MX2021001519A - Metodos para valorar acidos nucleicos integrados. - Google Patents

Metodos para valorar acidos nucleicos integrados.

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Publication number
MX2021001519A
MX2021001519A MX2021001519A MX2021001519A MX2021001519A MX 2021001519 A MX2021001519 A MX 2021001519A MX 2021001519 A MX2021001519 A MX 2021001519A MX 2021001519 A MX2021001519 A MX 2021001519A MX 2021001519 A MX2021001519 A MX 2021001519A
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MX
Mexico
Prior art keywords
nucleic acids
methods
genetically engineered
integrated
cell
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Application number
MX2021001519A
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English (en)
Inventor
Adrian Wrangham Briggs
Original Assignee
Juno Therapeutics Inc
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Publication date
Application filed by Juno Therapeutics Inc filed Critical Juno Therapeutics Inc
Publication of MX2021001519A publication Critical patent/MX2021001519A/es

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    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
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    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
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    • C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
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    • C12Q2545/00—Reactions characterised by their quantitative nature
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    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/159—Microreactors, e.g. emulsion PCR or sequencing, droplet PCR, microcapsules, i.e. non-liquid containers with a range of different permeability's for different reaction components

Abstract

Se proporcionan métodos para valorar secuencias de ácido nucleico integradas en un genoma de una célula modificada genéticamente, tal como una célula modificada genéticamente utilizada en terapia celular. En general, se modifican genéticamente células para expresar una proteína recombinante, tal como un receptor recombinante, mediante la introducción de un polinucleótido y la integración de ciertas secuencias en el polinucleótido, tal como secuencias recombinantes, en el genoma de la célula. En algunos aspectos, los métodos proporcionados se pueden usar para distinguir entre ácidos nucleicos integrados y ácidos nucleicos residuales no integrados.
MX2021001519A 2018-08-09 2019-08-09 Metodos para valorar acidos nucleicos integrados. MX2021001519A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862716972P 2018-08-09 2018-08-09
PCT/US2019/046048 WO2020033916A1 (en) 2018-08-09 2019-08-09 Methods for assessing integrated nucleic acids

Publications (1)

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MX2021001519A true MX2021001519A (es) 2021-05-27

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MX2021001519A MX2021001519A (es) 2018-08-09 2019-08-09 Metodos para valorar acidos nucleicos integrados.

Country Status (13)

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US (1) US20210230671A1 (es)
EP (1) EP3833759A1 (es)
JP (1) JP2021533747A (es)
KR (1) KR20210059715A (es)
CN (1) CN112805378A (es)
AU (1) AU2019316647A1 (es)
BR (1) BR112021002245A2 (es)
CA (1) CA3108698A1 (es)
EA (1) EA202190469A1 (es)
IL (1) IL280528A (es)
MX (1) MX2021001519A (es)
SG (1) SG11202101130VA (es)
WO (1) WO2020033916A1 (es)

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CN115852064A (zh) * 2020-09-30 2023-03-28 浙江大学 用于检测hbv基因t216c突变位点的引物和探针
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AU2019316647A1 (en) 2021-02-25
BR112021002245A2 (pt) 2021-05-04
CN112805378A (zh) 2021-05-14
KR20210059715A (ko) 2021-05-25
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