ATE538129T1 - Nicht natürliches proteinöses gerüst aus drei nicht kovalent assoziierten peptiden - Google Patents

Nicht natürliches proteinöses gerüst aus drei nicht kovalent assoziierten peptiden

Info

Publication number
ATE538129T1
ATE538129T1 AT08803854T AT08803854T ATE538129T1 AT E538129 T1 ATE538129 T1 AT E538129T1 AT 08803854 T AT08803854 T AT 08803854T AT 08803854 T AT08803854 T AT 08803854T AT E538129 T1 ATE538129 T1 AT E538129T1
Authority
AT
Austria
Prior art keywords
residues
natural
core
amino acid
peptide sequences
Prior art date
Application number
AT08803854T
Other languages
English (en)
Inventor
Johan Desmet
Ignace Lasters
Original Assignee
Complix N V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Complix N V filed Critical Complix N V
Application granted granted Critical
Publication of ATE538129T1 publication Critical patent/ATE538129T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2318/00—Antibody mimetics or scaffolds
    • C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT08803854T 2007-09-07 2008-09-08 Nicht natürliches proteinöses gerüst aus drei nicht kovalent assoziierten peptiden ATE538129T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97060707P 2007-09-07 2007-09-07
PCT/EP2008/061886 WO2009030780A2 (en) 2007-09-07 2008-09-08 Non-natural proteinaceous scaffold made of three non-covalently associated peptides

Publications (1)

Publication Number Publication Date
ATE538129T1 true ATE538129T1 (de) 2012-01-15

Family

ID=40349228

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08803854T ATE538129T1 (de) 2007-09-07 2008-09-08 Nicht natürliches proteinöses gerüst aus drei nicht kovalent assoziierten peptiden

Country Status (4)

Country Link
US (1) US9217011B2 (de)
EP (1) EP2188303B1 (de)
AT (1) ATE538129T1 (de)
WO (1) WO2009030780A2 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2161278B1 (de) * 2008-09-08 2012-05-23 Complix N.V. Gewundenes Spulengerüst aus einer einzelnen Kette
JP2012510806A (ja) * 2008-12-08 2012-05-17 コンプリクス エン ヴェー 単鎖逆平行コイルドコイルタンパク質
CN102369215B (zh) 2009-04-02 2015-01-21 罗切格利卡特公司 包含全长抗体和单链Fab片段的多特异性抗体
GB2471693A (en) * 2009-07-08 2011-01-12 Complix Nv Parathyroid hormone related protein antagonists
GB2471692A (en) * 2009-07-08 2011-01-12 Complix Nv HIV gp41-binding single-chain coiled-coil peptide comprising heptad repeats
JP6091894B2 (ja) * 2009-09-16 2017-03-15 ジェネンテック， インコーポレイテッド コイルドコイルおよび／またはテザー含有タンパク質複合体およびその使用
WO2012025530A1 (en) 2010-08-24 2012-03-01 F. Hoffmann-La Roche Ag Bispecific antibodies comprising a disulfide stabilized - fv fragment
US20130288373A1 (en) 2010-12-20 2013-10-31 Kenneth Verstraete Crystal structure of flt3 ligand-receptor complex
EP2655413B1 (de) 2010-12-23 2019-01-16 F.Hoffmann-La Roche Ag Polypeptid-polynukleotid-komplex und verwendung bei der gezielten effektorrest-bereitstellung
US20140294828A1 (en) * 2011-01-06 2014-10-02 Complix Sa Alphabodies specifically binding to viral proteins and methods for producing the same
BR112013017363A2 (pt) * 2011-01-06 2016-08-30 Complix Sa biblioteca de alphabody de cadeia única, mistura de bibliotecas de alphabody, ácido nucleico ou biblioteca de vetor, biblioteca de células hospedeiras, uso de uma biblioteca de alphabody de cadeia única, método para a produção de uma biblioteca de alphabody de cadeia única, método para a produção de um ou mais polipeptídeos de alphabody de cadeia única, polipeptíceo de alphabody de cadeia única, ácido nucleico, vetor e célula hospedeira
JP6486686B2 (ja) 2012-02-10 2019-03-20 ジェネンテック， インコーポレイテッド 単鎖抗体及び他のヘテロ多量体
CN104395339A (zh) 2012-06-27 2015-03-04 弗·哈夫曼-拉罗切有限公司 用于选择并产生含有至少两种不同结合实体的定制高度选择性和多特异性靶向实体的方法及其用途
MX2014014804A (es) 2012-06-27 2015-02-12 Hoffmann La Roche Metodo para la elaboracion de conjugados de la region fc de anticuerpos que comprenden por lo menos una entidad de union que se une especificamente a un objetivo y usos del mismo.
AU2014211570A1 (en) 2013-01-29 2015-07-23 The University Court Of The University Of Glasgow Methods and means for increasing stress tolerance and biomass in plants
CA2917105C (en) 2013-07-01 2023-09-26 Bayer Cropscience Nv Methods and means for modulating flowering time in monocot plants
WO2016050512A1 (en) 2014-10-03 2016-04-07 Bayer Cropscience Nv Methods and means for increasing stress tolerance and biomass in plants
PL3227332T3 (pl) 2014-12-03 2020-06-15 F. Hoffmann-La Roche Ag Wielospecyficzne przeciwciała
AU2016336812A1 (en) 2015-10-16 2018-06-07 Bayer Cropscience Nv Brassica plants with altered properties in seed production
CN106831997B (zh) * 2015-12-03 2020-04-24 中国科学院苏州纳米技术与纳米仿生研究所 多肽、脂蛋白样纳米粒子及其应用
KR20210065086A (ko) 2018-07-12 2021-06-03 헥사머 테라퓨틱스, 인코포레이티드 자가-조립형 펩타이드 스캐폴드
KR20210087959A (ko) * 2018-11-02 2021-07-13 유니버시티 오브 워싱톤 직교 단백질 이종이량체
CN113943353B (zh) * 2021-10-27 2024-05-03 百葵锐(深圳)生物科技有限公司 一种宽应激范围的智能多肽及其应用

