BR112017022298A2 - geranilgeranil pirofosfato sintase - Google Patents

geranilgeranil pirofosfato sintase

Info

Publication number
BR112017022298A2
BR112017022298A2 BR112017022298A BR112017022298A BR112017022298A2 BR 112017022298 A2 BR112017022298 A2 BR 112017022298A2 BR 112017022298 A BR112017022298 A BR 112017022298A BR 112017022298 A BR112017022298 A BR 112017022298A BR 112017022298 A2 BR112017022298 A2 BR 112017022298A2
Authority
BR
Brazil
Prior art keywords
geranylgeranyl pyrophosphate
acid sequence
pyrophosphate synthase
amino acid
sequence
Prior art date
Application number
BR112017022298A
Other languages
English (en)
Inventor
g lawrence Adam
Royer John
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Publication of BR112017022298A2 publication Critical patent/BR112017022298A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30—Artificial sweetening agents
    • A23L27/33—Artificial sweetening agents containing sugars or derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
    • C12N9/0038—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6) with a heme protein as acceptor (1.6.2)
    • C12N9/0042—NADPH-cytochrome P450 reductase (1.6.2.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y106/00—Oxidoreductases acting on NADH or NADPH (1.6)
    • C12Y106/02—Oxidoreductases acting on NADH or NADPH (1.6) with a heme protein as acceptor (1.6.2)
    • C12Y106/02004—NADPH-hemoprotein reductase (1.6.2.4), i.e. NADP-cytochrome P450-reductase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/01001—Dimethylallyltranstransferase (2.5.1.1)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

a presente invenção se refere a um hospedeiro recombinante capaz de produzir um glicosídeo de esteviol compreendendo uma sequência de ácidos nucleicos recombinante que codifica um polipeptídeo tendo atividade de geranilgeranil pirofosfato (ggpp) sintase, que compreende a sequência de aminoácidos estabelecida na seq id no: 1 ou uma sequência de aminoácidos tendo, pelo menos, cerca de 45 % de identidade de sequência com esta.
BR112017022298A 2015-04-21 2016-04-21 geranilgeranil pirofosfato sintase BR112017022298A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562150549P 2015-04-21 2015-04-21
US201562150402P 2015-04-21 2015-04-21
PCT/EP2016/058882 WO2016170045A1 (en) 2015-04-21 2016-04-21 Geranylgeranyl pyrophosphate synthase

Publications (1)

Publication Number Publication Date
BR112017022298A2 true BR112017022298A2 (pt) 2018-07-10

Family

ID=55809103

Family Applications (2)

Application Number Title Priority Date Filing Date
BR112017022298A BR112017022298A2 (pt) 2015-04-21 2016-04-21 geranilgeranil pirofosfato sintase
BR112017022488A BR112017022488A2 (pt) 2015-04-21 2016-04-21 produção microbiana de terpenoides

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR112017022488A BR112017022488A2 (pt) 2015-04-21 2016-04-21 produção microbiana de terpenoides

Country Status (6)

Country Link
US (2) US11332724B2 (pt)
EP (2) EP3286303A1 (pt)
CN (2) CN107532135A (pt)
BR (2) BR112017022298A2 (pt)
CA (1) CA2980649A1 (pt)
WO (2) WO2016170045A1 (pt)

