MA42902A - Lymphocytes infiltrant la moelle (mil) en tant que source de lymphocytes t pour une thérapie par des récepteurs chimériques d'un antigène (car) - Google Patents
Lymphocytes infiltrant la moelle (mil) en tant que source de lymphocytes t pour une thérapie par des récepteurs chimériques d'un antigène (car)Info
- Publication number
- MA42902A MA42902A MA42902A MA42902A MA42902A MA 42902 A MA42902 A MA 42902A MA 42902 A MA42902 A MA 42902A MA 42902 A MA42902 A MA 42902A MA 42902 A MA42902 A MA 42902A
- Authority
- MA
- Morocco
- Prior art keywords
- lymphocytes
- antigen receptor
- mil
- car
- marinal
- Prior art date
Links
- 210000004698 lymphocyte Anatomy 0.000 title abstract 2
- 102000006306 Antigen Receptors Human genes 0.000 title 1
- 108010083359 Antigen Receptors Proteins 0.000 title 1
- 210000001744 T-lymphocyte Anatomy 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 244000062793 Sorghum vulgare Species 0.000 abstract 4
- 235000019713 millet Nutrition 0.000 abstract 4
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 abstract 2
- 210000001185 bone marrow Anatomy 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 230000002463 transducing effect Effects 0.000 abstract 1
- 230000001131 transforming effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4631—Chimeric Antigen Receptors [CAR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
- A61K39/464411—Immunoglobulin superfamily
- A61K39/464412—CD19 or B4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0635—B lymphocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Abstract
Dans certains modes de réalisation, des lymphocytes infiltrant la moelle («mil») comprenant un récepteur d'antigène chimère («car») sont fournis. Dans certains aspects, les modes de réalisation concernent un procédé de fabrication d'un mil recombinant, comprenant l'obtention d'une moelle osseuse comprenant des mils; et transfectant, transformant ou transduisant les mil avec un acide nucléique codant pour un récepteur d'antigène chimère. Dans certains aspects, les modes de réalisation concernent une méthode de traitement d'une condition chez un sujet, comprenant l'administration au sujet d'un mil comprenant un car.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562189928P | 2015-07-08 | 2015-07-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA42902A true MA42902A (fr) | 2018-05-16 |
Family
ID=57686063
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA42902A MA42902A (fr) | 2015-07-08 | Lymphocytes infiltrant la moelle (mil) en tant que source de lymphocytes t pour une thérapie par des récepteurs chimériques d'un antigène (car) |
Country Status (12)
Country | Link |
---|---|
US (3) | US11478548B2 (fr) |
EP (1) | EP3320087A4 (fr) |
JP (2) | JP2018518978A (fr) |
KR (1) | KR20180039068A (fr) |
CN (1) | CN108026510A (fr) |
AU (1) | AU2016291199B2 (fr) |
CA (1) | CA2990694A1 (fr) |
HK (2) | HK1254313A1 (fr) |
IL (1) | IL256434A (fr) |
MA (1) | MA42902A (fr) |
MX (1) | MX2017017083A (fr) |
WO (1) | WO2017008019A1 (fr) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MA42902A (fr) | 2015-07-08 | 2018-05-16 | Univ Johns Hopkins | Lymphocytes infiltrant la moelle (mil) en tant que source de lymphocytes t pour une thérapie par des récepteurs chimériques d'un antigène (car) |
