ATE538129T1 - Nicht natürliches proteinöses gerüst aus drei nicht kovalent assoziierten peptiden - Google Patents

Nicht natürliches proteinöses gerüst aus drei nicht kovalent assoziierten peptiden

Info

Publication number
ATE538129T1
ATE538129T1 AT08803854T AT08803854T ATE538129T1 AT E538129 T1 ATE538129 T1 AT E538129T1 AT 08803854 T AT08803854 T AT 08803854T AT 08803854 T AT08803854 T AT 08803854T AT E538129 T1 ATE538129 T1 AT E538129T1
Authority
AT
Austria
Prior art keywords
residues
natural
core
amino acid
peptide sequences
Prior art date
Application number
AT08803854T
Other languages
English (en)
Inventor
Johan Desmet
Ignace Lasters
Original Assignee
Complix N V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Complix N V filed Critical Complix N V
Application granted granted Critical
Publication of ATE538129T1 publication Critical patent/ATE538129T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2318/00—Antibody mimetics or scaffolds
    • C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT08803854T 2007-09-07 2008-09-08 Nicht natürliches proteinöses gerüst aus drei nicht kovalent assoziierten peptiden ATE538129T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97060707P 2007-09-07 2007-09-07
PCT/EP2008/061886 WO2009030780A2 (en) 2007-09-07 2008-09-08 Non-natural proteinaceous scaffold made of three non-covalently associated peptides

Publications (1)

Publication Number Publication Date
ATE538129T1 true ATE538129T1 (de) 2012-01-15

Family

ID=40349228

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08803854T ATE538129T1 (de) 2007-09-07 2008-09-08 Nicht natürliches proteinöses gerüst aus drei nicht kovalent assoziierten peptiden

Country Status (4)

Country Link
US (1) US9217011B2 (de)
EP (1) EP2188303B1 (de)
AT (1) ATE538129T1 (de)
WO (1) WO2009030780A2 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2161278B1 (de) * 2008-09-08 2012-05-23 Complix N.V. Gewundenes Spulengerüst aus einer einzelnen Kette
JP2012510806A (ja) * 2008-12-08 2012-05-17 コンプリクス エン ヴェー 単鎖逆平行コイルドコイルタンパク質
EP2414391B1 (de) 2009-04-02 2018-11-28 Roche Glycart AG Multispezifische antikörper, umfassend vollständige antikörper und einzelketten-fab-fragmente
GB2471693A (en) * 2009-07-08 2011-01-12 Complix Nv Parathyroid hormone related protein antagonists
GB2471692A (en) * 2009-07-08 2011-01-12 Complix Nv HIV gp41-binding single-chain coiled-coil peptide comprising heptad repeats
US20120302737A1 (en) 2009-09-16 2012-11-29 Genentech, Inc. Coiled coil and/or tether containing protein complexes and uses thereof
EP2609111B1 (de) 2010-08-24 2017-11-01 F. Hoffmann-La Roche AG Bispezifische antikörper die ein disulfid-stabilisiertes fv enthalten
WO2012084895A2 (en) 2010-12-20 2012-06-28 Universiteit Gent Crystal structure of flt3 ligand-receptor complex
JP5766296B2 (ja) 2010-12-23 2015-08-19 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ポリペプチド−ポリヌクレオチド複合体、およびエフェクター成分の標的化された送達におけるその使用
EP2661443B1 (de) * 2011-01-06 2015-09-23 Complix SA Spezifisch an virale proteine bindende alphakörper und verfahren zu ihrer herstellung
CA2821579C (en) * 2011-01-06 2019-01-22 Complix Sa Alphabody libraries and methods for producing the same
BR112014019579A2 (pt) 2012-02-10 2019-10-15 Genentech, Inc Anticorpo de cadeia única, polinucleotídeo, vetor, célula hospedeira, método de produção de um anticorpo de cadeia única, heteromultímero e método de produção do heteromultímero
EP2867253B1 (de) 2012-06-27 2016-09-14 F. Hoffmann-La Roche AG Verfahren zur auswahl und herstellung massgeschneiderter, hochselektiver und multispezifischer targeting-einheiten mit mindestens zwei verschiedenen bindungseinheiten sowie verwendungen davon
JP6309002B2 (ja) 2012-06-27 2018-04-11 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 標的に特異的に結合する少なくとも１つの結合実体を含む抗体Ｆｃ領域結合体を作製するための方法およびその使用
CN104955947A (zh) 2013-01-29 2015-09-30 格拉斯哥大学董事会 用于增加植物中胁迫耐受性和生物量的方法和工具
EP3017049B1 (de) 2013-07-01 2018-08-22 Bayer CropScience NV Verfahren und mittel zur modulierung der blütezeit bei einkeimblättrigen pflanzen
WO2016050512A1 (en) 2014-10-03 2016-04-07 Bayer Cropscience Nv Methods and means for increasing stress tolerance and biomass in plants
CN107001482B (zh) 2014-12-03 2021-06-15 豪夫迈·罗氏有限公司 多特异性抗体
US20190153456A1 (en) 2015-10-16 2019-05-23 Bayer Cropscience Nv Brassica plants with altered properties in seed production
CN106831997B (zh) * 2015-12-03 2020-04-24 中国科学院苏州纳米技术与纳米仿生研究所 多肽、脂蛋白样纳米粒子及其应用
BR112021000455A2 (pt) * 2018-07-12 2021-04-06 Hexamer Therapeutics, Inc. Suporte de peptídeo de automontagem
KR20210087959A (ko) * 2018-11-02 2021-07-13 유니버시티 오브 워싱톤 직교 단백질 이종이량체
CN118307642A (zh) * 2021-10-27 2024-07-09 百葵锐(深圳)生物科技有限公司 一种宽应激范围的智能多肽及其应用

