MX2018003850A - Moleculas de transporte de antigeno modular mejoradas y sus usos en animales. - Google Patents
Moleculas de transporte de antigeno modular mejoradas y sus usos en animales.Info
- Publication number
- MX2018003850A MX2018003850A MX2018003850A MX2018003850A MX2018003850A MX 2018003850 A MX2018003850 A MX 2018003850A MX 2018003850 A MX2018003850 A MX 2018003850A MX 2018003850 A MX2018003850 A MX 2018003850A MX 2018003850 A MX2018003850 A MX 2018003850A
- Authority
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- Prior art keywords
- molecules
- animals
- imat
- module
- prevention
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
- C07K14/43531—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from mites
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
- C07K14/4359—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from fleas
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/577—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 tolerising response
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
- A61K2039/622—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier non-covalent binding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16033—Use of viral protein as therapeutic agent other than vaccine, e.g. apoptosis inducing or anti-inflammatory
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16071—Demonstrated in vivo effect
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Insects & Arthropods (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
Abstract
La presente invención se refiere a proteínas recombinantes (aisladas), también denominadas como moléculas de MAT mejoradas (iMAT), que comprenden al menos un módulo de translocación, al menos un módulo de direccionamiento y al menos un módulo del antígeno, donde al menos un residuo de cisteína está sustituido con un residuo de aminoácido diferente. Tales moléculas de iMAT son útiles específicamente como vacunas, por ejemplo, para terapia y/o prevención de alergias y/o enfermedades infecciosas y/o prevención de la transmisión de enfermedades infecciosas en animales, con más preferencia rumiantes, cerdos, perros y/o gatos, pero excluyendo equinos. La presente invención también se refiere a los ácidos nucleicos que codifican tales moléculas de iMAT, vectores correspondientes y células o líneas celulares primarias.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15187810 | 2015-09-30 | ||
PCT/EP2016/072898 WO2017055235A1 (en) | 2015-09-30 | 2016-09-27 | Improved modular antigen transportation molecules and uses therof in animals |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018003850A true MX2018003850A (es) | 2018-06-15 |
Family
ID=54266382
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018003850A MX2018003850A (es) | 2015-09-30 | 2016-09-27 | Moleculas de transporte de antigeno modular mejoradas y sus usos en animales. |
Country Status (10)
Country | Link |
---|---|
US (2) | US10898568B2 (es) |
EP (1) | EP3355917A1 (es) |
JP (3) | JP2018527395A (es) |
KR (1) | KR20180061338A (es) |
CN (1) | CN108136000B (es) |
AU (1) | AU2016333474A1 (es) |
CA (1) | CA2999930A1 (es) |
EA (1) | EA201890856A1 (es) |
MX (1) | MX2018003850A (es) |
WO (1) | WO2017055235A1 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106132996B (zh) | 2014-03-31 | 2020-10-09 | 勃林格殷格翰动物保健有限公司 | 经改良的模块化抗原转运分子及其用途 |
WO2017004561A1 (en) | 2015-07-01 | 2017-01-05 | Alk-Abelló A/S | Peptide combinations and uses thereof for treating grass allergy |
US10898568B2 (en) | 2015-09-30 | 2021-01-26 | Boehringer Ingelheim Vetmedica Gmbh | Modular antigen transportation molecules and uses thereof in animals |
EP3463449A1 (en) * | 2016-05-27 | 2019-04-10 | ALK-Abelló A/S | Immunogenic proteins and fragments thereof from allergenic mites |
JP6892079B2 (ja) * | 2017-06-29 | 2021-06-18 | 京都府公立大学法人 | 制御性t細胞誘導剤、アジュバント及び食品組成物 |
WO2023285489A1 (en) | 2021-07-13 | 2023-01-19 | Intervet International B.V. | Overcoming antibody-interference in avians |
CN113598072A (zh) * | 2021-08-31 | 2021-11-05 | 云麻溯源生物科技(上海)有限公司 | 一种具有抑菌除臭功能的工业大麻猫砂及其制备方法 |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5804604A (en) | 1989-12-21 | 1998-09-08 | Biogen, Inc. | Tat-derived transport polypeptides and fusion proteins |
US5633234A (en) | 1993-01-22 | 1997-05-27 | The Johns Hopkins University | Lysosomal targeting of immunogens |
