JO3407B1 - مركبات رباعي هيدرو بيرازولو بيريميدين - Google Patents
مركبات رباعي هيدرو بيرازولو بيريميدينInfo
- Publication number
- JO3407B1 JO3407B1 JOP/2013/0166A JOP20130166A JO3407B1 JO 3407 B1 JO3407 B1 JO 3407B1 JO P20130166 A JOP20130166 A JO P20130166A JO 3407 B1 JO3407 B1 JO 3407B1
- Authority
- JO
- Jordan
- Prior art keywords
- tetrahydropyrazolopyrimidine
- compounds
- tetrahydropyrazolopyrimidine compounds
- sle
- toll
- Prior art date
Links
- UGSCIXIGNBKLBH-UHFFFAOYSA-N 2,3,3a,6-tetrahydro-1h-pyrazolo[4,3-d]pyrimidine Chemical class N1C=NC2CNNC2=C1 UGSCIXIGNBKLBH-UHFFFAOYSA-N 0.000 title abstract 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 abstract 2
- 208000005777 Lupus Nephritis Diseases 0.000 abstract 1
- 102000002689 Toll-like receptor Human genes 0.000 abstract 1
- 108020000411 Toll-like receptor Proteins 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Abstract
يتعلق الاختراع الحالي بمركبات تتراهيدرو بيرازولو بيريميدين والتي تعمل كمضادات أو مثبطات للمستقبلات البروتينية المنشطة للمناعة 7 و/أو 8، واستخدامها في تركيبات صيدلانية فعالة لعلاج الذئبة الحمامية المجموعية (<span dir="LTR">SLE</span>) والتهاب الكلية الذئبي.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261654023P | 2012-05-31 | 2012-05-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
JO3407B1 true JO3407B1 (ar) | 2019-10-20 |
Family
ID=48626649
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JOP/2013/0166A JO3407B1 (ar) | 2012-05-31 | 2013-05-30 | مركبات رباعي هيدرو بيرازولو بيريميدين |
Country Status (34)
Country | Link |
---|---|
US (5) | US9126999B2 (ar) |
EP (1) | EP2855476B1 (ar) |
JP (2) | JP6285918B2 (ar) |
KR (2) | KR102268155B1 (ar) |
CN (2) | CN104507939B (ar) |
AR (1) | AR091236A1 (ar) |
AU (2) | AU2013267204B8 (ar) |
BR (1) | BR112014030060B1 (ar) |
CA (1) | CA2874445C (ar) |
CL (1) | CL2014003278A1 (ar) |
CY (1) | CY1122692T1 (ar) |
DK (1) | DK2855476T3 (ar) |
ES (1) | ES2709119T3 (ar) |
HK (1) | HK1203498A1 (ar) |
HR (1) | HRP20181889T1 (ar) |
HU (1) | HUE040562T2 (ar) |
IL (2) | IL268013B1 (ar) |
JO (1) | JO3407B1 (ar) |
LT (1) | LT2855476T (ar) |
MX (1) | MX368455B (ar) |
MY (1) | MY172926A (ar) |
NZ (1) | NZ703459A (ar) |
PE (2) | PE20190973A1 (ar) |
PH (2) | PH12014502660A1 (ar) |
PL (1) | PL2855476T3 (ar) |
PT (1) | PT2855476T (ar) |
RS (1) | RS57977B1 (ar) |
RU (2) | RU2733959C2 (ar) |
SG (1) | SG11201407890VA (ar) |
SI (1) | SI2855476T1 (ar) |
TW (1) | TWI572606B (ar) |
UA (1) | UA113440C2 (ar) |
WO (1) | WO2013181579A2 (ar) |
ZA (1) | ZA201409273B (ar) |
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TWI652014B (zh) * | 2013-09-13 | 2019-03-01 | 美商艾佛艾姆希公司 | 雜環取代之雙環唑殺蟲劑 |
CN105636945B (zh) | 2013-10-14 | 2017-11-17 | 卫材R&D管理有限公司 | 选择性取代的喹啉化合物 |
SI3057964T1 (sl) | 2013-10-14 | 2020-03-31 | Eisai R&D Management Co., Ltd. | Selektivno substituirane spojine kinolina |
EP3080124A1 (en) * | 2013-12-13 | 2016-10-19 | Takeda Pharmaceutical Company Limited | Pyrrolo[3,2-c]pyridine derivatives as tlr inhibitors |
AU2015238298B2 (en) * | 2014-03-27 | 2019-04-18 | Janssen Pharmaceutica Nv | Substituted 4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrimidine derivatives and 2,3-dihydro-1H-imidazo[1,2-b]pyrazole derivatives as ROS1 inhibitors |
TR201909606T4 (tr) | 2014-07-31 | 2019-07-22 | Basf Se | Pi̇razollari hazirlamak i̇çi̇n i̇şlem |
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AU2015401326B2 (en) * | 2015-07-03 | 2018-07-26 | China Agricultural University | Benzylhydrazone compounds and preparation method and application thereof |
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US10071079B2 (en) | 2016-06-29 | 2018-09-11 | Bristol-Myers Squibb Company | [1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds |
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CN109790126A (zh) * | 2016-08-02 | 2019-05-21 | 索尔维公司 | 用于制造吡唑甲酸及衍生物的肼基化合物的制造、肼基化合物及其用途 |
CN109641899B (zh) * | 2016-09-09 | 2022-07-22 | 诺华股份有限公司 | 作为内体Toll样受体抑制剂的化合物及组合物 |
CN109923108B (zh) * | 2016-09-09 | 2022-04-29 | 百时美施贵宝公司 | 吡啶基取代的吲哚化合物 |
WO2018210298A1 (zh) * | 2017-05-18 | 2018-11-22 | 江苏恒瑞医药股份有限公司 | 杂芳基并吡唑类衍生物、其制备方法及其在医药上的应用 |
CN110997670B (zh) | 2017-08-04 | 2022-11-01 | 百时美施贵宝公司 | [1,2,4]三唑并[4,3-a]吡啶基取代的吲哚化合物 |
CN110997656B (zh) | 2017-08-04 | 2023-04-14 | 百时美施贵宝公司 | 用作tlr7/8/9抑制剂的取代的吲哚化合物 |
CN111448190B (zh) | 2017-11-14 | 2023-09-26 | 百时美施贵宝公司 | 取代的吲哚化合物 |
KR102037494B1 (ko) | 2017-12-11 | 2019-10-28 | 씨제이헬스케어 주식회사 | 광학활성을 갖는 피페리딘 유도체의 중간체 및 이의 제조방법 |
CA3085333A1 (en) * | 2017-12-15 | 2019-06-20 | Bristol-Myers Squibb Company | Substituted indole ether compounds |
EA202091484A1 (ru) * | 2017-12-18 | 2021-03-25 | Бристол-Маерс Сквибб Компани | 4-азаиндольные соединения |
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