CO6430469A2 - Anticuerpos humanizados que se unen a cd19 y sus usos - Google Patents
Anticuerpos humanizados que se unen a cd19 y sus usosInfo
- Publication number
- CO6430469A2 CO6430469A2 CO11124710A CO11124710A CO6430469A2 CO 6430469 A2 CO6430469 A2 CO 6430469A2 CO 11124710 A CO11124710 A CO 11124710A CO 11124710 A CO11124710 A CO 11124710A CO 6430469 A2 CO6430469 A2 CO 6430469A2
- Authority
- CO
- Colombia
- Prior art keywords
- seq
- amino acid
- acid sequence
- humanized antibodies
- join
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3061—Blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
La presente invención se refiere a anticuerpos humanizados o fragmentos de los mismos que se unen al CD19 humano; más específicamente, la presente invención se refiere a un anticuerpo humanizado o fragmento del mismo que se une al CD19 humano, que comprende una CDR1 de cadena pesada que comprende la secuencia de aminoácidos del SEQ ID NO: 27, y/o una CDR2 de cadena pesada que comprende la secuencia de aminoácidos del SEQ ID NO: 28, y/o una CDR3 de cadena pesada que comprende la secuencia de aminoácidos del SEQ ID NO: 29; y/o que comprende una CDR1 de cadena ligera que comprende la secuencia de aminoácidos del SEQ ID NO: 30, y/o una CDR2 de cadena ligera que comprende la secuencia de aminoácidos del SEQ ID NO: 31, y/o una CDR3 de cadena ligera que comprende la secuencia de aminoácidos del SEQ ID NO: 32.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15452409P | 2009-02-23 | 2009-02-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6430469A2 true CO6430469A2 (es) | 2012-04-30 |
Family
ID=42115917
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO11124710A CO6430469A2 (es) | 2009-02-23 | 2011-09-23 | Anticuerpos humanizados que se unen a cd19 y sus usos |
Country Status (17)
Country | Link |
---|---|
US (2) | US8679492B2 (es) |
EP (1) | EP2398829A2 (es) |
JP (1) | JP2012518404A (es) |
KR (1) | KR20110122859A (es) |
CN (1) | CN102421800A (es) |
AP (1) | AP2011005859A0 (es) |
AU (1) | AU2010215239A1 (es) |
BR (1) | BRPI1005984A2 (es) |
CA (1) | CA2753158A1 (es) |
CL (1) | CL2011002039A1 (es) |
CO (1) | CO6430469A2 (es) |
EA (1) | EA201190132A1 (es) |
IL (1) | IL214725A0 (es) |
MX (1) | MX2011008843A (es) |
SG (1) | SG173654A1 (es) |
WO (1) | WO2010095031A2 (es) |
ZA (1) | ZA201106369B (es) |
Families Citing this family (97)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112012021261A2 (pt) * | 2010-02-23 | 2020-01-07 | Sanofi | Anticorpo de integrina anti-alfa2 humanizada, uso do mesmo, ácido nucleico isolado codificando um anticorpo de integrina anti-alfa2beta1, vetor, célula hospedeira, composição, kit e anticorpo |
UY33578A (es) | 2010-08-31 | 2012-03-30 | Sanofi Sa | PÉPTIDO O COMPLEJO PEPTÍDICO QUE SE UNE A INTEGRINA a(ALFA) Y MÉTODOS Y USOS QUE IMPLICAN A LOS MISMOS |
US9605320B2 (en) * | 2011-01-13 | 2017-03-28 | The Board Of Trustees Of The Leland Stanford Junior University | Method of predicting responsiveness of B cell lineage malignancies to active immunotherapy |