WO1994018999A1 (en) | 1993-02-26 | 1994-09-01 | Immtech International, Inc. | A mutant protein and methods and materials for making and using it |
US20020169104A1 (en) | 1997-05-01 | 2002-11-14 | Glenn Frank | Novel ectoparasite saliva proteins and apparatus to collect such proteins |
JP3993035B2 (ja) | 2001-07-19 | 2007-10-17 | 松下電器産業株式会社 | データ記録方法、記録媒体、および再生装置 |
JP2004081210A (ja) * | 2002-06-28 | 2004-03-18 | Japan Science & Technology Corp | システイン残基を改変したタンパク質からなる中空ナノ粒子およびそれを用いた薬剤 |
EP1408114B1 (de) * | 2002-10-11 | 2007-01-03 | Imvision GmbH | Moduläre Antigen-Transporter Moleküle (MAT-Moleküle) zur Modulierung von Immunreaktionen, zugehörige Konstrukte, Verfahren und Verwendungen |
US20090117136A1 (en) | 2003-04-24 | 2009-05-07 | Imvision Gmbh | Recombinant allergen |
ATE461278T1 (de) * | 2003-05-07 | 2010-04-15 | Chemo Sero Therapeut Res Inst | Verfahren zur reinigung des modifizierten hauptallergens von milben |
DE10359351A1 (de) | 2003-12-16 | 2005-07-21 | Merck Patent Gmbh | DNA-Sequenz und rekombinante Herstellung von Gruppe-4 Majorallergenen aus Getreiden |
WO2007065633A1 (en) | 2005-12-05 | 2007-06-14 | Imvision Ag | Modulation of the immune response by administration of intralymphatic transduction allergen (itag) -molecules |
GB0710529D0 (en) * | 2007-06-01 | 2007-07-11 | Circassia Ltd | Vaccine |
WO2009007418A1 (en) | 2007-07-12 | 2009-01-15 | Respiratorius Ab | Novel bronchodilating isoquinoline amides |
CN101820907B (zh) | 2007-08-15 | 2013-05-01 | 切尔卡西亚有限公司 | 针对过敏原去敏化的肽 |
EP2222694B1 (en) * | 2007-12-13 | 2014-01-15 | Roche Diagnostics GmbH | Novel rubella e1 envelope protein variants and their use in the detection of anti-rubella antibodies |
WO2009116524A1 (ja) * | 2008-03-17 | 2009-09-24 | 独立行政法人理化学研究所 | 改変タンパク質 |
ES2638308T3 (es) * | 2008-03-25 | 2017-10-19 | Bial Industrial Farmaceutica, S.A. | Proteínas híbridas hipoalergénicas de alérgenos de ácaros del grupo 1 y 2 principales para uso en el tratamiento de alergias |
SE535625C2 (sv) * | 2010-10-28 | 2012-10-16 | Toleranzia Ab | Nya kompositioner och förfaranden för behandling av autoimmuna och allergiska sjukdomar |
WO2012121395A1 (ja) | 2011-03-09 | 2012-09-13 | 国立大学法人徳島大学 | コレステロール依存性細胞溶解毒素の変異体及びそのddsへの利用 |
US9546200B2 (en) | 2011-06-09 | 2017-01-17 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Peptide for protection of allergic respiratory disorders |
FR2991996B1 (fr) * | 2012-06-13 | 2016-07-08 | Angany Genetics | Methode de production d'allergenes recombinants de haute qualite par expression transitoire chez nicotiana benthamiana |
CN104736555B (zh) * | 2012-10-23 | 2019-06-21 | 国家血清研究所 | 结核分枝杆菌疫苗 |
CN106132996B (zh) * | 2014-03-31 | 2020-10-09 | 勃林格殷格翰动物保健有限公司 | 经改良的模块化抗原转运分子及其用途 |
US10898568B2 (en) | 2015-09-30 | 2021-01-26 | Boehringer Ingelheim Vetmedica Gmbh | Modular antigen transportation molecules and uses thereof in animals |
-
2016
- 2016-09-27 US US15/276,922 patent/US10898568B2/en active Active
- 2016-09-27 KR KR1020187012465A patent/KR20180061338A/ko not_active Application Discontinuation
- 2016-09-27 EA EA201890856A patent/EA201890856A1/ru unknown
- 2016-09-27 EP EP16775160.1A patent/EP3355917A1/en not_active Withdrawn
- 2016-09-27 CA CA2999930A patent/CA2999930A1/en not_active Abandoned
- 2016-09-27 WO PCT/EP2016/072898 patent/WO2017055235A1/en active Application Filing
- 2016-09-27 MX MX2018003850A patent/MX2018003850A/es unknown
- 2016-09-27 JP JP2018515022A patent/JP2018527395A/ja active Pending
- 2016-09-27 CN CN201680057979.3A patent/CN108136000B/zh active Active
- 2016-09-27 AU AU2016333474A patent/AU2016333474A1/en not_active Abandoned
-
2019
- 2019-10-24 JP JP2019193302A patent/JP2020023561A/ja active Pending
-
2020
- 2020-12-15 US US17/122,593 patent/US20210128719A1/en not_active Abandoned
-
2021
- 2021-10-25 JP JP2021173721A patent/JP2022009452A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US20170087246A1 (en) | 2017-03-30 |
US10898568B2 (en) | 2021-01-26 |
JP2020023561A (ja) | 2020-02-13 |
JP2022009452A (ja) | 2022-01-14 |
EP3355917A1 (en) | 2018-08-08 |
EA201890856A1 (ru) | 2018-10-31 |
AU2016333474A1 (en) | 2018-03-22 |
KR20180061338A (ko) | 2018-06-07 |
CA2999930A1 (en) | 2017-04-06 |
CN108136000A (zh) | 2018-06-08 |
JP2018527395A (ja) | 2018-09-20 |
WO2017055235A1 (en) | 2017-04-06 |
US20210128719A1 (en) | 2021-05-06 |
CN108136000B (zh) | 2022-11-08 |
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