UY35468A - Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19 - Google Patents
Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19Info
- Publication number
- UY35468A UY35468A UY0001035468A UY35468A UY35468A UY 35468 A UY35468 A UY 35468A UY 0001035468 A UY0001035468 A UY 0001035468A UY 35468 A UY35468 A UY 35468A UY 35468 A UY35468 A UY 35468A
- Authority
- UY
- Uruguay
- Prior art keywords
- cancer treatment
- car
- receiver
- chemeric
- chemeric antigen
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 239000000427 antigen Substances 0.000 title 1
- 102000036639 antigens Human genes 0.000 title 1
- 108091007433 antigens Proteins 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 abstract 4
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 abstract 4
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 abstract 4
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3061—Blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4631—Chimeric Antigen Receptors [CAR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
- A61K39/464411—Immunoglobulin superfamily
- A61K39/464412—CD19 or B4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
La invención proporciona composiciones y métodos para tratar enfermedades asociadas con la expresión de CD19. La invención también se refiere a un receptor quimérico de antígeno (CAR) específico a CD19, vectores que codifican el mismo, y células T recombinantes que comprenden el CAR CD19. La invención también incluye métodos de administración de una célula T modificada genéticamente que expresa un CAR que comprende un dominio de unión a CD19.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361802629P | 2013-03-16 | 2013-03-16 | |
US201361838537P | 2013-06-24 | 2013-06-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY35468A true UY35468A (es) | 2014-10-31 |
Family
ID=50680172
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY0001035468A UY35468A (es) | 2013-03-16 | 2014-03-14 | Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19 |
Country Status (25)
Country | Link |
---|---|
US (3) | US10221245B2 (es) |
EP (3) | EP3539986B1 (es) |
JP (4) | JP6466401B2 (es) |
KR (1) | KR102293062B1 (es) |
CN (2) | CN115287292A (es) |
AU (3) | AU2014236098B8 (es) |
BR (1) | BR112015021819A2 (es) |
CA (1) | CA2907100C (es) |
DK (2) | DK3539986T3 (es) |
ES (2) | ES2923397T3 (es) |
HK (1) | HK1218922A1 (es) |
HR (1) | HRP20220767T1 (es) |
HU (2) | HUE058832T2 (es) |
IL (1) | IL241261B (es) |
LT (2) | LT2970482T (es) |
MX (2) | MX2015013194A (es) |
MY (1) | MY187624A (es) |
PL (2) | PL2970482T3 (es) |
PT (2) | PT3539986T (es) |
RU (2) | RU2020100865A (es) |
SG (2) | SG10201806293WA (es) |
SI (1) | SI3539986T1 (es) |
TW (1) | TWI654206B (es) |
UY (1) | UY35468A (es) |
WO (1) | WO2014153270A1 (es) |
Families Citing this family (390)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7435596B2 (en) | 2004-11-04 | 2008-10-14 | St. Jude Children's Research Hospital, Inc. | Modified cell line and method for expansion of NK cell |
US20130266551A1 (en) * | 2003-11-05 | 2013-10-10 | St. Jude Children's Research Hospital, Inc. | Chimeric receptors with 4-1bb stimulatory signaling domain |
WO2012142213A2 (en) | 2011-04-15 | 2012-10-18 | The Johns Hopkins University | Safe sequencing system |
CA3084919A1 (en) | 2012-02-22 | 2013-08-29 | The Trustees Of The University Of Pennsylvania | Compositions and methods for generating a persisting population of t cells useful for the treatment of cancer |
CN109457030B (zh) | 2012-10-29 | 2022-02-18 | 约翰·霍普金斯大学 | 卵巢和子宫内膜癌的帕帕尼科拉乌测试 |
CN105358576B (zh) | 2013-02-20 | 2020-05-05 | 诺华股份有限公司 | 使用人源化抗EGFRvIII嵌合抗原受体治疗癌症 |
WO2014130635A1 (en) | 2013-02-20 | 2014-08-28 | Novartis Ag | Effective targeting of primary human leukemia using anti-cd123 chimeric antigen receptor engineered t cells |
US9745368B2 (en) | 2013-03-15 | 2017-08-29 | The Trustees Of The University Of Pennsylvania | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
US9657105B2 (en) | 2013-03-15 | 2017-05-23 | City Of Hope | CD123-specific chimeric antigen receptor redirected T cells and methods of their use |
TWI654206B (zh) | 2013-03-16 | 2019-03-21 | 諾華公司 | 使用人類化抗-cd19嵌合抗原受體治療癌症 |
JP6779785B2 (ja) | 2013-12-19 | 2020-11-04 | ノバルティス アーゲー | ヒトメソテリンキメラ抗原受容体およびその使用 |
EP3087101B1 (en) | 2013-12-20 | 2024-06-05 | Novartis AG | Regulatable chimeric antigen receptor |
CA2934436A1 (en) * | 2013-12-20 | 2015-06-25 | Cellectis | Method of engineering multi-input signal sensitive t cell for immunotherapy |
EP3097117B1 (en) * | 2014-01-21 | 2023-10-04 | Novartis Ag | Enhanced antigen presenting ability of car t cells by co-introduction of costimulatory molecules |
US10189908B2 (en) | 2014-02-05 | 2019-01-29 | The University Of Chicago | Chimeric antigen receptors recognizing cancer-specific TN glycopeptide variants |
EP3105333B1 (en) | 2014-02-10 | 2020-04-08 | Emory University | Expression of chimeric polypeptide with variable lymphocyte receptors on immune cells and uses for treating cancer |
EP3119807B1 (en) * | 2014-03-19 | 2019-04-24 | Cellectis | Cd123 specific chimeric antigen receptors for cancer immunotherapy |
LT3129470T (lt) * | 2014-04-07 | 2021-07-12 | Novartis Ag | Vėžio gydymas naudojant anti-cd19 chimerinį antigeno receptorių |
CA2945320A1 (en) | 2014-04-10 | 2015-10-15 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Drug regulated transgene expression |
CN106459173A (zh) | 2014-05-02 | 2017-02-22 | 爱默蕾大学 | 人源化可变淋巴细胞受体(vlr)及其相关组合物和用途 |
US10428305B2 (en) | 2014-05-15 | 2019-10-01 | National University Of Singapore | Modified natural killer cells that express IL15 and uses thereof |
SG11201609960QA (en) | 2014-06-02 | 2016-12-29 | Us Health | Chimeric antigen receptors targeting cd-19 |
CN107075483A (zh) | 2014-07-15 | 2017-08-18 | 朱诺治疗学股份有限公司 | 用于过继细胞治疗的工程改造的细胞 |
AR101829A1 (es) | 2014-07-21 | 2017-01-18 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico de antígeno cll-1 |
EP3193915A1 (en) | 2014-07-21 | 2017-07-26 | Novartis AG | Combinations of low, immune enhancing. doses of mtor inhibitors and cars |
KR102594343B1 (ko) | 2014-07-21 | 2023-10-26 | 노파르티스 아게 | Cd33 키메라 항원 수용체를 사용한 암의 치료 |
US11542488B2 (en) | 2014-07-21 | 2023-01-03 | Novartis Ag | Sortase synthesized chimeric antigen receptors |
RU2751660C2 (ru) | 2014-07-21 | 2021-07-15 | Новартис Аг | Лечение злокачественного новообразования с использованием гуманизированного химерного антигенного рецептора против всма |
US20170226216A1 (en) | 2014-07-24 | 2017-08-10 | Bluebird Bio, Inc. | Bcma chimeric antigen receptors |
EP3174546B1 (en) | 2014-07-31 | 2019-10-30 | Novartis AG | Subset-optimized chimeric antigen receptor-containing t-cells |
EP3183268B1 (en) | 2014-08-19 | 2020-02-12 | Novartis AG | Anti-cd123 chimeric antigen receptor (car) for use in cancer treatment |
TWI805109B (zh) | 2014-08-28 | 2023-06-11 | 美商奇諾治療有限公司 | 對cd19具專一性之抗體及嵌合抗原受體 |
PL3194443T3 (pl) | 2014-09-17 | 2022-01-31 | Novartis Ag | Nakierowywanie komórek cytotoksycznych za pośrednictwem receptorów chimerycznych do immunoterapii adoptywnej |
JP2017531430A (ja) * | 2014-10-07 | 2017-10-26 | セレクティスCellectis | Carによって誘導される免疫細胞の活性を調節するための方法 |
CA2963935A1 (en) * | 2014-10-08 | 2016-04-14 | Novartis Ag | Biomarkers predictive of therapeutic responsiveness to chimeric antigen receptor therapy and uses thereof |
US20170239294A1 (en) * | 2014-10-15 | 2017-08-24 | Novartis Ag | Compositions and methods for treating b-lymphoid malignancies |
KR20170068598A (ko) | 2014-10-20 | 2017-06-19 | 주노 쎄러퓨티크스 인코퍼레이티드 | 입양 세포 치료에서 복용을 위한 방법 및 조성물 |
JP7005346B2 (ja) * | 2014-10-27 | 2022-02-04 | フレッド ハッチンソン キャンサー リサーチ センター | 養子細胞免疫療法の有効性を増強させるための組成物および方法 |
SG11201703656PA (en) * | 2014-11-05 | 2017-06-29 | Juno Therapeutics Inc | Methods for transduction and cell processing |
CA2969456A1 (en) | 2014-12-03 | 2016-06-09 | Juno Therapeutics, Inc. | Methods and compositions for adoptive cell therapy |
WO2016090034A2 (en) | 2014-12-03 | 2016-06-09 | Novartis Ag | Methods for b cell preconditioning in car therapy |
EP3971210A1 (en) | 2014-12-12 | 2022-03-23 | 2seventy bio, Inc. | Composition for use in the treatment of b cell related conditions in a subject in need thereof comprisine an effector cell comrising a bcma chimeric antigen receptors |
JP2018504104A (ja) * | 2014-12-17 | 2018-02-15 | セレクティスCellectis | 非T細胞伝達ドメインを発現する阻害性キメラ抗原受容体(iCARまたはN−CAR) |
RU2021118125A (ru) | 2014-12-29 | 2022-04-06 | Новартис Аг | Способы получения экспрессирующих химерный антигенный рецептор клеток |
US11382963B2 (en) | 2015-01-12 | 2022-07-12 | Pieris Pharmaceuticals Gmbh | Engineered T cells and uses therefor |
US11459390B2 (en) | 2015-01-16 | 2022-10-04 | Novartis Ag | Phosphoglycerate kinase 1 (PGK) promoters and methods of use for expressing chimeric antigen receptor |
GB201501004D0 (en) | 2015-01-21 | 2015-03-04 | Cancer Rec Tech Ltd | Inhibitors |
US10308719B2 (en) | 2015-01-26 | 2019-06-04 | The University Of Chicago | IL13Rα2 binding agents and use thereof in cancer treatment |
KR102661969B1 (ko) | 2015-01-26 | 2024-04-29 | 셀렉티스 에스.에이. | 조작된 면역 세포들의 분류/고갈을 위한 mAb-주도의 키메라 항원 수용체 시스템들 |
JP6912386B2 (ja) | 2015-01-26 | 2021-08-04 | ザ ユニバーシティー オブ シカゴ | 癌特異的なIL13Rα2を認識するCAR T細胞 |
JP6849600B6 (ja) | 2015-01-29 | 2021-06-30 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | キメラ抗原受容体、組成物及び方法 |
US11161907B2 (en) | 2015-02-02 | 2021-11-02 | Novartis Ag | Car-expressing cells against multiple tumor antigens and uses thereof |
US10722523B2 (en) | 2015-03-17 | 2020-07-28 | The Regents Of The University Of California | Chemoimmunotherapy for epithelial cancer |
ES2876974T3 (es) | 2015-04-07 | 2021-11-15 | Novartis Ag | Combinación de terapia con receptor de antígeno quimérico y derivados de amino pirimidina |
LT3280729T (lt) * | 2015-04-08 | 2022-08-10 | Novartis Ag | Terapijos cd20, terapijos cd22 ir kombinuotos terapijos su cd19 chimerinį antigeno receptorių (car) ekspresuojančia ląstele |
JP7114457B2 (ja) | 2015-04-17 | 2022-08-08 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | キメラ抗原受容体発現細胞の有効性および増殖を改善するための方法 |
GB201507111D0 (en) * | 2015-04-27 | 2015-06-10 | Ucl Business Plc | Nucleic acid construct |
GB201507368D0 (en) * | 2015-04-30 | 2015-06-17 | Ucl Business Plc | Cell |
CA2984677C (en) | 2015-05-01 | 2022-05-17 | The Regents Of The University Of California | Glycan-dependent immunotherapeutic molecules |
ES2819976T5 (es) | 2015-05-18 | 2024-02-23 | Tcr2 Therapeutics Inc | Composiciones y usos médicos para la reprogramación de TCR con proteínas de fusión |
US20180161369A1 (en) | 2015-05-29 | 2018-06-14 | Fred Hutchinson Cancer Research Center | Compositions for cellular immunotherapy |
HUE054201T2 (hu) | 2015-06-19 | 2021-08-30 | Endres Stefan Prof Dr | PD-1-CD28 fúziós fehérjék és gyógyászatban való alkalmazásuk |
MA42902A (fr) * | 2015-07-08 | 2018-05-16 | Univ Johns Hopkins | Lymphocytes infiltrant la moelle (mil) en tant que source de lymphocytes t pour une thérapie par des récepteurs chimériques d'un antigène (car) |
MA42895A (fr) | 2015-07-15 | 2018-05-23 | Juno Therapeutics Inc | Cellules modifiées pour thérapie cellulaire adoptive |
