MA43658A - Anticorps anti-ror1, anticorps bispécifiques ror1 x cd3, et leurs procédés d'utilisation - Google Patents

Anticorps anti-ror1, anticorps bispécifiques ror1 x cd3, et leurs procédés d'utilisation

Info

Publication number
MA43658A
MA43658A MA043658A MA43658A MA43658A MA 43658 A MA43658 A MA 43658A MA 043658 A MA043658 A MA 043658A MA 43658 A MA43658 A MA 43658A MA 43658 A MA43658 A MA 43658A
Authority
MA
Morocco
Prior art keywords
antibodies
mmr1
ror1
methods
bispecific antibodies
Prior art date
Application number
MA043658A
Other languages
English (en)
Inventor
Glenn Mark Anderson
Ricardo Attar
Eric T Baldwin
Rosa M F Cardoso
Francois Gaudet
Benjamin Harman
Yingzhe Li
Jinquan Luo
Ronan Mcdaid
Jennifer F Nemeth-Seay
Steven C Pomerantz
Susan H Tam
Alexey Teplyakov
Sheng-Jiun Wu
Original Assignee
Janssen Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Biotech Inc filed Critical Janssen Biotech Inc
Publication of MA43658A publication Critical patent/MA43658A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
MA043658A 2016-01-22 2017-01-19 Anticorps anti-ror1, anticorps bispécifiques ror1 x cd3, et leurs procédés d'utilisation MA43658A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662286121P 2016-01-22 2016-01-22

Publications (1)

Publication Number Publication Date
MA43658A true MA43658A (fr) 2018-11-28

Family

ID=57915166

Family Applications (1)

Application Number Title Priority Date Filing Date
MA043658A MA43658A (fr) 2016-01-22 2017-01-19 Anticorps anti-ror1, anticorps bispécifiques ror1 x cd3, et leurs procédés d'utilisation

Country Status (14)

Country Link
US (1) US20170210799A1 (fr)
EP (1) EP3405493A1 (fr)
JP (1) JP2019506158A (fr)
KR (1) KR20180100238A (fr)
CN (1) CN108495864A (fr)
AR (1) AR107442A1 (fr)
AU (1) AU2017209099A1 (fr)
BR (1) BR112018014760A2 (fr)
CA (1) CA3011419A1 (fr)
MA (1) MA43658A (fr)
MX (1) MX2018008934A (fr)
TW (1) TW201734049A (fr)
UY (1) UY37083A (fr)
WO (1) WO2017127499A1 (fr)

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HK1254836A1 (zh) 2015-10-30 2019-07-26 Nbe-Therapeutics Ag 抗-ror1抗体
MX2018008926A (es) 2016-01-20 2019-01-10 Scripps Research Inst Composiciones de anticuerpo contra ror1 y métodos relacionados.
AU2018289581C1 (en) 2017-06-23 2025-01-30 VelosBio Inc. ROR1 antibody immunoconjugates
GB201710835D0 (en) 2017-07-05 2017-08-16 Ucl Business Plc ROR1 Antibodies
GB201710838D0 (en) 2017-07-05 2017-08-16 Ucl Business Plc Bispecific antibodies
GB201710836D0 (en) 2017-07-05 2017-08-16 Ucl Business Plc ROR1 Car T-Cells
US20210139579A1 (en) * 2017-07-20 2021-05-13 Nbe-Therapeutics Ag Multispecific antibody product that binds to different ror1 epitopes
EP3665193A1 (fr) 2017-08-07 2020-06-17 NBE Therapeutics AG Conjugués anticorps-médicament à base d'anthracycline ayant une tolérabilité in vivo élevée
GB201721802D0 (en) 2017-12-22 2018-02-07 Almac Discovery Ltd Ror1-specific antigen binding molecules
CN112384533A (zh) * 2018-04-18 2021-02-19 埃克塞里艾克西斯公司 抗-ror抗体构建体
WO2019225777A1 (fr) 2018-05-23 2019-11-28 에이비엘바이오 주식회사 Anticorps anti-ror1 et son utilisation
US20220323598A1 (en) * 2018-08-01 2022-10-13 National University Corporation Tokai National Higher Education And Research System Anti-ror1 monoclonal antibody, functional fragment thereof, gene, drug delivery composition, and pharmaceutical composition
KR20210134321A (ko) * 2019-02-01 2021-11-09 노바록 바이오테라퓨틱스 리미티드 항-클라우딘 18 항체 및 이의 이용 방법
CA3139111A1 (fr) * 2019-05-23 2020-11-26 VelosBio Inc. Molecules de liaison bispecifiques anti-ror1/anti-cd3
CA3143242A1 (fr) * 2019-06-14 2020-12-17 Abl Bio Inc. Anticorps bispecifique dirige contre a-syn/igf1r et utilisation associee
MY207446A (en) 2019-08-12 2025-02-27 Abl Bio Inc Anti-claudin 18.2 and anti-4-1bb bispecific antibodies and uses thereof
WO2021101346A1 (fr) * 2019-11-21 2021-05-27 Dong-A St Co., Ltd. Anticorps bispécifiques anti-ror1/anti-4-1bb et leurs utilisations
WO2021101349A1 (fr) * 2019-11-21 2021-05-27 에이비엘바이오 주식회사 Anticorps se liant à ror1 et à b7-h3, conjugué anticorps-médicament le contenant et utilisation associée
CA3166286A1 (fr) 2020-02-07 2021-08-12 Jeffry D. Watkins Anticorps et compositions anti-ror1
TWI907489B (zh) * 2020-08-24 2025-12-11 香港商岸邁生物科技（香港）有限公司 抗ｒｏｒ１抗體及相關雙特異性結合蛋白
GB202020154D0 (en) 2020-12-18 2021-02-03 Almac Discovery Ltd ROR1-specific variant antigen binding molecules
KR20230166075A (ko) 2021-02-02 2023-12-06 누맙 세러퓨틱스 아게 Ror1 및 cd3에 대한 특이성을 가지는 다중 특이적 항체
WO2023000791A1 (fr) * 2021-07-23 2023-01-26 Zhejiang Shimai Pharmaceutical Co., Ltd. Anticorps contre ror1 et leurs utilisations
CN114605560B (zh) * 2022-03-30 2024-02-20 江苏蒙彼利生物科技有限公司 一种car-nk细胞及其制备方法与应用
TW202430553A (zh) * 2022-11-24 2024-08-01 中國大陸商上海藥明生物技術有限公司 Psma抗體及其用途
WO2024140980A1 (fr) * 2022-12-30 2024-07-04 上药生物治疗（香港）有限公司 Cellule exprimant un récepteur de chimiokine et son utilisation
EP4592319A1 (fr) * 2024-01-26 2025-07-30 Futuregen Biopharmaceutical (Beijing) Co., Ltd. Anticorps capables de se lier spécifiquement à tnf-like ligand 1a et leur utilisation
WO2026006495A1 (fr) 2024-06-25 2026-01-02 Alloy Therapeutics, Inc. Anticorps anti-wt1/hla-a2 et ses utilisations
WO2026006492A2 (fr) 2024-06-25 2026-01-02 Ypsilon Therapeutics, Inc. Anticorps anti-prame/hla-a2 et leurs utilisations

