UA40577C2 - Біспецифічна молекула, що використовується для лізису пухлинних клітин, спосіб її одержання, моноклональне антитіло (варіанти), фармацевтичний препарат, фармацевтичний набір (варіанти), спосіб видалення пухлинних клітин - Google Patents

Біспецифічна молекула, що використовується для лізису пухлинних клітин, спосіб її одержання, моноклональне антитіло (варіанти), фармацевтичний препарат, фармацевтичний набір (варіанти), спосіб видалення пухлинних клітин

Info

Publication number
UA40577C2
UA40577C2 UA94005274A UA94005274A UA40577C2 UA 40577 C2 UA40577 C2 UA 40577C2 UA 94005274 A UA94005274 A UA 94005274A UA 94005274 A UA94005274 A UA 94005274A UA 40577 C2 UA40577 C2 UA 40577C2
Authority
UA
Ukraine
Prior art keywords
lysis
tumor cells
variants
bispecific antigen
antigen molecule
Prior art date
Application number
UA94005274A
Other languages
English (en)
Russian (ru)
Inventor
Вольфганг Штріттматтер
Вольфганг ШТРИТТМАТТЕР
Карлота-Сільвія Яггл
Карлота-Сильвия Яггл
Стефан Мейєр
Стефан Мейер
Шравен Буркхардт
Мартін Вілд
Мартин Вилд
Original Assignee
Мерк Патент Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Патент Гмбх filed Critical Мерк Патент Гмбх
Publication of UA40577C2 publication Critical patent/UA40577C2/uk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2806—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation

Abstract

Даний винахід стосується нових біспецифічних фрагментів антитіл, що розпізнають CD2 лімфоцити і будь-який інший варіабельний пухлинний антиген. Біспецифічна молекула застосовується для лізису пухлинних клітин і містить детермінанти Х та Z , де Х є специфічною детермінантою для епітопу на пухлинному антигені, а Z є специфічною детермінантою для епітопу антигену CD2, зокрема Z являє собою моноклональне антитіло, позначене AICD2.Ml, одержане з гібридомної клітинної лінії 1 Н 10 (DSM АСС2118) або є іншим моноклональним антитілом, одержаним з гібридомної клітинної лінії 7 D 3 (DSMACC2119).
UA94005274A 1993-08-02 1994-06-22 Біспецифічна молекула, що використовується для лізису пухлинних клітин, спосіб її одержання, моноклональне антитіло (варіанти), фармацевтичний препарат, фармацевтичний набір (варіанти), спосіб видалення пухлинних клітин UA40577C2 (uk)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP93112330 1993-08-02

Publications (1)

Publication Number Publication Date
UA40577C2 true UA40577C2 (uk) 2001-08-15

Family

ID=8213129

Family Applications (1)

Application Number Title Priority Date Filing Date
UA94005274A UA40577C2 (uk) 1993-08-02 1994-06-22 Біспецифічна молекула, що використовується для лізису пухлинних клітин, спосіб її одержання, моноклональне антитіло (варіанти), фармацевтичний препарат, фармацевтичний набір (варіанти), спосіб видалення пухлинних клітин

Country Status (20)

Country Link
US (1) US5798229A (uk)
EP (1) EP0637593B1 (uk)
JP (2) JP3822653B2 (uk)
KR (1) KR100347465B1 (uk)
AT (1) ATE199378T1 (uk)
AU (1) AU683659B2 (uk)
CA (1) CA2129183C (uk)
CZ (1) CZ291071B6 (uk)
DE (1) DE69426743T2 (uk)
DK (1) DK0637593T3 (uk)
ES (1) ES2156587T3 (uk)
GR (1) GR3035926T3 (uk)
HU (1) HU218100B (uk)
NO (1) NO942850L (uk)
PL (1) PL176761B1 (uk)
PT (1) PT637593E (uk)
RU (1) RU2203319C2 (uk)
SK (1) SK283133B6 (uk)
UA (1) UA40577C2 (uk)
ZA (1) ZA945753B (uk)

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EP0637593A1 (en) 1995-02-08
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JP3822653B2 (ja) 2006-09-20
DE69426743T2 (de) 2001-08-16
NO942850L (no) 1995-02-03
SK283133B6 (sk) 2003-03-04
ES2156587T3 (es) 2001-07-01
KR950005327A (ko) 1995-03-20
DE69426743D1 (de) 2001-04-05
AU683659B2 (en) 1997-11-20
HUT71309A (en) 1995-11-28
JP2005336207A (ja) 2005-12-08
NO942850D0 (uk) 1994-08-01
CA2129183C (en) 2006-05-16
CA2129183A1 (en) 1995-02-03
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RU2203319C2 (ru) 2003-04-27
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KR100347465B1 (ko) 2003-03-03
GR3035926T3 (en) 2001-08-31
AU6869894A (en) 1995-02-09
CZ291071B6 (cs) 2002-12-11
ATE199378T1 (de) 2001-03-15
JP4231862B2 (ja) 2009-03-04
HU218100B (hu) 2000-06-28
EP0637593B1 (en) 2001-02-28
SK91294A3 (en) 1996-11-06
RU94028282A (ru) 1996-07-20
PT637593E (pt) 2001-08-30
HU9402220D0 (en) 1994-10-28
US5798229A (en) 1998-08-25
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