MX350539B - Compuestos de enediino, conjugados de los mismos y sus usos y metodos. - Google Patents

Compuestos de enediino, conjugados de los mismos y sus usos y metodos.

Info

Publication number
MX350539B
MX350539B MX2014009234A MX2014009234A MX350539B MX 350539 B MX350539 B MX 350539B MX 2014009234 A MX2014009234 A MX 2014009234A MX 2014009234 A MX2014009234 A MX 2014009234A MX 350539 B MX350539 B MX 350539B
Authority
MX
Mexico
Prior art keywords
conjugates
methods therefor
enediyne compounds
enediyne
compounds
Prior art date
Application number
MX2014009234A
Other languages
English (en)
Other versions
MX2014009234A (es
Inventor
Gangwar Sanjeev
S Chowdari Naidu
Sufi Bilal
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47722570&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX350539(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MX2014009234A publication Critical patent/MX2014009234A/es
Publication of MX350539B publication Critical patent/MX350539B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)

Abstract

La presente invención se refiere a compuestos de enediino que tienen una estructura de acuerdo con la fórmula (I), donde R0, R2, R3, R4, R5, R6, y R7 se definen en la presente, se pueden usar en fármacos quimioterapéuticos, especialmente en conjugados, para el tratamiento de enfermedades tal como cáncer.
MX2014009234A 2012-02-13 2013-02-08 Compuestos de enediino, conjugados de los mismos y sus usos y metodos. MX350539B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261598143P 2012-02-13 2012-02-13
US201261653785P 2012-05-31 2012-05-31
PCT/US2013/025247 WO2013122823A1 (en) 2012-02-13 2013-02-08 Enediyne compounds, conjugates thereof, and uses and methods therefor

Publications (2)

Publication Number Publication Date
MX2014009234A MX2014009234A (es) 2014-11-10
MX350539B true MX350539B (es) 2017-09-08

Family

ID=47722570

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014009234A MX350539B (es) 2012-02-13 2013-02-08 Compuestos de enediino, conjugados de los mismos y sus usos y metodos.

Country Status (30)

Country Link
US (2) US8709431B2 (es)
EP (1) EP2814829B1 (es)
JP (1) JP6113194B2 (es)
KR (1) KR101660146B1 (es)
CN (1) CN104220441B (es)
AR (1) AR089972A1 (es)
AU (1) AU2013221873B2 (es)
BR (1) BR112014019990A8 (es)
CA (1) CA2864420C (es)
CL (1) CL2014002096A1 (es)
CO (1) CO7061078A2 (es)
CY (1) CY1118899T1 (es)
DK (1) DK2814829T3 (es)
EA (1) EA027925B1 (es)
ES (1) ES2615268T3 (es)
HK (1) HK1204326A1 (es)
HR (1) HRP20170334T1 (es)
HU (1) HUE033704T2 (es)
IL (1) IL233965B (es)
LT (1) LT2814829T (es)
MX (1) MX350539B (es)
PE (1) PE20141791A1 (es)
PL (1) PL2814829T3 (es)
PT (1) PT2814829T (es)
RS (1) RS55763B1 (es)
SG (1) SG11201404667XA (es)
SI (1) SI2814829T1 (es)
TW (1) TW201336851A (es)
WO (1) WO2013122823A1 (es)
ZA (1) ZA201406723B (es)

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ME03806B (me) 2014-11-21 2021-04-20 Bristol Myers Squibb Co Antitela protiv cd73 i njihova upotreba
CN107250157B (zh) 2014-11-21 2021-06-29 百时美施贵宝公司 包含修饰的重链恒定区的抗体
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TWI618697B (zh) 2015-11-03 2018-03-21 財團法人工業技術研究院 化合物、連接子－藥物、及配體－藥物耦合體
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CN110183659B (zh) * 2018-02-21 2022-04-26 香港科技大学 含有杂环的聚合物、其制备方法及其应用
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Also Published As

Publication number Publication date
BR112014019990A2 (es) 2017-06-20
CA2864420A1 (en) 2013-08-22
US8709431B2 (en) 2014-04-29
TW201336851A (zh) 2013-09-16
AU2013221873B2 (en) 2016-11-17
JP2015508074A (ja) 2015-03-16
CO7061078A2 (es) 2014-09-19
US20130209494A1 (en) 2013-08-15
HUE033704T2 (en) 2017-12-28
EA201491447A1 (ru) 2014-11-28
PT2814829T (pt) 2017-02-15
HRP20170334T1 (hr) 2017-04-21
DK2814829T3 (en) 2017-03-20
EA027925B1 (ru) 2017-09-29
IL233965B (en) 2018-01-31
EP2814829A1 (en) 2014-12-24
KR101660146B1 (ko) 2016-09-26
EP2814829B1 (en) 2016-12-07
AU2013221873A1 (en) 2014-10-02
CY1118899T1 (el) 2018-01-10
KR20140120374A (ko) 2014-10-13
AR089972A1 (es) 2014-10-01
RS55763B1 (sr) 2017-07-31
US20140193438A1 (en) 2014-07-10
SG11201404667XA (en) 2014-09-26
US9156850B2 (en) 2015-10-13
WO2013122823A1 (en) 2013-08-22
PE20141791A1 (es) 2014-11-19
LT2814829T (lt) 2017-02-27
CN104220441B (zh) 2017-03-29
BR112014019990A8 (pt) 2017-07-11
JP6113194B2 (ja) 2017-04-12
ZA201406723B (en) 2016-05-25
HK1204326A1 (en) 2015-11-13
CN104220441A (zh) 2014-12-17
PL2814829T3 (pl) 2017-06-30
SI2814829T1 (sl) 2017-02-28
ES2615268T3 (es) 2017-06-06
MX2014009234A (es) 2014-11-10
CA2864420C (en) 2016-11-15
CL2014002096A1 (es) 2014-11-28

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