MX365435B - Metodos de modificacion de celulas huesped. - Google Patents
Metodos de modificacion de celulas huesped.Info
- Publication number
- MX365435B MX365435B MX2015004649A MX2015004649A MX365435B MX 365435 B MX365435 B MX 365435B MX 2015004649 A MX2015004649 A MX 2015004649A MX 2015004649 A MX2015004649 A MX 2015004649A MX 365435 B MX365435 B MX 365435B
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- host cell
- cell modification
- host cells
- nucleic acid
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/185—Escherichia
- C12R2001/19—Escherichia coli
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/64—General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/40—Systems of functionally co-operating vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La presente invención se refiere a métodos novedosos de inserción de secuencias de ácido nucleico en células huésped. En la presente también se describen células huésped genéticamente estables que comprenden secuencias de ácido nucleico insertadas, y métodos para utilizar tales células huésped en la generación de proteínas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261713281P | 2012-10-12 | 2012-10-12 | |
PCT/EP2013/071328 WO2014057109A1 (en) | 2012-10-12 | 2013-10-11 | Methods of host cell modification |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2015004649A MX2015004649A (es) | 2016-01-12 |
MX365435B true MX365435B (es) | 2019-06-03 |
Family
ID=49326691
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015004649A MX365435B (es) | 2012-10-12 | 2013-10-11 | Metodos de modificacion de celulas huesped. |
Country Status (16)
Country | Link |
---|---|
US (2) | US20150267207A1 (es) |
EP (2) | EP2906681B1 (es) |
JP (1) | JP6329554B2 (es) |
KR (1) | KR20150068998A (es) |
CN (2) | CN110423716A (es) |
AU (1) | AU2013328615B2 (es) |
BR (1) | BR112015008052A2 (es) |
CA (1) | CA2887133C (es) |
EA (1) | EA201590488A1 (es) |
ES (2) | ES2905107T3 (es) |
IL (1) | IL238024A0 (es) |
MX (1) | MX365435B (es) |
SG (2) | SG11201502638YA (es) |
TR (1) | TR201904022T4 (es) |
WO (1) | WO2014057109A1 (es) |
ZA (1) | ZA201502433B (es) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2889767C (en) * | 2012-11-07 | 2021-09-21 | Glycovaxyn Ag | Production of recombinant vaccine in e. coli by enzymatic conjugation |
MX365331B (es) | 2013-01-17 | 2019-05-29 | Arsanis Biosciences Gmbh | Anticuerpo específico contra e. coli mdr. |
CN105378096A (zh) * | 2013-03-14 | 2016-03-02 | 格里科比亚有限公司 | 寡糖组合物、糖蛋白以及在原核生物中产生它们的方法 |
MX371513B (es) * | 2013-10-11 | 2020-01-31 | Glaxosmithkline Biologicals Sa | Metodos de modificacion de celulas huespedes. |
AU2015220723C1 (en) | 2014-02-24 | 2018-04-05 | Glaxosmithkline Biologicals Sa | Novel polysaccharide and uses thereof |
LT3131577T (lt) * | 2014-04-17 | 2020-07-27 | Glaxosmithkline Biologicals S.A. | Modifikuotos ląstelės-šeimininkės ir jų naudojimas |
WO2016025759A1 (en) * | 2014-08-14 | 2016-02-18 | Shen Yuelei | Dna knock-in system |
BR112017017930A2 (pt) | 2015-02-26 | 2018-04-10 | Vaxnewmo Llc | o-oligossacaril-transferases de acinetobacter e usos das mesmas |
TWI715617B (zh) | 2015-08-24 | 2021-01-11 | 比利時商葛蘭素史密斯克藍生物品公司 | 對抗腸道外病原性大腸桿菌之免疫保護之方法及組合物 |
