HK1204326A1 - Enediyne compounds, conjugates thereof, and uses and methods therefor - Google Patents

Enediyne compounds, conjugates thereof, and uses and methods therefor

Info

Publication number
HK1204326A1
HK1204326A1 HK15104893.3A HK15104893A HK1204326A1 HK 1204326 A1 HK1204326 A1 HK 1204326A1 HK 15104893 A HK15104893 A HK 15104893A HK 1204326 A1 HK1204326 A1 HK 1204326A1
Authority
HK
Hong Kong
Prior art keywords
conjugates
methods therefor
enediyne compounds
enediyne
compounds
Prior art date
Application number
HK15104893.3A
Other languages
English (en)
Chinese (zh)
Inventor
Naidu S Chowdari
Sanjeev Gangwar
Bilal Sufi
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47722570&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1204326(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of HK1204326A1 publication Critical patent/HK1204326A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
HK15104893.3A 2012-02-13 2015-05-22 Enediyne compounds, conjugates thereof, and uses and methods therefor HK1204326A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261598143P 2012-02-13 2012-02-13
US201261653785P 2012-05-31 2012-05-31
PCT/US2013/025247 WO2013122823A1 (en) 2012-02-13 2013-02-08 Enediyne compounds, conjugates thereof, and uses and methods therefor

Publications (1)

Publication Number Publication Date
HK1204326A1 true HK1204326A1 (en) 2015-11-13

Family

ID=47722570

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15104893.3A HK1204326A1 (en) 2012-02-13 2015-05-22 Enediyne compounds, conjugates thereof, and uses and methods therefor

Country Status (30)

Country Link
US (2) US8709431B2 (xx)
EP (1) EP2814829B1 (xx)
JP (1) JP6113194B2 (xx)
KR (1) KR101660146B1 (xx)
CN (1) CN104220441B (xx)
AR (1) AR089972A1 (xx)
AU (1) AU2013221873B2 (xx)
BR (1) BR112014019990A8 (xx)
CA (1) CA2864420C (xx)
CL (1) CL2014002096A1 (xx)
CO (1) CO7061078A2 (xx)
CY (1) CY1118899T1 (xx)
DK (1) DK2814829T3 (xx)
EA (1) EA027925B1 (xx)
ES (1) ES2615268T3 (xx)
HK (1) HK1204326A1 (xx)
HR (1) HRP20170334T1 (xx)
HU (1) HUE033704T2 (xx)
IL (1) IL233965B (xx)
LT (1) LT2814829T (xx)
MX (1) MX350539B (xx)
PE (1) PE20141791A1 (xx)
PL (1) PL2814829T3 (xx)
PT (1) PT2814829T (xx)
RS (1) RS55763B1 (xx)
SG (1) SG11201404667XA (xx)
SI (1) SI2814829T1 (xx)
TW (1) TW201336851A (xx)
WO (1) WO2013122823A1 (xx)
ZA (1) ZA201406723B (xx)