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US10563190B2 (en) 2014-12-09 2020-02-18 Dsm Ip Assets B.V. Methods for producing abienol
CN107532135A (zh) * 2015-04-21 2018-01-02 帝斯曼知识产权资产管理有限公司 萜类化合物的微生物生产
AU2017350309A1 (en) 2016-10-27 2019-05-02 Dsm Ip Assets B.V. Geranylgeranyl pyrophosphate synthases
WO2018224698A1 (en) 2017-08-23 2018-12-13 Dsm Ip Assets B.V. Yoghurt comprising rebaudioside m
EP3688148A1 (en) 2017-09-25 2020-08-05 DSM IP Assets B.V. Production of retinol
BR112020005769A2 (pt) 2017-09-25 2020-09-24 Dsm Ip Assets B.V. produção de ésteres retinílicos
US20200239925A1 (en) 2017-09-25 2020-07-30 Dsm Ip Assets B.V. Production of retinyl esters
BR112020005770A2 (pt) 2017-09-25 2020-09-24 Dsm Ip Assets B.V. produção de trans-retinal
BR112020005774A2 (pt) 2017-09-25 2020-09-24 Dsm Ip Assets B.V. biossíntese de retinoides
WO2019126777A1 (en) * 2017-12-21 2019-06-27 Advanced Biotech Inc. Production of (r)-(e)-(+)-alpha-ionone in recombinant saccharomyces cerevisiae
CN108949599A (zh) * 2018-06-29 2018-12-07 华南理工大学 一种产β-紫罗兰酮基因工程菌及其构建方法与应用
BR112021012401A2 (pt) 2018-12-31 2021-12-14 Dsm Ip Assets Bv Acetil-transferases inovadoras
BR112022000683A2 (pt) 2019-07-16 2022-03-03 Dsm Ip Assets Bv Novas betacaroteno oxidases
CN114901816A (zh) 2019-12-30 2022-08-12 帝斯曼知识产权资产管理有限公司 脂肪酶修饰的菌株
CN111321087A (zh) * 2020-02-21 2020-06-23 华东理工大学 一种产β-胡萝卜素的解脂耶氏酵母基因工程菌及其应用
WO2022003130A2 (en) 2020-07-01 2022-01-06 Dsm Ip Assets B.V. Yeast expression system
WO2023006179A1 (en) 2020-07-27 2023-02-02 Dsm Ip Assets B.V. Method to produce retinyl acetate
WO2022084482A1 (en) 2020-10-22 2022-04-28 Dsm Ip Assets B.V. Microorganisms for diterpene production
CN116391044A (zh) 2020-10-30 2023-07-04 帝斯曼知识产权资产管理有限公司 类异戊二烯的发酵生产
US20240018564A1 (en) 2020-10-30 2024-01-18 Dsm Ip Assets B.V. In situ two-phase extraction system
CN114438159B (zh) * 2020-10-30 2024-05-03 中国科学院分子细胞科学卓越创新中心 诊断和治疗化疗耐药小细胞肺癌的新靶点及其应用
US11964121B2 (en) 2021-10-13 2024-04-23 Satio, Inc. Mono dose dermal patch for pharmaceutical delivery
US11877848B2 (en) 2021-11-08 2024-01-23 Satio, Inc. Dermal patch for collecting a physiological sample
WO2023275212A1 (en) 2021-07-01 2023-01-05 Dsm Ip Assets B.V. Sustainable production of retinyl fatty esters
WO2023006851A1 (en) 2021-07-27 2023-02-02 Dsm Ip Assets B.V. Fermentative production of retinyl acetate in the presence of ethanol
WO2023067030A1 (en) 2021-10-19 2023-04-27 Dsm Ip Assets B.V. Retinoid production
WO2023148187A1 (en) 2022-02-02 2023-08-10 Dsm Ip Assets B.V. Yarrowia production process
WO2023214072A2 (en) 2022-05-05 2023-11-09 Dsm Ip Assets B.V. Novel process

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WO1990014423A1 (en) 1989-05-18 1990-11-29 The Infergene Company Microorganism transformation
DE69033633T2 (de) 1989-07-07 2001-05-03 Unilever Nv Verfahren zur Herstellung eines Proteins mittels eines durch Mehrfachkopie-Integrierung eines Expressionsvektors tranformierten Pilzes
ATE238425T1 (de) 1993-07-23 2003-05-15 Dsm Nv Selektionmarker-genfreie rekombinante stämme: verfahren zur ihrer herstellung und die verwendung dieser stämme
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US8889381B2 (en) * 2011-11-21 2014-11-18 University Of British Columbia Diterpene synthases and method for producing diterpenoids
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CN105051195B (zh) * 2013-02-06 2019-09-06 埃沃尔瓦公司 用于提高莱鲍迪苷d和莱鲍迪苷m之产生的方法
CA2914900A1 (en) 2013-07-15 2015-01-22 Dsm Ip Assets B.V. Recombinant microorganism and process for the production of steviol glycosides
CN107532135A (zh) * 2015-04-21 2018-01-02 帝斯曼知识产权资产管理有限公司 萜类化合物的微生物生产

Also Published As

Publication number Publication date
US20180148697A1 (en) 2018-05-31
CN107532141A (zh) 2018-01-02
CN107532135A (zh) 2018-01-02
BR112017022488A2 (pt) 2018-07-17
EP3286302A1 (en) 2018-02-28
CA2980649A1 (en) 2016-10-27
US11332724B2 (en) 2022-05-17
WO2016172282A1 (en) 2016-10-27
EP3286303A1 (en) 2018-02-28
WO2016170045A1 (en) 2016-10-27
US20180132515A1 (en) 2018-05-17

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B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

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