US5569A
(en)
|
|
1848-05-16 |
|
Corn-sheller |
US825A
(en)
|
|
1838-07-09 |
|
Bail way cooking-stove |
GB1429184A
(en)
|
1972-04-20 |
1976-03-24 |
Allen & Hanburys Ltd |
Physically anti-inflammatory steroids for use in aerosols
|
US4044126A
(en)
|
1972-04-20 |
1977-08-23 |
Allen & Hanburys Limited |
Steroidal aerosol compositions and process for the preparation thereof
|
US4444887A
(en)
|
1979-12-10 |
1984-04-24 |
Sloan-Kettering Institute |
Process for making human antibody producing B-lymphocytes
|
US4716111A
(en)
|
1982-08-11 |
1987-12-29 |
Trustees Of Boston University |
Process for producing human antibodies
|
GB8308235D0
(en)
|
1983-03-25 |
1983-05-05 |
Celltech Ltd |
Polypeptides
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
US5807715A
(en)
|
1984-08-27 |
1998-09-15 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
|
JP2532858B2
(ja)
|
1985-04-01 |
1996-09-11 |
セルテツク リミテツド |
形質転換したミエロ―マ細胞系
|
GB8601597D0
(en)
|
1986-01-23 |
1986-02-26 |
Wilson R H |
Nucleotide sequences
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
GB8607679D0
(en)
|
1986-03-27 |
1986-04-30 |
Winter G P |
Recombinant dna product
|
US5869620A
(en)
|
1986-09-02 |
1999-02-09 |
Enzon, Inc. |
Multivalent antigen-binding proteins
|
WO1988007089A1
(en)
|
1987-03-18 |
1988-09-22 |
Medical Research Council |
Altered antibodies
|
GB8717430D0
(en)
|
1987-07-23 |
1987-08-26 |
Celltech Ltd |
Recombinant dna product
|
US5677425A
(en)
|
1987-09-04 |
1997-10-14 |
Celltech Therapeutics Limited |
Recombinant antibody
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
EP1892296A1
(en)
|
1988-09-02 |
2008-02-27 |
Dyax Corporation |
Generation and selection of recombinant varied binding proteins
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
US5413923A
(en)
|
1989-07-25 |
1995-05-09 |
Cell Genesys, Inc. |
Homologous recombination for universal donor cells and chimeric mammalian hosts
|
GB8928874D0
(en)
|
1989-12-21 |
1990-02-28 |
Celltech Ltd |
Humanised antibodies
|
US5585112A
(en)
|
1989-12-22 |
1996-12-17 |
Imarx Pharmaceutical Corp. |
Method of preparing gas and gaseous precursor-filled microspheres
|
US5780225A
(en)
|
1990-01-12 |
1998-07-14 |
Stratagene |
Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules
|
WO1991010737A1
(en)
|
1990-01-11 |
1991-07-25 |
Molecular Affinities Corporation |
Production of antibodies using gene libraries
|
US6075181A
(en)
|
1990-01-12 |
2000-06-13 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
EP1690935A3
(en)
|
1990-01-12 |
2008-07-30 |
Abgenix, Inc. |
Generation of xenogeneic antibodies
|
IT1246382B
(it)
|
1990-04-17 |
1994-11-18 |
Eurand Int |
Metodo per la cessione mirata e controllata di farmaci nell'intestino e particolarmente nel colon
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
DK0546073T3
(da)
|
1990-08-29 |
1998-02-02 |
Genpharm Int |
Frembringelse og anvendelse af transgene, ikke-humane dyr, der er i stand til at danne heterologe antistoffer
|
US5814318A
(en)
|
1990-08-29 |
1998-09-29 |
Genpharm International Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
US5698426A
(en)
|
1990-09-28 |
1997-12-16 |
Ixsys, Incorporated |
Surface expression libraries of heteromeric receptors
|
US5543390A
(en)
|
1990-11-01 |
1996-08-06 |
State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University |
Covalent microparticle-drug conjugates for biological targeting
|
ATE164395T1
(de)
|
1990-12-03 |
1998-04-15 |
Genentech Inc |
Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften
|
CA2108147C
(en)
|
1991-04-10 |
2009-01-06 |
Angray Kang |
Heterodimeric receptor libraries using phagemids
|
DE69233482T2
(de)
|
1991-05-17 |
2006-01-12 |
Merck & Co., Inc. |
Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen
|
AU2238292A
(en)
|
1991-06-14 |
1993-01-12 |
Xoma Corporation |
Microbially-produced antibody fragments and their conjugates
|
DK0590058T3
(da)
|
1991-06-14 |
2004-03-29 |
Genentech Inc |
Humaniseret heregulin-antistof
|
US5637481A
(en)
|
1993-02-01 |
1997-06-10 |
Bristol-Myers Squibb Company |
Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell
|
US5851795A
(en)
|
1991-06-27 |
1998-12-22 |
Bristol-Myers Squibb Company |
Soluble CTLA4 molecules and uses thereof
|
US5565332A
(en)
|
1991-09-23 |
1996-10-15 |
Medical Research Council |
Production of chimeric antibodies - a combinatorial approach
|
WO1993011236A1
(en)
|
1991-12-02 |
1993-06-10 |
Medical Research Council |
Production of anti-self antibodies from antibody segment repertoires and displayed on phage
|
US5766886A
(en)
|
1991-12-13 |
1998-06-16 |
Xoma Corporation |
Modified antibody variable domains
|
GB9203459D0
(en)
|
1992-02-19 |
1992-04-08 |
Scotgen Ltd |
Antibodies with germ-line variable regions
|
GB9206422D0
(en)
|
1992-03-24 |
1992-05-06 |
Bolt Sarah L |
Antibody preparation
|
US5733743A
(en)
|
1992-03-24 |
1998-03-31 |
Cambridge Antibody Technology Limited |
Methods for producing members of specific binding pairs
|
US6174666B1
(en)
|
1992-03-27 |
2001-01-16 |
The United States Of America As Represented By The Department Of Health And Human Services |
Method of eliminating inhibitory/instability regions from mRNA
|
US6010715A
(en)
|
1992-04-01 |
2000-01-04 |
Bertek, Inc. |
Transdermal patch incorporating a polymer film incorporated with an active agent
|
US6024975A
(en)
|
1992-04-08 |
2000-02-15 |
Americare International Diagnostics, Inc. |
Method of transdermally administering high molecular weight drugs with a polymer skin enhancer
|
WO1993022332A2
(en)
|
1992-04-24 |
1993-11-11 |
Board Of Regents, The University Of Texas System |
Recombinant production of immunoglobulin-like domains in prokaryotic cells
|
DK1589107T3
(da)
|
1992-08-21 |
2010-04-26 |
Univ Bruxelles |
Immonuglobuliner uden lette kæder
|
US6005079A
(en)
|
1992-08-21 |
1999-12-21 |
Vrije Universiteit Brussels |
Immunoglobulins devoid of light chains
|
US5639641A
(en)
|
1992-09-09 |
1997-06-17 |
Immunogen Inc. |
Resurfacing of rodent antibodies
|
DK0672142T3
(da)
|
1992-12-04 |
2001-06-18 |
Medical Res Council |
Multivalente og multispecifikke bindingsproteiner samt fremstilling og anvendelse af disse
|
US6274552B1
(en)
|
1993-03-18 |
2001-08-14 |
Cytimmune Sciences, Inc. |
Composition and method for delivery of biologically-active factors
|
US5523092A
(en)
|
1993-04-14 |
1996-06-04 |
Emory University |
Device for local drug delivery and methods for using the same
|
US5985307A
(en)
|
1993-04-14 |
1999-11-16 |
Emory University |
Device and method for non-occlusive localized drug delivery
|
ES2162863T3
(es)
|
1993-04-29 |
2002-01-16 |
Unilever Nv |
Produccion de anticuerpos o fragmentos (funcionalizados) de los mismos derivados de inmunoglobulinas de cadena pesada de camelidae.