CN116196426A (zh) | 2015-07-16 | 2023-06-02 | 百欧肯治疗有限公司 | 治疗癌症的组合物及方法 |
AU2016297014B2 (en) | 2015-07-21 | 2021-06-17 | Novartis Ag | Methods for improving the efficacy and expansion of immune cells |
WO2017015783A1 (en) * | 2015-07-24 | 2017-02-02 | Shanghai Sidansai Biotechnology Co., Ltd | Humanized anti-cd19 antibody and use thereof |
WO2018126369A1 (en) * | 2017-01-05 | 2018-07-12 | Shanghai Sidansai Biotechnology Co., Ltd | Humanized anti-cd19 antibody and use thereof with chimeric antigen receptor |
US10493139B2 (en) | 2015-07-24 | 2019-12-03 | Innovative Cellular Therapeutics CO., LTD. | Humanized anti-CD19 antibody and use thereof with chimeric antigen receptor |
WO2017027291A1 (en) | 2015-08-07 | 2017-02-16 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Bispecific car t-cells for solid tumor targeting |
WO2017027392A1 (en) | 2015-08-07 | 2017-02-16 | Novartis Ag | Treatment of cancer using chimeric cd3 receptor proteins |
CN105384825B (zh) * | 2015-08-11 | 2018-06-01 | 南京传奇生物科技有限公司 | 一种基于单域抗体的双特异性嵌合抗原受体及其应用 |
WO2017027653A1 (en) | 2015-08-11 | 2017-02-16 | The Johns Hopkins University | Assaying ovarian cyst fluid |
CN116212048A (zh) | 2015-08-12 | 2023-06-06 | 麻省理工学院 | 纳米颗粒的细胞表面偶联 |
CN106467906B (zh) * | 2015-08-20 | 2019-09-27 | 北京马力喏生物科技有限公司 | 构建体、转基因淋巴细胞及其制备方法和用途 |
US20180243340A1 (en) * | 2015-08-24 | 2018-08-30 | University Of Houston System | Combination therapy combining car + t cells with appropriately timed immunodulatory antibodies |
CN108780084B (zh) | 2015-09-03 | 2022-07-22 | 诺华股份有限公司 | 预测细胞因子释放综合征的生物标志物 |
MA44909A (fr) * | 2015-09-15 | 2018-07-25 | Acerta Pharma Bv | Association thérapeutique d'un inhibiteur du cd19 et d'un inhibiteur de la btk |
US10265379B2 (en) * | 2015-09-16 | 2019-04-23 | Annabelle Rodriguez Oquendo | Use of recombinant lymphocyte activation gene-3 as a companion therapeutic for patients at risk for cardiovascular disease and other chronic inflammatory diseases |
WO2017053556A1 (en) | 2015-09-22 | 2017-03-30 | The Trustees Of The University Of Pennsylvania | Method of redirecting t cells to treat hiv infection |
EP3352784A4 (en) * | 2015-09-23 | 2019-06-26 | Cytoimmune Therapeutics, LLC | FLT3-FACED CAR CELLS FOR IMMUNOTHERAPY |
EP3355937A4 (en) * | 2015-09-28 | 2019-04-17 | Regents of the University of Minnesota | CHIMERIC ANTIGEN RECEPTOR (CAR) T CELLS AS THERAPEUTIC INTERVENTIONS AT AUTO AND ALLO IMMUNITY |
US10421810B2 (en) * | 2015-10-09 | 2019-09-24 | Lentigen Technology, Inc. | Chimeric antigen receptors and methods of use |
MY196631A (en) | 2015-10-13 | 2023-04-24 | Eureka Therapeutics Inc | Antibody Agents Specific for Human Cd19 and uses Thereof |
CA3001833A1 (en) * | 2015-10-13 | 2017-04-20 | City Of Hope | Chimeric antigen receptors containing a chlorotoxin domain |
US11723922B2 (en) | 2015-10-16 | 2023-08-15 | Ludwig-Maximilians-Universität München | CXCR6-transduced T cells for targeted tumor therapy |
WO2017066583A1 (en) * | 2015-10-16 | 2017-04-20 | University Of Utah Research Foundation | A nanomaterial complex comprising graphene oxide associated with a therapeutic agent and methods of use |
MA44314A (fr) | 2015-11-05 | 2018-09-12 | Juno Therapeutics Inc | Récepteurs chimériques contenant des domaines induisant traf, et compositions et méthodes associées |
WO2017079703A1 (en) | 2015-11-05 | 2017-05-11 | Juno Therapeutics, Inc. | Vectors and genetically engineered immune cells expressing metabolic pathway modulators and uses in adoptive cell therapy |
CN105331585A (zh) * | 2015-11-13 | 2016-02-17 | 科济生物医药(上海)有限公司 | 携带pd-l1阻断剂的嵌合抗原受体修饰的免疫效应细胞 |
TW202216787A (zh) | 2015-11-18 | 2022-05-01 | 美商默沙東藥廠 | Pd1及/或 lag3結合劑 |
MA43378A (fr) * | 2015-12-03 | 2018-10-10 | Juno Therapeutics Inc | Compositions et méthodes pour la reduction de la réponse immunitaire contre récepteurs d'antigène chimériques |
JP7184645B2 (ja) | 2015-12-03 | 2022-12-06 | ジュノー セラピューティクス インコーポレイテッド | 修飾キメラ受容体ならびに関連する組成物および方法 |
MA43377A (fr) * | 2015-12-04 | 2021-05-19 | Hutchinson Fred Cancer Res | Méthodes et compositions liées à la toxicité associée à la thérapie cellulaire |
CA3006432A1 (en) | 2015-12-04 | 2017-06-08 | Novartis Ag | Compositions and methods for immunooncology |
MA44140A (fr) | 2015-12-22 | 2021-05-19 | Dana Farber Cancer Inst Inc | Récepteur d'antigène chimérique (car) contre la mésothéline et anticorps contre l'inhibiteur de pd-l1 pour une utilisation combinée dans une thérapie anticancéreuse |
JP2019500394A (ja) | 2015-12-30 | 2019-01-10 | ノバルティス アーゲー | 有効性が増強された免疫エフェクター細胞治療 |
EA201891614A1 (ru) | 2016-01-11 | 2019-02-28 | Те Борд Оф Трастиз Оф Те Лилэнд Стэнфорд Джуниор Юниверсити | Химерные белки и способы иммунотерапии |
CN105950645A (zh) * | 2016-01-11 | 2016-09-21 | 灏灵赛奥(天津)生物科技有限公司 | Car-cd19抗原受体的人源化融合基因片段、其构建方法及应用 |
IL260532B2 (en) | 2016-01-11 | 2023-12-01 | Univ Leland Stanford Junior | Systems containing chaperone proteins and their uses for controlling gene expression |
CN107034193B (zh) * | 2016-02-03 | 2020-06-05 | 北京马力喏生物科技有限公司 | 治疗b细胞白血病及b细胞淋巴瘤的治疗组合物 |
BR112018067679A2 (pt) | 2016-03-04 | 2019-01-15 | Novartis Ag | células que expressam múltiplas moléculas do receptor de antígeno quimérico (car) e seu uso |
US20190355459A1 (en) | 2016-03-16 | 2019-11-21 | Juno Therapeutics, Inc. | Methods for adaptive design of a treatment regimen and related treatments |
MA43758A (fr) | 2016-03-16 | 2018-11-28 | Yuan Ji | Procédés pour déterminer le dosage d'un agent thérapeutique et traitements associés |
WO2017161353A1 (en) | 2016-03-18 | 2017-09-21 | Fred Hutchinson Cancer Researh Center | Compositions and methods for cd20 immunotherapy |
CA3018588A1 (en) | 2016-03-22 | 2017-09-28 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Early intervention methods to prevent or ameliorate toxicity |
CA3017036A1 (en) * | 2016-03-23 | 2017-09-28 | Helmholtz Zentrum Munchen - Deutsches Forschungszentrum Fur Gesundheit Und Umwelt (Gmbh) | Fusion proteins of pd-1 and 4-1bb |
US11549099B2 (en) | 2016-03-23 | 2023-01-10 | Novartis Ag | Cell secreted minibodies and uses thereof |
CN109715207B (zh) * | 2016-03-29 | 2023-03-31 | 南加利福尼亚大学 | 靶向癌症的嵌合抗原受体 |
CN109069537B (zh) * | 2016-04-04 | 2022-04-15 | 亘喜生物科技(上海)有限公司 | 共刺激结构域中具有重复结合基序的car |
EP3443001A4 (en) | 2016-04-11 | 2020-04-29 | Obsidian Therapeutics, Inc. | REGULATED BIOCIRCUIT SYSTEMS |
BR112018071096A2 (pt) | 2016-04-15 | 2019-02-26 | Novartis Ag | composições e métodos para a expressão da proteína seletiva |
EP3452082A1 (en) | 2016-05-04 | 2019-03-13 | Fred Hutchinson Cancer Research Center | Cell-based neoantigen vaccines and uses thereof |
CN105969805B (zh) * | 2016-05-17 | 2019-03-29 | 上海优卡迪生物医药科技有限公司 | 一种靶向Mesothelin的复制缺陷性重组慢病毒CAR-T转基因载体及其构建方法和应用 |
CN105950663B (zh) * | 2016-05-17 | 2019-04-02 | 上海优卡迪生物医药科技有限公司 | 一种靶向cd30的复制缺陷性重组慢病毒car-t转基因载体及其构建方法和应用 |
CN105950662B (zh) * | 2016-05-17 | 2019-04-30 | 上海优卡迪生物医药科技有限公司 | 一种靶向cd22的复制缺陷性重组慢病毒car-t转基因载体及其构建方法和应用 |
CN105950664B (zh) * | 2016-05-17 | 2019-03-29 | 上海优卡迪生物医药科技有限公司 | 一种靶向cd123的复制缺陷性重组慢病毒car-t转基因载体及其构建方法和应用 |
WO2017210617A2 (en) | 2016-06-02 | 2017-12-07 | Porter, David, L. | Therapeutic regimens for chimeric antigen receptor (car)- expressing cells |
MX2018014991A (es) * | 2016-06-03 | 2019-08-29 | Memorial Sloan Kettering Cancer Center | Terapias adoptivas de celulas como opciones de tratamiento temprano. |
MA45341A (fr) * | 2016-06-06 | 2019-04-10 | Hutchinson Fred Cancer Res | Procédés de traitement de malignités de lymphocytes b au moyen d'une thérapie cellulaire adoptive |
EP3468356A4 (en) * | 2016-06-14 | 2020-02-26 | Regents Of The University Of Minnesota | GENETICALLY MODIFIED CELLS, TISSUES AND ORGANS FOR THE TREATMENT OF A DISEASE |
CN107523549A (zh) * | 2016-06-20 | 2017-12-29 | 上海细胞治疗研究院 | 一种高效稳定表达激活型抗体的car‑t细胞及其用途 |
CN107523548A (zh) * | 2016-06-20 | 2017-12-29 | 上海细胞治疗研究院 | 一种高效稳定表达抗体的t细胞及其用途 |
CN106117366A (zh) * | 2016-06-24 | 2016-11-16 | 安徽未名细胞治疗有限公司 | 一种cd19特异性嵌合抗原受体及其编码基因、应用 |
JP6987134B2 (ja) | 2016-06-27 | 2021-12-22 | ジュノー セラピューティクス インコーポレイテッド | ペプチドエピトープを同定する方法、そのようなエピトープに結合する分子および関連用途 |
MA45491A (fr) | 2016-06-27 | 2019-05-01 | Juno Therapeutics Inc | Épitopes à restriction cmh-e, molécules de liaison et procédés et utilisations associés |
BR112018077375A2 (pt) | 2016-06-30 | 2019-10-01 | F. Hoffmann-La Roche Ag | kits, moléculas de anticorpo biespecífico trivalente, composição farmacêutica, vetor de expressão, célula hospedeira e método para a produção de uma molécula de anticorpo biespecífico trivalente |
CN106267409B (zh) * | 2016-07-01 | 2019-02-01 | 翁炳焕 | 艾滋病生物治疗反应器 |
CN106178163B (zh) * | 2016-07-01 | 2019-02-01 | 翁炳焕 | 艾滋病生物细胞免疫治疗仪 |
CN107586342A (zh) * | 2016-07-08 | 2018-01-16 | 生命序有限公司 | 重组免疫检查点受体及其应用 |
CN107586341A (zh) * | 2016-07-08 | 2018-01-16 | 生命序有限公司 | 重组免疫检查点受体及免疫检查点抑制分子的共表达及应用 |
CN110461315A (zh) | 2016-07-15 | 2019-11-15 | 诺华股份有限公司 | 使用与激酶抑制剂组合的嵌合抗原受体治疗和预防细胞因子释放综合征 |
CN109641947B (zh) | 2016-07-20 | 2023-04-14 | 犹他大学研究基金会 | Cd229 car t细胞及其使用方法 |
CN106011174B (zh) * | 2016-07-26 | 2019-12-13 | 天晴干细胞股份有限公司 | 一种通用型慢病毒载体及其制备方法 |
SG11201900677SA (en) * | 2016-07-28 | 2019-02-27 | Novartis Ag | Combination therapies of chimeric antigen receptors adn pd-1 inhibitors |
KR102553195B1 (ko) | 2016-07-29 | 2023-07-07 | 주노 쎄러퓨티크스 인코퍼레이티드 | 항-cd19 항체에 대한 항-이디오타입 항체 |
US20190161542A1 (en) | 2016-08-01 | 2019-05-30 | Novartis Ag | Treatment of cancer using a chimeric antigen receptor in combination with an inhibitor of a pro-m2 macrophage molecule |
AU2017306432A1 (en) | 2016-08-02 | 2019-03-21 | TCR2 Therapeutics Inc. | Compositions and methods for TCR reprogramming using fusion proteins |
CN106399242B (zh) * | 2016-09-13 | 2019-01-22 | 北京多赢时代转化医学研究院 | 联合制备CAR-Vγ9Vδ2T细胞和CAR-NKT细胞的方法 |
CN106350487B (zh) * | 2016-09-13 | 2019-01-25 | 北京多赢时代转化医学研究院 | 联合制备car-nk细胞和car-nkt细胞的方法 |
JP6908710B2 (ja) | 2016-09-21 | 2021-07-28 | ザ ユナイテッド ステイツ オブ アメリカ, アズ リプレゼンテッド バイ ザ セクレタリー, デパートメント オブ ヘルス アンド ヒューマン サービシーズ | ケモカイン受容体ccr4を標的にするキメラ抗原受容体(car)およびその使用 |
WO2018064387A1 (en) | 2016-09-28 | 2018-04-05 | Novartis Ag | Porous membrane-based macromolecule delivery system |
US20190298771A1 (en) | 2016-09-28 | 2019-10-03 | Atossa Genetics Inc. | Methods of adoptive cell therapy |
CN106317228A (zh) * | 2016-09-28 | 2017-01-11 | 李华顺 | 一种嵌合抗原受体分子及其应用 |
US11155832B2 (en) | 2016-09-30 | 2021-10-26 | Genvec, Inc. | Adenovectors for delivery of therapeutic genetic material into T cells |
SG10201913823VA (en) | 2016-10-07 | 2020-03-30 | Novartis Ag | Chimeric antigen receptors for the treatment of cancer |
EP3445787B1 (en) | 2016-10-07 | 2020-12-02 | TCR2 Therapeutics Inc. | Compositions and methods for t-cell receptors reprogramming using fusion proteins |
KR20190084053A (ko) | 2016-10-13 | 2019-07-15 | 주노 쎄러퓨티크스 인코퍼레이티드 | 트립토판 대사 경로 조절인자 관련 면역 치료 방법 및 조성물 |
CN107988164B (zh) | 2016-10-26 | 2020-07-07 | 阿思科力(苏州)生物科技有限公司 | 一种pd-1 car nk-92细胞及其制备方法与应用 |
MX2019005029A (es) | 2016-11-03 | 2019-10-24 | Juno Therapeutics Inc | Terapia de combinación de una terapia de células t y un inhibidor de tirosina cinasa de bruton (btk). |