GB201518668D0 (en) | 2015-10-21 | 2015-12-02 | Glaxosmithkline Biolog Sa | Immunogenic Comosition |
GB201610599D0 (en) | 2016-06-17 | 2016-08-03 | Glaxosmithkline Biologicals Sa | Immunogenic Composition |
AR109621A1 (es) | 2016-10-24 | 2018-12-26 | Janssen Pharmaceuticals Inc | Formulaciones de vacunas contra glucoconjugados de expec |
CN106801029B (zh) * | 2017-01-22 | 2020-05-01 | 山东大学 | 一株重组大肠杆菌及其在制备抗志贺氏菌的糖疫苗中的应用 |
CN109385417A (zh) * | 2017-08-03 | 2019-02-26 | 华东理工大学 | 体内dna无缝组装方法 |
GB201712678D0 (en) | 2017-08-07 | 2017-09-20 | Glaxosmithkline Biologicals Sa | Process for the manipulation of nucleic acids |
GB201721576D0 (en) | 2017-12-21 | 2018-02-07 | Glaxosmithkline Biologicals Sa | Hla antigens and glycoconjugates thereof |
GB201721582D0 (en) | 2017-12-21 | 2018-02-07 | Glaxosmithkline Biologicals Sa | S aureus antigens and immunogenic compositions |
AU2019287659A1 (en) | 2018-06-16 | 2021-01-07 | Vaxnewmo Llc | Glycosylated ComP pilin variants, methods of making and uses thereof |
US11260119B2 (en) | 2018-08-24 | 2022-03-01 | Pfizer Inc. | Escherichia coli compositions and methods thereof |
KR20210088615A (ko) * | 2018-10-31 | 2021-07-14 | 지머젠 인코포레이티드 | Dna 라이브러리의 다중 결정적 어셈블리 |
JP2022525773A (ja) | 2019-03-18 | 2022-05-19 | ヤンセン ファーマシューティカルズ,インコーポレーテッド | 大腸菌o抗原多糖のバイオコンジュゲートを製造する方法、その組成物およびその使用方法 |
US11446370B2 (en) | 2019-03-18 | 2022-09-20 | Janssen Pharmaceuticals, Inc. | Bioconjugates of E. coli o-antigen polysaccharides, methods of production thereof, and methods of use thereof |
EP3770269A1 (en) | 2019-07-23 | 2021-01-27 | GlaxoSmithKline Biologicals S.A. | Quantification of bioconjugate glycosylation |
WO2021028303A1 (en) | 2019-08-09 | 2021-02-18 | Glaxosmithkline Biologicals Sa | Mutated pglb oligosaccharyltransferase enzymes |
CN115697396A (zh) * | 2020-06-18 | 2023-02-03 | 葛兰素史克生物有限公司 | 志贺氏菌-四价(Shigella4V)生物缀合物 |
JP2023531242A (ja) | 2020-06-25 | 2023-07-21 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 改変Exotoxin Aタンパク質 |
MX2023003169A (es) | 2020-09-17 | 2023-03-27 | Janssen Pharmaceuticals Inc | Composiciones de vacunas multivalentes y usos de las mismas. |
JP2022099419A (ja) * | 2020-12-23 | 2022-07-05 | トヨタ自動車株式会社 | 形質転換用プラスミド及びこれを用いた形質転換体の製造方法、並びに形質転換方法 |
EP4291673A2 (en) | 2021-02-11 | 2023-12-20 | GlaxoSmithKline Biologicals SA | Mutated pglb oligosaccharyltransferase enzymes |
JP2024513914A (ja) | 2021-04-08 | 2024-03-27 | ヤンセン ファーマシューティカルズ,インコーポレーテッド | バイオコンジュゲート生産のためのプロセス |
CN113528410A (zh) * | 2021-06-23 | 2021-10-22 | 云舟生物科技(广州)有限公司 | 一种用于快速高效诱导表达外源蛋白的大肠杆菌工程菌及其制备方法与应用 |
WO2023118033A1 (en) | 2021-12-22 | 2023-06-29 | Glaxosmithkline Biologicals Sa | Vaccine |
GB202302579D0 (en) | 2023-02-23 | 2023-04-12 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5057540A (en) | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
WO1995024488A1 (en) * | 1994-03-09 | 1995-09-14 | Abbott Laboratories | Transgenic animals producing oligosaccharides and glycoconjugates |
US6596541B2 (en) * | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
EP1364007A1 (en) * | 2000-11-07 | 2003-11-26 | Wilfried A. Jefferies | Circular extra-chromosomal dna elements |
US7126039B2 (en) * | 2001-03-21 | 2006-10-24 | Geron Corporation | Animal tissue with carbohydrate antigens compatible for human transplantation |
US7674621B2 (en) * | 2004-05-21 | 2010-03-09 | The United States Of America As Represented By The Department Of Health And Human Services | Plasmids and phages for homologous recombination and methods of use |
WO2006130925A1 (en) * | 2005-06-10 | 2006-12-14 | Monash University | Genetic manipulation of clostridium difficile |
EP2357184B1 (en) | 2006-03-23 | 2015-02-25 | Novartis AG | Imidazoquinoxaline compounds as immunomodulators |
EP2007765B1 (en) | 2006-03-23 | 2012-06-27 | Novartis AG | Immunopotentiating compounds |
CN101983070B (zh) * | 2008-02-20 | 2016-03-30 | 格林考瓦因有限公司 | 由来源于原核细胞的重组n-糖基化蛋白制备生物共轭物 |
WO2011138361A1 (en) | 2010-05-06 | 2011-11-10 | Glycovaxyn | Capsular gram-positive bacteria bioconjugate vaccines |
-
2013
- 2013-10-11 MX MX2015004649A patent/MX365435B/es active IP Right Grant
- 2013-10-11 US US14/434,945 patent/US20150267207A1/en not_active Abandoned
- 2013-10-11 AU AU2013328615A patent/AU2013328615B2/en not_active Expired - Fee Related
- 2013-10-11 EP EP13774455.3A patent/EP2906681B1/en active Active
- 2013-10-11 SG SG11201502638YA patent/SG11201502638YA/en unknown
- 2013-10-11 KR KR1020157012449A patent/KR20150068998A/ko not_active Application Discontinuation
- 2013-10-11 JP JP2015536160A patent/JP6329554B2/ja active Active
- 2013-10-11 EP EP19150645.0A patent/EP3527663B1/en active Active
- 2013-10-11 EA EA201590488A patent/EA201590488A1/ru unknown
- 2013-10-11 CA CA2887133A patent/CA2887133C/en active Active
- 2013-10-11 ES ES19150645T patent/ES2905107T3/es active Active
- 2013-10-11 WO PCT/EP2013/071328 patent/WO2014057109A1/en active Application Filing
- 2013-10-11 SG SG10201800777PA patent/SG10201800777PA/en unknown
- 2013-10-11 CN CN201811620603.6A patent/CN110423716A/zh active Pending
- 2013-10-11 ES ES13774455T patent/ES2720040T3/es active Active
- 2013-10-11 TR TR2019/04022T patent/TR201904022T4/tr unknown
- 2013-10-11 BR BR112015008052A patent/BR112015008052A2/pt not_active Application Discontinuation
- 2013-10-11 CN CN201380065287.XA patent/CN104837984A/zh active Pending
-
2015
- 2015-03-30 IL IL238024A patent/IL238024A0/en unknown
- 2015-04-10 ZA ZA2015/02433A patent/ZA201502433B/en unknown
-
2019
- 2019-03-13 US US16/352,462 patent/US20190218561A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
MX2015004649A (es) | 2016-01-12 |
WO2014057109A1 (en) | 2014-04-17 |
KR20150068998A (ko) | 2015-06-22 |
EP3527663B1 (en) | 2021-12-01 |
SG10201800777PA (en) | 2018-02-27 |
IL238024A0 (en) | 2015-05-31 |
US20150267207A1 (en) | 2015-09-24 |
CN104837984A (zh) | 2015-08-12 |
EA201590488A1 (ru) | 2015-09-30 |
CA2887133A1 (en) | 2014-04-17 |
AU2013328615B2 (en) | 2017-04-20 |
ZA201502433B (en) | 2017-11-29 |
JP6329554B2 (ja) | 2018-05-23 |
ES2720040T3 (es) | 2019-07-17 |
EP3527663A1 (en) | 2019-08-21 |
AU2013328615A1 (en) | 2015-04-30 |
EP2906681B1 (en) | 2019-01-09 |
BR112015008052A2 (pt) | 2017-11-28 |
TR201904022T4 (tr) | 2019-04-22 |
SG11201502638YA (en) | 2015-05-28 |
CA2887133C (en) | 2022-05-03 |
US20190218561A1 (en) | 2019-07-18 |
JP2015533497A (ja) | 2015-11-26 |
EP2906681A1 (en) | 2015-08-19 |
ES2905107T3 (es) | 2022-04-07 |
CN110423716A (zh) | 2019-11-08 |
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