|
EP0714409A1
(en)
|
1993-06-16 |
1996-06-05 |
Celltech Therapeutics Limited |
Antibodies
|
US6004534A
(en)
|
1993-07-23 |
1999-12-21 |
Massachusetts Institute Of Technology |
Targeted polymerized liposomes for improved drug delivery
|
EP0733070A1
(en)
|
1993-12-08 |
1996-09-25 |
Genzyme Corporation |
Process for generating specific antibodies
|
US5997873A
(en)
|
1994-01-13 |
1999-12-07 |
Mount Sinai School Of Medicine Of The City University Of New York |
Method of preparation of heat shock protein 70-peptide complexes
|
DK0744958T3
(da)
|
1994-01-31 |
2003-10-20 |
Univ Boston |
Polyklonale antistofbiblioteker
|
US6719972B1
(en)
|
1994-06-03 |
2004-04-13 |
Repligen Corporation |
Methods of inhibiting T cell proliferation or IL-2 accumulation with CTLA4- specific antibodies
|
US5516637A
(en)
|
1994-06-10 |
1996-05-14 |
Dade International Inc. |
Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage
|
US5759542A
(en)
|
1994-08-05 |
1998-06-02 |
New England Deaconess Hospital Corporation |
Compositions and methods for the delivery of drugs by platelets for the treatment of cardiovascular and other diseases
|
US5660854A
(en)
|
1994-11-28 |
1997-08-26 |
Haynes; Duncan H |
Drug releasing surgical implant or dressing material
|
US5869046A
(en)
|
1995-04-14 |
1999-02-09 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
US6121022A
(en)
|
1995-04-14 |
2000-09-19 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
US5983134A
(en)
|
1995-04-23 |
1999-11-09 |
Electromagnetic Bracing Systems Inc. |
Electrophoretic cuff apparatus drug delivery system
|
DE69637481T2
(de)
|
1995-04-27 |
2009-04-09 |
Amgen Fremont Inc. |
Aus immunisierten Xenomäusen stammende menschliche Antikörper gegen IL-8
|
AU2466895A
(en)
|
1995-04-28 |
1996-11-18 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
US6316652B1
(en)
|
1995-06-06 |
2001-11-13 |
Kosta Steliou |
Drug mitochondrial targeting agents
|
US5811097A
(en)
|
1995-07-25 |
1998-09-22 |
The Regents Of The University Of California |
Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
|
US6167301A
(en)
|
1995-08-29 |
2000-12-26 |
Flower; Ronald J. |
Iontophoretic drug delivery device having high-efficiency DC-to-DC energy conversion circuit
|
US5935576A
(en)
|
1995-09-13 |
1999-08-10 |
Fordham University |
Compositions and methods for the treatment and prevention of neoplastic diseases using heat shock proteins complexed with exogenous antigens
|
GB9601081D0
(en)
|
1995-10-06 |
1996-03-20 |
Cambridge Antibody Tech |
Specific binding members for human transforming growth factor beta;materials and methods
|
WO1997014719A1
(en)
|
1995-10-16 |
1997-04-24 |
Unilever N.V. |
A bifunctional or bivalent antibody fragment analogue
|
US6039975A
(en)
|
1995-10-17 |
2000-03-21 |
Hoffman-La Roche Inc. |
Colon targeted delivery system
|
JP2978435B2
(ja)
|
1996-01-24 |
1999-11-15 |
チッソ株式会社 |
アクリロキシプロピルシランの製造方法
|
WO1997034631A1
(en)
|
1996-03-18 |
1997-09-25 |
Board Of Regents, The University Of Texas System |
Immunoglobin-like domains with increased half lives
|
TW345603B
(en)
|
1996-05-29 |
1998-11-21 |
Gmundner Fertigteile Gmbh |
A noise control device for tracks
|
US6027947A
(en)
|
1996-08-20 |
2000-02-22 |
Ramtron International Corporation |
Partially or completely encapsulated top electrode of a ferroelectric capacitor
|
US5985317A
(en)
|
1996-09-06 |
1999-11-16 |
Theratech, Inc. |
Pressure sensitive adhesive matrix patches for transdermal delivery of salts of pharmaceutical agents
|
EP1007012A4
(en)
|
1996-10-01 |
2006-01-18 |
Cima Labs Inc |
TASTE-MASKED MICRO-CAPSULE COMPOSITION AND MANUFACTURING PROCESS
|
US5916771A
(en)
|
1996-10-11 |
1999-06-29 |
Abgenix, Inc. |
Production of a multimeric protein by cell fusion method
|
US6131570A
(en)
|
1998-06-30 |
2000-10-17 |
Aradigm Corporation |
Temperature controlling device for aerosol drug delivery
|
WO1998023289A1
(en)
|
1996-11-27 |
1998-06-04 |
The General Hospital Corporation |
MODULATION OF IgG BINDING TO FcRn
|
ATE387495T1
(de)
|
1996-12-03 |
2008-03-15 |
Amgen Fremont Inc |
Vollkommen humane antikörper die egfr binden
|
US20060034844A1
(en)
|
1996-12-04 |
2006-02-16 |
The Regents Of The University Of California |
Stimulation of T cells against self antigens using CTLA-4 blocking agents
|
US6017540A
(en)
|
1997-02-07 |
2000-01-25 |
Fordham University |
Prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases with heat shock/stress protein-peptide complexes
|
US5860957A
(en)
|
1997-02-07 |
1999-01-19 |
Sarcos, Inc. |
Multipathway electronically-controlled drug delivery system
|
US6277375B1
(en)
|
1997-03-03 |
2001-08-21 |
Board Of Regents, The University Of Texas System |
Immunoglobulin-like domains with increased half-lives
|
US6120751A
(en)
|
1997-03-21 |
2000-09-19 |
Imarx Pharmaceutical Corp. |
Charged lipids and uses for the same
|
WO1998042752A1
(en)
|
1997-03-21 |
1998-10-01 |
Brigham And Women's Hospital Inc. |
Immunotherapeutic ctla-4 binding peptides
|
TR199902553T2
(xx)
|
1997-04-14 |
2000-03-21 |
Micromet Gesellschaft F�R Biomedizinische Forschung Mbh |
�nsan v�cuduna kar�� antijen resept�rlerinin �retimi i�in yeni metod ve kullan�mlar�.