EP3534940A1 (en) | 2016-11-03 | 2019-09-11 | Juno Therapeutics, Inc. | Combination therapy of a cell based therapy and a microglia inhibitor |
WO2018098365A2 (en) | 2016-11-22 | 2018-05-31 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
EP3548622A1 (en) | 2016-12-02 | 2019-10-09 | Juno Therapeutics, Inc. | Engineered b cells and related compositions and methods |
US20190358262A1 (en) | 2016-12-03 | 2019-11-28 | Juno Therapeutics, Inc. | Methods for modulation of car-t cells |
EP3548046A2 (en) | 2016-12-03 | 2019-10-09 | Juno Therapeutics, Inc. | Methods and compositions for use of therapeutic t cells in combination with kinase inhibitors |
EP4279136A3 (en) | 2016-12-03 | 2024-03-20 | Juno Therapeutics, Inc. | Methods for determining car-t cells dosing |
EP3551197B1 (en) | 2016-12-12 | 2023-11-22 | Seattle Children's Hospital (DBA Seattle Children's Research Institute) | Chimeric transcription factor variants with augmented sensitivity to drug ligand induction of transgene expression in mammalian cells |
JP2020503015A (ja) * | 2016-12-13 | 2020-01-30 | カースゲン セラピューティクス リミテッドCarsgen Therapeutics Limited | 抗cd19のヒト化抗体及びcd19を標的とする免疫エフェクター細胞 |
CN108250301A (zh) | 2016-12-29 | 2018-07-06 | 天津天锐生物科技有限公司 | 一种多靶点嵌合抗原受体 |
EP3346001A1 (en) * | 2017-01-06 | 2018-07-11 | TXCell | Monospecific regulatory t cell population with cytotoxicity for b cells |
CA3048648A1 (en) * | 2017-01-10 | 2018-07-19 | The General Hospital Corporation | T cells expressing a chimeric antigen receptor |
MX2019008227A (es) | 2017-01-10 | 2020-08-17 | Juno Therapeutics Inc | Analisis epigenetico de terapia celular y metodos relacionados. |
CN107058390A (zh) * | 2017-01-17 | 2017-08-18 | 上海交通大学医学院附属第九人民医院 | 一种慢病毒载体、重组慢病毒质粒、病毒及病毒的应用 |
WO2018140725A1 (en) | 2017-01-26 | 2018-08-02 | Novartis Ag | Cd28 compositions and methods for chimeric antigen receptor therapy |
CN110582509A (zh) | 2017-01-31 | 2019-12-17 | 诺华股份有限公司 | 使用具有多特异性的嵌合t细胞受体蛋白治疗癌症 |
CN110612119A (zh) | 2017-02-07 | 2019-12-24 | 西雅图儿童医院(Dba西雅图儿童研究所) | 磷脂醚(ple)car t细胞肿瘤靶向(ctct)剂 |
EP4269594A3 (en) | 2017-02-17 | 2023-12-20 | Fred Hutchinson Cancer Center | Combination therapies for treatment of bcma-related cancers and autoimmune disorders |
AU2018224856A1 (en) | 2017-02-27 | 2019-08-29 | Juno Therapeutics, Inc. | Compositions, articles of manufacture and methods related to dosing in cell therapy |
EP3589647A1 (en) | 2017-02-28 | 2020-01-08 | Novartis AG | Shp inhibitor compositions and uses for chimeric antigen receptor therapy |
WO2018160622A1 (en) | 2017-02-28 | 2018-09-07 | Endocyte, Inc. | Compositions and methods for car t cell therapy |
BR112019019005A2 (pt) | 2017-03-14 | 2020-04-14 | Sara Elizabeth Church | métodos para armazenagem criogênica |
JP2020513832A (ja) | 2017-03-22 | 2020-05-21 | ノバルティス アーゲー | 免疫腫瘍学のための組成物および方法 |
JP7270253B2 (ja) | 2017-03-27 | 2023-05-10 | ナショナル ユニヴァーシティ オブ シンガポール | ナチュラルキラー細胞のエクスビボ拡大及び活性化のための刺激細胞株 |
MX2019011514A (es) | 2017-03-27 | 2020-01-27 | Nat Univ Singapore | Receptores quimericos nkg2d truncados y usos de los mismos en inmunoterapia con celulas asesinas naturales. |
CN107058232B (zh) * | 2017-04-12 | 2018-03-30 | 上海优卡迪生物医药科技有限公司 | 胆固醇转脂酶soat1被抑制的car‑t细胞及其制备方法和应用 |
EP3610261A1 (en) | 2017-04-14 | 2020-02-19 | Juno Therapeutics, Inc. | Methods for assessing cell surface glycosylation |
JOP20180042A1 (ar) * | 2017-04-24 | 2019-01-30 | Kite Pharma Inc | نطاقات ربط مولد ضد متوافقة مع البشر وطرق الاستخدام |
CN108728459B (zh) * | 2017-04-24 | 2023-08-04 | 上海恒润达生生物科技股份有限公司 | 靶向cd19的嵌合抗原受体并联合表达il-15的方法和用途 |
EP3615055A1 (en) | 2017-04-28 | 2020-03-04 | Novartis AG | Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor |
AU2018263887A1 (en) | 2017-05-01 | 2019-11-21 | Juno Therapeutics, Inc. | Combination of a cell therapy and an immunomodulatory compound |
AU2018271991A1 (en) | 2017-05-24 | 2020-01-16 | Effector Therapeutics, Inc. | Compositions and methods for an improved antitumor immune response |
CN108977453A (zh) * | 2017-06-02 | 2018-12-11 | 阿思科力(苏州)生物科技有限公司 | 一种以robo1为靶点的嵌合抗原受体细胞及其制备和应用 |
JP2020522489A (ja) | 2017-06-02 | 2020-07-30 | ジュノー セラピューティクス インコーポレイテッド | 養子細胞療法を用いる処置のための製造物品および方法 |
WO2018231759A1 (en) | 2017-06-12 | 2018-12-20 | Obsidian Therapeutics, Inc. | Pde5 compositions and methods for immunotherapy |
WO2019006427A1 (en) | 2017-06-29 | 2019-01-03 | Juno Therapeutics, Inc. | WALL MODEL FOR ASSESSING TOXICITIES ASSOCIATED WITH IMMUNOTHERAPIES |
CA3067914A1 (en) | 2017-06-30 | 2019-01-03 | Cellectis | Cellular immunotherapy for repetitive administration |
EP3662055A1 (en) * | 2017-08-02 | 2020-06-10 | Autolus Limited | Cells expressing a chimeric antigen receptor or engineered tcr and comprising a nucleotide sequence which is selectively expressed |
BR112020002555A2 (pt) | 2017-08-07 | 2020-08-11 | The Johns Hopkins University | métodos e materiais para avaliar e tratar câncer |
CN107383196B (zh) * | 2017-08-30 | 2019-12-17 | 广州百暨基因科技有限公司 | 人源化抗cd19的抗原结合片段 |
WO2019046832A1 (en) | 2017-09-01 | 2019-03-07 | Juno Therapeutics, Inc. | GENE EXPRESSION AND EVALUATION OF RISK OF DEVELOPMENT OF TOXICITY FOLLOWING CELL THERAPY |
AU2018331517A1 (en) * | 2017-09-15 | 2020-04-30 | Lentigen Technology, Inc. | Compositions and methods for treating cancer with anti-CD19 immunotherapy |
JP7190096B2 (ja) | 2017-09-18 | 2022-12-15 | 博雅▲緝▼因(北京)生物科技有限公司 | 遺伝子編集t細胞及びその使用 |
EP3684408A1 (en) | 2017-09-19 | 2020-07-29 | Massachusetts Institute of Technology | Compositions for chimeric antigen receptor t cell therapy and uses thereof |
WO2019067015A1 (en) * | 2017-09-29 | 2019-04-04 | City Of Hope | RECEPTORS OF CHIMERIC ANTIGENS AND BISPECIFIC ANTIBODIES FOR THE TREATMENT OF COAT CELL LYMPHOMA |
US10927180B2 (en) | 2017-10-13 | 2021-02-23 | Harpoon Therapeutics, Inc. | B cell maturation antigen binding proteins |
TWI829655B (zh) | 2017-10-18 | 2024-01-21 | 瑞士商諾華公司 | 用於選擇性蛋白質降解的組合物及方法 |
JP2021500894A (ja) | 2017-10-25 | 2021-01-14 | ノバルティス アーゲー | キメラ抗原受容体発現細胞を作製する方法 |
BR112020008727A2 (pt) | 2017-10-30 | 2020-10-20 | Neuropore Therapies, Inc. | fenil sulfonil fenil triazol tionas substituídas e usos destas |
CA3079747A1 (en) * | 2017-10-31 | 2019-05-09 | Allogene Therapeutics, Inc. | Methods and compositions for dosing of allogeneic chimeric antigen receptor t cells |
US20210179709A1 (en) | 2017-10-31 | 2021-06-17 | Novartis Ag | Anti-car compositions and methods |
US11564946B2 (en) | 2017-11-01 | 2023-01-31 | Juno Therapeutics, Inc. | Methods associated with tumor burden for assessing response to a cell therapy |
WO2019089982A1 (en) | 2017-11-01 | 2019-05-09 | Juno Therapeutics, Inc. | Method of assessing activity of recombinant antigen receptors |
MA50860A (fr) | 2017-11-01 | 2020-09-09 | Juno Therapeutics Inc | Récepterus chimériques d'antigène contre l'antigène de maturation des cellules b et polynucleotides codants |
US20200354677A1 (en) | 2017-11-01 | 2020-11-12 | Juno Therapeutics, Inc. | Process for generating therapeutic compositions of engineered cells |
US20210254000A1 (en) | 2017-11-01 | 2021-08-19 | Juno Therapeutics, Inc. | Process for producing a t cell composition |
WO2019089858A2 (en) | 2017-11-01 | 2019-05-09 | Juno Therapeutics, Inc. | Methods of assessing or monitoring a response to a cell therapy |
EP3706754A1 (en) | 2017-11-06 | 2020-09-16 | Juno Therapeutics, Inc. | Combination of a cell therapy and a gamma secretase inhibitor |
WO2019094404A1 (en) * | 2017-11-07 | 2019-05-16 | Temple University-Of The Commonwealth System Of Higher Education | Compositions and methods for improved t cells |
EP3707246B1 (en) * | 2017-11-07 | 2023-06-07 | City of Hope | Treatment of cns lymphoma and systemic lymphoma with intracerebroventricularly administered cd19 car |
US11802163B2 (en) | 2017-11-10 | 2023-10-31 | The U.S.A., As Represented By The Secretary, Department Of Health And Human Services | Chimeric antigen receptors targeting glypican-3 or mesothelin |
AU2018369883A1 (en) | 2017-11-15 | 2020-05-28 | Novartis Ag | BCMA-targeting chimeric antigen receptor, CD19-targeting chimeric antigen receptor, and combination therapies |
JP2021503277A (ja) * | 2017-11-20 | 2021-02-12 | ユリウス−マクシミリアン−ウニヴェルシテート・ヴュルツブルク | 非常に低レベルのcd19を発現する骨髄腫細胞を除去するcd19cart細胞 |
CN109836493A (zh) * | 2017-11-25 | 2019-06-04 | 深圳宾德生物技术有限公司 | 一种靶向cd19的单链抗体、嵌合抗原受体t细胞及其制备方法和应用 |
KR20200096253A (ko) | 2017-11-30 | 2020-08-11 | 노파르티스 아게 | Bcma-표적화 키메라 항원 수용체, 및 이의 용도 |
EP3716980A1 (en) | 2017-12-01 | 2020-10-07 | Juno Therapeutics, Inc. | Methods for dosing and for modulation of genetically engineered cells |
EP3722313A4 (en) * | 2017-12-06 | 2021-02-24 | AbClon Inc. | ANTIBODY OR ITS BINDING FRAGMENT TO THE ANTIGEN TO SPECIFICALLY RECOGNIZE A B-CELL MALIGNITY, CHEMERIC ANTIGEN RECEPTOR INCLUDING IT, AND ITS USE |
EP3720949A1 (en) | 2017-12-08 | 2020-10-14 | Juno Therapeutics, Inc. | Serum-free media formulation for culturing cells and methods of use thereof |
KR20200108278A (ko) | 2017-12-08 | 2020-09-17 | 주노 쎄러퓨티크스 인코퍼레이티드 | 조작된 t 세포의 조성물을 제조하는 방법 |
CN107880128B (zh) * | 2017-12-21 | 2021-03-02 | 常州费洛斯药业科技有限公司 | 一种抗cd19的全人源抗体或抗体片段及其方法和应用 |
CN109053899B (zh) | 2017-12-22 | 2021-11-16 | 湖南远泰生物技术有限公司 | 一种含人转铁蛋白抗原表位序列的嵌合体抗原受体 |
US11672827B2 (en) * | 2017-12-23 | 2023-06-13 | Uwell Biopharma Inc. | Pharmaceutical chimeric receptor composition and method thereof |
US20200368268A1 (en) | 2018-01-08 | 2020-11-26 | Novartis Ag | Immune-enhancing rnas for combination with chimeric antigen receptor therapy |
EP3544618A4 (en) * | 2018-01-11 | 2020-02-12 | Innovative Cellular Therapeutics Inc. | MODIFIED CELL EXPANSION AND USES THEREOF |
US10561686B2 (en) | 2018-01-12 | 2020-02-18 | Innovative Cellular Therapeutics CO., LTD. | Modified cell expansion and uses thereof |
JP7068498B2 (ja) * | 2018-01-12 | 2022-05-16 | クロセル インク. | 二重shRNAを用いて強化された免疫細胞及びそれを含む組成物 |
SG11202006886VA (en) | 2018-01-22 | 2020-08-28 | Seattle Childrens Hospital Dba Seattle Childrens Res Inst | Methods of use for car t cells |
CN108017717B (zh) * | 2018-01-24 | 2019-08-16 | 首都医科大学宣武医院 | 一种用于体外高效定向扩增的嵌合抗原受体及其应用 |
CN110093359B (zh) * | 2018-01-29 | 2023-10-13 | 华南生物医药研究院 | 含cd3启动子序列和car序列的可分离的核酸及应用 |
WO2019152660A1 (en) | 2018-01-31 | 2019-08-08 | Novartis Ag | Combination therapy using a chimeric antigen receptor |
CA3090148A1 (en) * | 2018-02-06 | 2019-08-15 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Closed-system manufacturing process for car-t cells |
WO2019154313A1 (zh) * | 2018-02-11 | 2019-08-15 | 江苏恒瑞医药股份有限公司 | 一种分离的嵌合抗原受体以及包含其的修饰t细胞及用途 |
WO2019160956A1 (en) | 2018-02-13 | 2019-08-22 | Novartis Ag | Chimeric antigen receptor therapy in combination with il-15r and il15 |
WO2019159193A1 (en) * | 2018-02-13 | 2019-08-22 | Indian Institute Of Technology Bombay | Novel humanized anti-cd19 chimeric antigen receptor, its nucelic acid sequence and its preparation |
EP3762012A1 (en) | 2018-03-09 | 2021-01-13 | Ospedale San Raffaele S.r.l. | Il-1 antagonist and toxicity induced by cell therapy |
MX2020009472A (es) * | 2018-03-14 | 2020-12-07 | Us Health | Receptores de antigenos quimericos anti-cd33 y sus usos. |
US10751399B2 (en) * | 2018-03-20 | 2020-08-25 | Cho Pharma Usa, Inc. | Chimeric antigen receptors that bind to SSEA4 and uses thereof |
