BR112016011095A2 - Sequência de endolisina el188 modificada - Google Patents
Sequência de endolisina el188 modificadaInfo
- Publication number
- BR112016011095A2 BR112016011095A2 BR112016011095A BR112016011095A BR112016011095A2 BR 112016011095 A2 BR112016011095 A2 BR 112016011095A2 BR 112016011095 A BR112016011095 A BR 112016011095A BR 112016011095 A BR112016011095 A BR 112016011095A BR 112016011095 A2 BR112016011095 A2 BR 112016011095A2
- Authority
- BR
- Brazil
- Prior art keywords
- sequence
- polypeptides
- present
- endolisin
- modified
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2462—Lysozyme (3.2.1.17)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01017—Lysozyme (3.2.1.17)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
SEQUÊNCIA DE ENDOLISINA EL188 MODIFICADA. A presente invenção se refere a polipeptídeos que compreendem uma sequência de aminoácidos que exibe pelo menos cerca de 90% de identidade de sequência com a sequência de SEQ ID NO: 1. Os ditos polipeptídeos degradam, preferencialmente, o peptidoglicano de bactérias Gram-negativas, em particular, de bactérias Pseudomonas e/ou Campylobacter. Além disso, a presente invenção se refere a ácidos nucleicos que codificam tais polipeptídeos, sendo que os vetores compreendem tais ácidos nucleicos e correspondem às células hospedeiras. Finalmente, a presente invenção se refere às composições que compreendem tais polipeptídeos, ácidos nucleicos, vetores e/ou células hospedeiras, de acordo com a presente invenção.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2013/073872 WO2015070912A1 (en) | 2013-11-14 | 2013-11-14 | Modified el188 endolysin sequence |
| PCT/EP2014/074678 WO2015071437A1 (en) | 2013-11-14 | 2014-11-14 | Modified el188 endolysin sequence |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112016011095A2 true BR112016011095A2 (pt) | 2017-09-19 |
Family
ID=49584734
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112016011095A BR112016011095A2 (pt) | 2013-11-14 | 2014-11-14 | Sequência de endolisina el188 modificada |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10167462B2 (pt) |
| KR (1) | KR20160079116A (pt) |
| CN (1) | CN105793420A (pt) |
| AU (1) | AU2014350105A1 (pt) |
| BR (1) | BR112016011095A2 (pt) |
| CA (1) | CA2929692A1 (pt) |
| EA (1) | EA201691011A1 (pt) |
| WO (2) | WO2015070912A1 (pt) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2989311A1 (en) | 2015-07-02 | 2017-01-05 | Dana-Farber Cancer Institute, Inc. | Stabilized anti-microbial peptides |
| JP7029805B2 (ja) | 2015-09-17 | 2022-03-04 | コントラフェクト コーポレイション | グラム陰性菌に対して活性を有する溶解素ポリペプチド |
| WO2017151617A1 (en) | 2016-02-29 | 2017-09-08 | Dana-Farber Cancer Institute, Inc. | Stapled intracellular-targeting antimicrobial peptides to treat infection |
| CA3059019A1 (en) * | 2017-04-03 | 2018-10-11 | Sasinapas Co., Ltd. | Engineered gram-negative endolysins |
| US11325955B2 (en) | 2017-07-19 | 2022-05-10 | Dana-Farber Cancer Institute, Inc. | Stabilized anti-microbial peptides for the treatment of antibiotic-resistant bacterial infections |
| CN111971058A (zh) * | 2017-12-12 | 2020-11-20 | 康特拉费克特公司 | 对铜绿假单胞菌具有细菌活性的溶素及其衍生物的鉴定 |
| EP3727451B1 (en) * | 2017-12-22 | 2023-05-10 | The Rockefeller University | Recombinant pseudomonas aeruginosa lysins |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0815484D0 (en) | 2008-08-26 | 2008-10-01 | Univ Leuven Kath | Antibacterial agents |
| WO2010149795A1 (en) | 2009-06-26 | 2010-12-29 | Lysando Holding Establishment | Antimicrobial agents |