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EP1940881B1 (fr) 2005-10-11 2016-11-30 Amgen Research (Munich) GmbH Compositions comportant des anticorps specifiques d'especes croisees et leurs utilisations
AU2006317242A1 (en) 2005-11-28 2007-05-31 Genmab A/S Recombinant monovalent antibodies and methods for production thereof
EP2139924B1 (fr) 2007-03-29 2016-07-06 Genmab A/S Anticorps bispécifiques et procédés de production de ceux-ci
US20100260668A1 (en) 2008-04-29 2010-10-14 Abbott Laboratories Dual Variable Domain Immunoglobulins and Uses Thereof
EP2421899B1 (fr) * 2009-04-23 2016-06-08 The United States of America, as represented by The Secretary, Department of Health and Human Services Anticorps anti-ror1 humain
EP2496605A1 (fr) * 2009-11-02 2012-09-12 Oxford Biotherapeutics Ltd. Ror1 comme cible thérapeutique et diagnostique
CN102712695B (zh) * 2009-12-18 2015-01-21 堪瑟拉公司 能够诱导细胞死亡的ror1生物抑制剂
RU2606264C2 (ru) 2009-12-25 2017-01-10 Чугаи Сеияку Кабушики Каиша Способ полипептидной модификации для очистки полипептидных мультимеров
PL2560993T3 (pl) 2010-04-20 2024-11-04 Genmab A/S Heterodimeryczne białka zawierające region FC przeciwciała i sposoby ich wytwarzania
PT3434767T (pt) 2010-11-30 2026-01-23 Chugai Pharmaceutical Co Ltd Agente terapêutico indutor de citotoxicidade
WO2012075158A1 (fr) * 2010-12-01 2012-06-07 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anticorps ror1 chimériques lapin/humain
US20140170148A1 (en) 2011-04-20 2014-06-19 Genmab A/S Bispecific antibodies against her2
WO2012158818A2 (fr) 2011-05-16 2012-11-22 Fabion Pharmaceuticals, Inc. Protéines de fusion contenant un fab multi-spécifique et procédé d'utilisation
CN107827985A (zh) 2011-05-21 2018-03-23 宏观基因有限公司 能够与人和非人cd3结合的cd3结合分子
PH12013502531A1 (en) 2011-08-23 2014-01-20 Roche Glycart Ag Bispecific t cell activating antigen binding molecules
HRP20181355T1 (hr) 2011-08-23 2018-10-19 Roche Glycart Ag Bispecifične molekule koje se vežu na antigen
CN107586340B (zh) 2011-08-23 2022-01-21 罗切格利卡特公司 对t细胞活化性抗原和肿瘤抗原特异性的双特异性抗体及使用方法
AR087601A1 (es) 2011-08-23 2014-04-03 Roche Glycart Ag Anticuerpos sin fc que comprenden dos fragmentos fab y metodos de utilizacion
EP2787078B1 (fr) 2011-10-31 2019-05-22 Chugai Seiyaku Kabushiki Kaisha Molécule de liaison à un antigène à conjugaison régulée entre une chaîne lourde et une chaîne légère
US9758591B2 (en) * 2012-08-24 2017-09-12 The Regents Of The University Of California Antibodies and vaccines for use in treating ROR1 cancers and inhibiting metastasis
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EP2789630A1 (fr) 2013-04-09 2014-10-15 EngMab AG Anticorps bispécifiques contre le CD3e et ROR1
TWI742423B (zh) * 2014-05-29 2021-10-11 美商宏觀基因股份有限公司 特異性結合多種癌症抗原的三特異性結合分子和其使用方法

Also Published As

Publication number Publication date
KR20180100238A (ko) 2018-09-07
WO2017127499A1 (fr) 2017-07-27
US20170210799A1 (en) 2017-07-27
BR112018014760A2 (pt) 2018-12-26
CN108495864A (zh) 2018-09-04
EP3405493A1 (fr) 2018-11-28
AR107442A1 (es) 2018-05-02
JP2019506158A (ja) 2019-03-07
AU2017209099A1 (en) 2018-08-02
TW201734049A (zh) 2017-10-01
UY37083A (es) 2017-07-31
MX2018008934A (es) 2019-03-28
CA3011419A1 (fr) 2017-07-27

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