MX2019008227A - Analisis epigenetico de terapia celular y metodos relacionados. - Google Patents

Analisis epigenetico de terapia celular y metodos relacionados.

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Publication number
MX2019008227A
MX2019008227A MX2019008227A MX2019008227A MX2019008227A MX 2019008227 A MX2019008227 A MX 2019008227A MX 2019008227 A MX2019008227 A MX 2019008227A MX 2019008227 A MX2019008227 A MX 2019008227A MX 2019008227 A MX2019008227 A MX 2019008227A
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Mexico
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cell therapy
epigenetic
cell
cells
methods
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MX2019008227A
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English (en)
Inventor
Mark L Bonyhadi
David G Kugler
Timothy G Johnstone
Ronald James Hause Jr
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Juno Therapeutics Inc
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Publication of MX2019008227A publication Critical patent/MX2019008227A/es

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Abstract

En la presente se proporcionan métodos para identificar la o las regiones genómicas predictivas de un resultado del tratamiento con una terapia celular y/o de un fenotipo de la función de las células. En algunas modalidades, los métodos incluyen análisis epigenéticos y/o epigenómicos de las células junto con métodos para preparar células modificadas para la terapia celular y/o predecir la respuesta a una terapia celular, por ejemplo, células modificadas para la terapia celular. En algunas modalidades, los métodos incluyen las etapas de evaluar, caracterizar y analizar cambios o modificaciones en una propiedad epigenética de una región o regiones de genes, tales como accesibilidad de cromatina, ocupación de nucleosomas, modificación de histonas, conformación cromosómica espacial, ocupación de factores de transcripción y/o metilación del ADN. En algunas modalidades, el análisis epigenético y/o epigenómico incluye determinar las propiedades epigenéticas de una célula, por ejemplo, una célula modificada para terapia celular.
MX2019008227A 2017-01-10 2018-01-10 Analisis epigenetico de terapia celular y metodos relacionados. MX2019008227A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762444802P 2017-01-10 2017-01-10
US201762551752P 2017-08-29 2017-08-29
US201762596662P 2017-12-08 2017-12-08
PCT/US2018/013227 WO2018132518A1 (en) 2017-01-10 2018-01-10 Epigenetic analysis of cell therapy and related methods

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MX2019008227A true MX2019008227A (es) 2020-08-17

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MX2019008227A MX2019008227A (es) 2017-01-10 2018-01-10 Analisis epigenetico de terapia celular y metodos relacionados.

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US (2) US11821027B2 (es)
EP (1) EP3568414A1 (es)
JP (1) JP7429338B2 (es)
CN (1) CN110691792A (es)
AU (1) AU2018207305A1 (es)
CA (1) CA3049461A1 (es)
MA (1) MA47283A (es)
MX (1) MX2019008227A (es)
WO (1) WO2018132518A1 (es)

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