SG188638A1 (en) | 2011-03-25 | 2013-05-31 | Glenmark Pharmaceuticals Sa | Hetero-dimeric immunoglobulins |
CN107915775B (zh) | 2011-07-11 | 2022-07-12 | 伊克诺斯科学公司 | 结合ox40的抗体及其用途 |
EP2744515B1 (en) | 2011-08-16 | 2022-02-09 | MorphoSys AG | Combination therapy with an anti-cd19 antibody and a nitrogen mustard |
LT2744826T (lt) | 2011-08-16 | 2022-04-25 | Morphosys Ag | Kombinuota terapija su anti-cd19 antikūnu ir purino analogu |
EP3401337A1 (en) | 2012-09-25 | 2018-11-14 | Glenmark Pharmaceuticals S.A. | Purification of hetero-dimeric immunoglobulins |
EP2906298B1 (en) | 2012-10-12 | 2018-10-03 | ADC Therapeutics SA | Pyrrolobenzodiazepine-antibody conjugates |
RS58921B1 (sr) | 2012-10-12 | 2019-08-30 | Medimmune Ltd | Pirolobenzodiazepini i njihovi konjugati |
MX364328B (es) | 2012-10-12 | 2019-04-23 | Medimmune Ltd | Conjugados del anticuerpo pirrolobenzodiazepina. |
AU2013204922B2 (en) | 2012-12-20 | 2015-05-14 | Celgene Corporation | Chimeric antigen receptors |
JP2016503818A (ja) | 2013-01-02 | 2016-02-08 | グレンマーク ファーマシューティカルズ, エセ.アー. | Tl1aと結合する抗体およびその使用 |
JP6493692B2 (ja) | 2013-03-15 | 2019-04-10 | セルジーン コーポレイション | 修飾されたtリンパ球 |
UY35468A (es) * | 2013-03-16 | 2014-10-31 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19 |
EP3013856A2 (en) | 2013-06-27 | 2016-05-04 | AbbVie Biotherapeutics Inc. | Fc variants with improved complement activation |
US9950078B2 (en) | 2013-10-11 | 2018-04-24 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
AU2014342020C1 (en) * | 2013-10-31 | 2019-09-05 | Fred Hutchinson Cancer Research Center | Modified hematopoietic stem/progenitor and non-T effector cells, and uses thereof |
AP2016009222A0 (en) | 2013-11-04 | 2016-05-31 | Glenmark Pharmaceuticals Sa | Production of t cell retargeting hetero-dimeric immunoglobulins |
WO2015090230A1 (en) | 2013-12-19 | 2015-06-25 | Novartis Ag | Human mesothelin chimeric antigen receptors and uses thereof |
IL280215B (en) | 2014-04-07 | 2022-07-01 | Novartis Ag | Cancer treatment using a chimeric receptor antigen (car) against cd19 |
TWI751102B (zh) * | 2014-08-28 | 2022-01-01 | 美商奇諾治療有限公司 | 對cd19具專一性之抗體及嵌合抗原受體 |
EP2990416B1 (en) | 2014-08-29 | 2018-06-20 | GEMoaB Monoclonals GmbH | Universal chimeric antigen receptor expressing immune cells for targeting of diverse multiple antigens and method of manufacturing the same and use of the same for treatment of cancer, infections and autoimmune disorders |
GB201416112D0 (en) | 2014-09-12 | 2014-10-29 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
WO2016061368A1 (en) * | 2014-10-15 | 2016-04-21 | The Children's Hospital Of Philadelphia | Compositions and methods for treating b-lymphoid malignancies |
MA41480A (fr) | 2014-10-17 | 2017-12-19 | Glenmark Pharmaceuticals Sa | Anticorps qui se lient au ccr6 et leurs utilisations |
US11773166B2 (en) | 2014-11-04 | 2023-10-03 | Ichnos Sciences SA | CD3/CD38 T cell retargeting hetero-dimeric immunoglobulins and methods of their production |