| ES2579806T3 (es) * | 2009-06-26 | 2016-08-16 | Katholieke Universiteit Leuven, K.U. Leuven R&D | Agentes antimicrobianos |
| CA2794603C (en) * | 2010-04-27 | 2019-05-21 | Lysando Ag | Method of reducing biofilms |
| EP2468856A1 (en) * | 2010-12-23 | 2012-06-27 | Lysando Aktiengesellschaft | Antimicrobial Agents |
-
2013
- 2013-11-14 WO PCT/EP2013/073872 patent/WO2015070912A1/en active Application Filing
-
2014
- 2014-11-14 US US15/036,583 patent/US10167462B2/en active Active
- 2014-11-14 AU AU2014350105A patent/AU2014350105A1/en not_active Abandoned
- 2014-11-14 CN CN201480062331.6A patent/CN105793420A/zh active Pending
- 2014-11-14 CA CA2929692A patent/CA2929692A1/en not_active Abandoned
- 2014-11-14 EA EA201691011A patent/EA201691011A1/ru unknown
- 2014-11-14 KR KR1020167015834A patent/KR20160079116A/ko not_active Application Discontinuation
- 2014-11-14 BR BR112016011095A patent/BR112016011095A2/pt not_active Application Discontinuation
- 2014-11-14 WO PCT/EP2014/074678 patent/WO2015071437A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| US10167462B2 (en) | 2019-01-01 |
| CN105793420A (zh) | 2016-07-20 |
| KR20160079116A (ko) | 2016-07-05 |
| CA2929692A1 (en) | 2015-05-21 |
| WO2015070912A1 (en) | 2015-05-21 |
| AU2014350105A1 (en) | 2016-05-12 |
| US20160298101A1 (en) | 2016-10-13 |
| EA201691011A1 (ru) | 2017-02-28 |
| WO2015071437A1 (en) | 2015-05-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112016011095A2 (pt) | Sequência de endolisina el188 modificada | |
| BR112017022298A2 (pt) | geranilgeranil pirofosfato sintase | |
| BR112017019625A2 (pt) | udp-glicosiltransferases | |
| BR112018010805A2 (pt) | mutantes de proteína f de rsv | |
| GB2569733A (en) | RNA-guided nucleic acid modifying enzymes and methods of use thereof | |
| BR112016011091A2 (pt) | sequência de endolisina kz144 modificada | |
| BR112017020308A2 (pt) | udp-glicosiltransferases | |
| BR112016002614A8 (pt) | Imunocitoquina, ácido nucleico, vetor, célula hospedeira e composição farmacêutica | |
| BR112017017884A2 (pt) | switches transcricionais desencadeados por ligação e métodos de uso dos mesmos | |
| BR122021004223A8 (pt) | Molécula de anticorpo, composição, sequência de nucleotídeo, vetor, molécula de anticorpo e uso de uma molécula de anticorpo | |
| MY176331A (en) | Carbohydrate degrading polypeptide and uses thereof | |
| BR112018077358A2 (pt) | tagatose-6-fosfato fosfatase termoestável inovadora e um método para produzir tagatose com o uso da mesma | |
| BR112016020517A2 (pt) | método de produção de lipídeo através da utilização de ss-cetoacil-acp sintase | |
| BR112018003753A2 (pt) | bifidobacterium longum | |
| BR112018077188A2 (pt) | frutose-6-fosfato-3-epimerase termoestável inovadora e um método para produzir alulose com o uso da mesma | |
| EA201401211A1 (ru) | Улучшенные варианты фермента химозина | |
| BR112015017797A2 (pt) | celobio-hidrolase termoestável | |
| BR112016020822A2 (pt) | Métodos e composições para secreção de polipeptídeos heterólogos | |
| EA201691981A1 (ru) | Улучшенные транспортные молекулы модулярного антигена и их применение | |
| EA201791118A1 (ru) | Кодон-оптимизированный полинуклеотид для экспрессии crmна высоком уровне | |
| BR112017013453A2 (pt) | novo peptídeo inibidor de pi3ky para o tratamento de doenças do sistema respiratório | |
| MX2021013879A (es) | Variantes de lipasa y polinucleotidos que las codifican. | |
| MY195726A (en) | Steviol Glycoside Transport | |
| MY187334A (en) | Xylanase | |
| BR112018003925A2 (pt) | composição líquida de detergência compreendendo uma protease e uma lipase |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |