AR080793A1 - Anticuerpos biespecificos - Google Patents

Anticuerpos biespecificos

Info

Publication number
AR080793A1
AR080793A1 ARP110100961A ARP110100961A AR080793A1 AR 080793 A1 AR080793 A1 AR 080793A1 AR P110100961 A ARP110100961 A AR P110100961A AR P110100961 A ARP110100961 A AR P110100961A AR 080793 A1 AR080793 A1 AR 080793A1
Authority
AR
Argentina
Prior art keywords
ns
seq
amino acid
acid sequence
heavy chain
Prior art date
Application number
ARP110100961A
Other languages
English (en)
Original Assignee
Roche Glycart Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP10003270 priority Critical
Application filed by Roche Glycart Ag filed Critical Roche Glycart Ag
Publication of AR080793A1 publication Critical patent/AR080793A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46Hybrid immunoglobulins
    • C07K16/468Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/40Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41Glycosylation, sialylation, or fucosylation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • C07K2317/526CH3 domain
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/624Disulfide-stabilized antibody (dsFv)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72Increased effector function due to an Fc-modification
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732Antibody-dependent cellular cytotoxicity [ADCC]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

Anticuerpos biespecíficos, métodos para su produccion, composiciones farmacéuticas para el tratamiento del cáncer que contienen dichos anticuerpos, y usos de los mismos. Vector de expresion molécula de acido nucleico, célula huésped. Reivindicacion 1: Un anticuerpo biespecífico que comprende a) la cadena ligera y la cadena pesada de un primer anticuerpo de longitud completa que se une específicamente a un primer antígeno; b) la cadena ligera y la cadena pesada de un segundo anticuerpo de longitud completa que se une específicamente a un segundo antígeno, en el que el extremo N terminal de la cadena pesada está conectado con el extremo C terminal de la cadena ligera mediante un péptido enlazante. Reivindicacion 7: El anticuerpo biespecífico de acuerdo con la reivindicacion 1, que se caracteriza en que a) el primer anticuerpo de longitud completa se une específicamente a IGF-1R y comprende una cadena pesada con la secuencia de aminoácidos de ID. De SEC. Ns 1, y una cadena ligera con la secuencia de aminoácidos de ID. De SEC. Ns 2: y b) el segundo anticuerpo de longitud completa se une específicamente a EGFR y comprende una cadena pesada conectada a la cadena ligera mediante un péptido enlazante en el que dichas cadenas pesada y ligera conectadas por péptido poseen la secuencia de aminoácidos de ID. De SEC. Ns 3. Reivindicacion 11: El anticuerpo biespecífico de acuerdo con la reivindicacion 1, que se caracteriza en que a) el primer anticuerpo de longitud completa se une específicamente a VEGF y comprende una cadena pesada con la secuencia de aminoácidos de ID. De SEC. Ns 9, y una cadena ligera con la secuencia de aminoácidos de ID. De SEC. Ns 10, y b) el segundo anticuerpo de longitud completa se une específicamente a ANG-2 y comprende una cadena pesada conectada con la cadena ligera mediante un péptido enlazante en el que dichas cadenas pesada y ligera conectadas por péptido poseen la secuencia de aminoácidos de ID. De SEC. Ns 11.
ARP110100961A 2010-03-26 2011-03-23 Anticuerpos biespecificos AR080793A1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP10003270 2010-03-26

Publications (1)

Publication Number Publication Date
AR080793A1 true AR080793A1 (es) 2012-05-09

Family

ID=42330134

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP110100961A AR080793A1 (es) 2010-03-26 2011-03-23 Anticuerpos biespecificos

Country Status (13)

Country Link
US (1) US10106600B2 (es)
EP (1) EP2552481B1 (es)
JP (1) JP5726287B2 (es)
KR (1) KR101498346B1 (es)
CN (1) CN102946902B (es)
AR (1) AR080793A1 (es)
BR (1) BR112012024312A2 (es)
CA (1) CA2789074A1 (es)
HK (1) HK1182625A1 (es)
MX (1) MX340124B (es)
RU (1) RU2573588C2 (es)
TW (1) TW201138821A (es)
WO (1) WO2011117330A1 (es)

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