JP7068820B2 (ja) | 2014-12-03 | 2022-05-17 | ジュノー セラピューティクス インコーポレイテッド | 養子細胞療法のための方法および組成物 |
GB201503742D0 (en) | 2015-03-05 | 2015-04-22 | Ucl Business Plc | Chimeric antigen receptor |
US10253086B2 (en) | 2015-04-08 | 2019-04-09 | Novartis Ag | CD20 therapies, CD22 therapies, and combination therapies with a CD19 chimeric antigen receptor (CAR)-expressing cell |
WO2016168769A1 (en) * | 2015-04-15 | 2016-10-20 | The California Institute For Biomedical Research | Chimeric receptor t cell switches for her2 |
JP6985934B2 (ja) * | 2015-04-29 | 2021-12-22 | フレッド ハッチンソン キャンサー リサーチ センター | 操作された造血幹細胞/前駆細胞及び非tエフェクター細胞、ならびにその使用 |
SG10201914069SA (en) | 2015-05-18 | 2020-03-30 | Tcr2 Therapeutics Inc | Compositions and methods for tcr reprogramming using fusion proteins |
RS59605B1 (sr) | 2015-05-26 | 2020-01-31 | Morphosys Ag | Kombinacija anti-cd19 antitela i inhibitora brutonove tirozin kinaze i njene upotrebe |
US10493139B2 (en) | 2015-07-24 | 2019-12-03 | Innovative Cellular Therapeutics CO., LTD. | Humanized anti-CD19 antibody and use thereof with chimeric antigen receptor |
EP3149046B1 (en) * | 2015-07-24 | 2020-02-26 | Innovative Cellular Therapeutics Co., Ltd. | Humanized anti-cd19 antibody and use thereof |
EP3337506B1 (en) | 2015-08-21 | 2021-07-21 | MorphoSys AG | Combinations and uses thereof |
MA44909A (fr) | 2015-09-15 | 2018-07-25 | Acerta Pharma Bv | Association thérapeutique d'un inhibiteur du cd19 et d'un inhibiteur de la btk |
AR106188A1 (es) * | 2015-10-01 | 2017-12-20 | Hoffmann La Roche | Anticuerpos anti-cd19 humano humanizados y métodos de utilización |
EP3913000A1 (en) * | 2015-10-02 | 2021-11-24 | F. Hoffmann-La Roche AG | Bispecific anti-cd19xcd3 t cell activating antigen binding molecules |
ES2928167T3 (es) * | 2015-12-03 | 2022-11-15 | Juno Therapeutics Inc | Composiciones y métodos para reducir las respuestas inmunitarias contra receptores de antígenos quiméricos |
GB201601431D0 (en) | 2016-01-26 | 2016-03-09 | Medimmune Ltd | Pyrrolobenzodiazepines |
GB201602356D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
GB201602359D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
GB201607478D0 (en) | 2016-04-29 | 2016-06-15 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
RS62155B1 (sr) | 2016-05-30 | 2021-08-31 | Morphosys Ag | Postupci predviđanja terapijske koristi anti-cd19 terapije kod pacijenata |
KR102533875B1 (ko) | 2016-06-27 | 2023-05-18 | 모르포시스 아게 | 항-cd19 항체 제제 |
EP3523331A1 (en) | 2016-10-07 | 2019-08-14 | Novartis AG | Chimeric antigen receptors for the treatment of cancer |
GB201617466D0 (en) | 2016-10-14 | 2016-11-30 | Medimmune Ltd | Pyrrolobenzodiazepine conjugates |
WO2018075820A2 (en) | 2016-10-20 | 2018-04-26 | Celgene Corporation | Cereblon-based heterodimerizable chimeric antigen receptors |
MX2019004942A (es) | 2016-10-28 | 2019-08-12 | Morphosys Ag | Combinacion de anticuerpo anti cd19 con un inhibidor de bcl-2 y usos de la misma. |
AU2017363311A1 (en) | 2016-11-22 | 2019-06-13 | TCR2 Therapeutics Inc. | Compositions and methods for TCR reprogramming using fusion proteins |
