MX2014002289A - Anticuerpos fc especificos en tandem. - Google Patents
Anticuerpos fc especificos en tandem.Info
- Publication number
- MX2014002289A MX2014002289A MX2014002289A MX2014002289A MX2014002289A MX 2014002289 A MX2014002289 A MX 2014002289A MX 2014002289 A MX2014002289 A MX 2014002289A MX 2014002289 A MX2014002289 A MX 2014002289A MX 2014002289 A MX2014002289 A MX 2014002289A
- Authority
- MX
- Mexico
- Prior art keywords
- tandem
- binding sites
- tfc
- bispecific antibodies
- region
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Abstract
La presente proporciona anticuerpos FCs en tándem y Fc en tándem ("TFcAs"), por ejemplo, anticuerpos FC biespecíficos en tándem ("TFc-BAs"), los cuales comprenden uno o al menos dos sitios de unión que específicamente se unen a uno o más receptores de superficie de célula. Los sitios de unión están conectados través de un TFc, dicho TFc comprende una primera región Fc y segunda región Fc, en donde las primera y segunda regiones están enlazadas a través de un enlazador TFc para formar polipéptido contiguo y dimerizan para formar un dímero Fc. TFcBAs ilustrativos inhiben la transducción de señal a través receptor(es) de superficie de célula para el cual los sitios de unión del TFcBA son específicos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161527802P | 2011-08-26 | 2011-08-26 | |
PCT/US2012/052490 WO2013033008A2 (en) | 2011-08-26 | 2012-08-27 | Tandem fc bispecific antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2014002289A true MX2014002289A (es) | 2015-03-20 |
Family
ID=46759126
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014002289A MX2014002289A (es) | 2011-08-26 | 2012-08-27 | Anticuerpos fc especificos en tandem. |
Country Status (11)
Country | Link |
---|---|
US (2) | US20140294834A1 (es) |
EP (1) | EP2748197A2 (es) |
JP (1) | JP2015527869A (es) |
KR (1) | KR20140054268A (es) |
CN (1) | CN103857700A (es) |
AU (1) | AU2012300279A1 (es) |
CA (1) | CA2843158A1 (es) |
HK (1) | HK1199883A1 (es) |
IL (1) | IL230772A0 (es) |
MX (1) | MX2014002289A (es) |
WO (1) | WO2013033008A2 (es) |
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-
2012
- 2012-08-27 JP JP2014527352A patent/JP2015527869A/ja not_active Withdrawn
- 2012-08-27 KR KR1020147006964A patent/KR20140054268A/ko not_active Application Discontinuation
- 2012-08-27 MX MX2014002289A patent/MX2014002289A/es unknown
- 2012-08-27 WO PCT/US2012/052490 patent/WO2013033008A2/en active Application Filing
- 2012-08-27 EP EP12753368.5A patent/EP2748197A2/en not_active Withdrawn
- 2012-08-27 AU AU2012300279A patent/AU2012300279A1/en not_active Abandoned
- 2012-08-27 CN CN201280049900.4A patent/CN103857700A/zh active Pending
- 2012-08-27 CA CA2843158A patent/CA2843158A1/en not_active Abandoned
-
2014
- 2014-02-02 IL IL230772A patent/IL230772A0/en unknown
- 2014-02-20 US US14/185,628 patent/US20140294834A1/en not_active Abandoned
- 2014-12-11 HK HK14113159.4A patent/HK1199883A1/xx unknown
-
2016
- 2016-12-09 US US15/374,557 patent/US20170218028A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20170218028A1 (en) | 2017-08-03 |
IL230772A0 (en) | 2014-03-31 |
CA2843158A1 (en) | 2013-03-07 |
WO2013033008A9 (en) | 2013-06-13 |
KR20140054268A (ko) | 2014-05-08 |
EP2748197A2 (en) | 2014-07-02 |
JP2015527869A (ja) | 2015-09-24 |
CN103857700A (zh) | 2014-06-11 |
WO2013033008A2 (en) | 2013-03-07 |
AU2012300279A1 (en) | 2014-04-03 |
WO2013033008A3 (en) | 2013-04-25 |
HK1199883A1 (en) | 2015-07-24 |
US20140294834A1 (en) | 2014-10-02 |
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