US20210155986A1 (en) | 2018-04-13 | 2021-05-27 | The Johns Hopkins University | Non-invasive detection of response to immunotherapy |
US20210079384A1 (en) | 2018-04-13 | 2021-03-18 | The Johns Hopkins University | Non-invasive detection of response to a targeted therapy |
US10869888B2 (en) | 2018-04-17 | 2020-12-22 | Innovative Cellular Therapeutics CO., LTD. | Modified cell expansion and uses thereof |
US20210047405A1 (en) | 2018-04-27 | 2021-02-18 | Novartis Ag | Car t cell therapies with enhanced efficacy |
EP3788369A1 (en) | 2018-05-01 | 2021-03-10 | Novartis Ag | Biomarkers for evaluating car-t cells to predict clinical outcome |
BR112020023587A2 (pt) | 2018-05-18 | 2021-02-09 | The Johns Hopkins University | método para determinar um perfil de fragmentação de dna livre de células (cfdna), método para identificar um mamífero como tendo câncer, método de identificação do tecido de origem de um câncer e método para tratar um mamífero com câncer |
EP3801769A1 (en) | 2018-05-25 | 2021-04-14 | Novartis AG | Combination therapy with chimeric antigen receptor (car) therapies |
EP3802611A2 (en) | 2018-06-01 | 2021-04-14 | Novartis AG | Binding molecules against bcma and uses thereof |
KR102544086B1 (ko) * | 2018-06-01 | 2023-06-16 | 카이트 파마 인코포레이티드 | 키메라 항원 수용체 t 세포 요법 |
WO2019237035A1 (en) | 2018-06-08 | 2019-12-12 | Intellia Therapeutics, Inc. | Compositions and methods for immunooncology |
WO2019241426A1 (en) | 2018-06-13 | 2019-12-19 | Novartis Ag | Bcma chimeric antigen receptors and uses thereof |
KR20190141511A (ko) * | 2018-06-14 | 2019-12-24 | 주식회사 녹십자랩셀 | 신규 펩티드, 이를 포함하는 키메라 항원 수용체 및 이를 발현하는 면역 세포 |
JP2021527421A (ja) * | 2018-06-22 | 2021-10-14 | ザ ジェネラル ホスピタル コーポレイション | Cd37及びcd19を標的とするキメラ抗原受容体 |
AR116109A1 (es) | 2018-07-10 | 2021-03-31 | Novartis Ag | Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos |
CA3107383A1 (en) | 2018-07-23 | 2020-01-30 | Magenta Therapeutics, Inc. | Use of anti-cd5 antibody drug conjugate (adc) in allogeneic cell therapy |
CN110819679A (zh) * | 2018-08-07 | 2020-02-21 | 上海恒润达生生物科技有限公司 | 一种评估cart细胞体内代谢的方法 |
MX2021001519A (es) | 2018-08-09 | 2021-05-27 | Juno Therapeutics Inc | Metodos para valorar acidos nucleicos integrados. |
US20220348682A1 (en) | 2018-08-30 | 2022-11-03 | Innovative Cellular Therapeutics Holdings, Ltd. | Chimeric antigen receptor cells for treating solid tumor |
EA202190573A1 (ru) * | 2018-08-30 | 2021-07-14 | Тср2 Терапьютикс Инк. | Композиции и способы перепрограммирования tcr с применением гибридных белков |
WO2020047449A2 (en) | 2018-08-31 | 2020-03-05 | Novartis Ag | Methods of making chimeric antigen receptor-expressing cells |
MX2021002393A (es) | 2018-08-31 | 2021-07-15 | Novartis Ag | Metodos de preparacion de celulas que expresan receptores de antigenos quimericos. |
JP7394840B2 (ja) | 2018-08-31 | 2023-12-08 | アンヴェクティ エスアー | 複数のhla-gアイソフォームに対するキメラ抗原レセプター |
MX2021003554A (es) | 2018-09-25 | 2021-05-27 | Harpoon Therapeutics Inc | Proteinas de union a dll3 y metodos de uso. |
EP3856782A1 (en) | 2018-09-28 | 2021-08-04 | Novartis AG | Cd19 chimeric antigen receptor (car) and cd22 car combination therapies |
US20220047633A1 (en) | 2018-09-28 | 2022-02-17 | Novartis Ag | Cd22 chimeric antigen receptor (car) therapies |
KR20210068478A (ko) | 2018-09-28 | 2021-06-09 | 메사추세츠 인스티튜트 오브 테크놀로지 | 콜라겐-국재화된 면역조정성 분자 및 그의 방법 |
EP3874024A1 (en) | 2018-10-31 | 2021-09-08 | Juno Therapeutics GmbH | Methods for selection and stimulation of cells and apparatus for same |
ES2968737T3 (es) | 2018-11-06 | 2024-05-13 | Juno Therapeutics Inc | Proceso para producir células T manipuladas genéticamente |
CA3117978A1 (en) | 2018-11-08 | 2020-05-14 | Juno Therapeutics, Inc. | Methods and combinations for treatment and t cell modulation |
AU2019381827A1 (en) | 2018-11-16 | 2021-06-10 | Juno Therapeutics, Inc. | Methods of dosing engineered T cells for the treatment of B cell malignancies |
US10918667B2 (en) | 2018-11-20 | 2021-02-16 | Innovative Cellular Therapeutics CO., LTD. | Modified cell expressing therapeutic agent and uses thereof |
EP3914619A4 (en) * | 2018-11-29 | 2022-12-21 | Zhejiang Ruijiamei Biotech Co., Ltd. | CAR-T CELLS CONTAINING HUMANIZED CD19 SCFV WITH MUTATION IN THE CDR-1 REGION |
BR112021010120A2 (pt) | 2018-11-30 | 2021-08-31 | Juno Therapeutics, Inc. | Métodos para dosagem e tratamento de malignidades celulares em terapia celular adotiva |
JP2022513685A (ja) | 2018-11-30 | 2022-02-09 | ジュノー セラピューティクス インコーポレイテッド | 養子細胞療法を用いた処置のための方法 |
CA3177829A1 (en) | 2018-12-12 | 2020-06-18 | Kite Pharma, Inc. | Chimeric antigen and t cell receptors and methods of use |
US20220047636A1 (en) * | 2018-12-13 | 2022-02-17 | The General Hospital Corporation | Chimeric antigen receptors targeting cd79b and cd19 |
ES2944062T3 (es) * | 2018-12-19 | 2023-06-19 | Inst Nat Sante Rech Med | Células T invariantes asociadas a la mucosa (MAIT) que expresan receptores de antígenos quiméricos |
KR20210106437A (ko) | 2018-12-20 | 2021-08-30 | 노파르티스 아게 | 3-(1-옥소이소인돌린-2-일)피페리딘-2,6-디온 유도체를 포함하는 투약 요법 및 약학적 조합물 |
CN109734813B (zh) | 2019-01-28 | 2022-06-17 | 广东昭泰体内生物医药科技有限公司 | 一种嵌合抗原受体及其应用 |
CN113710253A (zh) * | 2019-02-04 | 2021-11-26 | 普洛迈博生物技术公司 | 编码嵌合抗原受体和il-6或检查点抑制剂的短发夹rna序列的核酸序列 |
US11760786B2 (en) | 2019-02-06 | 2023-09-19 | The Regents Of The University Of Michigan | Chimeric antigen receptors targeting abnormal glycobiology |
CA3123519A1 (en) | 2019-02-15 | 2020-08-20 | Novartis Ag | Substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof |
EP3924054A1 (en) | 2019-02-15 | 2021-12-22 | Novartis AG | 3-(1-oxo-5-(piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof |
WO2020176397A1 (en) | 2019-02-25 | 2020-09-03 | Novartis Ag | Mesoporous silica particles compositions for viral delivery |
EP3773918A4 (en) | 2019-03-05 | 2022-01-05 | Nkarta, Inc. | CD19 DIRECTED CHIMERIC ANTIGEN RECEPTORS AND THEIR USES IN IMMUNOTHERAPY |
CN113966397A (zh) | 2019-03-08 | 2022-01-21 | 黑曜石疗法公司 | 人碳酸酐酶2组合物和用于可调调节的方法 |
EP3942025A1 (en) | 2019-03-21 | 2022-01-26 | Novartis AG | Car-t cell therapies with enhanced efficacy |
AU2020271123A1 (en) | 2019-04-10 | 2021-11-25 | Elevatebio Technologies, Inc. | FLT3-specific chimeric antigen receptors and methods of using the same |
WO2020210678A1 (en) | 2019-04-12 | 2020-10-15 | Novartis Ag | Methods of making chimeric antigen receptor-expressing cells |
WO2020219742A1 (en) | 2019-04-24 | 2020-10-29 | Novartis Ag | Compositions and methods for selective protein degradation |
WO2020247832A1 (en) | 2019-06-07 | 2020-12-10 | Juno Therapeutics, Inc. | Automated t cell culture |
CN114269371A (zh) | 2019-06-12 | 2022-04-01 | 朱诺治疗学股份有限公司 | 细胞介导的细胞毒性疗法与促存活bcl2家族蛋白的抑制剂的组合疗法 |
WO2020263399A1 (en) | 2019-06-26 | 2020-12-30 | Massachusetts Institute Of Technology | Immunomodulatory fusion protein-metal hydroxide complexes and methods thereof |
CN112390891B (zh) * | 2019-08-14 | 2022-06-03 | 苏州方德门达新药开发有限公司 | 嵌合抗原受体及其构建方法和应用 |
US20220298222A1 (en) | 2019-08-22 | 2022-09-22 | Juno Therapeutics, Inc. | Combination therapy of a t cell therapy and an enhancer of zeste homolog 2 (ezh2) inhibitor and related methods |
US11058725B2 (en) | 2019-09-10 | 2021-07-13 | Obsidian Therapeutics, Inc. | CA2 compositions and methods for tunable regulation |
WO2021061648A1 (en) | 2019-09-23 | 2021-04-01 | Massachusetts Institute Of Technology | Methods and compositions for stimulation of endogenous t cell responses |
JP2023500318A (ja) | 2019-10-30 | 2023-01-05 | ジュノ セラピューティクス ゲーエムベーハー | 細胞選択および/または細胞刺激デバイスならびに使用方法 |
TW202134285A (zh) | 2019-11-26 | 2021-09-16 | 瑞士商諾華公司 | Cd19和cd22嵌合抗原受體及其用途 |
BR112022010206A2 (pt) | 2019-11-26 | 2022-11-29 | Novartis Ag | Receptores de antígeno quiméricos e usos dos mesmos |
JP2023504740A (ja) | 2019-12-06 | 2023-02-06 | ジュノー セラピューティクス インコーポレイテッド | Bcma標的結合ドメインに対する抗イディオタイプ抗体ならびに関連する組成物および方法 |
KR20220132527A (ko) | 2019-12-06 | 2022-09-30 | 주노 쎄러퓨티크스 인코퍼레이티드 | B 세포 악성 종양을 치료하기 위한 세포 요법과 연관된 독성 및 반응과 관련된 방법 |
CN115335399A (zh) | 2019-12-06 | 2022-11-11 | 朱诺治疗学股份有限公司 | 针对gprc5d靶结合结构域的抗独特型抗体以及相关组合物和方法 |
US20230057071A1 (en) | 2019-12-20 | 2023-02-23 | Novartis Ag | Combination of anti tim-3 antibody mbg453 and anti tgf-beta antibody nis793, with or without decitabine or the anti pd-1 antibody spartalizumab, for treating myelofibrosis and myelodysplastic syndrome |
EP4086341A1 (en) | 2019-12-30 | 2022-11-09 | Edigene Biotechnology Inc. | Method for purifying ucart cell and use thereof |
WO2021136176A1 (zh) | 2019-12-30 | 2021-07-08 | 博雅辑因(北京)生物科技有限公司 | 一种靶向t细胞淋巴瘤细胞的通用型car-t及其制备方法和应用 |
MX2022008648A (es) | 2020-01-23 | 2022-12-15 | The Children´S Medical Center Corp | Diferenciacion de celulas t sin estroma a partir de celulas madre pluripotentes humanas. |
WO2021163618A1 (en) | 2020-02-14 | 2021-08-19 | Novartis Ag | Method of predicting response to chimeric antigen receptor therapy |
EP4110823A1 (en) | 2020-02-26 | 2023-01-04 | A2 Biotherapeutics, Inc. | Polypeptides targeting mage-a3 peptide-mhc complexes and methods of use thereof |
KR20220146530A (ko) | 2020-02-27 | 2022-11-01 | 노파르티스 아게 | 키메라 항원 수용체-발현 세포의 제조 방법 |
BR112022016633A2 (pt) | 2020-02-27 | 2022-12-13 | Novartis Ag | Métodos para produzir células que expressam receptor de antígeno quimérico |
TW202146646A (zh) | 2020-02-28 | 2021-12-16 | 美商千禧製藥公司 | 用於自富潛能幹細胞生產自然殺手細胞之方法 |
EP4114449A2 (en) | 2020-03-05 | 2023-01-11 | Neotx Therapeutics Ltd. | Methods and compositions for treating cancer with immune cells |
CN115768464A (zh) | 2020-03-10 | 2023-03-07 | 麻省理工学院 | 产生工程化记忆样nk细胞及其组合物的方法 |
WO2021183207A1 (en) | 2020-03-10 | 2021-09-16 | Massachusetts Institute Of Technology | COMPOSITIONS AND METHODS FOR IMMUNOTHERAPY OF NPM1c-POSITIVE CANCER |
CN113402612A (zh) | 2020-03-17 | 2021-09-17 | 西比曼生物科技(香港)有限公司 | 靶向cd19和cd20的联合嵌合抗原受体及其应用 |
CN111484561A (zh) * | 2020-04-07 | 2020-08-04 | 北京荣瑷医学生物科技有限责任公司 | 一种靶向于cd19分子的嵌合抗原受体 |
CN111411085A (zh) * | 2020-04-10 | 2020-07-14 | 格源致善(上海)生物科技有限公司 | 一种嵌合抗原受体t细胞及其应用 |
MX2022013530A (es) | 2020-04-28 | 2023-02-01 | Juno Therapeutics Inc | Combinación de terapia de células t dirigida a bcma y un compuesto inmunomodulador. |
WO2021221782A1 (en) | 2020-05-01 | 2021-11-04 | Massachusetts Institute Of Technology | Chimeric antigen receptor-targeting ligands and uses thereof |
US20210340524A1 (en) | 2020-05-01 | 2021-11-04 | Massachusetts Institute Of Technology | Methods for identifying chimeric antigen receptor-targeting ligands and uses thereof |
KR20230022868A (ko) | 2020-05-13 | 2023-02-16 | 주노 쎄러퓨티크스 인코퍼레이티드 | 재조합 수용체를 발현하는 공여자-배치 세포의 제조 방법 |
JP2023528215A (ja) | 2020-05-13 | 2023-07-04 | ジュノー セラピューティクス インコーポレイテッド | 臨床応答に関連する特徴量の特定方法およびその使用 |
CN116096862A (zh) | 2020-06-11 | 2023-05-09 | 诺华股份有限公司 | Zbtb32抑制剂及其用途 |
CA3182346A1 (en) | 2020-06-23 | 2021-12-30 | Novartis Ag | Dosing regimen comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives |
CN111733186A (zh) * | 2020-07-03 | 2020-10-02 | 天津英科赛奥科技有限公司 | 靶向cd19的人源化嵌合抗原受体制备及其应用 |
AU2021305084A1 (en) | 2020-07-07 | 2023-02-02 | Cancure, Llc | MIC antibodies and binding agents and methods of using the same |