GB201700621D0 (en) | 2017-01-13 | 2017-03-01 | Guest Ryan Dominic | Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue |
WO2018209115A1 (fr) * | 2017-05-10 | 2018-11-15 | Iovance Biotherapeutics, Inc. | Expansion de lymphocytes infiltrant des tumeurs à partir de tumeurs liquides et leurs utilisations thérapeutiques |
EP3714041A1 (fr) * | 2017-11-22 | 2020-09-30 | Iovance Biotherapeutics, Inc. | Expansion de lymphocytes de sang périphérique (pbl) à partir de sang périphérique |
EP3765094A4 (fr) | 2018-03-15 | 2021-12-22 | KSQ Therapeutics, Inc. | Compositions de régulation génique et procédés pour améliorer l'immunothérapie |
CN112074280A (zh) * | 2018-03-22 | 2020-12-11 | 温德弥尔治疗公司 | 前列腺癌特异性骨髓浸润淋巴细胞及其用途 |
EP3806910A4 (fr) * | 2018-06-12 | 2022-06-29 | H. Lee Moffitt Cancer Center & Research Institute, Inc. | Lymphocytes infiltrant une tumeur à récepteur d'antigène chimère |
JPWO2020004337A1 (ja) * | 2018-06-27 | 2021-08-02 | 国立大学法人東海国立大学機構 | Cd37特異的キメラ抗原レセプター |
WO2020011247A1 (fr) * | 2018-07-13 | 2020-01-16 | Nanjing Legend Biotech Co., Ltd. | Systèmes co-récepteurs pour le traitement de maladies infectieuses |
JP2022507113A (ja) * | 2018-11-05 | 2022-01-18 | ウィンドミル セラピューティクス インコーポレイテッド | クローン性の増大した骨髄浸潤リンパ球およびそれらの使用 |
JP2022513687A (ja) * | 2018-11-30 | 2022-02-09 | ウィンドミル セラピューティクス インコーポレイテッド | キメラ抗原受容体(car)を発現する骨髄浸潤リンパ球(mil)、その製造方法および治療における使用方法 |
WO2020198031A1 (fr) * | 2019-03-22 | 2020-10-01 | Windmil Therapeutics Inc. | Lymphocytes infiltrant la moelle spécifiques au cancer du poumon et utilisations associées |
MX2022007598A (es) | 2019-12-20 | 2022-09-23 | Instil Bio Uk Ltd | Dispositivos y métodos para el aislamiento de linfocitos infiltrantes de tumores y usos de los mismos. |
US20230100744A1 (en) * | 2020-02-28 | 2023-03-30 | Windmil Therapeutics, Inc. | Methods for enriching marrow infiltrating lymphocytes ("mils"), compositions containing enriched mils, and methods of using enriched mils |
WO2022066872A1 (fr) * | 2020-09-24 | 2022-03-31 | Windmil Therapeutics, Inc. | Lymphocytes infiltrant la moelle (mil) exprimant des récepteurs de lymphocytes t, procédés de fabrication de ceux-ci et procédé d'utilisation en thérapie |
WO2022076606A1 (fr) * | 2020-10-06 | 2022-04-14 | Iovance Biotherapeutics, Inc. | Traitement de patients souffrant de cpnpc avec des thérapies de lymphocytes infiltrant les tumeurs |
CA3195019A1 (fr) * | 2020-10-06 | 2022-04-14 | Maria Fardis | Traitement de patients souffrant de cpnpc avec des therapies de lymphocytes infiltrant les tumeurs |
WO2022098985A1 (fr) * | 2020-11-05 | 2022-05-12 | Windmil Therapeutics, Inc. | Lymphocytes infiltrant la moelle spécifique d'un glioblastome et utilisations associées |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20110223146A1 (en) * | 2008-11-03 | 2011-09-15 | The Johns Hopkins University | Methods for preparation and use of marrow infiltratng lymphoctyes (mils) |
NZ612512A (en) * | 2010-12-09 | 2015-03-27 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
WO2013063419A2 (fr) * | 2011-10-28 | 2013-05-02 | The Trustees Of The University Of Pennsylvania | Récepteur immunitaire chimérique spécifique complètement humain, anti-mésothéline pour un ciblage redirigé de cellules exprimant la mésothéline |
