PE20141791A1 - Compuestos de enediino, conjugados de los mismos y sus usos y metodos - Google Patents

Compuestos de enediino, conjugados de los mismos y sus usos y metodos

Info

Publication number
PE20141791A1
PE20141791A1 PE2014001257A PE2014001257A PE20141791A1 PE 20141791 A1 PE20141791 A1 PE 20141791A1 PE 2014001257 A PE2014001257 A PE 2014001257A PE 2014001257 A PE2014001257 A PE 2014001257A PE 20141791 A1 PE20141791 A1 PE 20141791A1
Authority
PE
Peru
Prior art keywords
compounds
enediin
conjugates
methods
alkyl
Prior art date
Application number
PE2014001257A
Other languages
English (en)
Inventor
Naidu Chowdari
Sanjeev Gangwar
Bilal Sufi
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47722570&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20141791(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PE20141791A1 publication Critical patent/PE20141791A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans

Abstract

SE REFIERE A COMPUESTOS DE ENEDIINO DE FORMULA (I) DONDE R0 ES F, Cl, Br, ENTRE OTROS; R2 ES H, R10, C(=O)R10 O C(=O)OR10, EN DONDE R10 ES ALQUILO(C1-C6), CICLOALQUILO, ENTRE OTROS; R3 Y R6 SON CADA UNO H O ALQUILO(C1-C6); R4, R5 Y R7 SON CADA UNO OH, SH, NH2, OR10, ENTRE OTROS; R5 Y R6 SE COMBINAN PARA FORMAR =O. SIENDO UN COMPUESTO PREFERIDO EL DE FORMULA (IIa), ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON CITOTOXINAS QUE SE UNEN AL ADN DANANDOLO Y SIENDO UTILES EN EL TRATAMIENTO DE CANCER
PE2014001257A 2012-02-13 2013-02-08 Compuestos de enediino, conjugados de los mismos y sus usos y metodos PE20141791A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261598143P 2012-02-13 2012-02-13
US201261653785P 2012-05-31 2012-05-31

Publications (1)

Publication Number Publication Date
PE20141791A1 true PE20141791A1 (es) 2014-11-19

Family

ID=47722570

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2014001257A PE20141791A1 (es) 2012-02-13 2013-02-08 Compuestos de enediino, conjugados de los mismos y sus usos y metodos

Country Status (30)

Country Link
US (2) US8709431B2 (es)
EP (1) EP2814829B1 (es)
JP (1) JP6113194B2 (es)
KR (1) KR101660146B1 (es)
CN (1) CN104220441B (es)
AR (1) AR089972A1 (es)
AU (1) AU2013221873B2 (es)
BR (1) BR112014019990A8 (es)
CA (1) CA2864420C (es)
CL (1) CL2014002096A1 (es)
CO (1) CO7061078A2 (es)
CY (1) CY1118899T1 (es)
DK (1) DK2814829T3 (es)
EA (1) EA027925B1 (es)
ES (1) ES2615268T3 (es)
HK (1) HK1204326A1 (es)
HR (1) HRP20170334T1 (es)
HU (1) HUE033704T2 (es)
IL (1) IL233965B (es)
LT (1) LT2814829T (es)
MX (1) MX350539B (es)
PE (1) PE20141791A1 (es)
PL (1) PL2814829T3 (es)
PT (1) PT2814829T (es)
RS (1) RS55763B1 (es)
SG (1) SG11201404667XA (es)
SI (1) SI2814829T1 (es)
TW (1) TW201336851A (es)
WO (1) WO2013122823A1 (es)
ZA (1) ZA201406723B (es)