US20230310606A1 (en) | 2020-07-17 | 2023-10-05 | Simurx, Inc. | Chimeric myd88 receptors for redirecting immunosuppressive signaling and related compositions and methods |
WO2022031597A1 (en) | 2020-08-03 | 2022-02-10 | Kyverna Therapeutics, Inc. | Methods of producing t regulatory cells, methods of transducing t cells, and uses of the same |
EP4188549A1 (en) | 2020-08-03 | 2023-06-07 | Novartis AG | Heteroaryl substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof |
KR20230095918A (ko) | 2020-08-05 | 2023-06-29 | 주노 쎄러퓨티크스 인코퍼레이티드 | Ror1-표적 결합 도메인에 대한 항이디오타입 항체 및 관련 조성물 및 방법 |
CN116390946A (zh) | 2020-08-13 | 2023-07-04 | 美国政府(由卫生和人类服务部的部长所代表) | 用于治疗实体瘤的靶向磷脂酰肌醇蛋白聚糖-1(gpc1)的含igg4铰链的嵌合抗原受体 |
JP2023538118A (ja) | 2020-08-21 | 2023-09-06 | ノバルティス アーゲー | Car発現細胞のインビボ生成のための組成物及び方法 |
EP4240494A1 (en) | 2020-11-06 | 2023-09-13 | Novartis AG | Anti-cd19 agent and b cell targeting agent combination therapy for treating b cell malignancies |
CN114438034A (zh) * | 2020-11-06 | 2022-05-06 | 上海赛比曼生物科技有限公司 | 一种基因修饰的细胞制备方法 |
IL302700A (en) | 2020-11-13 | 2023-07-01 | Novartis Ag | Combined treatments with cells expressing chimeric antigens (vehicle) |
CN116848147A (zh) * | 2020-11-20 | 2023-10-03 | 先声再明医药有限公司 | Cd19人源化抗体及其应用 |
CN116635519A (zh) * | 2020-11-26 | 2023-08-22 | 上海医药集团生物治疗技术有限公司 | 一种经修饰的免疫细胞及其应用 |
US11661459B2 (en) | 2020-12-03 | 2023-05-30 | Century Therapeutics, Inc. | Artificial cell death polypeptide for chimeric antigen receptor and uses thereof |
WO2022133030A1 (en) | 2020-12-16 | 2022-06-23 | Juno Therapeutics, Inc. | Combination therapy of a cell therapy and a bcl2 inhibitor |
AU2021401052A1 (en) | 2020-12-18 | 2023-06-22 | Century Therapeutics, Inc. | Chimeric antigen receptor systems with adaptable receptor specificity |
TW202242117A (zh) | 2020-12-30 | 2022-11-01 | 美商亞勞諾斯醫療公司 | 包含多順反子表現卡匣之重組載體及其使用方法 |
KR20230151513A (ko) | 2021-01-11 | 2023-11-01 | 사나 바이오테크놀로지, 인크. | Cd8 표적 바이러스 벡터의 용도 |
WO2022155375A2 (en) * | 2021-01-13 | 2022-07-21 | Washington University | MHC-INDEPENDENT TCRs AND METHODS OF MAKING AND USING SAME |
US20240115607A1 (en) | 2021-01-26 | 2024-04-11 | Cytocares (Shanghai) Inc. | Chimeric antigen receptor (car) constructs and nk cells expressing car constructs |
WO2022165419A1 (en) | 2021-02-01 | 2022-08-04 | Kyverna Therapeutics, Inc. | Methods for increasing t-cell function |
WO2022180586A1 (en) * | 2021-02-25 | 2022-09-01 | Senthil Natesan | Car t-cell product and method of preparation thereof |
EP4301755A1 (en) | 2021-03-03 | 2024-01-10 | Juno Therapeutics, Inc. | Combination of a t cell therapy and a dgk inhibitor |
WO2022204070A1 (en) | 2021-03-22 | 2022-09-29 | Juno Therapeutics, Inc. | Methods of determining potency of a therapeutic cell composition |
CN117858719A (zh) | 2021-03-29 | 2024-04-09 | 朱诺治疗学股份有限公司 | 使用检查点抑制剂疗法和car t细胞疗法的组合进行给药和治疗的方法 |
TW202304979A (zh) | 2021-04-07 | 2023-02-01 | 瑞士商諾華公司 | 抗TGFβ抗體及其他治療劑用於治療增殖性疾病之用途 |
CA3214683A1 (en) | 2021-04-16 | 2022-10-20 | Julie Ann RYTLEWSKI | Combination therapies with bcma-directed t cell therapy |
IL307598A (en) | 2021-04-16 | 2023-12-01 | Juno Therapeutics Inc | T-cell therapy in patients who have had a previous stem cell transplant |
CN118056008A (zh) | 2021-04-27 | 2024-05-17 | 诺华股份有限公司 | 病毒载体生产系统 |
WO2022234158A1 (es) * | 2021-05-06 | 2022-11-10 | Institut D'investigacions Biomèdiques August Pi I Sunyer (Idibaps) | Terapia de células t con receptor de antígeno quimérico específico de cd19 |
CN117916256A (zh) | 2021-05-06 | 2024-04-19 | 朱诺治疗学有限公司 | 用于刺激和转导t细胞的方法 |
EP4346912A1 (en) | 2021-05-25 | 2024-04-10 | Institut Curie | Myeloid cells overexpressing bcl2 |
CA3218590A1 (en) | 2021-06-07 | 2022-12-15 | Providence Health & Services - Oregon | Cxcr5, pd-1, and icos expressing tumor reactive cd4 t cells and their use |
BR112023026141A2 (pt) | 2021-06-15 | 2024-03-05 | Takeda Pharmaceuticals Co | Métodos para produzir uma população de células enriquecida em células nk, para produzir células nk derivadas de células-tronco pluripotentes induzidas, para tratar um sujeito em necessidade de terapia de células e para produzir uma população de células compreendendo células progenitoras hematopoiéticas cd34+, e, populações de células nk e de células não classificadas |
CN113549600B (zh) * | 2021-06-30 | 2022-08-30 | 徐州医科大学 | 一种具有CD19的特异性抗性的CAR-iNKT细胞 |
TW202321457A (zh) | 2021-08-04 | 2023-06-01 | 美商薩那生物科技公司 | 靶向cd4之病毒載體之用途 |
WO2023019128A1 (en) * | 2021-08-09 | 2023-02-16 | The Trustees Of The University Of Pennyslvania | Optimizing t cell differentiation state with micrornas |
WO2023021477A1 (en) | 2021-08-20 | 2023-02-23 | Novartis Ag | Methods of making chimeric antigen receptor–expressing cells |
WO2023081715A1 (en) | 2021-11-03 | 2023-05-11 | Viracta Therapeutics, Inc. | Combination of car t-cell therapy with btk inhibitors and methods of use thereof |
WO2023081735A1 (en) | 2021-11-03 | 2023-05-11 | Celgene Corporation | Chimeric antigen receptors specific for b-cell maturation antigen for use in treating myeloma |
WO2023086829A1 (en) | 2021-11-09 | 2023-05-19 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Igg4 hinge-containing chimeric antigen receptors targeting glypican-3 (gpc3) and use thereof |
TW202342498A (zh) | 2021-12-17 | 2023-11-01 | 美商薩那生物科技公司 | 經修飾副黏液病毒科融合醣蛋白 |
TW202342757A (zh) | 2021-12-17 | 2023-11-01 | 美商薩那生物科技公司 | 經修飾副黏液病毒科附著醣蛋白 |
WO2023150518A1 (en) | 2022-02-01 | 2023-08-10 | Sana Biotechnology, Inc. | Cd3-targeted lentiviral vectors and uses thereof |
WO2023158986A1 (en) | 2022-02-15 | 2023-08-24 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Cd28 hinge and transmembrane containing chimeric antigen receptors targeting gpc2 and use thereof |
WO2023156587A1 (en) | 2022-02-18 | 2023-08-24 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of tcr-deficient car-tregs in combination with anti-tcr complex monoclonal antibodies for inducing durable tolerance |
WO2023193015A1 (en) | 2022-04-01 | 2023-10-05 | Sana Biotechnology, Inc. | Cytokine receptor agonist and viral vector combination therapies |
WO2023208157A1 (zh) * | 2022-04-29 | 2023-11-02 | 上海先博生物科技有限公司 | 靶向cd19的嵌合抗原受体及其应用 |
WO2023215738A1 (en) | 2022-05-02 | 2023-11-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Compositions targeting gpc2 and gpc3 and their use for treating solid tumors |
WO2023213969A1 (en) | 2022-05-05 | 2023-11-09 | Juno Therapeutics Gmbh | Viral-binding protein and related reagents, articles, and methods of use |
WO2023214325A1 (en) | 2022-05-05 | 2023-11-09 | Novartis Ag | Pyrazolopyrimidine derivatives and uses thereof as tet2 inhibitors |
WO2023220641A2 (en) | 2022-05-11 | 2023-11-16 | Juno Therapeutics, Inc. | Methods and uses related to t cell therapy and production of same |
WO2023220655A1 (en) | 2022-05-11 | 2023-11-16 | Celgene Corporation | Methods to overcome drug resistance by re-sensitizing cancer cells to treatment with a prior therapy via treatment with a t cell therapy |
WO2023230581A1 (en) | 2022-05-25 | 2023-11-30 | Celgene Corporation | Methods of manufacturing t cell therapies |
WO2023230548A1 (en) | 2022-05-25 | 2023-11-30 | Celgene Corporation | Method for predicting response to a t cell therapy |
WO2023237663A1 (en) | 2022-06-09 | 2023-12-14 | Institut National de la Santé et de la Recherche Médicale | Use of the f359l missense irf4 variant for increasing the stability of regulatory t cells |
WO2023250400A1 (en) | 2022-06-22 | 2023-12-28 | Juno Therapeutics, Inc. | Treatment methods for second line therapy of cd19-targeted car t cells |
WO2024015995A2 (en) * | 2022-07-15 | 2024-01-18 | Albert Einstein College Of Medicine | Chimeric antigen receptors comprising a tmigd2 costimulatory domain and associated methods of using the same |
WO2024047110A1 (en) | 2022-08-31 | 2024-03-07 | Institut National de la Santé et de la Recherche Médicale | Method to generate more efficient car-t cells |
WO2024054944A1 (en) | 2022-09-08 | 2024-03-14 | Juno Therapeutics, Inc. | Combination of a t cell therapy and continuous or intermittent dgk inhibitor dosing |
WO2024056809A1 (en) | 2022-09-15 | 2024-03-21 | Novartis Ag | Treatment of autoimmune disorders using chimeric antigen receptor therapy |
WO2024074713A1 (en) | 2022-10-07 | 2024-04-11 | Institut National de la Santé et de la Recherche Médicale | Method to generate improving car-t cells |
WO2024081820A1 (en) | 2022-10-13 | 2024-04-18 | Sana Biotechnology, Inc. | Viral particles targeting hematopoietic stem cells |
US20240131068A1 (en) * | 2022-10-18 | 2024-04-25 | Kite Pharma, Inc. | Car-t constructs comprising a novel cd19 binder combined with il18 and methods of using the same |
WO2024089639A1 (en) | 2022-10-26 | 2024-05-02 | Novartis Ag | Lentiviral formulations |
WO2024097905A1 (en) | 2022-11-02 | 2024-05-10 | Celgene Corporation | Methods of treatment with t cell therapy and immunomodulatory agent maintenance therapy |
WO2024100604A1 (en) | 2022-11-09 | 2024-05-16 | Juno Therapeutics Gmbh | Methods for manufacturing engineered immune cells |
CN116063575A (zh) * | 2022-11-15 | 2023-05-05 | 北京瑜阳科技有限公司 | 一种嵌合抗原受体(car)以及在治疗肿瘤中的应用 |
WO2024124132A1 (en) | 2022-12-09 | 2024-06-13 | Juno Therapeutics, Inc. | Machine learning methods for predicting cell phenotype using holographic imaging |
Family Cites Families (234)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0090505B1 (en) | 1982-03-03 | 1990-08-08 | Genentech, Inc. | Human antithrombin iii, dna sequences therefor, expression vehicles and cloning vectors containing such sequences and cell cultures transformed thereby, a process for expressing human antithrombin iii, and pharmaceutical compositions comprising it |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4882282A (en) | 1985-08-16 | 1989-11-21 | Immunex Corporation | DNA sequences encoding bovine interleukin-2 |
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
US6548640B1 (en) | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
US5906936A (en) | 1988-05-04 | 1999-05-25 | Yeda Research And Development Co. Ltd. | Endowing lymphocytes with antibody specificity |
US6303121B1 (en) | 1992-07-30 | 2001-10-16 | Advanced Research And Technology | Method of using human receptor protein 4-1BB |
US6534055B1 (en) | 1988-11-23 | 2003-03-18 | Genetics Institute, Inc. | Methods for selectively stimulating proliferation of T cells |
US5858358A (en) | 1992-04-07 | 1999-01-12 | The United States Of America As Represented By The Secretary Of The Navy | Methods for selectively stimulating proliferation of T cells |
US6352694B1 (en) | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
US6905680B2 (en) | 1988-11-23 | 2005-06-14 | Genetics Institute, Inc. | Methods of treating HIV infected subjects |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
US5399346A (en) | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
US5585362A (en) | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
US6319494B1 (en) | 1990-12-14 | 2001-11-20 | Cell Genesys, Inc. | Chimeric chains for receptor-associated signal transduction pathways |
DK0517895T3 (da) | 1990-12-14 | 1997-04-07 | Univ California | Kimæriske kæder til receptorforbundne signaltransduktionsveje |