WO2013109759A1 (fr) * | 2012-01-17 | 2013-07-25 | Northeastern University | Méthodes et compositions de développement in vitro de lymphocytes t régulateurs immunosuppresseurs et utilisations de celles-ci |
US9765156B2 (en) * | 2012-07-13 | 2017-09-19 | The Trustees Of The University Of Pennsylvania | Enhancing activity of CAR T cells by co-introducing a bispecific antibody |
ES2862433T3 (es) * | 2012-11-27 | 2021-10-07 | Ivan Marques Borrello | Uso de linfocitos infiltrantes de médula ósea alogénicos tratados con ciclofosfamida postrasplante para aumentar la inmunidad antitumoral |
UY35468A (es) * | 2013-03-16 | 2014-10-31 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19 |
CA2934436A1 (fr) * | 2013-12-20 | 2015-06-25 | Cellectis | Procede d'ingenierie de lymphocytes t sensibles a de multiples signaux d'entree a des fins d'immunotherapie |
KR20170067751A (ko) * | 2014-09-04 | 2017-06-16 | 더 존스 홉킨스 유니버시티 | 저산소 및 정상산소 교대 조건에서 골수 침윤성 림프구의 활성화 |
MX2018000278A (es) * | 2015-06-29 | 2018-03-08 | Univ Johns Hopkins | Terapia de receptores quimericos de puntos de control inmunitarios. |
MA42902A (fr) | 2015-07-08 | 2018-05-16 | Univ Johns Hopkins | Lymphocytes infiltrant la moelle (mil) en tant que source de lymphocytes t pour une thérapie par des récepteurs chimériques d'un antigène (car) |
-
0
- MA MA42902A patent/MA42902A/fr unknown
-
2016
- 2016-07-08 MX MX2017017083A patent/MX2017017083A/es unknown
- 2016-07-08 CA CA2990694A patent/CA2990694A1/fr active Pending
- 2016-07-08 WO PCT/US2016/041521 patent/WO2017008019A1/fr active Application Filing
- 2016-07-08 KR KR1020187003768A patent/KR20180039068A/ko not_active Application Discontinuation
- 2016-07-08 AU AU2016291199A patent/AU2016291199B2/en active Active
- 2016-07-08 JP JP2017568133A patent/JP2018518978A/ja not_active Withdrawn
- 2016-07-08 EP EP16822042.4A patent/EP3320087A4/fr active Pending
- 2016-07-08 US US15/742,684 patent/US11478548B2/en active Active
- 2016-07-08 CN CN201680051121.6A patent/CN108026510A/zh active Pending
-
2017
- 2017-12-20 IL IL256434A patent/IL256434A/en unknown
-
2018
- 2018-10-16 HK HK18113281.1A patent/HK1254313A1/zh unknown
- 2018-11-09 HK HK18114336.4A patent/HK1255208A1/zh unknown
-
2021
- 2021-06-07 JP JP2021095119A patent/JP2021121230A/ja active Pending
-
2022
- 2022-09-15 US US17/945,729 patent/US20230016031A1/en active Pending
- 2022-11-30 US US18/072,164 patent/US20230210990A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
HK1254313A1 (zh) | 2019-07-19 |
US20230210990A1 (en) | 2023-07-06 |
JP2021121230A (ja) | 2021-08-26 |
AU2016291199A1 (en) | 2018-02-15 |
AU2016291199B2 (en) | 2022-12-22 |
IL256434A (en) | 2018-02-28 |
WO2017008019A1 (fr) | 2017-01-12 |
EP3320087A1 (fr) | 2018-05-16 |
US20230016031A1 (en) | 2023-01-19 |
EP3320087A4 (fr) | 2019-01-23 |
JP2018518978A (ja) | 2018-07-19 |
CN108026510A (zh) | 2018-05-11 |
CA2990694A1 (fr) | 2017-01-12 |
KR20180039068A (ko) | 2018-04-17 |
US11478548B2 (en) | 2022-10-25 |
US20180200367A1 (en) | 2018-07-19 |
MX2017017083A (es) | 2018-05-23 |
HK1255208A1 (zh) | 2019-08-09 |
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