|
US6060082A
(en)
|
1997-04-18 |
2000-05-09 |
Massachusetts Institute Of Technology |
Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery
|
US7951917B1
(en)
|
1997-05-02 |
2011-05-31 |
Genentech, Inc. |
Method for making multispecific antibodies having heteromultimeric and common components
|
US20020062010A1
(en)
|
1997-05-02 |
2002-05-23 |
Genentech, Inc. |
Method for making multispecific antibodies having heteromultimeric and common components
|
US6235883B1
(en)
|
1997-05-05 |
2001-05-22 |
Abgenix, Inc. |
Human monoclonal antibodies to epidermal growth factor receptor
|
US5948433A
(en)
|
1997-08-21 |
1999-09-07 |
Bertek, Inc. |
Transdermal patch
|
KR100719273B1
(ko)
|
1997-10-28 |
2007-05-18 |
반도 카가쿠 가부시키가이샤 |
피부 패치 시트 및 그것을 위한 베이스 시트의 제조 방법
|
US5948646A
(en)
|
1997-12-11 |
1999-09-07 |
Fordham University |
Methods for preparation of vaccines against cancer comprising heat shock protein-peptide complexes
|
US6852847B1
(en)
|
1998-03-19 |
2005-02-08 |
Heska Corporation |
Canine and feline B7-2 nucleic acid molecules and uses thereof
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
US6048736A
(en)
|
1998-04-29 |
2000-04-11 |
Kosak; Kenneth M. |
Cyclodextrin polymers for carrying and releasing drugs
|
PT1137436E
(pt)
|
1998-12-03 |
2008-09-15 |
Univ California |
Estimulação das células t contra auto-antigénios por meio de agentes bloqueadores de ctla-4
|
US6682736B1
(en)
|
1998-12-23 |
2004-01-27 |
Abgenix, Inc. |
Human monoclonal antibodies to CTLA-4
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
PL209786B1
(pl)
|
1999-01-15 |
2011-10-31 |
Genentech Inc |
Przeciwciało zawierające wariant regionu Fc ludzkiej IgG1, przeciwciało wiążące czynnik wzrostu śródbłonka naczyń oraz immunoadhezyna
|
US6271359B1
(en)
|
1999-04-14 |
2001-08-07 |
Musc Foundation For Research Development |
Tissue-specific and pathogen-specific toxic agents and ribozymes
|
US6256533B1
(en)
|
1999-06-09 |
2001-07-03 |
The Procter & Gamble Company |
Apparatus and method for using an intracutaneous microneedle array
|
WO2001014557A1
(en)
|
1999-08-23 |
2001-03-01 |
Dana-Farber Cancer Institute, Inc. |
Pd-1, a receptor for b7-4, and uses therefor
|
DE60033530T2
(de)
*
|
1999-08-24 |
2007-10-31 |
Medarex Inc. |
Humane antikörper gegen ctla-4 und deren verwendungen
|
US7605238B2
(en)
|
1999-08-24 |
2009-10-20 |
Medarex, Inc. |
Human CTLA-4 antibodies and their uses
|
PT1233987E
(pt)
|
1999-11-29 |
2009-12-28 |
Bac Ip B V |
Imobilização de moléculas de ligação ao antigénio de um domínio
|
WO2001039722A2
(en)
|
1999-11-30 |
2001-06-07 |
Mayo Foundation For Medical Education And Research |
B7-h1, a novel immunoregulatory molecule
|
AU2001233027A1
(en)
|
2000-01-27 |
2001-08-07 |
Genetics Institute, Llc |
Antibodies against ctla4 (cd152), conjugates comprising same, and uses thereof
|
EP1125905A1
(en)
|
2000-02-16 |
2001-08-22 |
Pepscan Systems B.V. |
Segment synthesis
|
US6261595B1
(en)
|
2000-02-29 |
2001-07-17 |
Zars, Inc. |
Transdermal drug patch with attached pocket for controlled heating device
|
US20030086932A1
(en)
|
2000-04-12 |
2003-05-08 |
Jeffrey A. Bluestone |
Surface-bound antigen binding portions of antibodies that bind to CTLA-4 and CD28 and uses therefor
|
EP1197755A1
(en)
|
2000-10-11 |
2002-04-17 |
Pepscan Systems B.V. |
Identification of protein binding sites
|
AU3942202A
(en)
|
2000-11-30 |
2002-06-11 |
Medarex Inc |
Transgenic transchromosomal rodents for making human antibodies
|
US7658921B2
(en)
|
2000-12-12 |
2010-02-09 |
Medimmune, Llc |
Molecules with extended half-lives, compositions and uses thereof
|
EP1355919B1
(en)
|
2000-12-12 |
2010-11-24 |
MedImmune, LLC |
Molecules with extended half-lives, compositions and uses thereof
|
AU2002230290B2
(en)
|
2001-02-16 |
2008-04-10 |
Pepscan Systems B.V. |
Arrays for determining binding of biomolecules
|
IL149701A0
(en)
*
|
2001-05-23 |
2002-11-10 |
Pfizer Prod Inc |
Use of anti-ctla-4 antibodies
|
MXPA05000511A
(es)
|
2001-07-12 |
2005-09-30 |
Jefferson Foote |
Anticuepros super humanizados.
|
EP1456652A4
(en)
|
2001-11-13 |
2005-11-02 |
Dana Farber Cancer Inst Inc |
IMMUNOCELL ACTIVATION MODULATING SUBSTANCES AND USE METHOD THEREFOR
|
AUPS054702A0
(en)
|
2002-02-14 |
2002-03-07 |
Immunaid Pty Ltd |
Cancer therapy
|
US20040132101A1
(en)
|
2002-09-27 |
2004-07-08 |
Xencor |
Optimized Fc variants and methods for their generation
|
US20040014194A1
(en)
|
2002-03-27 |
2004-01-22 |
Schering Corporation |
Beta-secretase crystals and methods for preparing and using the same
|
WO2003086459A1
(en)
|
2002-04-12 |
2003-10-23 |
Medarex, Inc. |
Methods of treatement using ctla-4 antibodies
|
AU2003234469A1
(en)
|
2002-05-02 |
2003-11-17 |
University Of Connecticut Health Center |
Use of heat shock proteins to enhance efficacy of antibody therapeutics
|
IL149820A0
(en)
|
2002-05-23 |
2002-11-10 |
Curetech Ltd |
Humanized immunomodulatory monoclonal antibodies for the treatment of neoplastic disease or immunodeficiency
|
EP2243493A1
(en)
|
2002-07-03 |
2010-10-27 |
Ono Pharmaceutical Co., Ltd. |
Immunopotentiative composition
|
JP2006500931A
(ja)
|
2002-09-30 |
2006-01-12 |
ファイザー・プロダクツ・インク |
高レベルのヒト配列抗体を産生するハイブリドーマ
|
MXPA05006828A
(es)
|
2002-12-23 |
2005-09-08 |
Wyeth Corp |
Anticuerpos contra pd-1, y sus usos.
