EA201691011A1 - Последовательность модифицированного эндолизина el188 - Google Patents

Последовательность модифицированного эндолизина el188

Info

Publication number
EA201691011A1
EA201691011A1 EA201691011A EA201691011A EA201691011A1 EA 201691011 A1 EA201691011 A1 EA 201691011A1 EA 201691011 A EA201691011 A EA 201691011A EA 201691011 A EA201691011 A EA 201691011A EA 201691011 A1 EA201691011 A1 EA 201691011A1
Authority
EA
Eurasian Patent Office
Prior art keywords
polypeptides
nucleic acids
sequence
relates
endolysine
Prior art date
Application number
EA201691011A
Other languages
English (en)
Inventor
Ирина Аносова
Original Assignee
Лисандо Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Лисандо Аг filed Critical Лисандо Аг
Publication of EA201691011A1 publication Critical patent/EA201691011A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2462—Lysozyme (3.2.1.17)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01017—Lysozyme (3.2.1.17)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Заявленное изобретение относится к полипептидам, содержащим аминокислотную последовательность, демонстрирующую как минимум примерно 90% идентичность с последовательностью SEQ ID NO: 1. Упомянутые полипептиды предпочтительно расщепляют пептидогликан грамотрицательных бактерий, в частности бактерий Pseudomonas и/или Campylobacter. Дополнительно заявленное изобретение относится к нуклеиновым кислотам, кодирующим упомянутые полипептиды, векторам, включающим упомянутые нуклеиновые кислоты, и соответствующим клеткам-хозяинам. И, наконец, заявленное изобретение относится к композициям, содержащим упомянутые полипептиды, нуклеиновые кислоты, векторы и/или клетки-хозяины, согласно заявленному изобретению.
EA201691011A 2013-11-14 2014-11-14 Последовательность модифицированного эндолизина el188 EA201691011A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP2013/073872 WO2015070912A1 (en) 2013-11-14 2013-11-14 Modified el188 endolysin sequence
PCT/EP2014/074678 WO2015071437A1 (en) 2013-11-14 2014-11-14 Modified el188 endolysin sequence

Publications (1)

Publication Number Publication Date
EA201691011A1 true EA201691011A1 (ru) 2017-02-28

Family

ID=49584734

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201691011A EA201691011A1 (ru) 2013-11-14 2014-11-14 Последовательность модифицированного эндолизина el188

Country Status (8)

Country Link
US (1) US10167462B2 (ru)
KR (1) KR20160079116A (ru)
CN (1) CN105793420A (ru)
AU (1) AU2014350105A1 (ru)
BR (1) BR112016011095A2 (ru)
CA (1) CA2929692A1 (ru)
EA (1) EA201691011A1 (ru)
WO (2) WO2015070912A1 (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2989311A1 (en) 2015-07-02 2017-01-05 Dana-Farber Cancer Institute, Inc. Stabilized anti-microbial peptides
CA2998484A1 (en) 2015-09-17 2017-03-23 Contrafect Corporation Use of lysin to restore/augment antibacterial activity in the presence of pulmonary surfactant of antibiotics inhibited thereby
AU2017228333C1 (en) 2016-02-29 2022-03-10 Dana-Farber Cancer Institute, Inc. Stapled intracellular-targeting antimicrobial peptides to treat infection
WO2018185634A1 (en) * 2017-04-03 2018-10-11 Sasinapas Co., Ltd. Engineered gram-negative endolysins
WO2019018499A2 (en) 2017-07-19 2019-01-24 Dana-Farber Cancer Institute, Inc. ANTIMICROBIAL PEPTIDES STABILIZED FOR THE TREATMENT OF ANTIBIOTIC-RESISTANT BACTERIAL INFECTIONS
JP2021506769A (ja) * 2017-12-12 2021-02-22 コントラフェクト コーポレイション シュードモナス・エルギノーサに対する殺菌活性を有する溶解素及びその誘導体の特定
EP3727451B1 (en) * 2017-12-22 2023-05-10 The Rockefeller University Recombinant pseudomonas aeruginosa lysins

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0815484D0 (en) 2008-08-26 2008-10-01 Univ Leuven Kath Antibacterial agents
KR20170024129A (ko) * 2009-06-26 2017-03-06 카톨리에케 유니버시테이트 루벤 항균제
MX2011013453A (es) 2009-06-26 2012-04-11 Lysando Holding Ag Agentes antimicrobianos.
DK2563916T3 (en) * 2010-04-27 2015-10-05 Lysando Ag METHOD FOR REDUCING biofilms
EP2468856A1 (en) * 2010-12-23 2012-06-27 Lysando Aktiengesellschaft Antimicrobial Agents

Also Published As

Publication number Publication date
CA2929692A1 (en) 2015-05-21
WO2015070912A1 (en) 2015-05-21
CN105793420A (zh) 2016-07-20
US20160298101A1 (en) 2016-10-13
KR20160079116A (ko) 2016-07-05
WO2015071437A1 (en) 2015-05-21
BR112016011095A2 (pt) 2017-09-19
US10167462B2 (en) 2019-01-01
AU2014350105A1 (en) 2016-05-12

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