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Publication number Priority date Publication date Assignee Title
US5824483A (en) 1994-05-18 1998-10-20 Pence Inc. Conformationally-restricted combinatiorial library composition and method
US6303317B1 (en) 1997-01-28 2001-10-16 The Regents Of The University Of California Peptide probes and methods for making the same
ES2231991T3 (es) 1997-06-11 2005-05-16 Borean Pharma A/S Modulo de trimerizacion.
WO1999016883A2 (en) 1997-10-01 1999-04-08 Dana-Farber Cancer Institute STABILIZATION OF ENVELOPE GLYCOPROTEIN TRIMERS BY DISULFIDE BONDS INTRODUCED INTO A gp41 GLYCOPROTEIN ECTODOMAIN
US6828106B2 (en) * 1999-02-26 2004-12-07 Cyclacel Limited Methods and compositions using coiled binding partners
US6872806B1 (en) 1999-06-25 2005-03-29 The Governors Of The University Of Alberta Polypeptide compositions formed using a coiled-coil template and methods of use
ATE380822T1 (de) 1999-12-16 2007-12-15 Whitehead Biomedical Inst Funf-helix protein
AU2001269833A1 (en) 2000-06-14 2001-12-24 Cytovax Biotechnologies, Inc. Use of coiled-coil structural scaffold to generate structure-specific peptides
WO2005018666A1 (en) 2003-08-14 2005-03-03 The Government Of The United States Of America, As Represented By The Department Of Health And Human Services Polypeptide multimers having antiviral activity
US20080027006A1 (en) 2004-02-12 2008-01-31 The Regents Of The University Of Colorado Compositions And Methods For Modification And Prevention Of Sars Coronavirus Infectivity
CN1968710B (zh) 2004-06-01 2013-12-25 默沙东公司 HIV gp41融合中间体的稳定的肽模拟物
JP2012510806A (ja) 2008-12-08 2012-05-17 コンプリクス エン ヴェー 単鎖逆平行コイルドコイルタンパク質
GB2471692A (en) 2009-07-08 2011-01-12 Complix Nv HIV gp41-binding single-chain coiled-coil peptide comprising heptad repeats

Also Published As

Publication number Publication date
US9217011B2 (en) 2015-12-22
EP2188303A2 (de) 2010-05-26
EP2188303B1 (de) 2011-12-21
WO2009030780A3 (en) 2009-04-30
US20100305304A1 (en) 2010-12-02
WO2009030780A2 (en) 2009-03-12

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