EA201691004A1 - Последовательность модифицированного эндолизина kz144 - Google Patents

Последовательность модифицированного эндолизина kz144

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Publication number
EA201691004A1
EA201691004A1 EA201691004A EA201691004A EA201691004A1 EA 201691004 A1 EA201691004 A1 EA 201691004A1 EA 201691004 A EA201691004 A EA 201691004A EA 201691004 A EA201691004 A EA 201691004A EA 201691004 A1 EA201691004 A1 EA 201691004A1
Authority
EA
Eurasian Patent Office
Prior art keywords
polypeptides
nucleic acids
sequence
relates
vectors
Prior art date
Application number
EA201691004A
Other languages
English (en)
Other versions
EA035959B1 (ru
Inventor
Стефан Миллер
Рейнхард Стернер
Хейке Стуер
Original Assignee
Лисандо Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Лисандо Аг filed Critical Лисандо Аг
Publication of EA201691004A1 publication Critical patent/EA201691004A1/ru
Publication of EA035959B1 publication Critical patent/EA035959B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2462—Lysozyme (3.2.1.17)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/503—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01017—Lysozyme (3.2.1.17)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Заявленное изобретение относится к полипептидам, содержащим аминокислотную последовательность, демонстрирующую как минимум примерно 90% идентичность с последовательностью SEQ ID NO: 1. Упомянутые полипептиды предпочтительно расщепляют пептидогликан грамотрицательных бактерий, в частности, бактерий Pseudomonas и/или Campylobacter. Дополнительно, заявленное изобретение относится к нуклеиновым кислотам, кодирующим упомянутые полипептиды, векторам, включающим упомянутые нуклеиновые кислоты и соответствующим клеткам-хозяинам. И, наконец, заявленное изобретение относится к композициям, содержащим упомянутые полипептиды, нуклеиновые кислоты, векторы и/или клетки-хозяины, согласно заявленному изобретению.
EA201691004A 2013-11-14 2014-11-14 Последовательность модифицированного эндолизина kz144 EA035959B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP2013/073869 WO2015070911A1 (en) 2013-11-14 2013-11-14 Modified kz144 endolysin sequence
PCT/EP2014/074671 WO2015071436A1 (en) 2013-11-14 2014-11-14 Modified kz144 endolysin sequence

Publications (2)

Publication Number Publication Date
EA201691004A1 true EA201691004A1 (ru) 2017-01-30
EA035959B1 EA035959B1 (ru) 2020-09-07

Family

ID=49582760

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201691004A EA035959B1 (ru) 2013-11-14 2014-11-14 Последовательность модифицированного эндолизина kz144

Country Status (10)

Country Link
US (1) US10184120B2 (ru)
JP (1) JP6745720B2 (ru)
KR (1) KR102302044B1 (ru)
CN (1) CN105793419B (ru)
AU (1) AU2014350104B2 (ru)
BR (1) BR112016011091B1 (ru)
CA (1) CA2929686C (ru)
EA (1) EA035959B1 (ru)
MX (1) MX2016006277A (ru)
WO (2) WO2015070911A1 (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2728682C2 (ru) 2015-09-17 2020-07-31 Контрафект Корпорейшн Применение лизина для восстановления/увеличения антибактериальной активности антибиотиков в присутствии легочного сурфактанта, который ингибирует указанные антибиотики
CN109072211B (zh) * 2016-04-28 2023-10-27 莱桑多股份公司 抗沙门氏菌的抗菌剂
US11208646B2 (en) 2016-05-27 2021-12-28 Sasinapas Co., Ltd. Endolysin variant
WO2018100408A1 (en) * 2016-11-30 2018-06-07 Sasinapas Co.,Ltd. Modified peptides
JP2020515295A (ja) * 2017-04-03 2020-05-28 サシナパス コーポレイション リミテッド 改変されたグラム陰性エンドリシン
CN111304181B (zh) * 2020-02-17 2021-11-23 华东理工大学 一种基因工程改造后的副溶血性弧菌噬菌体裂解酶及其制备方法和应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1289092C (en) * 1987-01-15 1991-09-17 Robert A. Hallewell Thermostable human cu/zn superoxide dismutase muteins
EP0285123A3 (en) 1987-04-03 1989-02-01 Stabra AG A method for complete mutagenesis of nucleic acids
ZA936811B (en) * 1992-10-28 1995-03-15 Upjohn Co Somatotropin modifications
JPH08127540A (ja) * 1994-09-09 1996-05-21 Takeda Chem Ind Ltd 抗潰瘍医薬
CN101952424A (zh) * 2007-08-22 2011-01-19 海格罗斯投资有限责任公司 用于人类和动物葡萄球菌感染的新蛋白
GB0815484D0 (en) 2008-08-26 2008-10-01 Univ Leuven Kath Antibacterial agents
BRPI1015192A2 (pt) * 2009-06-26 2019-09-17 Katholieke Univ Leuven K U Leuven R&D agentes antimicrobianos
JP6034188B2 (ja) 2009-06-26 2016-11-30 ライサンド アクツィエンゲゼルシャフト 抗微生物剤
AU2010288559B8 (en) * 2009-08-24 2015-08-13 Katholieke Universiteit Leuven, K.U. Leuven R&D New endolysin OBPgpLYS
DK2563916T3 (en) * 2010-04-27 2015-10-05 Lysando Ag METHOD FOR REDUCING biofilms
GB201018518D0 (en) * 2010-11-03 2010-12-15 Univ Leuven Kath Novel endolysin
EP2468856A1 (en) 2010-12-23 2012-06-27 Lysando Aktiengesellschaft Antimicrobial Agents
KR20130142837A (ko) * 2012-06-20 2013-12-30 한국외국어대학교 연구산학협력단 슈도모나스 에루기노사의 박테리오파아지 및 그 용도

Also Published As

Publication number Publication date
WO2015071436A1 (en) 2015-05-21
WO2015070911A1 (en) 2015-05-21
AU2014350104B2 (en) 2020-03-05
CN105793419A (zh) 2016-07-20
CA2929686C (en) 2023-08-08
EA035959B1 (ru) 2020-09-07
KR102302044B1 (ko) 2021-09-15
KR20160085342A (ko) 2016-07-15
CA2929686A1 (en) 2015-05-21
US20160281074A1 (en) 2016-09-29
CN105793419B (zh) 2021-06-01
BR112016011091B1 (pt) 2024-02-06
JP2016537979A (ja) 2016-12-08
JP6745720B2 (ja) 2020-08-26
BR112016011091A2 (pt) 2017-12-05
NZ719338A (en) 2022-03-25
AU2014350104A1 (en) 2016-05-12
US10184120B2 (en) 2019-01-22
MX2016006277A (es) 2017-01-05

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