en) 2015-10-01
TW201607554A (zh) 2016-03-01
AU2015239770B2 (en) 2020-07-02
CN106132996A (zh) 2016-11-16
EA201691981A1 (ru) 2017-03-31
US10919945B2 (en) 2021-02-16
TWI705823B (zh) 2020-10-01
AU2015239770A1 (en) 2016-08-04
EA034692B1 (ru) 2020-03-06

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