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JO3407B1 (ar) 2012-05-31 2019-10-20 Eisai R&D Man Co Ltd مركبات رباعي هيدرو بيرازولو بيريميدين
CA2921401A1 (en) * 2013-08-14 2015-02-19 William Marsh Rice University Derivatives of uncialamycin, methods of synthesis and their use as antitumor agents
EP3647322B1 (en) 2014-03-20 2021-10-20 Bristol-Myers Squibb Company Stabilized fibronectin based scaffold molecules
EP3789399A1 (en) 2014-11-21 2021-03-10 Bristol-Myers Squibb Company Antibodies comprising modified heavy constant regions
KR102569813B1 (ko) 2014-11-21 2023-08-24 브리스톨-마이어스 스큅 컴퍼니 Cd73에 대항한 항체 및 그의 용도
ES2822990T3 (es) 2014-11-25 2021-05-05 Bristol Myers Squibb Co Novedosos polipéptidos de unión a PD-L1 para obtención de imágenes
CN107531720A (zh) * 2015-01-08 2018-01-02 斯克利普斯研究院 抗癌症候选药物
WO2016144608A1 (en) 2015-03-10 2016-09-15 Bristol-Myers Squibb Company Antibodies conjugatable by transglutaminase and conjugates made therefrom
MY188049A (en) 2015-05-29 2021-11-12 Bristol Myers Squibb Co Antibodies against ox40 and uses thereof
ES2809125T3 (es) 2015-09-23 2021-03-03 Bristol Myers Squibb Co Moléculas de armazón a base de fibronectina de unión a glipicano-3
TWI660741B (zh) 2015-11-03 2019-06-01 財團法人工業技術研究院 抗體藥物複合物及其製造方法
KR20180089433A (ko) 2015-12-21 2018-08-08 브리스톨-마이어스 스큅 컴퍼니 부위-특이적 접합을 위한 변이체 항체
SG10201913033UA (en) 2016-03-04 2020-03-30 Bristol Myers Squibb Co Combination therapy with anti-cd73 antibodies
CN106267188A (zh) * 2016-08-15 2017-01-04 深圳大学 小分子免疫激动剂偶联pd‑1抗体的新型抗体及其在抗肿瘤中的应用
US20190218294A1 (en) 2016-09-09 2019-07-18 Bristol-Myers Squibb Company Use of an anti-pd-1 antibody in combination with an anti-mesothelin antibody in cancer treatment
CA3064321A1 (en) 2017-05-25 2018-11-29 Bristol-Myers Squibb Company Antibodies comprising modified heavy constant regions
EP3720504A1 (en) * 2017-12-06 2020-10-14 Synaffix B.V. Enediyne conjugates
CN110183659B (zh) * 2018-02-21 2022-04-26 香港科技大学 含有杂环的聚合物、其制备方法及其应用
EP3887397A1 (en) 2018-11-28 2021-10-06 Bristol-Myers Squibb Company Antibodies comprising modified heavy constant regions
JP7389803B2 (ja) 2018-11-30 2023-11-30 ブリストル－マイヤーズ スクイブ カンパニー グルタミンを含有する軽鎖ｃ末端に伸長部分を含む抗体およびそのコンジュゲートならびにその方法および用途
WO2020123425A2 (en) 2018-12-12 2020-06-18 Bristol-Myers Squibb Company Antibodies modified for transglutaminase conjugation, conjugates thereof, and methods and uses
JP2022532801A (ja) * 2019-05-22 2022-07-19 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム がんの治療において使用するための官能基化金カルベンナフトキノン錯体
WO2021055306A1 (en) 2019-09-16 2021-03-25 Bristol-Myers Squibb Company Dual capture method for analysis of antibody-drug conjugates
CN117794581A (zh) 2021-06-28 2024-03-29 拜奥迪斯私人有限公司 包含磷酸抗原的缀合物及其在治疗中的用途

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Also Published As

Publication number Publication date
CL2014002096A1 (es) 2014-11-28
PL2814829T3 (pl) 2017-06-30
US8709431B2 (en) 2014-04-29
MX350539B (es) 2017-09-08
KR101660146B1 (ko) 2016-09-26
HRP20170334T1 (hr) 2017-04-21
IL233965B (en) 2018-01-31
ES2615268T3 (es) 2017-06-06
PT2814829T (pt) 2017-02-15
SG11201404667XA (en) 2014-09-26
SI2814829T1 (sl) 2017-02-28
WO2013122823A1 (en) 2013-08-22
ZA201406723B (en) 2016-05-25
MX2014009234A (es) 2014-11-10
EA201491447A1 (ru) 2014-11-28
LT2814829T (lt) 2017-02-27
DK2814829T3 (en) 2017-03-20
CA2864420C (en) 2016-11-15
BR112014019990A2 (xx) 2017-06-20
RS55763B1 (sr) 2017-07-31
CA2864420A1 (en) 2013-08-22
TW201336851A (zh) 2013-09-16
US9156850B2 (en) 2015-10-13
CY1118899T1 (el) 2018-01-10
AU2013221873A1 (en) 2014-10-02
KR20140120374A (ko) 2014-10-13
BR112014019990A8 (pt) 2017-07-11
CN104220441B (zh) 2017-03-29
EA027925B1 (ru) 2017-09-29
CN104220441A (zh) 2014-12-17
PE20141791A1 (es) 2014-11-19
JP6113194B2 (ja) 2017-04-12
EP2814829B1 (en) 2016-12-07
US20140193438A1 (en) 2014-07-10
HUE033704T2 (en) 2017-12-28
CO7061078A2 (es) 2014-09-19
JP2015508074A (ja) 2015-03-16
AR089972A1 (es) 2014-10-01
EP2814829A1 (en) 2014-12-24
US20130209494A1 (en) 2013-08-15
AU2013221873B2 (en) 2016-11-17

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