MA50949A - Anticorps anti-ctla-4 et leurs procédés d'utilisation - Google Patents

Anticorps anti-ctla-4 et leurs procédés d'utilisation

Info

Publication number
MA50949A
MA50949A MA050949A MA50949A MA50949A MA 50949 A MA50949 A MA 50949A MA 050949 A MA050949 A MA 050949A MA 50949 A MA50949 A MA 50949A MA 50949 A MA50949 A MA 50949A
Authority
MA
Morocco
Prior art keywords
ctla
antibodies
processes
Prior art date
Application number
MA050949A
Other languages
English (en)
Other versions
MA50949B1 (fr
Inventor
Jean-Marie Cuillerot
Mark Arthur Findeis
Taha Merghoub
Cornelia Anne Mundt
Igor Proscurshim
Gerd Ritter
David Adam Savitsky
David Schaer
Olga Shebanova
Dennis John Underwood
Dijk Marc Van
Nicholas Stuart Wilson
Jedd David Wolchok
Original Assignee
Agenus Inc
Ludwig Inst For Cancer Res Ltd
Memorial Sloan Kettering Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agenus Inc, Ludwig Inst For Cancer Res Ltd, Memorial Sloan Kettering Cancer Center filed Critical Agenus Inc
Publication of MA50949A publication Critical patent/MA50949A/fr
Publication of MA50949B1 publication Critical patent/MA50949B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
MA50949A 2016-12-07 2017-12-07 Anticorps anti-ctla-4 et leurs procédés d'utilisation MA50949B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662431272P 2016-12-07 2016-12-07
PCT/US2017/065011 WO2018106862A1 (fr) 2016-12-07 2017-12-07 Anticorps anti-ctla-4 et leurs procédés d'utilisation

Publications (2)

Publication Number Publication Date
MA50949A true MA50949A (fr) 2020-10-14
MA50949B1 MA50949B1 (fr) 2023-12-29

Family

ID=60782393

Family Applications (1)

Application Number Title Priority Date Filing Date
MA50949A MA50949B1 (fr) 2016-12-07 2017-12-07 Anticorps anti-ctla-4 et leurs procédés d'utilisation

Country Status (25)

Country Link
US (4) US11013802B2 (fr)
EP (2) EP4289484A3 (fr)
JP (3) JP6992068B2 (fr)
KR (2) KR20230037664A (fr)
CN (1) CN110248961A (fr)
AU (2) AU2017373944B2 (fr)
BR (1) BR112019011651A2 (fr)
CA (1) CA3046205A1 (fr)
DK (1) DK3551660T5 (fr)
EA (1) EA201991383A1 (fr)
ES (1) ES2963226T3 (fr)
FI (1) FI3551660T3 (fr)
HR (1) HRP20231579T1 (fr)
HU (1) HUE065144T2 (fr)
IL (2) IL266918B2 (fr)
LT (1) LT3551660T (fr)
MA (1) MA50949B1 (fr)
MD (1) MD3551660T2 (fr)
MX (2) MX2019006340A (fr)
PL (1) PL3551660T3 (fr)
PT (1) PT3551660T (fr)
RS (1) RS64909B1 (fr)
SG (1) SG10201912560YA (fr)
SI (1) SI3551660T1 (fr)
WO (1) WO2018106862A1 (fr)

Families Citing this family (26)

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KR102492532B1 (ko) * 2015-05-29 2023-01-30 아게누스 인코포레이티드 항-ctla-4 항체 및 이의 사용 방법
NL2017270B1 (en) * 2016-08-02 2018-02-09 Aduro Biotech Holdings Europe B V New anti-hCTLA-4 antibodies
EP4289484A3 (fr) 2016-12-07 2024-03-06 Agenus Inc. Anticorps anti-ctla-4 et leurs procédés d'utilisation
MA50948A (fr) 2016-12-07 2020-10-14 Agenus Inc Anticorps et procédés d'utilisation de ceux-ci
MX2020002076A (es) 2017-08-25 2020-03-24 Five Prime Therapeutics Inc Anticuerpos de b7-h4 y metodos para usarlos.
MX2020009037A (es) 2018-03-02 2021-01-08 Five Prime Therapeutics Inc Anticuerpos de b7-h4 y métodos para usarlos.
EP3617230A1 (fr) * 2018-09-03 2020-03-04 BioInvent International AB Nouvelles séquences d'anticorps et de nucléotides et utilisations associées
AU2019359812A1 (en) * 2018-10-15 2021-05-20 Board Of Regents, The University Of Texas System Monoclonal antibodies against human dickkopf3 and uses thereof
WO2020081497A1 (fr) * 2018-10-15 2020-04-23 Five Prime Therapeutics, Inc. Polythérapie contre le cancer
PT3880186T (pt) * 2018-11-14 2024-05-28 Regeneron Pharma Administração intralesional de inibidores de pd-1 para o tratamento do cancro de pele
US20230071889A1 (en) 2018-12-21 2023-03-09 Ose Immunotherapeutics Bifunctional anti-pd-1/il-7 molecule
US20220064301A1 (en) * 2018-12-26 2022-03-03 Xilio Development, Inc. Anti-ctla4 antibodies and methods of use thereof
WO2020165374A1 (fr) 2019-02-14 2020-08-20 Ose Immunotherapeutics Molécule bifonctionnelle comprenant il-15ra
US20210079094A1 (en) * 2019-03-29 2021-03-18 Xencor, Inc. Dosing of a bispecific antibody that binds pd1 and ctla4
AU2020406083A1 (en) 2019-12-17 2022-06-16 Ose Immunotherapeutics Bifunctional molecules comprising an IL-7 variant
AR122043A1 (es) * 2020-05-12 2022-08-03 Bristol Myers Squibb Co Dosificación y administración del anticuerpo anti-ctla-4 activable
CA3186108A1 (fr) * 2020-07-21 2022-01-27 Zhiwei Pan Anticorps anti-ctla-4 et son utilisation
CN116390949A (zh) * 2020-11-06 2023-07-04 百时美施贵宝公司 作为单一疗法给药和施用非岩藻糖基化抗ctla-4抗体
WO2022112198A1 (fr) 2020-11-24 2022-06-02 Worldwide Innovative Network Procédé de sélection des thérapies optimales par points de contrôle immunitaire
MX2023011964A (es) 2021-04-09 2024-01-08 Ose Immunotherapeutics Nuevo andamio para moléculas bifuncionales con propiedades mejoradas.
WO2022214652A1 (fr) 2021-04-09 2022-10-13 Ose Immunotherapeutics Échafaudage pour molécules bifonctionnelles comprenant des domaines de liaison pd-1 ou cd28 et sirp
WO2024003360A1 (fr) 2022-07-01 2024-01-04 Institut Curie Biomarqueurs et leurs utilisations pour le traitement du neuroblastome
WO2024028386A1 (fr) 2022-08-02 2024-02-08 Ose Immunotherapeutics Molécule multifonctionnelle dirigée contre cd28
WO2024049203A1 (fr) * 2022-09-02 2024-03-07 주식회사 시클리드 Anticorps monoclonal anti-ctla-4 et utilisation associée
WO2024091999A1 (fr) * 2022-10-25 2024-05-02 Seismic Therapeutic, Inc. Polypeptides igg fc variants et leurs utilisations
US12030945B2 (en) 2022-10-25 2024-07-09 Seismic Therapeutic, Inc. Variant IgG Fc polypeptides and uses thereof

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