HRP20120759T1 - Bispecifična veziva specifična između vrsta - Google Patents
Bispecifična veziva specifična između vrsta Download PDFInfo
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- HRP20120759T1 HRP20120759T1 HRP20120759AT HRP20120759T HRP20120759T1 HR P20120759 T1 HRP20120759 T1 HR P20120759T1 HR P20120759A T HRP20120759A T HR P20120759AT HR P20120759 T HRP20120759 T HR P20120759T HR P20120759 T1 HRP20120759 T1 HR P20120759T1
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- 239000011230 binding agent Substances 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 claims 19
- 102000004196 processed proteins & peptides Human genes 0.000 claims 19
- 108090000765 processed proteins & peptides Proteins 0.000 claims 19
- 125000003275 alpha amino acid group Chemical group 0.000 claims 7
- 238000000034 method Methods 0.000 claims 4
- 150000007523 nucleic acids Chemical group 0.000 claims 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- QPILHXCDZYWYLQ-UHFFFAOYSA-N 2-nonyl-1,3-dioxolane Chemical compound CCCCCCCCCC1OCCO1 QPILHXCDZYWYLQ-UHFFFAOYSA-N 0.000 claims 1
- 241000288950 Callithrix jacchus Species 0.000 claims 1
- 206010011878 Deafness Diseases 0.000 claims 1
- 101150029707 ERBB2 gene Proteins 0.000 claims 1
- 101000851593 Homo sapiens Separin Proteins 0.000 claims 1
- 101000946860 Homo sapiens T-cell surface glycoprotein CD3 epsilon chain Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 241000282577 Pan troglodytes Species 0.000 claims 1
- 241000288906 Primates Species 0.000 claims 1
- 241000288960 Saguinus oedipus Species 0.000 claims 1
- 241000282696 Saimiri sciureus Species 0.000 claims 1
- 102100036750 Separin Human genes 0.000 claims 1
- 102100035794 T-cell surface glycoprotein CD3 epsilon chain Human genes 0.000 claims 1
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 1
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 1
- 208000026278 immune system disease Diseases 0.000 claims 1
- 230000000116 mitigating effect Effects 0.000 claims 1
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3053—Skin, nerves, brain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
- C07K16/4291—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig against IgE
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/626—Diabody or triabody
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
- C07K2319/43—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a FLAG-tag
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Polyesters Or Polycarbonates (AREA)
Claims (18)
1. Polipeptid, naznačen time što sadrži prvu vežuću domenu, koja je protutijelo koje se može vezati na epitop iz CD3ε lanca iz čovjeka i majmunskih vrsta Callithrix jacchus, Saguinus oedipus ili Saimiri sciureus, gdje je epitop dio aminokiselinskog slijeda koji se nalazi u skupini koju čine SEQ ID NO:2, 4, 6, ili 8 i u najmanju ruku sadrži aminokiselinski slijed Gln-Asp-Gly-Asn-Glu, a druga vežuća domena se može vezati na EGFR, Her2/neu ili IgE iz čovjeka i/ili primata koji nije čimpanza.
2. Polipeptid u skladu s patentnim zahtjevom 1, naznačen time što je epitop dio aminokiselinskog slijeda koji se nalazi u skupini koju čine SEQ ID NO:2, 4, 6, i 8 i u najmanju ruku sadrži aminokiselinski slijed Gln-Asp-Gly-Asn-Glu.
3. Polipeptid u skladu s bilo kojim od patentnih zahtjeva 1 ili 2, naznačen time što prva vežuća domena sadrži VL područje, koje sadrži CDR-L1, CDR-L2 i CDR-L3 kojeg se bira između:
(a) CDR-L1 kao što je opisan u SEQ ID NO:27, CDR-L2 kao što je opisan u SEQ ID NO:28 i CDR-L3 kao što je opisan u SEQ ID NO:29;
(b) CDR-L1 kao što je opisan u SEQ ID NO:117, CDR-L2 kao što je opisan u SEQ ID NO:118 i CDR-L3 kao što je opisan u SEQ ID NO:119; i
(c) CDR-L1 kao što je opisan u SEQ ID NO:153, CDR-L2 kao što je opisan u SEQ ID NO:154 i CDR-L3 kao što je opisan u SEQ ID NO:155.