|
US9068234B2
(en)
|
2003-01-21 |
2015-06-30 |
Ptc Therapeutics, Inc. |
Methods and agents for screening for compounds capable of modulating gene expression
|
US8388955B2
(en)
|
2003-03-03 |
2013-03-05 |
Xencor, Inc. |
Fc variants
|
US7465446B2
(en)
|
2003-05-30 |
2008-12-16 |
Medarex, Inc. |
Surrogate therapeutic endpoint for anti-CTLA4-based immunotherapy of disease
|
CA2537055A1
(en)
|
2003-08-22 |
2005-04-21 |
Medimmune, Inc. |
Humanization of antibodies
|
WO2005092380A2
(en)
|
2004-03-26 |
2005-10-06 |
Pfizer Products Inc |
Uses of anti-ctla-4 antibodies
|
US7494779B2
(en)
|
2004-06-14 |
2009-02-24 |
Li-Te Chin |
Method for producing human antibodies to human CD152 with properties of agonist, antagonist, or inverse agonist
|
US20060057626A1
(en)
|
2004-09-03 |
2006-03-16 |
Nichol Geoffrey M |
Assessment of CTLA-4 polymorphisms in CTLA-4 blockade therapy
|
EP1793858A4
(en)
|
2004-09-08 |
2008-12-10 |
Univ Ohio State Res Found |
HUMAN MONOCLONAL ANTI-CTLA4 ANTIBODIES FOR CANCER TREATMENT
|
DE102004063494A1
(de)
|
2004-12-23 |
2006-07-13 |
Tegenero Ag |
Antikörper
|
US20090110681A1
(en)
|
2005-03-08 |
2009-04-30 |
Pfizer, Inc. |
Anti-M-CSF Antibody Compositions
|
US20060240006A1
(en)
|
2005-04-20 |
2006-10-26 |
Chishih Chu |
Novel antibody structures derived from human germline sequences
|
SI2161336T1
(sl)
|
2005-05-09 |
2013-11-29 |
Ono Pharmaceutical Co., Ltd. |
Humana monoklonska protitelesa za programirano smrt 1 (PD-1) in postopki za zdravljenje raka ob uporabi anti-PD-1 protiteles samih ali v kombinaciji z drugimi imunoterapevtiki
|
JP2006327937A
(ja)
|
2005-05-23 |
2006-12-07 |
Ritsutoku Kin |
ヒト胚細胞系遺伝子構造を具えたヒト抗体構造及びその誘導フラグメント
|
NZ564243A
(en)
|
2005-06-08 |
2011-03-31 |
Dana Farber Cancer Inst Inc |
Methods and compositions for the treatment of persistent infections by inhibiting the programmed cell death 1 (PD-1) pathway
|
BRPI0613361A2
(pt)
|
2005-07-01 |
2011-01-04 |
Medarex Inc |
anticorpo monoclonal humano isolado, composição, imunoconjugado, molécula biespecìfica, molécula de ácido nucleico isolada, vetor de expressão, célula hospedeira, camundongo transgênico, método para modular uma resposta imune num indivìduo, método para inibir crescimento de células tumorais num indivìduo, método para tratar uma doença infecciosa num indivìduo, método para aumentar uma resposta imune a um antìgeno num indivìduo, método para tratar ou prevenir uma doença inflamatória num indivìduo e método para preparar o anticorpo anti-pd-l1
|
US20070243184A1
(en)
|
2005-11-08 |
2007-10-18 |
Steven Fischkoff |
Prophylaxis and treatment of enterocolitis associated with anti-ctla-4 antibody therapy
|
EP1954311A4
(en)
|
2005-12-07 |
2009-12-23 |
Medarex Inc |
CTLA-4 ANTIBODY DOSAGE ESCALATION THERAPY
|
HRP20131196T4
(hr)
|
2005-12-20 |
2022-06-10 |
Bristol-Myers Squibb Company |
Stabilne formulacije proteina
|
JP6092497B2
(ja)
|
2006-03-30 |
2017-03-08 |
ユニバーシティー オブ カリフォルニア |
抗ctla−4抗体の限局性分泌のための方法および組成物
|
US7919079B2
(en)
|
2006-03-31 |
2011-04-05 |
Biosante Pharmaceuticals, Inc. |
Cancer immunotherapy compositions and methods of use
|
EP2007423A2
(en)
|
2006-04-05 |
2008-12-31 |
Pfizer Products Incorporated |
Ctla4 antibody combination therapy
|
CN101074264B
(zh)
|
2006-05-17 |
2011-08-17 |
上海抗体药物国家工程研究中心有限公司 |
一种重组抗ctla4单克隆抗体及其制备方法和用途
|
AU2007331672A1
(en)
|
2006-12-15 |
2008-06-19 |
Ablynx N.V. |
Amino acid sequences that modulate the interaction between cells of the immune system
|
CN101663323A
(zh)
|
2006-12-27 |
2010-03-03 |
埃默里大学 |
用于治疗传染病和肿瘤的组合物和方法
|
US20100055111A1
(en)
|
2007-02-14 |
2010-03-04 |
Med. College Of Georgia Research Institute, Inc. |
Indoleamine 2,3-dioxygenase, pd-1/pd-l pathways, and ctla4 pathways in the activation of regulatory t cells
|
US9244059B2
(en)
|
2007-04-30 |
2016-01-26 |
Immutep Parc Club Orsay |
Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease
|
EP2535354B1
(en)
|
2007-06-18 |
2017-01-11 |
Merck Sharp & Dohme B.V. |
Antibodies to human programmed death receptor pd-1
|
ES2591281T3
(es)
|
2007-07-12 |
2016-11-25 |
Gitr, Inc. |
Terapias de combinación que emplean moléculas de enlazamiento a GITR
|
PE20120259A1
(es)
*
|
2007-08-09 |
2012-04-04 |
Boehringer Ingelheim Int |
Anticuerpos anti-cd37
|
CA3128656A1
(en)
|
2007-08-22 |
2009-02-26 |
The Regents Of The University Of California |
Activatable binding polypeptides and methods of identification and use thereof
|
US7968300B2
(en)
|
2007-11-21 |
2011-06-28 |
Li-Te Chin |
Method of isolating regulatory T cells from human samples
|
US8227577B2
(en)
|
2007-12-21 |
2012-07-24 |
Hoffman-La Roche Inc. |
Bivalent, bispecific antibodies
|
JP2011509299A
(ja)
|
2008-01-08 |
2011-03-24 |
ブリストル−マイヤーズ スクイブ カンパニー |
増殖性疾患治療のための、抗ctla−4抗体とチューブリン調節剤との組み合わせ
|
WO2009100140A1
(en)
*
|
2008-02-04 |
2009-08-13 |
Medarex, Inc. |
Anti-clta-4 antibodies with reduced blocking of binding of ctla-4 to b7 and uses thereof
