MA51291A - Protéines de fusion il-2 fc modifiées - Google Patents

Protéines de fusion il-2 fc modifiées

Info

Publication number
MA51291A
MA51291A MA051291A MA51291A MA51291A MA 51291 A MA51291 A MA 51291A MA 051291 A MA051291 A MA 051291A MA 51291 A MA51291 A MA 51291A MA 51291 A MA51291 A MA 51291A
Authority
MA
Morocco
Prior art keywords
modified
fusion proteins
fusion
proteins
Prior art date
Application number
MA051291A
Other languages
English (en)
Inventor
Matthew J Bernett
John Desjarlais
Rumana Rashid
Suzanne Schubbert
Rajat Varma
Original Assignee
Xencor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xencor Inc filed Critical Xencor Inc
Publication of MA51291A publication Critical patent/MA51291A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
MA051291A 2017-12-19 2018-11-30 Protéines de fusion il-2 fc modifiées MA51291A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762607850P 2017-12-19 2017-12-19
US201862675070P 2018-05-22 2018-05-22

Publications (1)

Publication Number Publication Date
MA51291A true MA51291A (fr) 2020-10-28

Family

ID=65009801

Family Applications (1)

Application Number Title Priority Date Filing Date
MA051291A MA51291A (fr) 2017-12-19 2018-11-30 Protéines de fusion il-2 fc modifiées

Country Status (12)

Country Link
US (2) US11319355B2 (fr)
EP (1) EP3728302A1 (fr)
JP (2) JP2021506291A (fr)
KR (1) KR20200100098A (fr)
CN (1) CN111655718A (fr)
AU (2) AU2018390418B2 (fr)
CA (1) CA3086199A1 (fr)
IL (1) IL275426A (fr)
MA (1) MA51291A (fr)
MX (1) MX2020006322A (fr)
SG (1) SG11202005732XA (fr)
WO (1) WO2019125732A1 (fr)

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EP3630163A4 (fr) 2017-05-24 2021-06-09 Pandion Operations, Inc. Immunotolérance ciblée
US10174091B1 (en) 2017-12-06 2019-01-08 Pandion Therapeutics, Inc. IL-2 muteins
US10946068B2 (en) 2017-12-06 2021-03-16 Pandion Operations, Inc. IL-2 muteins and uses thereof
MX2021014178A (es) 2019-05-20 2022-01-04 Pandion Operations Inc Inmunotolerancia dirigida a la molecula de adhesion celular de adresina vascular de mucosas (madcam).
CN114245802A (zh) * 2019-06-20 2022-03-25 石药集团巨石生物制药有限公司 修饰的il-2蛋白、peg偶联物及其用途
KR20220044834A (ko) * 2019-08-15 2022-04-11 사이팀 테라퓨틱스, 인크. 변형된 인터루킨 2 (il-2) 폴리펩타이드, 컨쥬게이트 및 이의 용도
MX2022002171A (es) * 2019-08-22 2022-05-13 Cidara Therapeutics Inc Dominios fc variantes y usos de estos.
US11692020B2 (en) 2019-11-20 2023-07-04 Anwita Biosciences, Inc. Cytokine fusion proteins, and their pharmaceutical compositions and therapeutic applications
CN115023444A (zh) 2019-12-20 2022-09-06 再生元制药公司 新型il2激动剂及其使用方法
CA3162406A1 (fr) 2020-01-10 2021-07-15 Vijaya Raghavan PATTABIRAMAN Polypeptides il-2 modifies et leurs utilisations
JP2023526743A (ja) 2020-04-15 2023-06-23 アルカームス ファーマ アイルランド リミテッド 血管新生阻害剤と組み合わせた免疫刺激剤
PE20231648A1 (es) 2020-04-22 2023-10-17 Merck Sharp And Dohme Llc CONJUGADOS DE INTERLEUCINA 2 HUMANA SESGADOS AL DIMERO DEL RECEPTOR DE INTERLEUCINA 2 byc Y CONJUGADOS CON UN POLIMERO HIDROSOLUBLE NO PEPTIDICO
WO2021222150A2 (fr) 2020-04-28 2021-11-04 Anwita Biosciences, Inc. Polypeptides d'interleukine-2 et protéines de fusion de ceux-ci, ainsi que leurs compositions pharmaceutiques et leurs applications thérapeutiques
CN115768788A (zh) * 2020-07-09 2023-03-07 Eutilex股份有限公司 Il-2变体
TWI815194B (zh) 2020-10-22 2023-09-11 美商基利科學股份有限公司 介白素2-Fc融合蛋白及使用方法
CN116806225A (zh) * 2020-12-23 2023-09-26 默沙东有限责任公司 用于治疗自身免疫性和炎性疾病的il-2突变蛋白
KR20240041378A (ko) * 2021-07-09 2024-03-29 브라이트 피크 테라퓨틱스 아게 체크포인트 억제제와 il-2의 접합체 및 이의 용도
US20230183331A1 (en) * 2021-07-09 2023-06-15 Bright Peak Therapeutics Ag Modified tnf-alpha antibodies and uses thereof
WO2023001987A2 (fr) * 2021-07-22 2023-01-26 University Of Dundee Mutéines thérapeutiques
TW202320862A (zh) * 2021-09-22 2023-06-01 大陸商信達生物製藥（蘇州）有限公司 介白素２突變體以及其融合蛋白
WO2024037572A1 (fr) * 2022-08-16 2024-02-22 Kine Biotech Co., Ltd. Variants d'interleukine-2 et leurs utilisations dans le traitement de cancers
WO2024043643A1 (fr) * 2022-08-23 2024-02-29 머스트바이오 주식회사 Variant d'il2 et complexe protéique le comprenant
WO2024054868A1 (fr) * 2022-09-07 2024-03-14 Xencor, Inc. Protéine de fusion fc d'il-2 destinée à être utilisée dans des méthodes pour le traitement du psoriasis en plaque et de la dermatite atopique
CN116041539B (zh) * 2022-10-31 2023-07-21 山东博安生物技术股份有限公司 Il-2突变体免疫缀合物

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AU2018390418A1 (en) 2020-07-09
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