BR112016026842A2 - preparação compreendendo fator viii e peptídeos de fator de von willebrand - Google Patents
preparação compreendendo fator viii e peptídeos de fator de von willebrandInfo
- Publication number
- BR112016026842A2 BR112016026842A2 BR112016026842A BR112016026842A BR112016026842A2 BR 112016026842 A2 BR112016026842 A2 BR 112016026842A2 BR 112016026842 A BR112016026842 A BR 112016026842A BR 112016026842 A BR112016026842 A BR 112016026842A BR 112016026842 A2 BR112016026842 A2 BR 112016026842A2
- Authority
- BR
- Brazil
- Prior art keywords
- von willebrand
- factor
- preparation
- peptides
- willebrand factor
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Wood Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Water Supply & Treatment (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
a presente invenção refere-se à composição que compreende um complexo do fator viii e um ou mais peptídeos do fator de von willebrand, em que os peptídeos do fator de von willebrand compreendem pelo menos os aminoácidos 764 a 1035 e 1691 a 1905 do seq id no. 1, mas não aminoácidos 2255 a 2645 do seq id no. 1.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14171579 | 2014-06-06 | ||
PCT/EP2015/062730 WO2015185758A2 (en) | 2014-06-06 | 2015-06-08 | Preparation comprising factor viii and von willebrand factor peptides |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112016026842A2 true BR112016026842A2 (pt) | 2017-12-12 |
Family
ID=50884302
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112016026842A BR112016026842A2 (pt) | 2014-06-06 | 2015-06-08 | preparação compreendendo fator viii e peptídeos de fator de von willebrand |
Country Status (13)
Country | Link |
---|---|
US (1) | US10251940B2 (pt) |
EP (2) | EP3360895B1 (pt) |
JP (1) | JP6605593B2 (pt) |
KR (1) | KR20170010895A (pt) |
CN (1) | CN106414492B (pt) |
AU (1) | AU2015270394B2 (pt) |
BR (1) | BR112016026842A2 (pt) |
CA (1) | CA2949323A1 (pt) |
DK (2) | DK3152230T3 (pt) |
ES (2) | ES2747815T3 (pt) |
IL (1) | IL249294A0 (pt) |
RU (1) | RU2714154C2 (pt) |
WO (1) | WO2015185758A2 (pt) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3010720A1 (en) | 2016-01-07 | 2017-07-13 | Csl Behring Recombinant Facility Ag | Mutated truncated von willebrand factor |
US20190169268A1 (en) | 2016-05-20 | 2019-06-06 | Octapharma Ag | Glycosylated vwf fusion proteins with improved pharmacokinetics |
KR20190073576A (ko) | 2016-11-11 | 2019-06-26 | 체에스엘 베링 렝나우 아게 | 혈액 응고 장애의 치료 또는 예방에서 혈관외 투여를 위한 절단된 폰 빌레브란트 인자 폴리펩타이드 |
KR20200018690A (ko) | 2017-06-22 | 2020-02-19 | 체에스엘 베링 렝나우 아게 | 절단된 vwf에 의한 fviii 면역원성의 조절 |
KR20210020030A (ko) | 2018-05-18 | 2021-02-23 | 바이오버라티브 테라퓨틱스 인크. | A형 혈우병의 치료 방법 |
JP2022538357A (ja) * | 2019-07-04 | 2022-09-01 | ツェー・エス・エル・ベーリング・レングナウ・アクチエンゲゼルシャフト | 第VIII凝固因子のin vitroでの安定性を向上させるための切断型フォン・ヴィレブランド因子(VWF) |
US20220305089A1 (en) | 2019-08-16 | 2022-09-29 | Octapharma Ag | Stabilizing buffer for factor viii and vwf |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE504074C2 (sv) | 1993-07-05 | 1996-11-04 | Pharmacia Ab | Proteinberedning för subkutan, intramuskulär eller intradermal administrering |
IL113010A0 (en) | 1994-03-31 | 1995-10-31 | Pharmacia Ab | Pharmaceutical formulation comprising factor VIII or factor ix with an activity of at least 200 IU/ml and an enhancer for improved subcutaneous intramuscular or intradermal administration |
CA2690218C (en) | 2007-06-13 | 2017-02-28 | Csl Behring Gmbh | Use of vwf stabilized fviii preparations and of vwf preparations without fviii for extravascular administration in the therapy and prophylactic treatment of bleeding disorders |