US7049136B2 (en) | 1991-03-07 | 2006-05-23 | The General Hospital Corporation | Redirection of cellular immunity by receptor chimeras |
IE920716A1 (en) | 1991-03-07 | 1992-09-09 | Gen Hospital Corp | Redirection of cellular immunity by receptor chimeras |
US6004811A (en) | 1991-03-07 | 1999-12-21 | The Massachussetts General Hospital | Redirection of cellular immunity by protein tyrosine kinase chimeras |
EP0519596B1 (en) | 1991-05-17 | 2005-02-23 | Merck & Co. Inc. | A method for reducing the immunogenicity of antibody variable domains |
US5199942A (en) | 1991-06-07 | 1993-04-06 | Immunex Corporation | Method for improving autologous transplantation |
DK0590058T3 (da) | 1991-06-14 | 2004-03-29 | Genentech Inc | Humaniseret heregulin-antistof |
ES2136092T3 (es) | 1991-09-23 | 1999-11-16 | Medical Res Council | Procedimientos para la produccion de anticuerpos humanizados. |
GB9125768D0 (en) | 1991-12-04 | 1992-02-05 | Hale Geoffrey | Therapeutic method |
ATE249840T1 (de) | 1991-12-13 | 2003-10-15 | Xoma Corp | Verfahren und materialien zur herstellung von modifizierten variablen antikörperdomänen und ihre therapeutische verwendung |
GB9203459D0 (en) | 1992-02-19 | 1992-04-08 | Scotgen Ltd | Antibodies with germ-line variable regions |
US8211422B2 (en) | 1992-03-18 | 2012-07-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Chimeric receptor genes and cells transformed therewith |
IL104570A0 (en) | 1992-03-18 | 1993-05-13 | Yeda Res & Dev | Chimeric genes and cells transformed therewith |
US5350674A (en) | 1992-09-04 | 1994-09-27 | Becton, Dickinson And Company | Intrinsic factor - horse peroxidase conjugates and a method for increasing the stability thereof |
US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
US7211259B1 (en) | 1993-05-07 | 2007-05-01 | Immunex Corporation | 4-1BB polypeptides and DNA encoding 4-1BB polypeptides |
JPH09503911A (ja) | 1993-09-16 | 1997-04-22 | インディアナ・ユニバーシティー・ファウンデーション | ヒトh4−1bb受容体 |
NZ285395A (en) | 1994-05-02 | 1998-10-28 | Novartis Ag | Chimeric antibody, cancer treatment |
US7175843B2 (en) | 1994-06-03 | 2007-02-13 | Genetics Institute, Llc | Methods for selectively stimulating proliferation of T cells |
US5786464C1 (en) | 1994-09-19 | 2012-04-24 | Gen Hospital Corp | Overexpression of mammalian and viral proteins |
US5712149A (en) | 1995-02-03 | 1998-01-27 | Cell Genesys, Inc. | Chimeric receptor molecules for delivery of co-stimulatory signals |
US6103521A (en) | 1995-02-06 | 2000-08-15 | Cell Genesys, Inc. | Multispecific chimeric receptors |
PT871495E (pt) | 1995-02-24 | 2005-10-31 | Gen Hospital Corp | Redireccionamento de imunidade celular atraves de receptores quimericos |
US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
US6692964B1 (en) | 1995-05-04 | 2004-02-17 | The United States Of America As Represented By The Secretary Of The Navy | Methods for transfecting T cells |
US7067318B2 (en) | 1995-06-07 | 2006-06-27 | The Regents Of The University Of Michigan | Methods for transfecting T cells |
GB9526131D0 (en) | 1995-12-21 | 1996-02-21 | Celltech Therapeutics Ltd | Recombinant chimeric receptors |
US5874240A (en) | 1996-03-15 | 1999-02-23 | Human Genome Sciences, Inc. | Human 4-1BB receptor splicing variant |
US6111090A (en) | 1996-08-16 | 2000-08-29 | Schering Corporation | Mammalian cell surface antigens; related reagents |
EP1947183B1 (en) | 1996-08-16 | 2013-07-17 | Merck Sharp & Dohme Corp. | Mammalian cell surface antigens; related reagents |
US6114148C1 (en) | 1996-09-20 | 2012-05-01 | Gen Hospital Corp | High level expression of proteins |
EP0937095A4 (en) | 1996-10-25 | 1999-12-22 | Cell Genesys Inc | TARGETED CYTOLYSIS OF CANCER CELLS |
GB9713473D0 (en) | 1997-06-25 | 1997-09-03 | Celltech Therapeutics Ltd | Biological products |
US20030060444A1 (en) | 1997-06-25 | 2003-03-27 | Celltech Therapeutics, Ltd. | Cell activation process and reagents therefor |
WO1999015555A1 (en) | 1997-09-19 | 1999-04-01 | The General Hospital Corporation | Car receptors and related molecules and methods |
US6509173B1 (en) | 1997-10-21 | 2003-01-21 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptor-like proteins TR11, TR11SV1, and TR11SV2 |
PT1047449E (pt) | 1997-10-28 | 2004-04-30 | Univ British Columbia | Composicoes imunologicas e metodos de utilizacao para alterar transitoriamente a mielina do sistema nervoso central mamifero para promover a regeneracao neuronal |
JP2002502607A (ja) | 1998-02-09 | 2002-01-29 | ジェネンテク・インコーポレイテッド | 新規な腫瘍壊死因子レセプター相同体及びそれをコードする核酸 |
JP4843138B2 (ja) | 1998-04-15 | 2011-12-21 | ザ・ブリガーム・アンド・ウーメンズ・ホスピタル・インコーポレーテッド | T細胞阻害性受容体組成物およびその使用 |
GB9809658D0 (en) | 1998-05-06 | 1998-07-01 | Celltech Therapeutics Ltd | Biological products |
CA2343156A1 (en) | 1998-09-04 | 2000-03-16 | Sloan-Kettering Institute For Cancer Research | Fusion receptors specific for prostate-specific membrane antigen and uses thereof |
US6410319B1 (en) | 1998-10-20 | 2002-06-25 | City Of Hope | CD20-specific redirected T cells and their use in cellular immunotherapy of CD20+ malignancies |
EP1171596A1 (en) | 1999-04-16 | 2002-01-16 | Celltech Therapeutics Limited | Synthetic transmembrane components |
IL147442A0 (en) | 1999-07-12 | 2002-08-14 | Genentech Inc | Promotion or inhibition of angiogenesis and cardiovscularization by tumor necrosis factor ligand/receptor homologs |
AU1086501A (en) | 1999-10-15 | 2001-04-30 | Carnegie Institution Of Washington | Rna interference pathway genes as tools for targeted genetic interference |
GB9925848D0 (en) | 1999-11-01 | 1999-12-29 | Celltech Therapeutics Ltd | Biological products |
US6326193B1 (en) | 1999-11-05 | 2001-12-04 | Cambria Biosciences, Llc | Insect control agent |
CA2391129A1 (en) | 1999-11-10 | 2001-05-17 | The Uab Research Foundation | Lentiviral vector transduction of hematopoietic stem cells |
US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
JP2004500095A (ja) | 2000-02-24 | 2004-01-08 | エクサイト セラピーズ, インコーポレイテッド | 細胞の同時の刺激および濃縮 |
US6867041B2 (en) | 2000-02-24 | 2005-03-15 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
US6797514B2 (en) | 2000-02-24 | 2004-09-28 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
IL136511A0 (en) | 2000-06-01 | 2001-06-14 | Gavish Galilee Bio Appl Ltd | Genetically engineered mhc molecules |
AU2001275474A1 (en) | 2000-06-12 | 2001-12-24 | Akkadix Corporation | Materials and methods for the control of nematodes |
GB0025307D0 (en) | 2000-10-16 | 2000-11-29 | Celltech Chiroscience Ltd | Biological products |
AU2001297703B2 (en) | 2000-11-07 | 2006-10-19 | City Of Hope | CD19-specific redirected immune cells |
CN1294148C (zh) | 2001-04-11 | 2007-01-10 | 中国科学院遗传与发育生物学研究所 | 环状单链三特异抗体 |
US7070995B2 (en) | 2001-04-11 | 2006-07-04 | City Of Hope | CE7-specific redirected immune cells |
US7514537B2 (en) | 2001-04-30 | 2009-04-07 | City Of Hope | Chimeric immunoreceptor useful in treating human gliomas |
US20090257994A1 (en) | 2001-04-30 | 2009-10-15 | City Of Hope | Chimeric immunoreceptor useful in treating human cancers |
EP1392818A4 (en) | 2001-04-30 | 2005-01-05 | Hope City | FOR THE TREATMENT OF CANCER DISEASES IN HUMAN CERTAIN IMMUNE RECEPTOR |
US20030148982A1 (en) | 2001-11-13 | 2003-08-07 | Brenner Malcolm K. | Bi-spcific chimeric T cells |
US7745140B2 (en) | 2002-01-03 | 2010-06-29 | The Trustees Of The University Of Pennsylvania | Activation and expansion of T-cells using an engineered multivalent signaling platform as a research tool |
WO2003057171A2 (en) | 2002-01-03 | 2003-07-17 | The Trustees Of The University Of Pennsylvania | Activation and expansion of t-cells using an engineered multivalent signaling platform |
US7638326B2 (en) | 2002-01-03 | 2009-12-29 | The Trustees Of The University Of Pennsylvania | Activation and expansion of T-cells using an engineered multivalent signaling platform |
AU2003210787B2 (en) | 2002-02-01 | 2009-04-23 | Medinol Ltd. | Phosphorus-containing compounds & uses thereof |
US7446190B2 (en) | 2002-05-28 | 2008-11-04 | Sloan-Kettering Institute For Cancer Research | Nucleic acids encoding chimeric T cell receptors |
ES2263984T3 (es) | 2002-06-28 | 2006-12-16 | Domantis Limited | Ligandos doble-especificos con una vida media serica aumentada. |
AU2003288675B2 (en) | 2002-12-23 | 2010-07-22 | Medimmune Limited | Antibodies against PD-1 and uses therefor |
US20050129671A1 (en) | 2003-03-11 | 2005-06-16 | City Of Hope | Mammalian antigen-presenting T cells and bi-specific T cells |
US7402431B2 (en) | 2004-03-01 | 2008-07-22 | Immunovative Therapies, Ltd. | T-cell therapy formulation |
US7618632B2 (en) | 2003-05-23 | 2009-11-17 | Wyeth | Method of treating or ameliorating an immune cell associated pathology using GITR ligand antibodies |
JP5026072B2 (ja) | 2003-07-01 | 2012-09-12 | イミューノメディクス、インコーポレイテッド | 二重特異性抗体の多価キャリヤー |
EP1660126A1 (en) | 2003-07-11 | 2006-05-31 | Schering Corporation | Agonists or antagonists of the clucocorticoid-induced tumour necrosis factor receptor (gitr) or its ligand for the treatment of immune disorders, infections and cancer |
JP4934426B2 (ja) | 2003-08-18 | 2012-05-16 | メディミューン,エルエルシー | 抗体のヒト化 |
US20050042664A1 (en) | 2003-08-22 | 2005-02-24 | Medimmune, Inc. | Humanization of antibodies |
US8198020B2 (en) | 2003-08-22 | 2012-06-12 | Potentia Pharmaceuticals, Inc. | Compositions and methods for enhancing phagocytosis or phagocyte activity |
US7435596B2 (en) | 2004-11-04 | 2008-10-14 | St. Jude Children's Research Hospital, Inc. | Modified cell line and method for expansion of NK cell |
US20050113564A1 (en) | 2003-11-05 | 2005-05-26 | St. Jude Children's Research Hospital | Chimeric receptors with 4-1BB stimulatory signaling domain |
WO2005055808A2 (en) | 2003-12-02 | 2005-06-23 | Genzyme Corporation | Compositions and methods to diagnose and treat lung cancer |
GB0409799D0 (en) | 2004-04-30 | 2004-06-09 | Isis Innovation | Method of generating improved immune response |
WO2005118788A2 (en) | 2004-05-27 | 2005-12-15 | The Trustees Of The University Of Pennsylvania | Novel artificial antigen presenting cells and uses therefor |
WO2006083289A2 (en) | 2004-06-04 | 2006-08-10 | Duke University | Methods and compositions for enhancement of immunity by in vivo depletion of immunosuppressive cell activity |
WO2006020258A2 (en) | 2004-07-17 | 2006-02-23 | Imclone Systems Incorporated | Novel tetravalent bispecific antibody |
US7994298B2 (en) | 2004-09-24 | 2011-08-09 | Trustees Of Dartmouth College | Chimeric NK receptor and methods for treating cancer |
US7462697B2 (en) | 2004-11-08 | 2008-12-09 | Epitomics, Inc. | Methods for antibody engineering |
WO2006060878A1 (en) | 2004-12-10 | 2006-06-15 | Peter Maccallum Cancer Institute | Methods and compositions for adoptive immunotherapy |
PT2343320T (pt) | 2005-03-25 | 2018-01-23 | Gitr Inc | Anticorpos anti-gitr e as suas utilizações |
PT2161336E (pt) | 2005-05-09 | 2013-10-03 | Ono Pharmaceutical Co | Anticorpos monoclonais humanos para morte programada 1 (pd-1) e métodos de tratamento do cancro utilizando anticorpos anti- pd-1 sozinhos ou em combinação com outros agentes imunoterapêuticos¿ |
