AR076018A1 - Anticuerpos multiespecificos especialmente biespecificos - Google Patents
Anticuerpos multiespecificos especialmente biespecificosInfo
- Publication number
- AR076018A1 AR076018A1 ARP100101064A AR076018A1 AR 076018 A1 AR076018 A1 AR 076018A1 AR P100101064 A ARP100101064 A AR P100101064A AR 076018 A1 AR076018 A1 AR 076018A1
- Authority
- AR
- Argentina
- Prior art keywords
- antibody
- full length
- specific antibodies
- length antibody
- fab fragments
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/626—Diabody or triabody
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Abstract
La presente tambien está relacionada con métodos para su produccion, composiciones farmacéuticas que contienen dichos anticuerpos, y usos de los mismos. Reivindicacion 1. Un anticuerpo multiespecífico que comprende a) un anticuerpo de longitud completa que se une específicamente a un primer antígeno y que consta de dos cadenas pesadas de anticuerpo, dos cadenas ligeras de anticuerpo; y b) uno o más fragmentos Fab de cadena sencilla que se unen a uno o más antígenos adicionales, en el que dichos fragmentos Fab de cadena sencilla bajo b) están fusionados a dicho anticuerpo de longitud completa bajo a) mediante un péptido conector en el extremo C- o N- terminal de la cadena pesada o ligera de dicho anticuerpo de longitud completa.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09004909 | 2009-04-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR076018A1 true AR076018A1 (es) | 2011-05-11 |
Family
ID=40937376
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP100101064 AR076018A1 (es) | 2009-04-02 | 2010-03-31 | Anticuerpos multiespecificos especialmente biespecificos |
Country Status (19)
Country | Link |
---|---|
US (1) | US9382323B2 (es) |
EP (1) | EP2414391B1 (es) |
JP (1) | JP5501439B2 (es) |
KR (1) | KR101431318B1 (es) |
CN (1) | CN102369215B (es) |
AR (1) | AR076018A1 (es) |
AU (1) | AU2010230563A1 (es) |
BR (1) | BRPI1014089A2 (es) |
CA (1) | CA2756244A1 (es) |
CL (1) | CL2011002380A1 (es) |
HK (1) | HK1167669A1 (es) |
IL (1) | IL214756A0 (es) |
MX (1) | MX2011010159A (es) |
PE (1) | PE20120591A1 (es) |
RU (1) | RU2598248C2 (es) |
SG (1) | SG175004A1 (es) |
TW (1) | TW201040265A (es) |
WO (1) | WO2010112193A1 (es) |
ZA (1) | ZA201106666B (es) |
Families Citing this family (274)
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CN102369215B (zh) | 2009-04-02 | 2015-01-21 | 罗切格利卡特公司 | 包含全长抗体和单链Fab片段的多特异性抗体 |
PT2417156E (pt) | 2009-04-07 | 2015-04-29 | Roche Glycart Ag | Anticorpos trivalentes, biespecíficos |
SG176219A1 (en) | 2009-05-27 | 2011-12-29 | Hoffmann La Roche | Tri- or tetraspecific antibodies |
US9676845B2 (en) | 2009-06-16 | 2017-06-13 | Hoffmann-La Roche, Inc. | Bispecific antigen binding proteins |
US8703132B2 (en) * | 2009-06-18 | 2014-04-22 | Hoffmann-La Roche, Inc. | Bispecific, tetravalent antigen binding proteins |
US9493578B2 (en) | 2009-09-02 | 2016-11-15 | Xencor, Inc. | Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens |
US20120302737A1 (en) | 2009-09-16 | 2012-11-29 | Genentech, Inc. | Coiled coil and/or tether containing protein complexes and uses thereof |
GB201005064D0 (en) * | 2010-03-25 | 2010-05-12 | Ucb Pharma Sa | Biological products |
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BR112013001847A2 (pt) | 2010-08-24 | 2016-05-31 | Hoffmann La Roche | anticorpo biespecífico, método de preparação do anticorpo biespecífico, do anticorpo biespecífico trivalente, métodos e composição farmacêutica |
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BR112014004168A2 (pt) * | 2011-08-23 | 2017-12-12 | Roche Glycart Ag | anticorpo biespecífico, composição farmacêutica, uso do anticorpo biespecífico, célula hospedeira procariótica ou eucariótica, método de produção de anticorpo e invenção |
EP2758435A1 (en) | 2011-09-23 | 2014-07-30 | Roche Glycart AG | Bispecific anti-egfr/anti igf-1r antibodies |
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EP2414391A1 (en) | 2012-02-08 |
IL214756A0 (en) | 2011-11-30 |
HK1167669A1 (en) | 2012-12-07 |
TW201040265A (en) | 2010-11-16 |
JP5501439B2 (ja) | 2014-05-21 |
KR20110130525A (ko) | 2011-12-05 |
RU2598248C2 (ru) | 2016-09-20 |
PE20120591A1 (es) | 2012-05-23 |
RU2011143905A (ru) | 2013-05-10 |
US9382323B2 (en) | 2016-07-05 |
SG175004A1 (en) | 2011-11-28 |
WO2010112193A1 (en) | 2010-10-07 |
KR101431318B1 (ko) | 2014-08-20 |
BRPI1014089A2 (pt) | 2016-04-19 |
CN102369215A (zh) | 2012-03-07 |
ZA201106666B (en) | 2012-05-30 |
US20100256338A1 (en) | 2010-10-07 |
AU2010230563A1 (en) | 2011-09-22 |
CA2756244A1 (en) | 2010-10-07 |
MX2011010159A (es) | 2011-10-17 |
CL2011002380A1 (es) | 2012-06-15 |
EP2414391B1 (en) | 2018-11-28 |
CN102369215B (zh) | 2015-01-21 |
JP2012522493A (ja) | 2012-09-27 |
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