PE20141908A1 - Anticuerpos cd47 y metodos de uso los mismos - Google Patents

Anticuerpos cd47 y metodos de uso los mismos

Info

Publication number
PE20141908A1
PE20141908A1 PE2014001225A PE2014001225A PE20141908A1 PE 20141908 A1 PE20141908 A1 PE 20141908A1 PE 2014001225 A PE2014001225 A PE 2014001225A PE 2014001225 A PE2014001225 A PE 2014001225A PE 20141908 A1 PE20141908 A1 PE 20141908A1
Authority
PE
Peru
Prior art keywords
seq
established
sequence
cdr1
cdr2
Prior art date
Application number
PE2014001225A
Other languages
English (en)
Inventor
Brendan Eckelman
John Timmer
Amir Razai
Quinn Deveraux
Kyle Jones
Peter L Nguy
Original Assignee
Inhibrx Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48947976&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20141908(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Inhibrx Llc filed Critical Inhibrx Llc
Publication of PE20141908A1 publication Critical patent/PE20141908A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

SE REFIERE A UN ANTICUERPO MONOCLONAL AISLADO QUE SE UNE A CD47 O UN FRAGMENTO INMUNOLOGICAMENTE ACTIVO DEL MISMO, EL CUAL COMPRENDE: A) UNA REGION DE CADENA PESADA VARIABLE (VH) QUE CONTIENE UNA SECUENCIA DE AMINOACIDOS SELECCIONADA DE LA SEQ ID N�: 5 A 30; B) UNA REGION DE CADENA LIVIANA VARIABLE (VL) QUE CONTIENE UNA SECUENCIA DE AMINOACIDOS SELECCIONADA DE LA SEQ ID N�: 31 A 47; C) UNA SECUENCIA DE i) CDR1 DE VH ESTABLECIDA EN LA SEQ ID N�: 50, 57, 58, 59, ENTRE OTROS, ii) CDR2 DE VH ESTABLECIDA EN LA SEQ ID N�: 51, 72, 73, 74, ENTRE OTROS, Y iii) CDR3 DE VH ESTABLECIDA EN LA SEQ ID N�: 52 O 77; Y D) UNA SECUENCIA DE i) CDR1 DE VL ESTABLECIDA EN LA SEQ ID N�: 53, 67 O 68, ii) CDR2 DE VL ESTABLECIDA EN LA SEQ ID N�: 54, 69, 70 O 71, Y iii) CDR3 DE VL ESTABLECIDA EN LA SEQ ID N�: 55; EN DONDE EL ANTICUERPO PROMUEVE LA FAGOCITOSIS MEDIADA POR MACROFAGO DE UNA CELULA QUE EXPRESA CD47 Y NO PROVOCA UN NIVEL SIGNIFICATIVO DE AGLUTINACION DE CELULAS DESPUES DE SU ADMINISTRACION. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA UTIL EN EL TRATAMIENTO DE CANCER
PE2014001225A 2012-02-06 2013-02-06 Anticuerpos cd47 y metodos de uso los mismos PE20141908A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261595216P 2012-02-06 2012-02-06
US201261659752P 2012-06-14 2012-06-14

Publications (1)

Publication Number Publication Date
PE20141908A1 true PE20141908A1 (es) 2014-12-21

Family

ID=48947976

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2014001225A PE20141908A1 (es) 2012-02-06 2013-02-06 Anticuerpos cd47 y metodos de uso los mismos

Country Status (35)

Country Link
US (4) US9045541B2 (es)
EP (2) EP2812443B1 (es)
JP (1) JP6273212B2 (es)
KR (2) KR102338833B1 (es)
CN (2) CN104271757B (es)
AU (1) AU2013217114B2 (es)
BR (1) BR112014019331A2 (es)
CA (1) CA2863834C (es)
CL (1) CL2014002086A1 (es)
CO (1) CO7111273A2 (es)
CR (1) CR20140406A (es)
CY (1) CY1121911T1 (es)
DK (1) DK2812443T3 (es)
EA (1) EA034778B1 (es)
EC (1) ECSP14016994A (es)
ES (1) ES2743203T3 (es)
HR (1) HRP20191500T1 (es)
HU (1) HUE13746964T2 (es)
IL (1) IL233934B (es)
LT (1) LT2812443T (es)
ME (1) ME03512B (es)
MX (1) MX360772B (es)
MY (1) MY169341A (es)
NZ (1) NZ628314A (es)
PE (1) PE20141908A1 (es)
PH (1) PH12014501758B1 (es)
PL (1) PL2812443T3 (es)
PT (1) PT2812443T (es)
RS (1) RS59159B1 (es)
SG (2) SG10201700160RA (es)
SI (1) SI2812443T1 (es)
SM (1) SMT201900453T1 (es)
UA (1) UA116772C2 (es)
WO (1) WO2013119714A1 (es)
ZA (1) ZA201405864B (es)

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