MX2021009793A - Constructos de anticuerpo para dll3 y cd3. - Google Patents

Constructos de anticuerpo para dll3 y cd3.

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Publication number
MX2021009793A
MX2021009793A MX2021009793A MX2021009793A MX2021009793A MX 2021009793 A MX2021009793 A MX 2021009793A MX 2021009793 A MX2021009793 A MX 2021009793A MX 2021009793 A MX2021009793 A MX 2021009793A MX 2021009793 A MX2021009793 A MX 2021009793A
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MX
Mexico
Prior art keywords
antibody construct
bispecific antibody
antibody constructs
polynucleotide
constructs binding
Prior art date
Application number
MX2021009793A
Other languages
English (en)
Inventor
Elisabeth Nahrwold
Ralf Lutterbuese
Tobias Raum
Patrick Hoffmann
Peter Kufer
Christoph Dahlhoff
Jochen Pendzialek
Claudia Bluemel
Original Assignee
Amgen Res Munich Gmbh
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Publication date
Application filed by Amgen Res Munich Gmbh filed Critical Amgen Res Munich Gmbh
Publication of MX2021009793A publication Critical patent/MX2021009793A/es

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    • A61K39/0011—Cancer antigens
    • A61K39/00113—Growth factors
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/46443—Growth factors
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
    • A61K2239/55—Lung
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
    • A61K2239/57—Skin; melanoma
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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Abstract

La presente invención se refiere a un constructo de anticuerpo biespecífico que comprende un primer dominio de unión que se une a DLL3 humana en la superficie de una célula diana y un segundo dominio de unión que se une a CD3 humano en la superficie de una célula T. Más aún, la invención provee un polinucleótido que codifica el constructo de anticuerpo, un vector que comprende dicho polinucleótido y una célula hospedante transformada o transfectada con dicho polinucleótido o vector. Además, la invención provee un polinucleótido que codifica el constructo de anticuerpo de la invención, un uso médico de dicho constructo de anticuerpo y un kit que comprende dicho constructo de anticuerpo.
MX2021009793A 2015-07-31 2018-01-26 Constructos de anticuerpo para dll3 y cd3. MX2021009793A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562199930P 2015-07-31 2015-07-31
US201662290896P 2016-02-03 2016-02-03

Publications (1)

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MX2021009793A true MX2021009793A (es) 2021-09-08

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ID=56800252

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MX2018001154A MX2018001154A (es) 2015-07-31 2016-08-01 Constructos de anticuerpo para dll3 y cd3.
MX2021009793A MX2021009793A (es) 2015-07-31 2018-01-26 Constructos de anticuerpo para dll3 y cd3.

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US (5) US10294300B2 (es)
EP (3) EP3328889B1 (es)
JP (4) JP6824245B2 (es)
KR (2) KR20220075455A (es)
CN (2) CN108271376B (es)
AU (2) AU2016302569B2 (es)
BR (1) BR112018000475A2 (es)
CA (2) CA3212157A1 (es)
CL (2) CL2018000267A1 (es)
CO (1) CO2018000877A2 (es)
CR (1) CR20180066A (es)
CY (1) CY1124472T1 (es)
DK (1) DK3328889T3 (es)
ES (1) ES2884211T3 (es)
HK (1) HK1249525A1 (es)
HR (1) HRP20211073T1 (es)
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JO (1) JO3671B1 (es)
LT (1) LT3328889T (es)
MA (1) MA42530B1 (es)
MD (1) MD3328889T2 (es)
MX (2) MX2018001154A (es)
MY (1) MY184895A (es)
NZ (1) NZ737339A (es)
PE (1) PE20181152A1 (es)
PH (1) PH12018500241A1 (es)
PL (1) PL3328889T3 (es)
PT (1) PT3328889T (es)
RS (1) RS62248B1 (es)
SG (1) SG10201911548QA (es)
SI (1) SI3328889T1 (es)
TN (1) TN2017000549A1 (es)
TW (2) TW202346349A (es)
UA (1) UA126964C2 (es)
WO (1) WO2017021349A1 (es)
ZA (1) ZA202006983B (es)

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