EP3609536B1 (en) * | 2017-01-05 | 2022-03-09 | Innovative Cellular Therapeutics Holdings, Ltd. | Humanized anti-cd19 antibody and use thereof with chimeric antigen receptor |
GB201702031D0 (en) | 2017-02-08 | 2017-03-22 | Medlmmune Ltd | Pyrrolobenzodiazepine-antibody conjugates |
ES2871001T3 (es) | 2017-02-08 | 2021-10-28 | Adc Therapeutics Sa | Conjugados de pirrolobenzodiazepinas y anticuerpos |
CN106967171B (zh) * | 2017-02-23 | 2021-04-27 | 郑州大学 | 一种全人源重组CD40L单抗Fab片段及其制备方法 |
PT3612537T (pt) | 2017-04-18 | 2022-08-29 | Medimmune Ltd | Conjugados de pirrolobenzodiazepina |
CN110753555A (zh) | 2017-04-19 | 2020-02-04 | 得克萨斯州大学系统董事会 | 表达工程化抗原受体的免疫细胞 |
JOP20180042A1 (ar) * | 2017-04-24 | 2019-01-30 | Kite Pharma Inc | نطاقات ربط مولد ضد متوافقة مع البشر وطرق الاستخدام |
KR102455340B1 (ko) * | 2017-05-10 | 2022-10-18 | 더 위스타 인스티튜트 오브 아나토미 앤드 바이올로지 | 최적화된 핵산 항체 작제물 |
SI3630177T1 (sl) | 2017-05-31 | 2023-12-29 | Morphosys Ag | Paradigma zdravljenja za protitelo proti cd19 in kombinirano zdravljenje z venetoklaksom |
WO2018229222A1 (en) | 2017-06-14 | 2018-12-20 | Adc Therapeutics Sa | Dosage regimes for the administration of an anti-cd19 adc |
US11634488B2 (en) | 2017-07-10 | 2023-04-25 | International—Drug—Development—Biotech | Treatment of B cell malignancies using afucosylated pro-apoptotic anti-CD19 antibodies in combination with anti CD20 antibodies or chemotherapeutics |
CA3099487A1 (en) * | 2017-07-20 | 2019-01-24 | Nbe-Therapeutics Ag | Human antibodies binding to ror2 |
MY194477A (en) | 2017-08-18 | 2022-11-30 | Medimmune Ltd | Pyrrolobenzodiazepine conjugates |
WO2019057100A1 (en) | 2017-09-21 | 2019-03-28 | Wuxi Biologics (Shanghai) Co., Ltd. | NEW ANTI-CD19 ANTIBODIES |
JP7277473B2 (ja) | 2017-10-30 | 2023-05-19 | ニューロポア セラピーズ インコーポレイテッド | 置換フェニルスルホニルフェニルトリアゾールチオンおよびその使用法 |
WO2019112347A2 (ko) * | 2017-12-06 | 2019-06-13 | 앱클론(주) | 악성 b 세포를 특이적으로 인지하는 항체 또는 그의 항원 결합 단편, 이를 포함하는 키메라 항원 수용체 및 이의 용도 |
CN109053899B (zh) * | 2017-12-22 | 2021-11-16 | 湖南远泰生物技术有限公司 | 一种含人转铁蛋白抗原表位序列的嵌合体抗原受体 |
JP7080514B2 (ja) * | 2017-12-22 | 2022-06-06 | アブクロン・インコーポレイテッド | 悪性b細胞を特異的に認知する抗体またはその抗原結合断片、これを含むキメラ抗原受容体及びその用途 |
CN108047332B (zh) * | 2018-01-15 | 2021-08-24 | 阿思科力(苏州)生物科技有限公司 | 以cd19为靶点的特异性抗体、car-nk细胞及其制备和应用 |
GB201803342D0 (en) | 2018-03-01 | 2018-04-18 | Medimmune Ltd | Methods |
GB201806022D0 (en) | 2018-04-12 | 2018-05-30 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
MX2020013443A (es) | 2018-06-13 | 2021-02-26 | Novartis Ag | Receptores de antigeno quimerico de bcma y usos de los mismos. |
CN109293774B (zh) * | 2018-10-16 | 2021-05-28 | 南京医科大学 | 特异性结合cd19的全人源化抗体及应用 |
CN116726362A (zh) | 2018-11-19 | 2023-09-12 | 比奥拉治疗股份有限公司 | 用生物治疗剂治疗疾病的方法和装置 |
SG11202106302WA (en) | 2018-12-12 | 2021-07-29 | Kite Pharma Inc | Chimeric antigen receptors and car-t cells and methods of use |
JP2021528048A (ja) * | 2019-03-05 | 2021-10-21 | ンカルタ・インコーポレイテッドNkarta, Inc. | Cd19指向性キメラ抗原受容体および免疫療法におけるその使用 |