|
CN104548091A
(zh)
|
2008-02-11 |
2015-04-29 |
治疗科技公司 |
用于肿瘤治疗的单克隆抗体
|
US8168757B2
(en)
|
2008-03-12 |
2012-05-01 |
Merck Sharp & Dohme Corp. |
PD-1 binding proteins
|
PE20110308A1
(es)
|
2008-07-08 |
2011-06-10 |
Incyte Corp |
1,2,5-oxadiazoles como inhibidores de indolamina 2,3-dioxigenasa
|
WO2010014784A2
(en)
|
2008-08-01 |
2010-02-04 |
Bristol-Myers Squibb Company |
Combination of anti-ctla4 antibody with diverse therapeutic regimens for the synergistic treatment of proliferative diseases
|
AR072999A1
(es)
|
2008-08-11 |
2010-10-06 |
Medarex Inc |
Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
|
ES2545609T3
(es)
|
2008-08-25 |
2015-09-14 |
Amplimmune, Inc. |
Composiciones de antagonistas de PD-1 y métodos de uso
|
US8927697B2
(en)
|
2008-09-12 |
2015-01-06 |
Isis Innovation Limited |
PD-1 specific antibodies and uses thereof
|
AU2009296392B2
(en)
|
2008-09-26 |
2016-06-02 |
Dana-Farber Cancer Institute, Inc. |
Human anti-PD-1, PD-L1, and PD-L2 antibodies and uses therefor
|
KR20210060670A
(ko)
|
2008-12-09 |
2021-05-26 |
제넨테크, 인크. |
항-pd-l1 항체 및 t 세포 기능을 향상시키기 위한 그의 용도
|
JP5851842B2
(ja)
|
2009-01-12 |
2016-02-03 |
サイトムエックス セラピューティクス, インク.CytomX Therapeutics, Inc. |
改変した抗体組成物、それを作製および使用する方法
|
GB0903325D0
(en)
|
2009-02-26 |
2009-04-08 |
Univ Aberdeen |
Antibody molecules
|
CN103833855A
(zh)
|
2009-06-26 |
2014-06-04 |
瑞泽恩制药公司 |
容易地分离的具有天然免疫球蛋白形式的双特异性抗体
|
EP3381937A3
(en)
|
2009-08-13 |
2018-10-31 |
The Johns Hopkins University |
Methods of modulating immune function
|
EP2488553B1
(en)
|
2009-10-12 |
2015-06-17 |
Pfizer Inc. |
Cancer treatment
|
GB0920258D0
(en)
|
2009-11-19 |
2010-01-06 |
Alligator Bioscience Ab |
New medical agents and use thereof
|
BR122021025338B1
(pt)
|
2009-11-24 |
2023-03-14 |
Medimmune Limited |
Anticorpo isolado ou fragmento de ligação do mesmo contra b7-h1, composição farmacêutica e seus usos
|
CN102134276A
(zh)
|
2010-01-22 |
2011-07-27 |
上海抗体药物国家工程研究中心有限公司 |
一种抗ctla-4嵌合抗体
|
CA2790134A1
(en)
|
2010-02-16 |
2011-08-25 |
Valorisation-Recherche, Limited Partnership |
Pd-1 modulation and uses thereof for modulating hiv replication
|
US8993731B2
(en)
|
2010-03-11 |
2015-03-31 |
Ucb Biopharma Sprl |
PD-1 antibody
|
JP2013528357A
(ja)
|
2010-03-29 |
2013-07-11 |
ザイムワークス,インコーポレイテッド |
強化又は抑制されたエフェクター機能を有する抗体
|
DE102011002045B4
(de)
|
2010-08-13 |
2014-09-11 |
Johnson Controls Gmbh |
Einsatz für Polsterausnehmung und Fahrzeugsitz
|
GB201103955D0
(en)
|
2011-03-09 |
2011-04-20 |
Antitope Ltd |
Antibodies
|
KR101970025B1
(ko)
|
2011-04-20 |
2019-04-17 |
메디뮨 엘엘씨 |
B7-h1 및 pd-1과 결합하는 항체 및 다른 분자들
|
US9328170B2
(en)
|
2011-05-25 |
2016-05-03 |
Merck Sharp & Dohme Corp. |
Method for preparing Fc containing polypeptides having improved properties
|
US9132281B2
(en)
|
2011-06-21 |
2015-09-15 |
The Johns Hopkins University |
Focused radiation for augmenting immune-based therapies against neoplasms
|
BR112013032552A2
(pt)
|
2011-07-24 |
2017-12-12 |
Curetech Ltd |
variantes de anticorpos monoclonais humanizados imunomoduladores
|
EP2742953B1
(en)
|
2011-08-11 |
2021-09-22 |
ONO Pharmaceutical Co., Ltd. |
Therapeutic agent for autoimmune diseases comprising pd-1 agonist
|
US8920075B2
(en)
|
2011-09-01 |
2014-12-30 |
Halo Maritime Defense Systems, Inc. |
Marine barrier and gate
|
WO2013043569A1
(en)
|
2011-09-20 |
2013-03-28 |
Vical Incorporated |
Synergistic anti-tumor efficacy using alloantigen combination immunotherapy
|
HUE051954T2
(hu)
|
2011-11-28 |
2021-03-29 |
Merck Patent Gmbh |
ANTI-PD-L1 ellenanyagok és alkalmazásaik
|
JP2015509592A
(ja)
|
2012-02-23 |
2015-03-30 |
スローン − ケッタリング インスティチュート フォー キャンサー リサーチ |
免疫調節治療剤を用いた処置に対する反応性の予測及びこのような処置の間のアブスコパル効果をモニターする方法
|
US20150079100A1
(en)
|
2012-03-23 |
2015-03-19 |
Bristol-Myers Squibb Company |
Methods of treatments using ctla-4 antibodies
|
EP3563865A3
(en)
|
2012-05-04 |
2019-12-04 |
Pfizer Inc |
Prostate-associated antigens and vaccine-based immunotherapy regimens
|
WO2013169388A1
(en)
|
2012-05-08 |
2013-11-14 |
H. Lee Moffitt Cancer Center And Research Institute, Inc. |
Predictive biomarkers for ctla-4 blockade therapy and for pd-1 blockade therapy
|
US9856320B2
(en)
|
2012-05-15 |
2018-01-02 |
Bristol-Myers Squibb Company |
Cancer immunotherapy by disrupting PD-1/PD-L1 signaling
|
WO2013181634A2
(en)
|
2012-05-31 |
2013-12-05 |
Sorrento Therapeutics Inc. |
Antigen binding proteins that bind pd-l1
|
US9856314B2
(en)
|
2012-06-22 |
2018-01-02 |
Cytomx Therapeutics, Inc. |
Activatable antibodies having non-binding steric moieties and methods of using the same
|
PE20150643A1
(es)
|
2012-06-22 |
2015-05-29 |
Cytomx Therapeutics Inc |
Anticuerpos de reaccion cruzada anti-jagged 1/jagged 2 anticuerpos anti-jagged activables y metodos de uso de los mismos
|
UY34887A
(es)
|
2012-07-02 |
2013-12-31 |
Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware |