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JO3407B1 (ar) 2012-05-31 2019-10-20 Eisai R&D Man Co Ltd مركبات رباعي هيدرو بيرازولو بيريميدين
JP6474404B2 (ja) * 2013-08-14 2019-02-27 ウィリアム マーシュ ライス ユニバーシティＷｉｌｌｉａｍ Ｍａｒｓｈ Ｒｉｃｅ Ｕｎｉｖｅｒｓｉｔｙ ウンシアラマイシン誘導体、合成方法、および抗腫瘍薬としてのそれらの使用
EP3647322B1 (en) 2014-03-20 2021-10-20 Bristol-Myers Squibb Company Stabilized fibronectin based scaffold molecules
EP3221346B1 (en) 2014-11-21 2020-09-02 Bristol-Myers Squibb Company Antibodies comprising modified heavy constant regions
RS60631B1 (sr) 2014-11-21 2020-09-30 Bristol Myers Squibb Co Antitela protiv cd73 i njihova upotreba
EP3224277B1 (en) 2014-11-25 2020-08-26 Bristol-Myers Squibb Company Novel pd-l1 binding polypeptides for imaging
CN107531720A (zh) * 2015-01-08 2018-01-02 斯克利普斯研究院 抗癌症候选药物
JP2018510864A (ja) 2015-03-10 2018-04-19 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ トランスグルタミナーゼによって結合可能な抗体およびそれによって製造される結合体
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EA201891983A8 (ru) 2016-03-04 2020-05-28 Бристол-Майерс Сквибб Компани Комбинированная терапия антителами к cd73
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WO2018048975A1 (en) 2016-09-09 2018-03-15 Bristol-Myers Squibb Company Use of an anti-pd-1 antibody in combination with an anti-mesothelin antibody in cancer treatment
KR20220167342A (ko) 2017-05-25 2022-12-20 브리스톨-마이어스 스큅 컴퍼니 변형된 중쇄 불변 영역을 포함하는 항체
WO2019110725A1 (en) * 2017-12-06 2019-06-13 Synaffix B.V. Enediyne conjugates
CN110183659B (zh) * 2018-02-21 2022-04-26 香港科技大学 含有杂环的聚合物、其制备方法及其应用
JP2022513653A (ja) 2018-11-28 2022-02-09 ブリストル－マイヤーズ スクイブ カンパニー 修飾された重鎖定常領域を含む抗体
SI3886914T1 (sl) 2018-11-30 2023-06-30 Bristol-Myers Squibb Company Protitelo, ki vsebuje C-terminalni podaljšek lahke verige, ki vsebuje glutamin, njegove konjugate ter metode in uporabe
US20220031860A1 (en) 2018-12-12 2022-02-03 Bristol-Myers Squibb Company Antibodies modified for transglutaminase conjugation, conjugates thereof, and methods and uses
JP2022532801A (ja) * 2019-05-22 2022-07-19 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム がんの治療において使用するための官能基化金カルベンナフトキノン錯体
WO2021055306A1 (en) 2019-09-16 2021-03-25 Bristol-Myers Squibb Company Dual capture method for analysis of antibody-drug conjugates
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Also Published As

Publication number Publication date
US20130209494A1 (en) 2013-08-15
US9156850B2 (en) 2015-10-13
AR089972A1 (es) 2014-10-01
EP2814829B1 (en) 2016-12-07
MX350539B (es) 2017-09-08
US8709431B2 (en) 2014-04-29
US20140193438A1 (en) 2014-07-10
EA201491447A1 (ru) 2014-11-28
CY1118899T1 (el) 2018-01-10
AU2013221873B2 (en) 2016-11-17
TW201336851A (zh) 2013-09-16
MX2014009234A (es) 2014-11-10
HUE033704T2 (en) 2017-12-28
CN104220441B (zh) 2017-03-29
SG11201404667XA (en) 2014-09-26
IL233965B (en) 2018-01-31
CL2014002096A1 (es) 2014-11-28
KR101660146B1 (ko) 2016-09-26
CO7061078A2 (es) 2014-09-19
ES2615268T3 (es) 2017-06-06
LT2814829T (lt) 2017-02-27
CA2864420C (en) 2016-11-15
BR112014019990A8 (pt) 2017-07-11
KR20140120374A (ko) 2014-10-13
WO2013122823A1 (en) 2013-08-22
PT2814829T (pt) 2017-02-15
ZA201406723B (en) 2016-05-25
JP2015508074A (ja) 2015-03-16
PL2814829T3 (pl) 2017-06-30
EA027925B1 (ru) 2017-09-29
CA2864420A1 (en) 2013-08-22
DK2814829T3 (en) 2017-03-20
EP2814829A1 (en) 2014-12-24
CN104220441A (zh) 2014-12-17
HK1204326A1 (en) 2015-11-13
AU2013221873A1 (en) 2014-10-02
HRP20170334T1 (hr) 2017-04-21
SI2814829T1 (sl) 2017-02-28
JP6113194B2 (ja) 2017-04-12
BR112014019990A2 (es) 2017-06-20
RS55763B1 (sr) 2017-07-31

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