4. Polipeptid u skladu s bilo kojim od patentnih zahtjeva 1 ili 2, naznačen time što prva vežuća domena sadrži VH područje, koje sadrži CDR-HL, CDR-H2 i CDR-H3 kojeg se bira između:
(a) CDR-H1 kao što je opisan u SEQ ID NO:12, CDR-H2 kao što je opisan u SEQ ID NO:13 i CDR-H3 kao što je opisan u SEQ ID NO:14;
(b) CDR-H1 kao što je opisan u SEQ ID NO:30, CDR-H2 kao što je opisan u SEQ ID NO:31 i CDR-H3 kao što je opisan u SEQ ID NO:32;
(c) CDR-H1 kao što je opisan u SEQ ID NO:48, CDR-H2 kao što je opisan u SEQ ID NO:49 i CDR-H3 kao što je opisan u SEQ ID NO:50;
(d) CDR-H1 kao što je opisan u SEQ ID NO:66, CDR-H2 kao što je opisan u SEQ ID NO:67 i CDR-H3 kao što je opisan u SEQ ID NO:68;
(e) CDR-H1 kao što je opisan u SEQ ID NO:84, CDR-H2 kao što je opisan u SEQ ID NO:85 i CDR-H3 kao što je opisan u SEQ ID NO:86;
(f) CDR-H1 kao što je opisan u SEQ ID NO:102, CDR-H2 kao što je opisan u SEQ ID NO:103 i CDR-H3 kao što je opisan u SEQ ID NO:104;
(g) CDR-H1 kao što je opisan u SEQ ID NO:120, CDR-H2 kao što je opisan u SEQ ID NO:121 i CDR-H3 kao što je opisan u SEQ ID NO:122;
(h) CDR-H1 kao što je opisan u SEQ ID NO:138, CDR-H2 kao što je opisan u SEQ ID NO:139 i CDR-H3 kao što je opisan u SEQ ID NO:140;
(i) CDR-H1 kao što je opisan u SEQ ID NO:156, CDR-H2 kao što je opisan u SEQ ID NO:157 i CDR-H3 kao što je opisan u SEQ ID NO:158; i
(j) CDR-H1 kao što je opisan u SEQ ID NO:174, CDR-H2 kao što je opisan u SEQ ID NO:175 i CDR-H3 kao što je opisan u SEQ ID NO:176.
5. Polipeptid u skladu s bilo kojim od patentnih zahtjeva 1 do 3, naznačen time što prva vežuća domena sadrži VL područje koje se bira iz skupine koju čine VL područje, kao što je opisano u SEQ ID NO:35, 39, 125, 129, 161 ili 165.
6. Polipeptid u skladu s bilo kojim od patentnih zahtjeva 1 do 4, naznačen time što prva vežuća domena sadrži VH područje koje se bira iz skupine koju čine VH područje, kao što je opisano u SEQ ID NO:15, 19, 33, 37, 51, 55, 69, 73, 87, 91, 105, 109, 123, 127, 141, 145, 159, 163, 177 ili 181.
7. Polipeptid u skladu s bilo kojim od patentnih zahtjeva 1 do 6, naznačen time što prva vežuća domena sadrži VL područje i VH područje koje se bira iz skupine koju čine:
(a) VL područje, kao što je opisano u SEQ ID NO:17 ili 21 i VH područje, kao što je opisano u SEQ I D NO:15 ili 19;
(b) VL područje, kao što je opisano u SEQ ID NO:35 ili 39 i VH područje, kao što je opisano u SEQ ID NO:33 ili 37;
(c) VL područje, kao što je opisano u SEQ ID NO:53 ili 57 i VH područje, kao što je opisano u SEQ ID NO:51 ili 55;
(d) VL područje, kao što je opisano u SEQ ID NO:71 ili 75 i VH područje, kao što je opisano u SEQ ID NO:69 ili 73;
(e) VL područje, kao što je opisano u SEQ ID NO:89 ili 93 i VH područje, kao što je opisano u SEPA ID NO:87 ili 91 ;
(f) VL područje, kao što je opisano u SEQ ID NO:107 ili 111 i VH područje, kao što je opisano u SEQ ID NO:105 ili 109;
(g) VL područje, kao što je opisano u SEQ ID NO:125 ili 129 i VH područje, kao što je opisano u SEQ ID NO:123 ili 127;
(h) VL područje, kao što je opisano u SEQ ID NO:143 ili 147 i VH područje, kao što je opisano u SEQ ID NO:141 ili 145;
(i) VL područje, kao što je opisano u SEQ ID NO:161 ili 165 i VH područje, kao što je opisano u SEQ ID NO:159 ili 163; i
(j) VL područje, kao što je opisano u SEQ ID NO:179 ili 183 i VH područje, kao što je opisano u SEQ ID NO:177 ili 181.
8. Polipeptid u skladu s patentnim zahtjevom 7, naznačen time što prva vežuća domena sadrži aminokiselinski slijed kojeg se bira iz skupine koju čine SEQ ID NO:23, 25, 41, 43, 59, 61, 77, 79, 95, 97, 113, 115, 131, 133, 149, 151, 167, 169, 185 ili 187.
9. Polipeptid u skladu s bilo kojim od patentnih zahtjeva 1 do 8, naznačen time što je navedeni polipeptid bispecifična jednolančana molekula protutijela.
10. Polipeptid u skladu s patentnim zahtjevom 9, naznačen time što bispecifična jednolančana molekula protutijela sadrži skupinu sljedećih sljedova poput CDR H1, CDR H2, CDR H3, CDR L1, CDR L2 i CDR L3 u drugoj vežućoj domeni koju se bira između SEQ ID NO:441-446, SEQ ID NO:453-458, SEQ ID NO:463-468, SEQ ID NO:481-486.
