PE20231511A1 - Moleculas biespecificas de celulas t activadas por proteasas que se unen especificamente al receptor 1 de folato (folr1) y cd3 - Google Patents
Moleculas biespecificas de celulas t activadas por proteasas que se unen especificamente al receptor 1 de folato (folr1) y cd3Info
- Publication number
- PE20231511A1 PE20231511A1 PE2023001613A PE2023001613A PE20231511A1 PE 20231511 A1 PE20231511 A1 PE 20231511A1 PE 2023001613 A PE2023001613 A PE 2023001613A PE 2023001613 A PE2023001613 A PE 2023001613A PE 20231511 A1 PE20231511 A1 PE 20231511A1
- Authority
- PE
- Peru
- Prior art keywords
- cdr
- seq
- amino acid
- acid sequence
- binding
- Prior art date
Links
- 108091005804 Peptidases Proteins 0.000 title abstract 4
- 239000004365 Protease Substances 0.000 title abstract 4
- 102000035195 Peptidases Human genes 0.000 title abstract 3
- 102000010451 Folate receptor alpha Human genes 0.000 title 2
- 108050001931 Folate receptor alpha Proteins 0.000 title 2
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 12
- 239000000427 antigen Substances 0.000 abstract 6
- 102000036639 antigens Human genes 0.000 abstract 6
- 108091007433 antigens Proteins 0.000 abstract 6
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 5
- 230000000873 masking effect Effects 0.000 abstract 3
- 108010047041 Complementarity Determining Regions Proteins 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
- 230000003213 activating effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
- C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
- C07K16/4258—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
Referida a un metodo para producir la molecula de celulas T activada por proteasas, donde la molecula biespecifica activadora de celulas T activable por proteasas comprende (a) un primer resto de union a antigeno capaz de unirse especificamente a CD3; (b) un segundo resto de union a antigeno capaz de unirse especificamente a un antigeno de celula diana; y (c) un resto de enmascaramiento unido covalentemente a la molecula de union a celulas T biespecifica a traves de un enlazador escindible por proteasas, en donde el resto de enmascaramiento es capaz de unirse especificamente al idiotipo del primero o del segundo resto de union a antigeno, escondiendo de este modo de manera reversible el primero o el segundo resto de union a antigeno; el metodo comprende las etapas de i) cultivar la celula hospedadora de la invencion en condiciones adecuadas para la expresion de la molecula de celulas T activada por proteasas y ii) recuperar la molecula de celulas T activada por proteasas. El resto de enmascaramiento comprende una region variable de cadena pesada que comprende: (a) una secuencia de aminoacidos de region determinante de la complementariedad (CDR H) 1 de cadena pesada de SYGVS (SEQ ID NO: 26); (b) una secuencia de aminoacidos de CDR H2 de IIWGDGSTNYHSALIS (SEQ ID NO: 27); (c) una secuencia de aminoacidos de CDR H3 de GITTVVDDYYAMDY (SEQ ID NO: 28); y una region variable de cadena ligera que comprende: (d) una secuencia de aminoacidos (CDR L)1 de cadena ligera de RASENIDSYLA (SEQ ID NO: 29); (e) una secuencia de aminoacidos de CDR L2 de AATFLAD (SEQ ID NO: 30); y (f) una secuencia de aminoacidos de CDR L3 de QHYYSTPYT (SEQ ID NO: 31). El primer resto de union a antigeno es capaz de unirse especificamente a CD3 y comprende una region variable de cadena pesada que comprende: a) una secuencia de aminoacidos de region determinante de la complementariedad (CDR H) 1 de cadena pesada de TYAMN (SEQ ID NO: 44); b) una secuencia de aminoacidos de CDR H2 de RIRSKYNNYATYYADSVKG (SEQ ID NO: 45); y c) una secuencia de aminoacidos de CDR H3 de HGNFGNSYVSWFAY (SEQ ID NO: 46); y una region variable de cadena ligera que comprende: d) una secuencia de aminoacidos de (CDR L)1 de cadena ligera de GSSTGAVTTSNYAN (SEQ ID NO: 17); e) una secuencia de aminoacidos de CDR L2 de GTNKRAP (SEQ ID NO: 18); y f) una secuencia de aminoacidos de CDR L3 de ALWYSNLWV (SEQ ID NO: 19).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16161740 | 2016-03-22 | ||
| US201662433327P | 2016-12-13 | 2016-12-13 | |
| PCT/EP2017/056556 WO2017162587A1 (en) | 2016-03-22 | 2017-03-20 | Protease-activated t cell bispecific molecules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20231511A1 true PE20231511A1 (es) | 2023-09-26 |
Family
ID=65529185
