MX2016011394A - Moleculas de andamiaje a base de fibronectina estabilizada. - Google Patents
Moleculas de andamiaje a base de fibronectina estabilizada.Info
- Publication number
- MX2016011394A MX2016011394A MX2016011394A MX2016011394A MX2016011394A MX 2016011394 A MX2016011394 A MX 2016011394A MX 2016011394 A MX2016011394 A MX 2016011394A MX 2016011394 A MX2016011394 A MX 2016011394A MX 2016011394 A MX2016011394 A MX 2016011394A
- Authority
- MX
- Mexico
- Prior art keywords
- based scaffold
- fibronectin based
- fbs
- domain
- scaffold molecules
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6435—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a connective tissue peptide, e.g. collagen, fibronectin or gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/66—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid the modifying agent being a pre-targeting system involving a peptide or protein for targeting specific cells
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- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
- C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2318/00—Antibody mimetics or scaffolds
- C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
Abstract
Se proporcionan aquí proteínas que comprenden un dominio de andamiaje a base de fibronectina (FBS), por ejemplo, moléculas de 10Fn3, que se unen específicamente a un objetivo, y en donde el dominio de FBS está enlazado en su extremo C-terminal a una región que consiste de PmXn, en donde P es prolina, X es cualquier aminoácido y en donde n es 0 o un número entero que es al menos 1 y m es un número entero que es al menos 1, y en donde la porción de PmXn proporciona una propiedad mejorada al dominio de FBS, por ejemplo, una estabilidad mejorada, con relación a la proteína que no está enlazada a la porción de PmXn.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461955975P | 2014-03-20 | 2014-03-20 | |
US201462084270P | 2014-11-25 | 2014-11-25 | |
PCT/US2015/021466 WO2015143156A1 (en) | 2014-03-20 | 2015-03-19 | Stabilized fibronectin based scaffold molecules |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2016011394A true MX2016011394A (es) | 2016-11-16 |
MX371403B MX371403B (es) | 2020-01-29 |
Family
ID=52808183
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016011394A MX371403B (es) | 2014-03-20 | 2015-03-19 | Moleculas de andamiaje a base de fibronectina estabilizada. |
Country Status (15)
Country | Link |
---|---|
US (3) | US10450363B2 (es) |
EP (2) | EP3647322B1 (es) |
JP (1) | JP6644701B2 (es) |
KR (1) | KR102494646B1 (es) |
CN (2) | CN115322253A (es) |
AU (1) | AU2015231210B2 (es) |
BR (1) | BR112016020492A2 (es) |
CA (1) | CA2943228C (es) |
EA (1) | EA201691589A1 (es) |
ES (2) | ES2750563T3 (es) |
IL (1) | IL247826B (es) |
MX (1) | MX371403B (es) |
SG (1) | SG11201607818WA (es) |
WO (1) | WO2015143156A1 (es) |
ZA (1) | ZA201606525B (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
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EP3647322B1 (en) | 2014-03-20 | 2021-10-20 | Bristol-Myers Squibb Company | Stabilized fibronectin based scaffold molecules |
CA2943241C (en) | 2014-03-20 | 2023-09-19 | Bristol-Myers Squibb Company | Serum albumin-binding fibronectin type iii domains |
EP3223866B1 (en) | 2014-11-25 | 2023-03-08 | Bristol-Myers Squibb Company | Methods and compositions for 18f-radiolabeling of the fibronectin type (iii) domain |
EP3224277B1 (en) | 2014-11-25 | 2020-08-26 | Bristol-Myers Squibb Company | Novel pd-l1 binding polypeptides for imaging |
KR20180056701A (ko) | 2015-09-23 | 2018-05-29 | 브리스톨-마이어스 스큅 컴퍼니 | 패스트-오프 레이트 혈청 알부민 결합 피브로넥틴 유형 iii 도메인 |
EP3733698A1 (en) * | 2015-09-23 | 2020-11-04 | Bristol-Myers Squibb Company | Glypican-3 binding fibronectin based scafflold molecules |
US10994033B2 (en) | 2016-06-01 | 2021-05-04 | Bristol-Myers Squibb Company | Imaging methods using 18F-radiolabeled biologics |
CN109562195A (zh) | 2016-06-01 | 2019-04-02 | 百时美施贵宝公司 | 用pd-l1结合多肽进行pet成像 |
EP3793612A4 (en) * | 2018-05-16 | 2022-03-02 | LIB Therapeutics, LLC | COMPOSITIONS CONTAINING PCSK9 BINDING MOLECULES AND METHODS OF USE |
RU2711111C1 (ru) * | 2018-09-05 | 2020-01-15 | Илья Владимирович Духовлинов | Гибридный белок igf-1-long для лечения инсульта, нуклеиновая кислота, вектор, клетка, фармацевтическая композиция, способ лечения |
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EP3733698A1 (en) | 2015-09-23 | 2020-11-04 | Bristol-Myers Squibb Company | Glypican-3 binding fibronectin based scafflold molecules |
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CN109562195A (zh) | 2016-06-01 | 2019-04-02 | 百时美施贵宝公司 | 用pd-l1结合多肽进行pet成像 |
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2015
- 2015-03-19 EP EP19193367.0A patent/EP3647322B1/en active Active
- 2015-03-19 AU AU2015231210A patent/AU2015231210B2/en active Active
- 2015-03-19 BR BR112016020492A patent/BR112016020492A2/pt active Search and Examination
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CN115322253A (zh) | 2022-11-11 |
WO2015143156A1 (en) | 2015-09-24 |
CA2943228A1 (en) | 2015-09-24 |
CA2943228C (en) | 2023-03-14 |
CN106795214A (zh) | 2017-05-31 |
BR112016020492A2 (pt) | 2017-10-10 |
EP3647322A1 (en) | 2020-05-06 |
IL247826B (en) | 2020-06-30 |
CN106795214B (zh) | 2022-09-02 |
EP3647322B1 (en) | 2021-10-20 |
IL247826A0 (en) | 2016-11-30 |
JP2017509651A (ja) | 2017-04-06 |
MX371403B (es) | 2020-01-29 |
AU2015231210B2 (en) | 2019-09-12 |
ZA201606525B (en) | 2022-05-25 |
US20200062824A1 (en) | 2020-02-27 |
KR20160138133A (ko) | 2016-12-02 |
ES2750563T3 (es) | 2020-03-26 |
KR102494646B1 (ko) | 2023-01-31 |
EP3119803A1 (en) | 2017-01-25 |
SG11201607818WA (en) | 2016-10-28 |
EA201691589A1 (ru) | 2017-02-28 |
EP3119803B1 (en) | 2019-09-11 |
US20170183393A1 (en) | 2017-06-29 |
AU2015231210A1 (en) | 2016-09-29 |
JP6644701B2 (ja) | 2020-02-12 |
US10450363B2 (en) | 2019-10-22 |
ES2898273T3 (es) | 2022-03-04 |
US20230192812A1 (en) | 2023-06-22 |
US11407815B2 (en) | 2022-08-09 |
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