NZ563263A (en) | 2005-05-17 | 2010-04-30 | Univ Connecticut | Composition and methods for immunomodulation in an organism |
KR101607288B1 (ko) | 2005-07-01 | 2016-04-05 | 이. 알. 스퀴부 앤드 선즈, 엘.엘.씨. | 예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날 항체 |
US20070036773A1 (en) | 2005-08-09 | 2007-02-15 | City Of Hope | Generation and application of universal T cells for B-ALL |
EP1928506A4 (en) | 2005-08-19 | 2009-10-21 | Abbott Lab | IMMUNOGLOBULIN HAVING TWO VARIABLE DOMAINS AND USES THEREOF |
AU2007207785B2 (en) | 2006-01-13 | 2013-11-14 | The Government Of The United States, As Represented By The Secretary Of The Department Of Health And Human Services, National Institutes Of Health | Codon optimized IL- 15 and IL- 15R-alpha genes for expression in mammalian cells |
EP1981969A4 (en) | 2006-01-19 | 2009-06-03 | Genzyme Corp | ANTI-GITRANT ANTIBODIES FOR THE TREATMENT OF CANCER |
PL2526771T3 (pl) | 2006-09-22 | 2017-06-30 | Pharmacyclics Llc | Inhibitory kinazy tyrozynowej Brutona |
WO2008045437A2 (en) | 2006-10-09 | 2008-04-17 | The General Hospital Corporation | Chimeric t-cell receptors and t-cells targeting egfrviii on tumors |
US9382327B2 (en) * | 2006-10-10 | 2016-07-05 | Vaccinex, Inc. | Anti-CD20 antibodies and methods of use |
EP1916259A1 (en) | 2006-10-26 | 2008-04-30 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Anti-glycoprotein VI SCFV fragment for treatment of thrombosis |
US20080131415A1 (en) | 2006-11-30 | 2008-06-05 | Riddell Stanley R | Adoptive transfer of cd8 + t cell clones derived from central memory cells |
CA2584494A1 (en) | 2007-03-27 | 2008-09-27 | Jeffrey A. Medin | Vector encoding therapeutic polypeptide and safety elements to clear transduced cells |
SI2856876T1 (en) | 2007-03-30 | 2018-04-30 | Memorial Sloan-Kettering Cancer Center | Constituent expression of costimulatory ligands on indirectly transmitted T lymphocytes |
ES2616355T3 (es) | 2007-06-18 | 2017-06-12 | Merck Sharp & Dohme B.V. | Anticuerpos para el receptor humano de muerte programada PD-1 |
NZ616254A (en) | 2007-06-27 | 2015-04-24 | Us Sec Dep Of Health And Human Services | Complexes of il-15 and il-15ralpha and uses thereof |
AU2008275589B2 (en) | 2007-07-12 | 2013-11-21 | Gitr, Inc. | Combination therapies employing GITR binding molecules |
SI2211904T1 (sl) * | 2007-10-19 | 2016-12-30 | Seattle Genetics, Inc. | CD19 vezavna sredstva in njihove uporabe |
CA2703947C (en) | 2007-10-26 | 2018-12-04 | Governing Council Of The University Of Toronto | Therapeutic and diagnostic methods using tim-3 |
WO2009091826A2 (en) * | 2008-01-14 | 2009-07-23 | The Board Of Regents Of The University Of Texas System | Compositions and methods related to a human cd19-specific chimeric antigen receptor (h-car) |
US10059923B2 (en) | 2008-01-30 | 2018-08-28 | Memorial Sloan Kettering Cancer Center | Methods for off-the-shelf tumor immunotherapy using allogeneic T-cell precursors |
EP2242773B1 (en) | 2008-02-11 | 2017-06-14 | Cure Tech Ltd. | Monoclonal antibodies for tumor treatment |
US8379824B2 (en) | 2008-03-06 | 2013-02-19 | At&T Intellectual Property I, Lp | Methods and apparatus to provide a network-based caller identification service in a voice over internet protocol network |
US8168757B2 (en) | 2008-03-12 | 2012-05-01 | Merck Sharp & Dohme Corp. | PD-1 binding proteins |
AU2009266873A1 (en) | 2008-07-02 | 2010-01-07 | Emergent Product Development Seattle, Llc | TGF-beta antagonist multi-target binding proteins |
AR072999A1 (es) | 2008-08-11 | 2010-10-06 | Medarex Inc | Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos |
AU2009288289B2 (en) | 2008-08-25 | 2012-11-08 | Amplimmune, Inc. | PD-1 antagonists and methods of use thereof |
EP2350129B1 (en) | 2008-08-25 | 2015-06-10 | Amplimmune, Inc. | Compositions of pd-1 antagonists and methods of use |
HUE058891T2 (hu) | 2008-08-26 | 2022-09-28 | Hope City | Módszer és készítmények a T-sejtek fokozott tumorellenes effektor mûködésének fokozására |
CN102149820B (zh) | 2008-09-12 | 2014-07-23 | 国立大学法人三重大学 | 能够表达外源gitr配体的细胞 |
EP3929216A1 (en) | 2008-12-09 | 2021-12-29 | F. Hoffmann-La Roche AG | Anti-pd-l1 antibodies and their use to enhance t-cell function |
EP2389443B1 (en) | 2009-01-23 | 2018-11-14 | Roger Williams Hospital | Retroviral vectors encoding multiple highly homologous non-viral polypeptides and the use of same |
US8383778B2 (en) * | 2009-01-29 | 2013-02-26 | Abbvie Inc. | IL-1 binding proteins |
JP5844159B2 (ja) | 2009-02-09 | 2016-01-13 | ユニヴェルシテ デクス−マルセイユUniversite D’Aix−Marseille | Pd−1抗体およびpd−l1抗体ならびにその使用 |
US8679492B2 (en) * | 2009-02-23 | 2014-03-25 | Glenmark Pharmaceuticals S.A. | Humanized antibodies that bind to CD19 and their uses |
EP3135294B1 (en) | 2009-08-14 | 2020-06-03 | The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services | Use of il-15-il-15 receptor heterodimers to treat lymphopenia |
BR112012004823B1 (pt) | 2009-09-03 | 2021-11-30 | Merck Sharp & Dohme Corp | Anticorpo ou fragmento de ligação de antígeno do mesmo, uso de um anticorpo ou um fragmento de ligação de antígeno do mesmo, e composição farmacêutica |
EP2483301A1 (en) | 2009-10-01 | 2012-08-08 | The United States Of America, As Represented By The Secretary, Department of Health and Human Services | Anti-vascular endothelial growth factor receptor-2 chimeric antigen receptors and use of same for the treatment of cancer |
WO2011059836A2 (en) | 2009-10-29 | 2011-05-19 | Trustees Of Dartmouth College | T cell receptor-deficient t cell compositions |
GB0919054D0 (en) | 2009-10-30 | 2009-12-16 | Isis Innovation | Treatment of obesity |
JP2013512251A (ja) | 2009-11-24 | 2013-04-11 | アンプリミューン、インコーポレーテッド | Pd−l1/pd−l2の同時阻害 |
DK2519543T3 (en) | 2009-12-29 | 2016-09-26 | Emergent Product Dev Seattle | HETERODIMER BINDING PROTEINS AND USE THEREOF |
WO2011097477A1 (en) | 2010-02-04 | 2011-08-11 | The Trustees Of The University Of Pennsylvania | Icos critically regulates the expansion and function of inflammatory human th17 cells |
WO2012050374A2 (en) * | 2010-10-13 | 2012-04-19 | Innocell, Inc. | Immunotherapy for solid tumors |
CN103501816A (zh) | 2010-10-27 | 2014-01-08 | 贝勒医学院 | 使t细胞重定向针对cd70阳性恶性肿瘤的嵌合cd27受体 |
DK3214091T3 (en) | 2010-12-09 | 2019-01-07 | Univ Pennsylvania | USE OF CHEMICAL ANTIGEN RECEPTOR MODIFIED T CELLS FOR TREATMENT OF CANCER |
EP2651442B1 (en) | 2010-12-14 | 2020-04-22 | University of Maryland, Baltimore | Universal anti-tag chimeric antigen receptor-expressing t cells and methods of treating cancer |
MX2013008376A (es) | 2011-01-18 | 2013-08-12 | Univ Pennsylvania | Composiciones y metodos para el tratamiento de cancer. |
MX359513B (es) | 2011-03-23 | 2018-10-01 | Hutchinson Fred Cancer Res | Metodo y composiciones para inmunoterapia celular. |
WO2012127464A2 (en) | 2011-03-23 | 2012-09-27 | Gavish-Galilee Bio Applications Ltd | Constitutively activated t cells for use in adoptive cell therapy |
JP6082997B2 (ja) | 2011-04-01 | 2017-02-22 | メモリアル スローン−ケタリング キャンサー センター | Hla−a2により提示されるwt1ペプチドへのt細胞受容体様抗体 |
CN103596981B (zh) | 2011-04-08 | 2017-06-16 | 美国卫生和人力服务部 | 抗‑表皮生长因子受体变体iii嵌合抗原受体及其用于治疗癌症的用途 |
NZ616405A (en) | 2011-04-08 | 2015-11-27 | Baylor College Medicine | Reversing the effects of the tumor microenvironment using chimeric cytokine receptors |
US20130071414A1 (en) | 2011-04-27 | 2013-03-21 | Gianpietro Dotti | Engineered cd19-specific t lymphocytes that coexpress il-15 and an inducible caspase-9 based suicide gene for the treatment of b-cell malignancies |
EP3290055A3 (en) | 2011-07-25 | 2018-05-30 | Nationwide Children's Hospital, Inc. | Recombinant virus products and methods for inhibition of expression of dux4 |
EP3915588A1 (en) * | 2011-07-29 | 2021-12-01 | The Trustees of the University of Pennsylvania | Switch costimulatory receptors |
WO2013033626A2 (en) | 2011-08-31 | 2013-03-07 | Trustees Of Dartmouth College | Nkp30 receptor targeted therapeutics |
WO2013039954A1 (en) | 2011-09-14 | 2013-03-21 | Sanofi | Anti-gitr antibodies |
MX2014003176A (es) | 2011-09-16 | 2015-08-05 | Univ Pennsylvania | Celulas t diseñadas mediante arn para el tratamiento de cancer. |
US20140255363A1 (en) | 2011-09-16 | 2014-09-11 | Baylor College Of Medicine | Targeting the tumor microenvironment using manipulated nkt cells |
EP2768863B1 (en) | 2011-10-20 | 2017-09-27 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Anti-cd22 chimeric antigen receptors |
SG11201404284SA (en) | 2012-02-22 | 2014-10-30 | Univ Pennsylvania | Use of the cd2 signaling domain in second-generation chimeric antigen receptors |
CA3084919A1 (en) | 2012-02-22 | 2013-08-29 | The Trustees Of The University Of Pennsylvania | Compositions and methods for generating a persisting population of t cells useful for the treatment of cancer |
EA201491574A1 (ru) | 2012-02-22 | 2014-12-30 | Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания | Применение car, основанных на icos, для усиления противоопухолевой активности и длительного сохранения car |
WO2014011993A2 (en) | 2012-07-13 | 2014-01-16 | The Trustees Of The University Of Pennsylvania | Epitope spreading associated with car t-cells |
WO2014012001A2 (en) | 2012-07-13 | 2014-01-16 | The Trustees Of The University Of Pennsylvania | Use of cart19 to deplete normal b cells to induce tolerance |
US9572836B2 (en) | 2012-07-13 | 2017-02-21 | The Trustees Of The University Of Pennsylvania | Methods for assessing the suitability of transduced T cells for administration |
SG11201408787PA (en) * | 2012-07-13 | 2015-01-29 | Univ Pennsylvania | Enhancing activity of car t cells by co-introducing a bispecific antibody |
SG11201408398UA (en) | 2012-07-13 | 2015-02-27 | Univ Pennsylvania | Compositions and methods for regulating car t cells |
EP4019041B1 (en) | 2012-07-13 | 2022-12-28 | The Trustees of the University of Pennsylvania | Toxicity management for anti-tumor activity of cars |
LT2884999T (lt) | 2012-08-20 | 2021-04-12 | Fred Hutchinson Cancer Research Center | Ląstelinės imunoterapijos būdas ir kompozicijos |
WO2014039513A2 (en) | 2012-09-04 | 2014-03-13 | The Trustees Of The University Of Pennsylvania | Inhibition of diacylglycerol kinase to augment adoptive t cell transfer |
TW201414837A (zh) | 2012-10-01 | 2014-04-16 | Univ Pennsylvania | 標定基質細胞以治療癌症之組合物和方法 |
WO2014055657A1 (en) | 2012-10-05 | 2014-04-10 | The Trustees Of The University Of Pennsylvania | Use of a trans-signaling approach in chimeric antigen receptors |
WO2014130635A1 (en) | 2013-02-20 | 2014-08-28 | Novartis Ag | Effective targeting of primary human leukemia using anti-cd123 chimeric antigen receptor engineered t cells |
CN105358576B (zh) | 2013-02-20 | 2020-05-05 | 诺华股份有限公司 | 使用人源化抗EGFRvIII嵌合抗原受体治疗癌症 |
US9657105B2 (en) | 2013-03-15 | 2017-05-23 | City Of Hope | CD123-specific chimeric antigen receptor redirected T cells and methods of their use |
US9745368B2 (en) | 2013-03-15 | 2017-08-29 | The Trustees Of The University Of Pennsylvania | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
TWI654206B (zh) | 2013-03-16 | 2019-03-21 | 諾華公司 | 使用人類化抗-cd19嵌合抗原受體治療癌症 |
WO2015057852A1 (en) | 2013-10-15 | 2015-04-23 | The California Institute For Biomedical Research | Chimeric antigen receptor t cell switches and uses thereof |