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Publication number Priority date Publication date Assignee Title
US5824483A (en) 1994-05-18 1998-10-20 Pence Inc. Conformationally-restricted combinatiorial library composition and method
WO1998032848A1 (en) 1997-01-28 1998-07-30 The Regents Of The University Of California Peptide probes to coil proteins and methods for making the same
ES2231991T3 (es) 1997-06-11 2005-05-16 Borean Pharma A/S Modulo de trimerizacion.
AU9678598A (en) 1997-10-01 1999-04-23 Dana-Farber Cancer Institute Stabilization of envelope glycoprotein trimers by disulfide bonds introduced into a gp41 glycoprotein ectodomain
US6828106B2 (en) * 1999-02-26 2004-12-07 Cyclacel Limited Methods and compositions using coiled binding partners
US6872806B1 (en) 1999-06-25 2005-03-29 The Governors Of The University Of Alberta Polypeptide compositions formed using a coiled-coil template and methods of use
EP1237912B1 (de) 1999-12-16 2007-12-12 Whitehead Institute For Biomedical Research Funf-helix protein
JP2004503565A (ja) 2000-06-14 2004-02-05 サイトヴァックス・バイオテクノロジーズ・インコーポレーテッド 構造特異的ペプチドを生産するためのコイルドコイル構造的骨格の使用
AU2003265420A1 (en) 2003-08-14 2005-03-10 The Government Of The United States Of America, As Represented By The Department Of Health And Human Services Polypeptide multimers having antiviral activity
WO2005077103A2 (en) * 2004-02-12 2005-08-25 Regents Of The University Of Colorado Compositions and methods for modification and prevention of sars coronavirus infectivity
CN1968710B (zh) 2004-06-01 2013-12-25 默沙东公司 HIV gp41融合中间体的稳定的肽模拟物
JP2012510806A (ja) 2008-12-08 2012-05-17 コンプリクス エン ヴェー 単鎖逆平行コイルドコイルタンパク質
GB2471692A (en) 2009-07-08 2011-01-12 Complix Nv HIV gp41-binding single-chain coiled-coil peptide comprising heptad repeats

Also Published As

Publication number Publication date
EP2188303B1 (de) 2011-12-21
US20100305304A1 (en) 2010-12-02
WO2009030780A3 (en) 2009-04-30
US9217011B2 (en) 2015-12-22
EP2188303A2 (de) 2010-05-26
WO2009030780A2 (en) 2009-03-12

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