CL2021000716A1 - Constructos de anticuerpo para flt3 y cd3. (divisional sol. 201800269) - Google Patents

Constructos de anticuerpo para flt3 y cd3. (divisional sol. 201800269)

Info

Publication number
CL2021000716A1
CL2021000716A1 CL2021000716A CL2021000716A CL2021000716A1 CL 2021000716 A1 CL2021000716 A1 CL 2021000716A1 CL 2021000716 A CL2021000716 A CL 2021000716A CL 2021000716 A CL2021000716 A CL 2021000716A CL 2021000716 A1 CL2021000716 A1 CL 2021000716A1
Authority
CL
Chile
Prior art keywords
antibody construct
flt3
antibody constructs
polynucleotide
binds
Prior art date
Application number
CL2021000716A
Other languages
English (en)
Inventor
Tobias Raum
Patrick Hoffmann
Jochen Pendzialek
Claudia Bluemel
Christoph Dahlhoff
Elisabeth Nahrwold
Franziska Bott
Original Assignee
Amgen Res Munich Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Amgen Res Munich Gmbh filed Critical Amgen Res Munich Gmbh
Publication of CL2021000716A1 publication Critical patent/CL2021000716A1/es

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/31Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invención se refiere a un constructo de anticuerpo biespecífico que comprende un primer dominio de unión que se une a FLT3 humana en la superficie de una célula diana y un segundo dominio de unión que se une a CD3 humano en la superficie de una célula T. Además, la invención provee un polinucleótido que codifica el constructo de anticuerpo, un vector que comprende dicho polinucleótido y una célula hospedante transformada o transfectada con dicho polinucleótido o vector. Adicionalmente, la invención provee un procedimiento para la producción del constructo de anticuerpo de la invención, un uso médico de dicho constructo de anticuerpo y un kit que comprende dicho constructo de anticuerpo.
CL2021000716A 2015-07-31 2021-03-23 Constructos de anticuerpo para flt3 y cd3. (divisional sol. 201800269) CL2021000716A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562199944P 2015-07-31 2015-07-31
US201662290861P 2016-02-03 2016-02-03

Publications (1)

Publication Number Publication Date
CL2021000716A1 true CL2021000716A1 (es) 2021-08-20

Family

ID=56800254

Family Applications (3)

Application Number Title Priority Date Filing Date
CL2018000269A CL2018000269A1 (es) 2015-07-31 2018-01-30 Constructos de anticuerpo para flt3 y cd3
CL2021000716A CL2021000716A1 (es) 2015-07-31 2021-03-23 Constructos de anticuerpo para flt3 y cd3. (divisional sol. 201800269)
CL2022002448A CL2022002448A1 (es) 2015-07-31 2022-09-08 Constructos de anticuerpo para flt3 y cd3 (divisional sol.: 201800269)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CL2018000269A CL2018000269A1 (es) 2015-07-31 2018-01-30 Constructos de anticuerpo para flt3 y cd3

Family Applications After (1)

Application Number Title Priority Date Filing Date
CL2022002448A CL2022002448A1 (es) 2015-07-31 2022-09-08 Constructos de anticuerpo para flt3 y cd3 (divisional sol.: 201800269)

Country Status (36)

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US (2) US11447567B2 (es)
EP (2) EP3328891B1 (es)
JP (2) JP7011574B2 (es)
KR (1) KR20180030852A (es)
CN (2) CN115925964A (es)
AU (1) AU2016302580B2 (es)
BR (1) BR112018001042A2 (es)
CA (1) CA2991607A1 (es)
CL (3) CL2018000269A1 (es)
CO (1) CO2018000882A2 (es)
CR (1) CR20180067A (es)
CY (1) CY1126145T1 (es)
DK (1) DK3328891T5 (es)
EA (1) EA201890337A8 (es)
ES (1) ES2943147T3 (es)
FI (1) FI3328891T3 (es)
HR (1) HRP20230401T1 (es)
HU (1) HUE061579T2 (es)
IL (2) IL289894B2 (es)
JO (1) JO3792B1 (es)
LT (1) LT3328891T (es)
MD (1) MD3328891T2 (es)
MX (1) MX2018001159A (es)
MY (1) MY193235A (es)
PE (1) PE20181082A1 (es)
PH (1) PH12018500157A1 (es)
PL (1) PL3328891T3 (es)
PT (1) PT3328891T (es)
RS (1) RS64184B1 (es)
SG (1) SG10202000793XA (es)
SI (1) SI3328891T1 (es)
SM (1) SMT202300131T1 (es)
TN (1) TN2017000550A1 (es)
TW (1) TWI829617B (es)
UA (1) UA125717C2 (es)
WO (1) WO2017021362A1 (es)

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