MA41375A - Anticorps igg bispécifiques et leurs procédés de préparation - Google Patents

Anticorps igg bispécifiques et leurs procédés de préparation

Info

Publication number
MA41375A
MA41375A MA041375A MA41375A MA41375A MA 41375 A MA41375 A MA 41375A MA 041375 A MA041375 A MA 041375A MA 41375 A MA41375 A MA 41375A MA 41375 A MA41375 A MA 41375A
Authority
MA
Morocco
Prior art keywords
igg antibodies
preparation processes
bispecific igg
bispecific
processes
Prior art date
Application number
MA041375A
Other languages
English (en)
Inventor
Hector Aldaz
Shane Atwell
Stephen J Demarest
Karen J Froning
Brian Arthur Kuhlman
Andrew Philip Leaver-Fay
Original Assignee
Lilly Co Eli
Univ North Carolina Chapel Hill
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli, Univ North Carolina Chapel Hill filed Critical Lilly Co Eli
Publication of MA41375A publication Critical patent/MA41375A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/522—CH1 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
MA041375A 2015-01-22 2016-01-20 Anticorps igg bispécifiques et leurs procédés de préparation MA41375A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562106494P 2015-01-22 2015-01-22

Publications (1)

Publication Number Publication Date
MA41375A true MA41375A (fr) 2017-11-28

Family

ID=55358122

Family Applications (1)

Application Number Title Priority Date Filing Date
MA041375A MA41375A (fr) 2015-01-22 2016-01-20 Anticorps igg bispécifiques et leurs procédés de préparation

Country Status (5)

Country Link
US (2) US10774156B2 (fr)
EP (1) EP3247721B1 (fr)
ES (1) ES3031036T3 (fr)
MA (1) MA41375A (fr)
WO (1) WO2016118742A1 (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2970435B1 (fr) * 2013-03-15 2020-08-12 Eli Lilly and Company Procédés de production de fab et d'anticorps bispécifiques
DK3478830T3 (da) 2016-07-01 2024-05-21 Resolve Therapeutics Llc Optimerede binucleasefusioner og metoder
WO2018118616A1 (fr) 2016-12-22 2018-06-28 Eli Lilly And Company Procédés de production d'anticorps bispécifiques fabs et igg
JP7116736B2 (ja) 2017-03-02 2022-08-10 ノバルティス アーゲー 操作されたヘテロ二量体タンパク質
US20200155702A1 (en) 2017-06-16 2020-05-21 Eli Lilly And Company Engineered Antibody Compounds and Conjuates Thereof
MX2020002070A (es) 2017-08-22 2020-03-24 Sanabio Llc Receptores solubles de interferon y usos de los mismos.
DK3728328T5 (da) 2017-12-22 2025-02-17 Argenx Bvba Bispecifik antigenbindende konstruktion
GB201802487D0 (en) 2018-02-15 2018-04-04 Argenx Bvba Cytokine combination therapy
US20240132626A1 (en) * 2018-04-13 2024-04-25 Eli Lilly And Company Fab-Based Trispecific Antibodies
TWI722535B (zh) 2018-08-21 2021-03-21 美商美國禮來大藥廠 測定蛋白質或肽濃度的方法及其用途
US20220176011A1 (en) * 2019-02-18 2022-06-09 Lankenau Institute For Medical Research Scar reducing wound closure materials
KR20220017909A (ko) * 2019-05-09 2022-02-14 메뤼스 엔.페. 단백질 다량체화를 위한 변이체 도메인 및 그의 분리
WO2021046072A1 (fr) 2019-09-06 2021-03-11 Eli Lilly And Company Protéines comprenant des domaines constants de récepteur de lymphocytes t
US20230242671A1 (en) 2020-03-25 2023-08-03 Eli Lilly And Company Multispecific binding proteins and methods of developing the same
EP4271714A4 (fr) * 2021-01-11 2025-06-25 Adimab, LLC Domaines ch3 variants modifiés pour une hétérodimérisation ch3 préférentielle, anticorps multi-spécifiques les comprenant, et leurs procédés de fabrication
CN114106192B (zh) * 2021-12-20 2024-06-14 广州爱思迈生物医药科技有限公司 双特异性抗体及其应用
WO2025042709A1 (fr) 2023-08-22 2025-02-27 Eli Lilly And Company Agents d'arni de protéine précurseur amyloïde (app)
WO2025085352A1 (fr) 2023-10-18 2025-04-24 Eli Lilly And Company Protéines de liaison au récepteur de la transferrine et leurs utilisations
WO2025166111A1 (fr) 2024-02-02 2025-08-07 Eli Lilly And Company Conjugués comportant une protéine de liaison au récepteur de la transferrine
WO2025166107A1 (fr) 2024-02-02 2025-08-07 Eli Lilly And Company Agents arni de sarm1 ciblant le snc
WO2025224084A1 (fr) 2024-04-22 2025-10-30 Engimmune Therapeutics Ag Protéines comprenant des domaines constants du récepteur des lymphocytes t
WO2025250605A1 (fr) 2024-05-31 2025-12-04 Eli Lilly And Company Agents d'interférence d'arn acvr2a et acvr2b