EP3953385A4 (en) * | 2019-04-08 | 2022-12-21 | Memorial Sloan Kettering Cancer Center | CD19 ANTIBODIES AND METHODS OF USE THEREOF |
BR112021021542A2 (pt) * | 2019-04-30 | 2022-04-19 | Crispr Therapeutics Ag | Terapia celular alogênica de malignidades de células b com o uso de células t geneticamente modificadas que têm como alvo cd19 |
WO2020225196A1 (en) | 2019-05-03 | 2020-11-12 | Morphosys Ag | Anti-cd19 therapy in patients having a limited number of nk cells |
WO2020261219A1 (en) * | 2019-06-27 | 2020-12-30 | Crispr Therapeutics Ag | Use of chimeric antigen receptor t cells and nk cell inhibitors for treating cancer |
CN110396129B (zh) * | 2019-07-10 | 2020-11-24 | 武汉思安医疗技术有限公司 | 人源化cd19抗原结合单链抗体及其嵌合抗原受体、免疫细胞和应用 |
JP2022550435A (ja) | 2019-10-04 | 2022-12-01 | ウルトラジェニックス ファーマシューティカル インコーポレイテッド | 組換えaavの改善された治療的使用のための方法 |
JP2022554324A (ja) | 2019-10-31 | 2022-12-28 | モルフォシス・アーゲー | 抗cd19抗体及びガンマデルタt細胞を含む抗腫瘍併用療法 |
AU2020376305A1 (en) | 2019-10-31 | 2022-05-12 | Incyte Corporation | Anti-CD19 therapy in combination with lenalidomide for the treatment of leukemia or lymphoma |
CN115666704A (zh) | 2019-12-13 | 2023-01-31 | 比奥拉治疗股份有限公司 | 用于将治疗剂递送至胃肠道的可摄取装置 |
WO2021255155A1 (en) | 2020-06-19 | 2021-12-23 | F. Hoffmann-La Roche Ag | Antibodies binding to cd3 and cd19 |
AU2021298106A1 (en) | 2020-06-22 | 2023-01-19 | Gilead Sciences, Inc. | Anti-tumor combination therapy comprising anti-CD19 antibody and polypeptides blocking the SIRPalpha-CD47 innate immune checkpoint |
TW202229349A (zh) | 2020-10-06 | 2022-08-01 | 美商山可爾股份有限公司 | 用於治療包括全身性紅斑性狼瘡(sle)的自體免疫疾病之生物標記、方法及組合物 |
CN116848147A (zh) * | 2020-11-20 | 2023-10-03 | 先声再明医药有限公司 | Cd19人源化抗体及其应用 |
KR20230131464A (ko) | 2020-12-04 | 2023-09-13 | 모르포시스 아게 | 항-cd19 병용 요법 |
WO2022155375A2 (en) * | 2021-01-13 | 2022-07-21 | Washington University | MHC-INDEPENDENT TCRs AND METHODS OF MAKING AND USING SAME |
CN112679612B (zh) * | 2021-01-29 | 2022-07-01 | 武汉华美生物工程有限公司 | 抗cd19人源化抗体及其制备方法与应用 |
CA3217586A1 (en) * | 2021-05-07 | 2022-11-10 | Eliezer Katz | Use of an anti-cd19 antibody to treat myasthenia gravis |
WO2023073645A1 (en) | 2021-10-29 | 2023-05-04 | Takeda Pharmaceutical Company Limited | Therapy comprising anti-cd19 antibody and sumo-activating enzyme inhibitor |
WO2024038115A1 (en) | 2022-08-17 | 2024-02-22 | Morphosys Ag | Therapy comprising anti-cd19 antibody and ezh2 modulators |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3883899T3 (de) * | 1987-03-18 | 1999-04-22 | Sb2 Inc | Geänderte antikörper. |
US5677425A (en) * | 1987-09-04 | 1997-10-14 | Celltech Therapeutics Limited | Recombinant antibody |
US5571894A (en) * | 1991-02-05 | 1996-11-05 | Ciba-Geigy Corporation | Recombinant antibodies specific for a growth factor receptor |
US5587458A (en) * | 1991-10-07 | 1996-12-24 | Aronex Pharmaceuticals, Inc. | Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof |
ATE419355T1 (de) | 1992-02-06 | 2009-01-15 | Novartis Vaccines & Diagnostic | Marker für krebs und biosynthetisches bindeprotein dafür |