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2023001613A PE20231511A1 (es) | 2016-03-22 | 2017-03-20 | Moleculas biespecificas de celulas t activadas por proteasas que se unen especificamente al receptor 1 de folato (folr1) y cd3 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US11242390B2 (es) |
| JP (1) | JP7015244B2 (es) |
| CL (1) | CL2018002507A1 (es) |
| DK (1) | DK3433280T3 (es) |
| ES (1) | ES2947230T3 (es) |
| FI (1) | FI3433280T3 (es) |
| HR (1) | HRP20230528T1 (es) |
| HU (1) | HUE061946T2 (es) |
| IL (1) | IL260637B2 (es) |
| LT (1) | LT3433280T (es) |
| MX (1) | MX2018011542A (es) |
| PE (1) | PE20231511A1 (es) |
| PH (1) | PH12018502035A1 (es) |
| PL (1) | PL3433280T3 (es) |
| RS (1) | RS64266B1 (es) |
| RU (1) | RU2018136567A (es) |
| SI (1) | SI3433280T1 (es) |
| UA (1) | UA127308C2 (es) |
| ZA (1) | ZA201804973B (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3478722A1 (en) * | 2016-06-30 | 2019-05-08 | F. Hoffmann-La Roche AG | Improved adoptive t-cell therapy |
| WO2018108759A1 (en) * | 2016-12-13 | 2018-06-21 | F. Hoffmann-La Roche Ag | Method to determine the presence of a target antigen in a tumor sample |
| EP3829595A4 (en) | 2018-08-02 | 2022-08-24 | Dyne Therapeutics, Inc. | MUSCLE TARGETING COMPLEXES AND THEIR USES FOR THE TREATMENT OF DYSTROPHINOPATHIES |
| CN113260379B (zh) * | 2018-12-21 | 2022-09-02 | 浙江时迈药业有限公司 | 蛋白酶可切割的双特异性抗体及其用途 |
| EP3950713A4 (en) * | 2019-03-29 | 2023-08-09 | Green Cross Corporation | FUSION PROTEIN COMPRISING ANTI-MESOTHELIN ANTIBODY, ANTI-CD3 ANTIBODY OR ANTI-EGFR ANTIBODY, BISPECIFIC OR TRISPECIFIC ANTIBODIES COMPRISING THEM, AND USES THEREOF |
| CA3177239A1 (en) * | 2020-06-19 | 2021-12-23 | F. Hoffmann-La Roche Ag | Protease-activated t cell bispecific antibodies |
| EP4263607A1 (en) * | 2020-12-16 | 2023-10-25 | Molecular Partners AG | Novel slow-release prodrugs |
| US11638761B2 (en) | 2021-07-09 | 2023-05-02 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating Facioscapulohumeral muscular dystrophy |
| WO2023283629A1 (en) * | 2021-07-09 | 2023-01-12 | Dyne Therapeutics, Inc. | Muscle targeting complexes and formulations thereof for treating facioscapulohumeral muscular dystrophy |
| US11771776B2 (en) | 2021-07-09 | 2023-10-03 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
| KR20240032945A (ko) * | 2021-07-09 | 2024-03-12 | 다인 세라퓨틱스, 인크. | 근육 표적화 복합체 및 디스트로핀병증을 치료하기 위한 그의 용도 |
| US11969475B2 (en) | 2021-07-09 | 2024-04-30 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy |
| WO2023283624A2 (en) * | 2021-07-09 | 2023-01-12 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
| EP4392452A1 (en) * | 2021-08-23 | 2024-07-03 | Concept to Medicine Biotech Co., Ltd. | Antibody prodrugs with constant domains |
| US11931421B2 (en) | 2022-04-15 | 2024-03-19 | Dyne Therapeutics, Inc. | Muscle targeting complexes and formulations for treating myotonic dystrophy |
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-
2017
- 2017-03-20 JP JP2018549865A patent/JP7015244B2/ja active Active
- 2017-03-20 UA UAA201810280A patent/UA127308C2/uk unknown
- 2017-03-20 DK DK17711223.2T patent/DK3433280T3/da active
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- 2017-03-20 HR HRP20230528TT patent/HRP20230528T1/hr unknown
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- 2017-03-20 PL PL17711223.2T patent/PL3433280T3/pl unknown
- 2017-03-20 HU HUE17711223A patent/HUE061946T2/hu unknown
- 2017-03-20 ES ES17711223T patent/ES2947230T3/es active Active
- 2017-03-20 LT LTEPPCT/EP2017/056556T patent/LT3433280T/lt unknown
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| MX2018011542A (es) | 2019-02-07 |
| CL2018002507A1 (es) | 2018-12-21 |
| IL260637A (es) | 2018-09-20 |
| RU2018136567A (ru) | 2020-04-22 |
| US20220275087A1 (en) | 2022-09-01 |
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| US20230119537A1 (en) | 2023-04-20 |
| JP7015244B2 (ja) | 2022-02-02 |
| UA127308C2 (uk) | 2023-07-19 |
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| ES2947230T3 (es) | 2023-08-03 |
| PH12018502035A1 (en) | 2019-07-08 |
| FI3433280T3 (fi) | 2023-06-06 |
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| US20190119383A1 (en) | 2019-04-25 |
| JP2019514850A (ja) | 2019-06-06 |
| HUE061946T2 (hu) | 2023-09-28 |
| IL260637B2 (en) | 2023-08-01 |
| SI3433280T1 (sl) | 2023-07-31 |
| RS64266B1 (sr) | 2023-07-31 |
| LT3433280T (lt) | 2023-07-10 |
| HRP20230528T1 (hr) | 2023-08-04 |
| IL260637B1 (en) | 2023-04-01 |
| ZA201804973B (en) | 2023-02-22 |
| RU2018136567A3 (es) | 2021-02-19 |
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