US9512084B2 (en) | 2013-11-29 | 2016-12-06 | Novartis Ag | Amino pyrimidine derivatives |
BR122021025085B1 (pt) | 2013-12-17 | 2023-04-04 | Genentech, Inc | Anticorpo anti-cd3, célula hospedeira procariótica, método de produção do anticorpo biespecífico, imunoconjugado, composição, uso do anticorpo biespecífico e kit |
JP6779785B2 (ja) | 2013-12-19 | 2020-11-04 | ノバルティス アーゲー | ヒトメソテリンキメラ抗原受容体およびその使用 |
EP3087101B1 (en) | 2013-12-20 | 2024-06-05 | Novartis AG | Regulatable chimeric antigen receptor |
EP3097117B1 (en) | 2014-01-21 | 2023-10-04 | Novartis Ag | Enhanced antigen presenting ability of car t cells by co-introduction of costimulatory molecules |
US20170335281A1 (en) | 2014-03-15 | 2017-11-23 | Novartis Ag | Treatment of cancer using chimeric antigen receptor |
ES2857226T3 (es) | 2014-03-15 | 2021-09-28 | Novartis Ag | Receptor de antígeno quimérico regulable |
SG10201808053XA (en) | 2014-03-19 | 2018-10-30 | Infinity Pharmaceuticals Inc | Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders |
LT3129470T (lt) | 2014-04-07 | 2021-07-12 | Novartis Ag | Vėžio gydymas naudojant anti-cd19 chimerinį antigeno receptorių |
EP3193915A1 (en) | 2014-07-21 | 2017-07-26 | Novartis AG | Combinations of low, immune enhancing. doses of mtor inhibitors and cars |
KR102594343B1 (ko) | 2014-07-21 | 2023-10-26 | 노파르티스 아게 | Cd33 키메라 항원 수용체를 사용한 암의 치료 |
US20170226495A1 (en) | 2014-07-21 | 2017-08-10 | Novartis Ag | Sortase molecules and uses thereof |
US20170274014A1 (en) | 2014-07-21 | 2017-09-28 | Jennifer Brogdon | Combinations of low, immune enhancing, doses of mtor inhibitors and cars |
RU2751660C2 (ru) | 2014-07-21 | 2021-07-15 | Новартис Аг | Лечение злокачественного новообразования с использованием гуманизированного химерного антигенного рецептора против всма |
US11542488B2 (en) | 2014-07-21 | 2023-01-03 | Novartis Ag | Sortase synthesized chimeric antigen receptors |
AR101829A1 (es) | 2014-07-21 | 2017-01-18 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico de antígeno cll-1 |
EP3174546B1 (en) | 2014-07-31 | 2019-10-30 | Novartis AG | Subset-optimized chimeric antigen receptor-containing t-cells |
CA2958200A1 (en) | 2014-08-14 | 2016-02-18 | Novartis Ag | Treatment of cancer using a gfr alpha-4 chimeric antigen receptor |
EP3183268B1 (en) | 2014-08-19 | 2020-02-12 | Novartis AG | Anti-cd123 chimeric antigen receptor (car) for use in cancer treatment |
PL3194443T3 (pl) | 2014-09-17 | 2022-01-31 | Novartis Ag | Nakierowywanie komórek cytotoksycznych za pośrednictwem receptorów chimerycznych do immunoterapii adoptywnej |
CA2963935A1 (en) | 2014-10-08 | 2016-04-14 | Novartis Ag | Biomarkers predictive of therapeutic responsiveness to chimeric antigen receptor therapy and uses thereof |
US20170239294A1 (en) | 2014-10-15 | 2017-08-24 | Novartis Ag | Compositions and methods for treating b-lymphoid malignancies |
RU2021118125A (ru) | 2014-12-29 | 2022-04-06 | Новартис Аг | Способы получения экспрессирующих химерный антигенный рецептор клеток |
US11459390B2 (en) | 2015-01-16 | 2022-10-04 | Novartis Ag | Phosphoglycerate kinase 1 (PGK) promoters and methods of use for expressing chimeric antigen receptor |
US11161907B2 (en) | 2015-02-02 | 2021-11-02 | Novartis Ag | Car-expressing cells against multiple tumor antigens and uses thereof |
ES2876974T3 (es) | 2015-04-07 | 2021-11-15 | Novartis Ag | Combinación de terapia con receptor de antígeno quimérico y derivados de amino pirimidina |
LT3280729T (lt) | 2015-04-08 | 2022-08-10 | Novartis Ag | Terapijos cd20, terapijos cd22 ir kombinuotos terapijos su cd19 chimerinį antigeno receptorių (car) ekspresuojančia ląstele |
JP7114457B2 (ja) | 2015-04-17 | 2022-08-08 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | キメラ抗原受容体発現細胞の有効性および増殖を改善するための方法 |
EP3286211A1 (en) | 2015-04-23 | 2018-02-28 | Novartis AG | Treatment of cancer using chimeric antigen receptor and protein kinase a blocker |
AU2016297014B2 (en) | 2015-07-21 | 2021-06-17 | Novartis Ag | Methods for improving the efficacy and expansion of immune cells |
WO2017027392A1 (en) | 2015-08-07 | 2017-02-16 | Novartis Ag | Treatment of cancer using chimeric cd3 receptor proteins |
CN108780084B (zh) | 2015-09-03 | 2022-07-22 | 诺华股份有限公司 | 预测细胞因子释放综合征的生物标志物 |
KR20180051625A (ko) | 2015-09-17 | 2018-05-16 | 노파르티스 아게 | 증진된 효능을 갖는 car t 세포 요법 |
MA44140A (fr) | 2015-12-22 | 2021-05-19 | Dana Farber Cancer Inst Inc | Récepteur d'antigène chimérique (car) contre la mésothéline et anticorps contre l'inhibiteur de pd-l1 pour une utilisation combinée dans une thérapie anticancéreuse |
JP2019500394A (ja) | 2015-12-30 | 2019-01-10 | ノバルティス アーゲー | 有効性が増強された免疫エフェクター細胞治療 |
CN110461315A (zh) | 2016-07-15 | 2019-11-15 | 诺华股份有限公司 | 使用与激酶抑制剂组合的嵌合抗原受体治疗和预防细胞因子释放综合征 |
SG11201900677SA (en) | 2016-07-28 | 2019-02-27 | Novartis Ag | Combination therapies of chimeric antigen receptors adn pd-1 inhibitors |
US20190161542A1 (en) | 2016-08-01 | 2019-05-30 | Novartis Ag | Treatment of cancer using a chimeric antigen receptor in combination with an inhibitor of a pro-m2 macrophage molecule |
JP2019532953A (ja) | 2016-09-30 | 2019-11-14 | ノバルティス アーゲー | 増強された有効性を有する免疫エフェクター細胞治療 |
SG10201913823VA (en) | 2016-10-07 | 2020-03-30 | Novartis Ag | Chimeric antigen receptors for the treatment of cancer |
WO2018140725A1 (en) | 2017-01-26 | 2018-08-02 | Novartis Ag | Cd28 compositions and methods for chimeric antigen receptor therapy |
CN110582509A (zh) | 2017-01-31 | 2019-12-17 | 诺华股份有限公司 | 使用具有多特异性的嵌合t细胞受体蛋白治疗癌症 |
EP3589647A1 (en) | 2017-02-28 | 2020-01-08 | Novartis AG | Shp inhibitor compositions and uses for chimeric antigen receptor therapy |
CN110831619A (zh) | 2017-03-22 | 2020-02-21 | 诺华股份有限公司 | 具有增强功效的生物标志和car t细胞疗法 |
EP3615055A1 (en) | 2017-04-28 | 2020-03-04 | Novartis AG | Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor |
US20200061113A1 (en) | 2018-04-12 | 2020-02-27 | Novartis Ag | Chimeric antigen receptor therapy characterization assays and uses thereof |
US20200085869A1 (en) | 2018-05-16 | 2020-03-19 | Novartis Ag | Therapeutic regimens for chimeric antigen receptor therapies |
WO2019241426A1 (en) | 2018-06-13 | 2019-12-19 | Novartis Ag | Bcma chimeric antigen receptors and uses thereof |
-
2014
- 2014-03-14 TW TW103109821A patent/TWI654206B/zh active
- 2014-03-14 UY UY0001035468A patent/UY35468A/es not_active Application Discontinuation
- 2014-03-15 PT PT191583681T patent/PT3539986T/pt unknown
- 2014-03-15 SG SG10201806293WA patent/SG10201806293WA/en unknown
- 2014-03-15 US US14/214,728 patent/US10221245B2/en active Active
- 2014-03-15 ES ES19158368T patent/ES2923397T3/es active Active
- 2014-03-15 HR HRP20220767TT patent/HRP20220767T1/hr unknown
- 2014-03-15 HU HUE19158368A patent/HUE058832T2/hu unknown
- 2014-03-15 PL PL14722469T patent/PL2970482T3/pl unknown
- 2014-03-15 AU AU2014236098A patent/AU2014236098B8/en active Active
- 2014-03-15 PT PT14722469T patent/PT2970482T/pt unknown
- 2014-03-15 HU HUE14722469A patent/HUE042803T2/hu unknown
- 2014-03-15 CN CN202210634273.6A patent/CN115287292A/zh active Pending
- 2014-03-15 DK DK19158368.1T patent/DK3539986T3/da active
- 2014-03-15 SI SI201431971T patent/SI3539986T1/sl unknown
- 2014-03-15 RU RU2020100865A patent/RU2020100865A/ru unknown
- 2014-03-15 KR KR1020157029649A patent/KR102293062B1/ko active IP Right Grant
- 2014-03-15 MY MYPI2015702773A patent/MY187624A/en unknown
- 2014-03-15 LT LTEP14722469.5T patent/LT2970482T/lt unknown
- 2014-03-15 EP EP19158368.1A patent/EP3539986B1/en active Active
- 2014-03-15 DK DK14722469.5T patent/DK2970482T3/en active
- 2014-03-15 EP EP22159001.1A patent/EP4067382A1/en active Pending
- 2014-03-15 CN CN201480027401.4A patent/CN105392888B/zh active Active
- 2014-03-15 RU RU2015144332A patent/RU2711975C2/ru active
- 2014-03-15 LT LTEP19158368.1T patent/LT3539986T/lt unknown
- 2014-03-15 ES ES14722469T patent/ES2734549T3/es active Active
- 2014-03-15 CA CA2907100A patent/CA2907100C/en active Active
- 2014-03-15 WO PCT/US2014/029943 patent/WO2014153270A1/en active Application Filing
- 2014-03-15 PL PL19158368.1T patent/PL3539986T3/pl unknown
- 2014-03-15 EP EP14722469.5A patent/EP2970482B1/en active Active
- 2014-03-15 MX MX2015013194A patent/MX2015013194A/es active IP Right Grant
- 2014-03-15 SG SG11201506603PA patent/SG11201506603PA/en unknown
- 2014-03-15 BR BR112015021819A patent/BR112015021819A2/pt not_active Application Discontinuation
- 2014-03-15 JP JP2016503288A patent/JP6466401B2/ja active Active
-
2015
- 2015-09-07 IL IL241261A patent/IL241261B/en active IP Right Grant
- 2015-09-15 MX MX2020007021A patent/MX2020007021A/es unknown
-
2016
- 2016-06-14 HK HK16106845.6A patent/HK1218922A1/zh unknown
-
2018
- 2018-11-15 US US16/192,375 patent/US10927184B2/en active Active
-
2019
- 2019-01-09 JP JP2019001925A patent/JP7187327B2/ja active Active
- 2019-08-15 AU AU2019216689A patent/AU2019216689C1/en active Active
-
2020
- 2020-12-23 US US17/132,674 patent/US20210284752A1/en active Pending
-
2021
- 2021-02-22 JP JP2021026430A patent/JP7439002B2/ja active Active
-
2022
- 2022-03-23 AU AU2022202024A patent/AU2022202024A1/en active Pending
-
2024
- 2024-02-14 JP JP2024020429A patent/JP2024056877A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
UY35468A (es) | Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19 | |
CO2017000506A2 (es) | Receptor quimérico de antígeno cll-1 | |
CO2017000510A2 (es) | Constructos de car | |
MY190711A (en) | Treatment of cancer using humanized anti-egfrviii chimeric antigen receptor | |
MY181834A (en) | Treatment of cancer using humanized anti-bcma chimeric antigen receptor | |
CO2017001573A2 (es) | Receptor quimérico de antígeno anti-cd123 | |
PH12019500750A1 (en) | Chimeric antigen receptors for the treatment of cancer | |
MX2016008076A (es) | Receptores quimericos de antigeno de mesotelina humana y uso de los mismos. | |
MX2020001450A (es) | Composiciones para reducir la inmunosupresion por celulas de tumor. | |
MX2022010623A (es) | Terapias de combinacion que comprenden un receptor quimerico de antigeno cd19 para el cancer. | |
WO2015142675A3 (en) | Treatment of cancer using chimeric antigen receptor | |
MX2019000643A (es) | Receptores de antigenos quimericos y metodos de uso. | |
BR112017019914A2 (pt) | receptores de antígenos quiméricos direcionados para antígeno de amadurecimento de células b | |
CR20170079A (es) | Agentes de unión a cd123 y usos de estos | |
AR090973A1 (es) | Anticuerpos utiles para el diagnostico del cancer | |
MX2017002459A (es) | Anticuerpos y receptores de antigeno quimericos especificos para cd19. | |
MX2018004121A (es) | Receptores de antigeno y usos de los mismos. | |
AR101592A1 (es) | Tratamiento de cáncer usando un receptor quimérico de antígeno cd123 | |
AR118751A2 (es) | Tratamiento de cáncer utilizando receptor de antígeno quimérico anti-cd19 | |
AR098848A1 (es) | Receptores de antígeno quimérico de mesotelina humana y usos de los mismos |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
109 | Application deemed to be withdrawn |
Effective date: 20211206 |