EP0640094A1 (en) * | 1992-04-24 | 1995-03-01 | The Board Of Regents, The University Of Texas System | Recombinant production of immunoglobulin-like domains in prokaryotic cells |
EP0672142B1 (en) | 1992-12-04 | 2001-02-28 | Medical Research Council | Multivalent and multispecific binding proteins, their manufacture and use |
EP0714409A1 (en) | 1993-06-16 | 1996-06-05 | Celltech Therapeutics Limited | Antibodies |
US5641870A (en) * | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
US6121022A (en) * | 1995-04-14 | 2000-09-19 | Genentech, Inc. | Altered polypeptides with increased half-life |
US5869046A (en) * | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
US6277375B1 (en) * | 1997-03-03 | 2001-08-21 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
US6194551B1 (en) * | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
EP2386574A3 (en) | 1999-01-15 | 2012-06-27 | Genentech, Inc. | Polypeptide variants with altered effector function |
ATE338124T1 (de) * | 2000-11-07 | 2006-09-15 | Hope City | Cd19-spezifische umgezielte immunzellen |
WO2002097395A2 (en) * | 2001-05-31 | 2002-12-05 | Chiron Corporation | P-cadherin as a target for anti-cancer therapy |
KR100988949B1 (ko) * | 2001-10-25 | 2010-10-20 | 제넨테크, 인크. | 당단백질 조성물 |
US20040002587A1 (en) * | 2002-02-20 | 2004-01-01 | Watkins Jeffry D. | Fc region variants |
KR20050089151A (ko) * | 2002-11-26 | 2005-09-07 | 프로테인 디자인 랩스 인코포레이티드 | 혈관형성을 조절하는 α5β1 인테그린에 대한 키메라성 및인간화 항체 |
EP2216342B1 (en) * | 2003-07-31 | 2015-04-22 | Immunomedics, Inc. | Anti-CD19 antibodies |
WO2005047324A2 (en) * | 2003-11-10 | 2005-05-26 | Schering Corp | ANTI-INTERLEUKIN ANTIBODY-10 |
EP2548575A1 (en) * | 2005-02-15 | 2013-01-23 | Duke University | Anti-CD19 antibodies that mediate ADCC for use in treating autoimmune diseases |
WO2006121852A2 (en) * | 2005-05-05 | 2006-11-16 | Duke University | Anti-cd19 antibody therapy for autoimmune disease |
EP1899379B1 (en) * | 2005-06-20 | 2018-04-11 | E. R. Squibb & Sons, L.L.C. | Cd19 antibodies and their uses |
US20090068110A1 (en) * | 2006-12-22 | 2009-03-12 | Genentech, Inc. | Antibodies to insulin-like growth factor receptor |
-
2010
- 2010-02-23 CA CA2753158A patent/CA2753158A1/en not_active Abandoned
- 2010-02-23 AU AU2010215239A patent/AU2010215239A1/en not_active Abandoned
- 2010-02-23 EA EA201190132A patent/EA201190132A1/ru unknown
- 2010-02-23 BR BRPI1005984A patent/BRPI1005984A2/pt not_active IP Right Cessation
- 2010-02-23 AP AP2011005859A patent/AP2011005859A0/xx unknown
- 2010-02-23 SG SG2011058013A patent/SG173654A1/en unknown
- 2010-02-23 MX MX2011008843A patent/MX2011008843A/es not_active Application Discontinuation
- 2010-02-23 KR KR1020117022435A patent/KR20110122859A/ko not_active Application Discontinuation
- 2010-02-23 JP JP2011550666A patent/JP2012518404A/ja active Pending
- 2010-02-23 CN CN2010800177548A patent/CN102421800A/zh active Pending
- 2010-02-23 US US12/710,442 patent/US8679492B2/en not_active Expired - Fee Related
- 2010-02-23 EP EP10706363A patent/EP2398829A2/en not_active Withdrawn
- 2010-02-23 WO PCT/IB2010/000353 patent/WO2010095031A2/en active Application Filing