11. Polipeptid u skladu s patentnim zahtjevom 9, naznačen time što bispecifična jednolančana molekula protutijela sadrži slijed kojeg se bira između:
(a) aminokiselinskog slijeda kao što je opisan u bilo kojem od SEQ ID NO:389, 391, 393, 395, 397, 399, 409, 411, 413, 415, 417, 419, 429, 431, 433, 435, 437, 439, 447, 449, 451, 469, 471, 473, 475, 477, 479, 495, 497, 499, 501, 503 i 505; i
(b) aminokiselinskog slijeda kojeg kodira nukleinskokiselinski slijed kao što je opisan u bilo kojem od SEQ ID NO:390, 392, 394, 396, 398, 400, 410, 412, 414, 416, 418, 420, 430, 432, 434, 436, 438, 440, 448, 450, 452, 470, 472, 474, 476, 478, 480, 496, 498, 500, 502, 504 i 506.
12. Nukleinskokiselinski slijed, naznačen time što kodira polipeptid u skladu s bilo kojim od patentnih zahtjeva 1 do 11.
13. Vektor, naznačen time što sadrži nukleinskokiselinski slijed u skladu s patentnim zahtjevom 12.
14. Stanica-domaćin, naznačena time što ju se transformira ili transficira vektorom u skladu s patentnim zahtjevom 13.
15. Postupak dobivanja polipeptida u skladu s bilo kojim od patentnih zahtjeva 1 do 11, naznačen time što se navedeni postupak sastoji u uzgoju stanice-domaćina u skladu s patentnim zahtjevom 14 u uvjetima koji omogućuju eksprimiranje polipeptida u skladu s bilo kojim od patentnih zahtjeva 1 do 11 i prikupljanje dobivenog polipeptida iz kulture.
16. Farmaceutski pripravak, naznačen time što sadrži polipeptid u skladu s bilo kojim od patentnih zahtjeva 1 do 11, ili kojeg se dobiva postupkom u skladu s patentnim zahtjevom 15.
17. Polipeptid u skladu s bilo kojim od patentnih zahtjeva 1 do 11, ili kojeg se dobiva postupkom u skladu s patentnim zahtjevom 15, naznačen time što je namijenjen upotrebi u sprječavanju, liječenju ili ublažavanju bolesti koju se bira između proliferativne bolesti, tumorske bolesti, ili imunološkog poremećaja.
18. Komplet, naznačen time što sadrži polipeptid u skladu s bilo kojim od patentnih zahtjeva 1 do 11, molekula nukleinske kiseline u skladu s patentnim zahtjevom 12, vektor u skladu s patentnim zahtjevom 13, ili stanicu-domaćina u skladu s patentnim zahtjevom 14.
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07006988 | 2007-04-03 | ||
EP07006990 | 2007-04-03 | ||
US91366807P | 2007-04-24 | 2007-04-24 | |
EP07020646 | 2007-10-22 | ||
EP07020641 | 2007-10-22 | ||
EP07020640 | 2007-10-22 | ||
EP08004741 | 2008-03-13 | ||
PCT/EP2008/002663 WO2008119566A2 (en) | 2007-04-03 | 2008-04-03 | Cross-species-specific bispecific binders |
Publications (1)
Publication Number | Publication Date |
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HRP20120759T1 true HRP20120759T1 (hr) | 2012-10-31 |
Family
ID=39609399
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20120759AT HRP20120759T1 (hr) | 2007-04-03 | 2012-09-26 | Bispecifična veziva specifična između vrsta |
Country Status (14)
Country | Link |
---|---|
US (4) | US20100183615A1 (hr) |
EP (1) | EP2155788B1 (hr) |
JP (1) | JP6016747B2 (hr) |
KR (1) | KR101626988B1 (hr) |
CN (1) | CN101675077B (hr) |
AU (1) | AU2008234019B2 (hr) |
CA (1) | CA2682626A1 (hr) |
HK (1) | HK1141299A1 (hr) |
HR (1) | HRP20120759T1 (hr) |
IL (1) | IL201338A (hr) |
MX (1) | MX2009010611A (hr) |
PL (1) | PL2155788T3 (hr) |
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CA2682626A1 (en) | 2008-10-09 |
WO2008119566A3 (en) | 2009-01-08 |
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PL2155788T3 (pl) | 2013-02-28 |
IL201338A0 (en) | 2010-05-31 |
AU2008234019B2 (en) | 2014-05-29 |
KR101626988B1 (ko) | 2016-06-02 |
US20200095319A1 (en) | 2020-03-26 |
EP2155788A2 (en) | 2010-02-24 |
AU2008234019A1 (en) | 2008-10-09 |
EP2155788B1 (en) | 2012-06-27 |
CN101675077B (zh) | 2013-09-04 |
CN101675077A (zh) | 2010-03-17 |
HK1141299A1 (en) | 2010-11-05 |
KR20100016199A (ko) | 2010-02-12 |
WO2008119566A2 (en) | 2008-10-09 |
US20100183615A1 (en) | 2010-07-22 |
ZA200907116B (en) | 2011-03-30 |
US20160152707A1 (en) | 2016-06-02 |
JP2014064568A (ja) | 2014-04-17 |
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