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US573168A (en) 1896-12-15 silberman
US7754208B2 (en) * 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
US7754209B2 (en) * 2003-07-26 2010-07-13 Trubion Pharmaceuticals Binding constructs and methods for use thereof
US7476724B2 (en) 2004-08-05 2009-01-13 Genentech, Inc. Humanized anti-cmet antibodies
CN101198698B (zh) 2005-03-31 2014-03-19 中外制药株式会社 通过调节多肽缔合制备多肽的方法
SG170750A1 (en) 2006-03-17 2011-05-30 Biogen Idec Inc Stabilized polypeptide compositions
WO2007147901A1 (fr) 2006-06-22 2007-12-27 Novo Nordisk A/S Production d'anticorps bispécifiques
AU2008234248C1 (en) 2007-03-29 2015-01-22 Genmab A/S Bispecific antibodies and methods for production thereof
WO2009083009A2 (fr) * 2008-01-03 2009-07-09 Genmab A/S Anticorps monoclonaux anti-cd32b
AU2009204501B2 (en) 2008-01-07 2015-02-12 Amgen Inc. Method for making antibody Fc-heterodimeric molecules using electrostatic steering effects
WO2011028952A1 (fr) 2009-09-02 2011-03-10 Xencor, Inc. Compositions et procédés pour une co-liaison bivalente et monovalente simultanée d'antigènes
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AU2011325833C1 (en) 2010-11-05 2017-07-13 Zymeworks Bc Inc. Stable heterodimeric antibody design with mutations in the Fc domain
US9683052B2 (en) 2011-03-25 2017-06-20 Glenmark Pharmaceuticals S.A. Hetero-dimeric immunoglobulins
EP2748197A2 (fr) 2011-08-26 2014-07-02 Merrimack Pharmaceuticals, Inc. Anticorps bispécifiques à fc en tandem
WO2013063702A1 (fr) * 2011-11-04 2013-05-10 Zymeworks Inc. Structure d'anticorps hétérodimérique stable comprenant des mutations dans le domaine fc
UY35148A (es) 2012-11-21 2014-05-30 Amgen Inc Immunoglobulinas heterodiméricas
US9914785B2 (en) 2012-11-28 2018-03-13 Zymeworks Inc. Engineered immunoglobulin heavy chain-light chain pairs and uses thereof
EP2970435B1 (fr) 2013-03-15 2020-08-12 Eli Lilly and Company Procédés de production de fab et d'anticorps bispécifiques
TW201517916A (zh) 2013-03-15 2015-05-16 Lilly Co Eli Ｖｅｇｆｒ１抗體之治療用途
WO2014154254A1 (fr) 2013-03-26 2014-10-02 Nokia Solutions And Networks Oy Méthode et appareil
WO2016016299A1 (fr) * 2014-07-29 2016-02-04 F. Hoffmann-La Roche Ag Anticorps multispécifiques
EP3356420B1 (fr) * 2015-10-02 2023-11-01 F. Hoffmann-La Roche AG Anticorps multispécifiques
WO2018118616A1 (fr) * 2016-12-22 2018-06-28 Eli Lilly And Company Procédés de production d'anticorps bispécifiques fabs et igg
JP7116736B2 (ja) * 2017-03-02 2022-08-10 ノバルティス アーゲー 操作されたヘテロ二量体タンパク質
AR112341A1 (es) * 2017-08-02 2019-10-16 Lilly Co Eli ANTICUERPOS BIESPECÍFICOS ANTI-TNF- / ANTI-IL-23 DE IgG
US20240132626A1 (en) * 2018-04-13 2024-04-25 Eli Lilly And Company Fab-Based Trispecific Antibodies

Also Published As

Publication number Publication date
US11976136B2 (en) 2024-05-07
US10774156B2 (en) 2020-09-15
US20210054103A1 (en) 2021-02-25
WO2016118742A1 (fr) 2016-07-28
ES3031036T3 (en) 2025-07-03
EP3247721B1 (fr) 2025-05-07
US20180009908A1 (en) 2018-01-11
EP3247721A1 (fr) 2017-11-29

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