PE20150220A1 - Compuestos de tetrahidropirazolopirimidina - Google Patents
Compuestos de tetrahidropirazolopirimidinaInfo
- Publication number
- PE20150220A1 PE20150220A1 PE2014002228A PE2014002228A PE20150220A1 PE 20150220 A1 PE20150220 A1 PE 20150220A1 PE 2014002228 A PE2014002228 A PE 2014002228A PE 2014002228 A PE2014002228 A PE 2014002228A PE 20150220 A1 PE20150220 A1 PE 20150220A1
- Authority
- PE
- Peru
- Prior art keywords
- compound
- tetrahydropirazolopyrimidine
- compounds
- tetrahidropirazolo
- nefritis
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 201000000596 systemic lupus erythematosus Diseases 0.000 abstract 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 abstract 1
- 101100099924 Drosophila melanogaster Toll-7 gene Proteins 0.000 abstract 1
- 101100099925 Drosophila melanogaster Tollo gene Proteins 0.000 abstract 1
- -1 PIPERIDINYL Chemical group 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 206010025135 lupus erythematosus Diseases 0.000 abstract 1
- WSFSSNUMVMOOMR-BJUDXGSMSA-N methanone Chemical compound O=[11CH2] WSFSSNUMVMOOMR-BJUDXGSMSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA (I), DONDE R1 ES PIPERIDINILO, PIRIDILO, ENTRE OTROS; R7 ES -CF3, -CHF2; R8 SE SELECCIONA DE LA FIGURA (II), R9 ES BR, CL, F, ENTRE OTROS. ES COMPUESTO PREFERIDO (4-(5-(3,4-DIMETOXIFENIL)-7-(TRIFLUOROMETIL)-4,5,6,7-TETRAHIDROPIRAZOLO[1,5-A]PIRIMIDIN-2-IL)FENIL)(PIPERAZIN-1-IL ) METANONA. DICHO COMPUESTO ACTUA COMO ANTAGONISTA O INHIBIDOR DE RECEPTORES SIMILARES A TOLL 7 Y/U 8, Y CON SU USO EN COMPOSICIONES FARMACEUTICAS EFICACES PARA EL TRATAMIENTO DEL LUPUS ERITEMATOSO SISTEMICO (SLE) Y LA NEFRITIS POR LUPUS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261654023P | 2012-05-31 | 2012-05-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20150220A1 true PE20150220A1 (es) | 2015-02-14 |
Family
ID=48626649
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2014002228A PE20150220A1 (es) | 2012-05-31 | 2013-05-31 | Compuestos de tetrahidropirazolopirimidina |
PE2019000725A PE20190973A1 (es) | 2012-05-31 | 2013-05-31 | Compuestos de tetrahidropirazolopirimidina |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2019000725A PE20190973A1 (es) | 2012-05-31 | 2013-05-31 | Compuestos de tetrahidropirazolopirimidina |
Country Status (34)
Country | Link |
---|---|
US (5) | US9126999B2 (es) |
EP (1) | EP2855476B1 (es) |
JP (2) | JP6285918B2 (es) |
KR (2) | KR102268155B1 (es) |
CN (2) | CN107344941B (es) |
AR (1) | AR091236A1 (es) |
AU (2) | AU2013267204B8 (es) |
BR (1) | BR112014030060B1 (es) |
CA (1) | CA2874445C (es) |
CL (1) | CL2014003278A1 (es) |
CY (1) | CY1122692T1 (es) |
DK (1) | DK2855476T3 (es) |
ES (1) | ES2709119T3 (es) |
HK (1) | HK1203498A1 (es) |
HR (1) | HRP20181889T1 (es) |
HU (1) | HUE040562T2 (es) |
IL (2) | IL268013B2 (es) |
JO (1) | JO3407B1 (es) |
LT (1) | LT2855476T (es) |
MX (1) | MX368455B (es) |
MY (1) | MY172926A (es) |
NZ (1) | NZ703459A (es) |
PE (2) | PE20150220A1 (es) |
PH (2) | PH12014502660A1 (es) |
PL (1) | PL2855476T3 (es) |
PT (1) | PT2855476T (es) |
RS (1) | RS57977B1 (es) |
RU (2) | RU2677291C2 (es) |
SG (1) | SG11201407890VA (es) |
SI (1) | SI2855476T1 (es) |
TW (1) | TWI572606B (es) |
UA (1) | UA113440C2 (es) |
WO (1) | WO2013181579A2 (es) |
ZA (1) | ZA201409273B (es) |
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MX363708B (es) | 2013-10-14 | 2019-03-29 | Eisai R&D Man Co Ltd | Compuestos de quinolina selectivamente sustituidos. |
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DK3411360T3 (da) * | 2016-02-02 | 2020-06-08 | Basf Se | Fremgangsmåde til katalytisk hydrogenering til fremstilling af pyrazoler |
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US10071079B2 (en) | 2016-06-29 | 2018-09-11 | Bristol-Myers Squibb Company | [1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds |
EA038972B1 (ru) | 2016-07-30 | 2021-11-16 | Бристол-Маерс Сквибб Компани | Диметоксифенилзамещенные соединения индола в качестве ингибиторов tlr7, tlr8 или tlr9 |
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US10660877B2 (en) | 2016-09-09 | 2020-05-26 | Bristol-Myers Squibb Company | Pyridyl substituted indole compounds |
CN115215886A (zh) * | 2016-09-09 | 2022-10-21 | 诺华股份有限公司 | 作为内体Toll样受体抑制剂的化合物及组合物 |
TW201900647A (zh) | 2017-05-18 | 2019-01-01 | 大陸商江蘇恒瑞醫藥股份有限公司 | 雜芳基并吡唑類衍生物、其製備方法及其在醫藥上的應用 |
JP7266576B2 (ja) | 2017-08-04 | 2023-04-28 | ブリストル-マイヤーズ スクイブ カンパニー | [1,2,4]トリアゾロ[4,3-a]ピリジニル置換のインドール化合物 |
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JP7265554B2 (ja) | 2017-11-14 | 2023-04-26 | ブリストル-マイヤーズ スクイブ カンパニー | 置換インドール化合物 |
KR102037494B1 (ko) | 2017-12-11 | 2019-10-28 | 씨제이헬스케어 주식회사 | 광학활성을 갖는 피페리딘 유도체의 중간체 및 이의 제조방법 |
CN111527080B (zh) * | 2017-12-15 | 2023-09-22 | 百时美施贵宝公司 | 取代的吲哚醚化合物 |
DK3728252T3 (da) | 2017-12-18 | 2023-11-13 | Bristol Myers Squibb Co | 4-azaindolforbindelser |
MX2020005873A (es) | 2017-12-19 | 2020-08-13 | Bristol Myers Squibb Co | Compuestos de 6-azaindol. |
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