Optimización de anticuerpos que se fijan al gen de activación de linfocitos 3 (lag-3) y sus usos
|
BR112015000167B1
(pt)
|
2012-07-06 |
2021-11-23 |
Genmab B.V. |
Proteína dimérica, proteína, composição, kit de partes e seus usos, bem como método para aumentar a oligomerização em solução de uma proteína dimérica compreendendo um primeiro e segundo polipeptídeo, cada um compreendendo pelo menos as regiões ch2 e ch3 de uma cadeia pesada de igg1 humana e proteína dimérica variante
|
WO2014022758A1
(en)
|
2012-08-03 |
2014-02-06 |
Dana-Farber Cancer Institute, Inc. |
Single agent anti-pd-l1 and pd-l2 dual binding antibodies and methods of use
|
KR101947702B1
(ko)
|
2012-10-04 |
2019-02-14 |
다나-파버 캔서 인스티튜트 인크. |
인간 단클론 항-pd-l1 항체 및 사용 방법
|
EP2912063A1
(en)
|
2012-10-23 |
2015-09-02 |
Bristol-Myers Squibb Company |
Combination of anti-kir and anti-ctla-4 antibodies to treat cancer
|
US10034939B2
(en)
|
2012-10-26 |
2018-07-31 |
The University Of Chicago |
Synergistic combination of immunologic inhibitors for the treatment of cancer
|
CN104968364A
(zh)
|
2012-12-03 |
2015-10-07 |
百时美施贵宝公司 |
强化免疫调变性Fc融合蛋白的抗癌活性
|
AR093984A1
(es)
|
2012-12-21 |
2015-07-01 |
Merck Sharp & Dohme |
Anticuerpos que se unen a ligando 1 de muerte programada (pd-l1) humano
|
RU2015132436A
(ru)
|
2013-01-04 |
2017-02-09 |
Сайтомкс Терапьютикс, Инк. |
Способы обнаружения активности протеазы в биологических системах и композиции для их осуществления
|
CA2902831C
(en)
|
2013-03-15 |
2023-04-25 |
Glaxosmithkline Intellectual Property Development Limited |
Anti-lag-3 binding proteins
|
ES2699599T3
(es)
|
2013-03-15 |
2019-02-11 |
Abbvie Biotherapeutics Inc |
Variantes de Fc
|
US20160075753A1
(en)
|
2013-04-30 |
2016-03-17 |
La Jolla Institute For Allergy And Immunology |
MODULATION OF REGULATORY T CELL FUNCTION VIA PROTEIN KINASE C-eta
|
DK2992017T3
(da)
|
2013-05-02 |
2021-01-25 |
Anaptysbio Inc |
Antistoffer rettet mod programmeret død-1 (pd-1)
|
CN111423511B
(zh)
|
2013-05-31 |
2024-02-23 |
索伦托药业有限公司 |
与pd-1结合的抗原结合蛋白
|
WO2014209804A1
(en)
|
2013-06-24 |
2014-12-31 |
Biomed Valley Discoveries, Inc. |
Bispecific antibodies
|
CN104250302B
(zh)
|
2013-06-26 |
2017-11-14 |
上海君实生物医药科技股份有限公司 |
抗pd‑1抗体及其应用
|
PT3021869T
(pt)
|
2013-07-16 |
2020-09-10 |
Hoffmann La Roche |
Métodos de tratamento do cancro com antagonistas da ligação ao eixo pd-1 e inibidores do tigit
|
AU2014296887A1
(en)
|
2013-08-02 |
2016-01-28 |
Aduro Biotech Holdings, Europe B.V. |
Combining CD27 agonists and immune checkpoint inhibition for immune stimulation
|
US20160200814A1
(en)
|
2013-08-22 |
2016-07-14 |
The Council Of The Queensland Institute Of Medical Research |
Immunoreceptor modulation for treating cancer and viral infections
|
WO2015035112A1
(en)
|
2013-09-05 |
2015-03-12 |
The Johns Hopkins University |
Cancer therapy via a combination of epigenetic modulation and immune modulation
|
WO2015036394A1
(en)
|
2013-09-10 |
2015-03-19 |
Medimmune Limited |
Antibodies against pd-1 and uses thereof
|
CN107011441B
(zh)
|
2013-09-13 |
2020-12-01 |
百济神州(广州)生物科技有限公司 |
抗pd1抗体及其作为治疗剂与诊断剂的用途
|
RS64268B1
(sr)
|
2013-09-20 |
2023-07-31 |
Bristol Myers Squibb Co |
Kombinacija anti-lag-3 antitela i anti-pd-1 antitela za lečenje tumora
|
EP3049442A4
(en)
|
2013-09-26 |
2017-06-28 |
Costim Pharmaceuticals Inc. |
Methods for treating hematologic cancers
|
CA2926853C
(en)
|
2013-10-18 |
2022-04-26 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions comprising a combination of a vegf antagonist and an anti-ctla-4 antibody
|
CN104558177B
(zh)
|
2013-10-25 |
2020-02-18 |
苏州思坦维生物技术股份有限公司 |
拮抗抑制程序性死亡受体pd-1与其配体结合的单克隆抗体及其编码序列与用途
|
EP3060581A4
(en)
|
2013-10-25 |
2017-06-07 |
Dana-Farber Cancer Institute, Inc. |
Anti-pd-l1 monoclonal antibodies and fragments thereof
|
AU2014346852A1
(en)
|
2013-11-05 |
2016-06-16 |
Cognate Bioservices, Inc. |
Combinations of checkpoint inhibitors and therapeutics to treat cancer
|
PT3081576T
(pt)
|
2013-12-12 |
2019-10-15 |
Jiangsu Hengrui Medicine Co |
Anticorpo pd-1, fragmento de ligação ao antigénio do mesmo e aplicação médica do mesmo
|
CN113603788A
(zh)
|
2014-01-15 |
2021-11-05 |
卡德门企业有限公司 |
免疫调节剂
|
TWI680138B
(zh)
|
2014-01-23 |
2019-12-21 |
美商再生元醫藥公司 |
抗pd-l1之人類抗體
|
DK3556775T3
(da)
|
2014-01-28 |
2022-01-03 |
Bristol Myers Squibb Co |
Anti-lag-3 antistoffer til behandling af hæmatologiske maligniteter
|
JP6731346B2
(ja)
|
2014-02-10 |
2020-07-29 |
メルク パテント ゲーエムベーハー |
標的TGFβ阻害
|
WO2015134605A1
(en)
|
2014-03-05 |
2015-09-11 |
Bristol-Myers Squibb Company |
Treatment of renal cancer using a combination of an anti-pd-1 antibody and another anti-cancer agent
|
CR20160425A
(es)
|
2014-03-14 |
2017-05-26 |
Novartis Ag |
Moléculas de anticuerpos que se unen a lag-3 y usos de las mismas
|
US20150283237A1
(en)
|
2014-04-02 |
2015-10-08 |
Mitchell S. Felder |
Ctla-4 blockade with metronomic chemotherapy for the treatment of cancer