ES2298096B1 (es) * | 2008-01-08 | 2009-01-01 | Grifols, S.A. | Procedimiento para la obtencion de un concentrado de factor von willebrand o del complejo de factor viii/factor von willebrand y utilizacionde los mismos. |
CA2732423A1 (en) | 2008-08-21 | 2010-02-25 | Octapharma Ag | Recombinantly produced human factor viii and ix |
KR20120061898A (ko) | 2009-08-20 | 2012-06-13 | 체에스엘 베링 게엠베하 | 출혈성 장애의 치료요법 및 예방 치료에 있어서의 비정맥내 투여를 위한 알부민 융합 응고 인자 |
CA2771232A1 (en) * | 2009-08-20 | 2011-02-24 | Baxter International Inc. | Purification of vwf for increased removal of non-lipid enveloped viruses |
CN103889445A (zh) | 2011-10-18 | 2014-06-25 | 德国杰特贝林生物制品有限公司 | 硫酸化糖胺聚糖用于改善因子viii的生物利用度的用途 |
CN104411323A (zh) * | 2012-04-24 | 2015-03-11 | 诺和诺德A/S(股份有限公司) | 适用于治疗血友病的药物组合物 |
CN104411716B (zh) * | 2012-04-24 | 2018-09-07 | 诺和诺德股份有限公司 | 适用于治疗血友病的化合物 |
-
2015
- 2015-06-08 ES ES15732554T patent/ES2747815T3/es active Active
- 2015-06-08 JP JP2017516207A patent/JP6605593B2/ja active Active
- 2015-06-08 BR BR112016026842A patent/BR112016026842A2/pt not_active Application Discontinuation
- 2015-06-08 KR KR1020177000328A patent/KR20170010895A/ko not_active Application Discontinuation
- 2015-06-08 AU AU2015270394A patent/AU2015270394B2/en active Active
- 2015-06-08 CA CA2949323A patent/CA2949323A1/en not_active Abandoned
- 2015-06-08 EP EP18159816.0A patent/EP3360895B1/en active Active
- 2015-06-08 RU RU2016152151A patent/RU2714154C2/ru active
- 2015-06-08 US US15/316,711 patent/US10251940B2/en active Active
- 2015-06-08 ES ES18159816T patent/ES2895798T3/es active Active
- 2015-06-08 DK DK15732554T patent/DK3152230T3/da active
- 2015-06-08 WO PCT/EP2015/062730 patent/WO2015185758A2/en active Application Filing
- 2015-06-08 DK DK18159816.0T patent/DK3360895T3/da active
- 2015-06-08 EP EP15732554.9A patent/EP3152230B1/en active Active
- 2015-06-08 CN CN201580029649.9A patent/CN106414492B/zh active Active
-
2016
- 2016-11-30 IL IL249294A patent/IL249294A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
RU2016152151A3 (pt) | 2019-02-06 |
KR20170010895A (ko) | 2017-02-01 |
EP3360895A2 (en) | 2018-08-15 |
CA2949323A1 (en) | 2015-12-10 |
JP6605593B2 (ja) | 2019-11-13 |
US20180185455A1 (en) | 2018-07-05 |
JP2017518376A (ja) | 2017-07-06 |
IL249294A0 (en) | 2017-02-28 |
WO2015185758A3 (en) | 2016-02-11 |
CN106414492A (zh) | 2017-02-15 |
EP3152230B1 (en) | 2019-08-07 |
EP3152230A2 (en) | 2017-04-12 |
DK3360895T3 (da) | 2021-11-15 |
ES2895798T3 (es) | 2022-02-22 |
ES2747815T3 (es) | 2020-03-11 |
RU2714154C2 (ru) | 2020-02-12 |
AU2015270394A1 (en) | 2016-11-24 |
DK3152230T3 (da) | 2019-11-11 |
EP3360895B1 (en) | 2021-08-11 |
EP3360895A3 (en) | 2018-10-17 |
WO2015185758A2 (en) | 2015-12-10 |
RU2016152151A (ru) | 2018-07-10 |
AU2015270394B2 (en) | 2017-12-21 |
US10251940B2 (en) | 2019-04-09 |
CN106414492B (zh) | 2021-07-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NAO 10196/2001, QUE MODIFICOU A LEI NAO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUAANCIA PRA VIA DA ANVISA. CONSIDERANDO A APROVAA AO DOS TERMOS DO PARECER NAO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NAO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDAANCIAS CABA-VEIS. |
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B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
B07G | Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette] |
Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO EM FUNCAO DA REVOGACAO DO ART. 229-C DA LEI NO 9.279, DE 1996, POR FORCA DA LEI NO 14.195, DE 2021 |
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B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |