ATE538129T1 - Nicht natürliches proteinöses gerüst aus drei nicht kovalent assoziierten peptiden - Google Patents

Nicht natürliches proteinöses gerüst aus drei nicht kovalent assoziierten peptiden

Info

Publication number
ATE538129T1
ATE538129T1 AT08803854T AT08803854T ATE538129T1 AT E538129 T1 ATE538129 T1 AT E538129T1 AT 08803854 T AT08803854 T AT 08803854T AT 08803854 T AT08803854 T AT 08803854T AT E538129 T1 ATE538129 T1 AT E538129T1
Authority
AT
Austria
Prior art keywords
residues
natural
core
amino acid
peptide sequences
Prior art date
Application number
AT08803854T
Other languages
English (en)
Inventor
Johan Desmet
Ignace Lasters
Original Assignee
Complix N V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Complix N V filed Critical Complix N V
Application granted granted Critical
Publication of ATE538129T1 publication Critical patent/ATE538129T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2318/00—Antibody mimetics or scaffolds
    • C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT08803854T 2007-09-07 2008-09-08 Nicht natürliches proteinöses gerüst aus drei nicht kovalent assoziierten peptiden ATE538129T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97060707P 2007-09-07 2007-09-07
PCT/EP2008/061886 WO2009030780A2 (en) 2007-09-07 2008-09-08 Non-natural proteinaceous scaffold made of three non-covalently associated peptides

Publications (1)

Publication Number Publication Date
ATE538129T1 true ATE538129T1 (de) 2012-01-15

Family

ID=40349228

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08803854T ATE538129T1 (de) 2007-09-07 2008-09-08 Nicht natürliches proteinöses gerüst aus drei nicht kovalent assoziierten peptiden

Country Status (4)

Country Link
US (1) US9217011B2 (de)
EP (1) EP2188303B1 (de)
AT (1) ATE538129T1 (de)
WO (1) WO2009030780A2 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2161278B1 (de) * 2008-09-08 2012-05-23 Complix N.V. Gewundenes Spulengerüst aus einer einzelnen Kette
DK2367840T3 (en) 2008-12-08 2015-10-12 Complix N V SINGLE CHAIN ​​antiparallel coiled-coil PROTEINS
PE20120591A1 (es) 2009-04-02 2012-05-23 Roche Glycart Ag Anticuerpos multiespecificos que comprenden anticuerpos de longitud completa y fragmentos fab de cadena sencilla
GB2471693A (en) * 2009-07-08 2011-01-12 Complix Nv Parathyroid hormone related protein antagonists
GB2471692A (en) * 2009-07-08 2011-01-12 Complix Nv HIV gp41-binding single-chain coiled-coil peptide comprising heptad repeats
WO2011034605A2 (en) * 2009-09-16 2011-03-24 Genentech, Inc. Coiled coil and/or tether containing protein complexes and uses thereof
RU2013110875A (ru) 2010-08-24 2014-09-27 Ф.Хоффманн-Ля Рош Аг БИСПЕЦИФИЧЕСКИЕ АНТИТЕЛА, СОДЕРЖАЩИЕ СТАБИЛИЗИРОВАННЫЙ ДИСУЛЬФИДОМ ФРАГМЕНТ Fv
EP2656079A2 (de) 2010-12-20 2013-10-30 Universiteit Gent Kristallstruktur eines flt3-ligand-rezeptorkomplexes
JP5766296B2 (ja) 2010-12-23 2015-08-19 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ポリペプチド−ポリヌクレオチド複合体、およびエフェクター成分の標的化された送達におけるその使用
US20140294828A1 (en) * 2011-01-06 2014-10-02 Complix Sa Alphabodies specifically binding to viral proteins and methods for producing the same
CN103328507B (zh) * 2011-01-06 2016-09-07 康普里斯股份有限公司 Alphabody文库及其产生方法
MX2014009565A (es) 2012-02-10 2014-11-10 Genentech Inc Anticuerpos monocatenarios y otros heteromultimeros.
JP6203838B2 (ja) 2012-06-27 2017-09-27 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 少なくとも２つの異なる結合実体を含む、テーラーメイドの高度に選択的かつ多重特異的なターゲティング実体を選択および作製するための方法、ならびにその使用
RU2015100656A (ru) 2012-06-27 2016-08-20 Ф. Хоффманн-Ля Рош Аг Способ получения конъюгатов fc-фрагмента антитела, включающих по меньшей мере одну связывающую группировку, которая специфически связывается с мишенью, и их применения
EP2951298A1 (de) 2013-01-29 2015-12-09 The University Court of The University Of Glasgow Verfahren und mittels zur erhöhung der stresstoleranz und biomasse in pflanzen
PL3017049T3 (pl) 2013-07-01 2019-06-28 Bayer Cropscience Nv Sposoby i środki do modulowania czasu kwitnienia roślin jednoliściennych
WO2016050512A1 (en) 2014-10-03 2016-04-07 Bayer Cropscience Nv Methods and means for increasing stress tolerance and biomass in plants
WO2016087416A1 (en) 2014-12-03 2016-06-09 F. Hoffmann-La Roche Ag Multispecific antibodies
EP3361858A1 (de) 2015-10-16 2018-08-22 Bayer CropScience NV Brassica-pflanzen mit veränderten eigenschaften in der saatgutproduktion
CN106831997B (zh) * 2015-12-03 2020-04-24 中国科学院苏州纳米技术与纳米仿生研究所 多肽、脂蛋白样纳米粒子及其应用
MA52591A (fr) 2018-07-12 2021-06-02 Hexamer Therapeutics Inc Échafaudage peptidique autoassemblé
AU2019371462A1 (en) 2018-11-02 2021-05-20 University Of Washington Orthogonal protein heterodimers
CN113943353B (zh) * 2021-10-27 2024-05-03 百葵锐(深圳)生物科技有限公司 一种宽应激范围的智能多肽及其应用
KR20240149030A (ko) 2023-04-04 2024-10-14 주식회사 지놈앤컴퍼니 항-bcam 항체 및 항체-약물 접합체

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Publication number Priority date Publication date Assignee Title
US5824483A (en) * 1994-05-18 1998-10-20 Pence Inc. Conformationally-restricted combinatiorial library composition and method
US6303317B1 (en) * 1997-01-28 2001-10-16 The Regents Of The University Of California Peptide probes and methods for making the same
ATE282092T1 (de) 1997-06-11 2004-11-15 Borean Pharma As Trimerisierendes modul
AU9678598A (en) 1997-10-01 1999-04-23 Dana-Farber Cancer Institute Stabilization of envelope glycoprotein trimers by disulfide bonds introduced into a gp41 glycoprotein ectodomain
US6828106B2 (en) * 1999-02-26 2004-12-07 Cyclacel Limited Methods and compositions using coiled binding partners
US6872806B1 (en) * 1999-06-25 2005-03-29 The Governors Of The University Of Alberta Polypeptide compositions formed using a coiled-coil template and methods of use
ES2296665T3 (es) * 1999-12-16 2008-05-01 Whitehead Institute For Biomedical Research Proteina cinco-helice.
AU2001269833A1 (en) * 2000-06-14 2001-12-24 Cytovax Biotechnologies, Inc. Use of coiled-coil structural scaffold to generate structure-specific peptides
AU2003265420A1 (en) 2003-08-14 2005-03-10 The Government Of The United States Of America, As Represented By The Department Of Health And Human Services Polypeptide multimers having antiviral activity
US20080027006A1 (en) * 2004-02-12 2008-01-31 The Regents Of The University Of Colorado Compositions And Methods For Modification And Prevention Of Sars Coronavirus Infectivity
JP5069558B2 (ja) 2004-06-01 2012-11-07 メルク・シャープ・エンド・ドーム・コーポレイション ＨＩＶｇｐ４１融合中間物質の安定したペプチド模倣薬
DK2367840T3 (en) * 2008-12-08 2015-10-12 Complix N V SINGLE CHAIN ​​antiparallel coiled-coil PROTEINS
GB2471692A (en) * 2009-07-08 2011-01-12 Complix Nv HIV gp41-binding single-chain coiled-coil peptide comprising heptad repeats

Also Published As

Publication number Publication date
EP2188303B1 (de) 2011-12-21
EP2188303A2 (de) 2010-05-26
WO2009030780A3 (en) 2009-04-30
US20100305304A1 (en) 2010-12-02
US9217011B2 (en) 2015-12-22
WO2009030780A2 (en) 2009-03-12

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