|
KR20170003692A
(ko)
|
2014-05-15 |
2017-01-09 |
브리스톨-마이어스 스큅 컴퍼니 |
항-pd-1 항체 및 또 다른 항암제의 조합물을 사용한 폐암의 치료
|
CA2947932C
(en)
|
2014-05-29 |
2021-03-30 |
Spring Bioscience Corporation |
Pd-l1 antibodies and uses thereof
|
WO2015195163A1
(en)
|
2014-06-20 |
2015-12-23 |
R-Pharm Overseas, Inc. |
Pd-l1 antagonist fully human antibody
|
TWI693232B
(zh)
|
2014-06-26 |
2020-05-11 |
美商宏觀基因股份有限公司 |
與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法
|
KR102003754B1
(ko)
|
2014-07-03 |
2019-07-25 |
베이진 엘티디 |
Pd-l1 항체와 이를 이용한 치료 및 진단
|
CA2954841A1
(en)
|
2014-07-16 |
2016-01-21 |
Transgene Sa |
Oncolytic virus for expression of immune checkpoint modulators
|
CN105330740B
(zh)
|
2014-07-30 |
2018-08-17 |
珠海市丽珠单抗生物技术有限公司 |
抗pd-1抗体及其应用
|
CN105296433B
(zh)
|
2014-08-01 |
2018-02-09 |
中山康方生物医药有限公司 |
一种ctla4抗体、其药物组合物及其用途
|
DK3177644T3
(da)
|
2014-08-05 |
2021-01-11 |
MabQuest SA |
Immunologiske reagenser, som binder til PD-1
|
JO3663B1
(ar)
|
2014-08-19 |
2020-08-27 |
Merck Sharp & Dohme |
الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين
|
WO2016030455A1
(en)
|
2014-08-28 |
2016-03-03 |
Medimmune Limited |
Anti-b7-h1 and anti-ctla-4 antibodies for treating non-small lung cancer
|
PL3186283T3
(pl)
|
2014-08-29 |
2020-05-18 |
F. Hoffmann-La Roche Ag |
Terapia skojarzona z zastosowaniem skierowanej przeciw nowotworowi, opartej na wariancie IL2 immunocytokiny oraz przeciwciał przeciwko ludzkiemu ligandowi programowanej śmierci PD-L1
|
CN107206071A
(zh)
|
2014-09-13 |
2017-09-26 |
诺华股份有限公司 |
Alk抑制剂的联合疗法
|
US20170209574A1
(en)
|
2014-10-03 |
2017-07-27 |
Novartis Ag |
Combination therapies
|
ES2952717T3
(es)
|
2014-10-14 |
2023-11-03 |
Novartis Ag |
Moléculas de anticuerpos contra PD-L1 y usos de las mismas
|
WO2016075174A1
(en)
|
2014-11-11 |
2016-05-19 |
Medimmune Limited |
Therapeutic combinations for treating neoplasia
|
CA2966660A1
(en)
|
2014-11-13 |
2016-05-19 |
The Johns Hopkins University |
Checkpoint blockade and microsatellite instability
|
EP3233123A4
(en)
|
2014-12-16 |
2018-05-09 |
Bristol-Myers Squibb Company |
Use of immune checkpoint inhibitors in central nervous systems neoplasms
|
WO2016100882A1
(en)
|
2014-12-19 |
2016-06-23 |
Novartis Ag |
Combination therapies
|
JP6797803B2
(ja)
|
2014-12-31 |
2020-12-09 |
セルジーン コーポレイション |
ナチュラルキラー細胞を用いて血液障害、固形腫瘍、又は感染性疾患を治療する方法
|
EP3256165B1
(en)
|
2015-02-13 |
2021-07-14 |
Sorrento Therapeutics, Inc. |
Antibody therapeutics that bind ctla4
|
US10196445B1
(en)
|
2015-03-17 |
2019-02-05 |
Bristol-Myers Squibb Company |
Ipilimumab variant with enhanced ADCC
|
WO2016149387A1
(en)
|
2015-03-18 |
2016-09-22 |
The Johns Hopkins University |
Androgen deprivation with immune checkpoint blockade delays the development of castration resistant prostate cancer
|
WO2016168809A1
(en)
*
|
2015-04-17 |
2016-10-20 |
Krishnan Nandabalan |
Compositions and methods for preventing tumor growth and treating cancer by targeting lectin galactoside-binding soluble 3 binding protein
|
US20180134771A1
(en)
*
|
2015-05-07 |
2018-05-17 |
Bioxcel Corporation |
Novel immunomodulatory therapeutic strategies targeting tumors in cancer
|
WO2016183469A1
(en)
|
2015-05-13 |
2016-11-17 |
Robert Kirken |
Anti-ctla-4 blockade
|
US20160347848A1
(en)
|
2015-05-28 |
2016-12-01 |
Medimmune Limited |
Therapeutic combinations and methods for treating neoplasia
|
PT3303394T
(pt)
*
|
2015-05-29 |
2020-07-01 |
Ludwig Inst For Cancer Res Ltd |
Anticorpos anti-ctla-4 e métodos de uso dos mesmos
|
WO2016196389A1
(en)
|
2015-05-29 |
2016-12-08 |
Bristol-Myers Squibb Company |
Treatment of renal cell carcinoma
|
US10995140B2
(en)
|
2015-06-05 |
2021-05-04 |
H. Lee Moffitt Cancer Center And Research Institute, Inc. |
GM-CSF/CD40L vaccine and checkpoint inhibitor combination therapy
|
SI3322731T1
(sl)
|
2015-07-14 |
2021-03-31 |
Bristol-Myers Squibb Company |
Postopek za zdravljenje raka z uporabo imunskega inhibitorja kontrolne točke; protitelo ki veže programiran receptor smrti (PD-1) ali programiran smrtni ligand 1 (PD-L1)
|
US20180222990A1
(en)
|
2015-08-04 |
2018-08-09 |
Glaxosmithkline Intellectual Property Development Limited |
Combination Treatments and Uses and Methods Thereof
|
US20180230431A1
(en)
|
2015-08-07 |
2018-08-16 |
Glaxosmithkline Intellectual Property Development Limited |
Combination Therapy
|
KR20220131277A
(ko)
|
2015-09-01 |
2022-09-27 |
아게누스 인코포레이티드 |
항-pd-1 항체 및 이를 이용하는 방법
|
WO2017062615A2
(en)
|
2015-10-08 |
2017-04-13 |
Macrogenics, Inc. |
Combination therapy for the treatment of cancer
|
WO2017079303A1
(en)
|
2015-11-02 |
2017-05-11 |
The Cleveland Clinic Foundation |
Sequentially orchestrated immune checkpoint therapy for the treatment and prevention of cancer
|
MX2018006925A
(es)
|
2015-12-15 |
2018-08-01 |
Oncoimmune Inc |
Anticuerpos monoclonales anti-ctla4 humano quimericos y humanizados y sus usos.