-
2011
- 2011-08-18 IL IL214725A patent/IL214725A0/en unknown
- 2011-08-22 CL CL2011002039A patent/CL2011002039A1/es unknown
- 2011-08-31 ZA ZA2011/06369A patent/ZA201106369B/en unknown
- 2011-09-23 CO CO11124710A patent/CO6430469A2/es not_active Application Discontinuation
-
2014
- 2014-01-30 US US14/168,927 patent/US20140286934A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CL2011002039A1 (es) | 2012-03-30 |
US20100215651A1 (en) | 2010-08-26 |
KR20110122859A (ko) | 2011-11-11 |
IL214725A0 (en) | 2011-11-30 |
US8679492B2 (en) | 2014-03-25 |
AU2010215239A1 (en) | 2011-09-15 |
AP2011005859A0 (en) | 2011-10-31 |
BRPI1005984A2 (pt) | 2016-10-04 |
EP2398829A2 (en) | 2011-12-28 |
US20140286934A1 (en) | 2014-09-25 |
CN102421800A (zh) | 2012-04-18 |
CA2753158A1 (en) | 2010-08-26 |
JP2012518404A (ja) | 2012-08-16 |
SG173654A1 (en) | 2011-09-29 |
MX2011008843A (es) | 2011-12-14 |
WO2010095031A2 (en) | 2010-08-26 |
WO2010095031A3 (en) | 2010-11-04 |
ZA201106369B (en) | 2012-05-30 |
EA201190132A1 (ru) | 2013-01-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CO6430469A2 (es) | Anticuerpos humanizados que se unen a cd19 y sus usos | |
CY1120414T1 (el) | Αντισωματα που συνδεονται me οχ40 και οι χρησεις τους | |
AU2018256487A1 (en) | Antibodies that bind to TL1A and their uses | |
ES2687282T3 (es) | Anticuerpos humanizados ANTI-CD134 (OX40) y sus usos | |
ES2776179T3 (es) | Anticuerpos dirigidos contra determinantes de la superficie de S. aureus | |
NZ709390A (en) | Folate receptor 1 antibodies and immunoconjugates and uses thereof | |
PE20131403A1 (es) | Anticuerpos anti-ox40 y metodos de uso de los mismos | |
PE20141398A1 (es) | Anticuerpos neutralizantes de citomegalovirus humano | |
NZ712765A (en) | Antibodies that bind csf1r | |
PE20190737A1 (es) | Anticuerpos anti-cd27 | |
CO6231038A2 (es) | Proteinas de union, incluyendo anticuerpos derivados de anticuerpo y fragmentos de anticuerpo que se unen especificamente a cd154 y sus usos | |
PE20160553A1 (es) | Anticuerpo antagonista especifico para el heterodimero de alfa-4-beta-7 | |
AR065506A1 (es) | Anticuerpos antagonistas ox40 y su uso en el tratamiento de enfermedades | |
AR096617A1 (es) | Anticuerpos anti-tweakr y sus usos | |
ES2572231T3 (es) | Anticuerpos monoclonales anti-IL-21 humana | |
CO2017004753A2 (es) | Anticuerpos que se unen a ccr6 | |
AR065312A1 (es) | Nuevos anticuerpos | |
PE20191319A1 (es) | Anticuerpos novedosos contra el factor xi y sus usos | |
AR107083A1 (es) | Anticuerpos dirigidos a cd32b y métodos de uso de los mismos | |
AR122257A2 (es) | Anticuerpos e inmunoconjugados del receptor 1 de folato y sus usos | |
NZ623840A (en) | Anti-cd134 (ox40) antibodies and uses thereof | |
AR101565A1 (es) | Anticuerpos anti tigit | |
NZ620100A (en) | Rspo binding agents and uses thereof | |
ES2670405T3 (es) | Anticuerpos capaces de unirse específicamente a oligómeros de beta amiloides, y su utilización |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC | Application refused |