|
WO2017117521A1
(en)
|
2015-12-31 |
2017-07-06 |
Berkeley Lights, Inc. |
Tumor infilitrating cells engineered to express a pro-inflammatory polypeptide
|
MA43587A
(fr)
|
2016-01-10 |
2018-11-14 |
Modernatx Inc |
Arnm thérapeutiques codant pour des anticorps anti-ctla-4
|
JP6970099B2
(ja)
|
2016-01-28 |
2021-11-24 |
アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル |
ガンの処置のための方法及び医薬組成物
|
US20170233476A1
(en)
|
2016-02-12 |
2017-08-17 |
Sorrento Therapeutics, Inc. |
Antibody Therapeutics That Bind CTLA4
|
EP3213768A1
(en)
|
2016-03-01 |
2017-09-06 |
LODOCO CLINICAL Kft |
Combination of low dose immune checkpoint blockade with high dose il-2 for treating metastatic cancer
|
JP2019507180A
(ja)
|
2016-03-04 |
2019-03-14 |
アイオー バイオテック エーピーエスIO Biotech ApS |
がんに対する組合せ療法
|
JP7208492B2
(ja)
|
2016-03-10 |
2023-01-19 |
シージー オンコロジー, インコーポレイテッド |
併用療法によって固形腫瘍又はリンパ系腫瘍を処置する方法
|
US20190077856A1
(en)
|
2016-03-15 |
2019-03-14 |
Memorial Sloan Kettering Cancer Center |
Method of treating diseases using kinase modulators
|
SG10201603721TA
(en)
|
2016-05-10 |
2017-12-28 |
Agency Science Tech & Res |
Anti-CTLA-4 Antibodies
|
CN107400166A
(zh)
|
2016-05-19 |
2017-11-28 |
苏州康宁杰瑞生物科技有限公司 |
针对ctla4的单域抗体及其衍生蛋白
|
ES2912131T3
(es)
|
2016-05-20 |
2022-05-24 |
Biohaven Therapeutics Ltd |
Uso de agentes moduladores del glutamato con inmunoterapias para tratar el cáncer
|
CN109475634A
(zh)
|
2016-06-03 |
2019-03-15 |
百时美施贵宝公司 |
用于治疗复发性小细胞肺癌的方法的抗-pd-1抗体
|
RU2767357C2
(ru)
*
|
2016-06-14 |
2022-03-17 |
Ксенкор, Инк. |
Биспецифические антитела-ингибиторы контрольных точек
|
US10711312B2
(en)
|
2016-07-12 |
2020-07-14 |
The Regents Of The University Of California |
Methods for immunotherapy-based treatment and assessment of cancer
|
JP7373991B2
(ja)
|
2016-07-15 |
2023-11-06 |
ビラクタ セラピューティクス,インク. |
免疫療法で使用するためのヒストン脱アセチル化酵素阻害剤
|
JP7239463B2
(ja)
|
2016-08-18 |
2023-03-14 |
ザ ユーエイビー リサーチ ファンデイション |
がん免疫療法のための組成物および方法
|
US10793632B2
(en)
*
|
2016-08-30 |
2020-10-06 |
Xencor, Inc. |
Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
|
EP3526259A4
(en)
|
2016-10-13 |
2020-06-17 |
Dana-Farber Cancer Institute, Inc. |
COMPOSITIONS AND METHODS FOR PREDICTING THE REACTION AND RESISTANCE TO A CTLA4 BLOCKAGE IN MELANOMAS USING A GENE EXPRESSION SIGNATURE
|
WO2018081621A1
(en)
|
2016-10-28 |
2018-05-03 |
Bristol-Myers Squibb Company |
Methods of treating urothelial carcinoma using an anti-pd-1 antibody
|
US11644467B2
(en)
|
2016-12-01 |
2023-05-09 |
Yale University |
Prediction of response to immune-modulatory therapies
|
CA3046082A1
(en)
|
2016-12-07 |
2018-06-14 |
Agenus Inc. |
Antibodies and methods of use thereof
|
AU2017373944B2
(en)
|
2016-12-07 |
2022-02-03 |
Agenus Inc. |
Anti-CTLA-4 antibodies and methods of use thereof
|
US11319372B2
(en)
|
2017-02-21 |
2022-05-03 |
Remd Biotherapeutics, Inc. |
Cancer treatment using antibodies that bind cytotoxic T-lymphocyte antigen-4 (CTLA-4)
|
JP2020509037A
(ja)
|
2017-02-28 |
2020-03-26 |
ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company |
ワクチンに対する免疫応答を増強するための、adccが増強された抗ctla−4抗体の使用
|
EP3597735A4
(en)
|
2017-03-15 |
2020-11-25 |
Suzhou Galaxy Biopharma, Co., Ltd. |
CTLA4 ANTIBODIES, PHARMACEUTICAL COMPOSITION AND USES THEREOF
|
WO2018178989A1
(en)
|
2017-03-30 |
2018-10-04 |
Tel Hashomer Medical Research Infrastructure And Services Ltd. |
Methods for treating melanoma
|
CN110505882A
(zh)
|
2017-03-31 |
2019-11-26 |
默沙东公司 |
用pd-1的拮抗剂和抗ctla4抗体的组合治疗癌症的组合物和方法
|
EP3619236A1
(en)
|
2017-05-02 |
2020-03-11 |
Alligator Bioscience AB |
Bispecific antibody against ox40 and ctla-4
|
WO2018204343A1
(en)
|
2017-05-02 |
2018-11-08 |
Merck Sharp & Dohme Corp. |
Stable formulations of anti-ctla4 antibodies alone and in combination with programmed death receptor 1 (pd-1) antibodies and methods of use thereof
|
EA201992755A1
(ru)
|
2017-05-19 |
2020-04-22 |
Уси Байолоджикс (Шанхай) Ко. Лтд. |
Новые моноклональные антитела к белку 4, ассоциированному с цитотоксическими т-лимфоцитами, (ctla-4)
|
JP2020525434A
(ja)
|
2017-06-22 |
2020-08-27 |
ムーンショット ファーマ エルエルシー |
アンレキサノクス及び免疫調節剤を含む組成物で癌を治療する方法
|
WO2018237173A1
(en)
|
2017-06-22 |
2018-12-27 |
Novartis Ag |
ANTIBODY MOLECULES DIRECTED AGAINST CD73 AND CORRESPONDING USES
|
TWI799432B
(zh)
|
2017-07-27 |
2023-04-21 |
美商再生元醫藥公司 |
抗ctla-4抗體及其用途
|
CN109420167B
(zh)
|
2017-08-28 |
2022-02-11 |
四川九章生物科技有限公司 |
一种治疗肿瘤的联合用药物
|
JP7145895B2
(ja)
|
2017-09-01 |
2022-10-03 |
四川科倫博泰生物医薬股▲フン▼有限公司 |
組換え二重特異性抗体
|
BR112020005496A2
(pt)
|
2017-09-21 |
2020-09-29 |
Eucure (Beijing) Biopharma Co., Ltd |
anticorpos anti-ctla4 e usos dos mesmos
|
EP3691694A4
(en)
|
2017-10-06 |
2021-07-07 |
The Wistar Institute Of Anatomy And Biology |
MONOCLONAL DNA ANTIBODIES AGAINST CTLA-4 FOR TREATMENT AND PREVENTION OF CANCER
|
EP3707164A4
(en)
|
2017-11-07 |
2021-11-24 |
Memorial Sloan-Kettering Cancer Center |
INHIBITION OF CTLA-4 AND / OR PD-1 FOR THE REGULATION OF T-LYMPHOCYTES
|
WO2019113072A1
(en)
|
2017-12-05 |
2019-06-13 |
Intendet Services, Inc. |
Immune-stimulating peptides and checkpoint inhibitors, and uses thereof for treating cancer
|